JP2015508648A5 - - Google Patents
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- JP2015508648A5 JP2015508648A5 JP2014557308A JP2014557308A JP2015508648A5 JP 2015508648 A5 JP2015508648 A5 JP 2015508648A5 JP 2014557308 A JP2014557308 A JP 2014557308A JP 2014557308 A JP2014557308 A JP 2014557308A JP 2015508648 A5 JP2015508648 A5 JP 2015508648A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- polypeptide
- antigen
- particle
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002245 particle Substances 0.000 claims 37
- 239000000427 antigen Substances 0.000 claims 29
- 102000036639 antigens Human genes 0.000 claims 29
- 108091007433 antigens Proteins 0.000 claims 29
- 229920001184 polypeptide Polymers 0.000 claims 28
- 102000004196 processed proteins & peptides Human genes 0.000 claims 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 12
- 241001502567 Chikungunya virus Species 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 241000700605 Viruses Species 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000003612 virological effect Effects 0.000 claims 4
- 241000710929 Alphavirus Species 0.000 claims 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 3
- 101710091045 Envelope protein Proteins 0.000 claims 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 3
- 101710188315 Protein X Proteins 0.000 claims 3
- 102100021696 Syncytin-1 Human genes 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 241000710946 Barmah Forest virus Species 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 2
- 241000710831 Flavivirus Species 0.000 claims 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 2
- 241000710951 Western equine encephalitis virus Species 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 241000178568 Aura virus Species 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 241000231314 Babanki virus Species 0.000 claims 1
- 241000868138 Cabassou virus Species 0.000 claims 1
- 108090000565 Capsid Proteins Proteins 0.000 claims 1
- 102100023321 Ceruloplasmin Human genes 0.000 claims 1
- 108010041986 DNA Vaccines Proteins 0.000 claims 1
- 229940021995 DNA vaccine Drugs 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 241000710945 Eastern equine encephalitis virus Species 0.000 claims 1
- 241000353621 Eilat virus Species 0.000 claims 1
- 206010066919 Epidemic polyarthritis Diseases 0.000 claims 1
- 241000465885 Everglades virus Species 0.000 claims 1
- 241000231322 Fort Morgan virus Species 0.000 claims 1
- 241000710948 Highlands J virus Species 0.000 claims 1
- 241000231318 Kyzylagach virus Species 0.000 claims 1
- 241000608292 Mayaro virus Species 0.000 claims 1
- 241000763097 Me Tri virus Species 0.000 claims 1
- 241000710949 Middelburg virus Species 0.000 claims 1
- 241000465889 Mosso das Pedras virus Species 0.000 claims 1
- 208000016222 Pancreatic disease Diseases 0.000 claims 1
- 241000710942 Ross River virus Species 0.000 claims 1
- 241001660014 Salmon pancreas disease virus Species 0.000 claims 1
- 241000710961 Semliki Forest virus Species 0.000 claims 1
- 241000710960 Sindbis virus Species 0.000 claims 1
- 241001472492 Southern elephant seal virus Species 0.000 claims 1
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims 1
- 241000868137 Tonate virus Species 0.000 claims 1
- 241000951300 Trocara virus Species 0.000 claims 1
- 241000608278 Una virus Species 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108091005573 modified proteins Proteins 0.000 claims 1
- 102000035118 modified proteins Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261599746P | 2012-02-16 | 2012-02-16 | |
| US61/599,746 | 2012-02-16 | ||
| PCT/JP2013/054422 WO2013122262A1 (en) | 2012-02-16 | 2013-02-15 | Virus like particle composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017202679A Division JP2018064556A (ja) | 2012-02-16 | 2017-10-19 | ウイルス様粒子組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508648A JP2015508648A (ja) | 2015-03-23 |
| JP2015508648A5 true JP2015508648A5 (OSRAM) | 2016-03-24 |
| JP6306518B2 JP6306518B2 (ja) | 2018-04-04 |
Family
ID=48984367
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014557308A Active JP6306518B2 (ja) | 2012-02-16 | 2013-02-15 | ウイルス様粒子組成物 |
| JP2017202679A Pending JP2018064556A (ja) | 2012-02-16 | 2017-10-19 | ウイルス様粒子組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017202679A Pending JP2018064556A (ja) | 2012-02-16 | 2017-10-19 | ウイルス様粒子組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9249191B2 (OSRAM) |
| EP (1) | EP2814847B1 (OSRAM) |
| JP (2) | JP6306518B2 (OSRAM) |
| KR (1) | KR102181258B1 (OSRAM) |
| CN (2) | CN113248626A (OSRAM) |
| AP (1) | AP2014007864A0 (OSRAM) |
| AR (1) | AR092796A1 (OSRAM) |
| AU (1) | AU2013221187B9 (OSRAM) |
| BR (1) | BR112014020052B8 (OSRAM) |
| CA (1) | CA2863695C (OSRAM) |
| MX (1) | MX357202B (OSRAM) |
| NZ (2) | NZ628206A (OSRAM) |
| RU (1) | RU2705301C2 (OSRAM) |
| SG (2) | SG10201606635SA (OSRAM) |
| TW (1) | TWI695844B (OSRAM) |
| WO (1) | WO2013122262A1 (OSRAM) |
| ZA (1) | ZA201405694B (OSRAM) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ628206A (en) | 2012-02-16 | 2016-03-31 | Vlp Therapeutics Llc | Virus like particle composition |
| EP2712871A1 (en) * | 2012-09-27 | 2014-04-02 | Institut Pasteur | Recombinant Measles virus expressing Chikungunya virus polypeptides and their applications |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| SG10201709917VA (en) * | 2013-06-03 | 2017-12-28 | Vlp Therapeutics Llc | Malaria vaccine |
| TWI676636B (zh) * | 2013-07-12 | 2019-11-11 | Ｖｌｐ醫療股份有限公司 | 包含ｐｄ－１抗原或ｐｄ－１配體抗原的類病毒粒子 |
| AU2014315287A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| TWI720946B (zh) * | 2014-08-08 | 2021-03-11 | 美商Ｖｌｐ醫療股份有限公司 | 包含改質套膜蛋白質ｅ３之類病毒粒子 |
| US10385101B2 (en) | 2014-08-08 | 2019-08-20 | Vlp Therapeutics, Llc | Virus like particle comprising modified envelope protein E3 |
| JP6942309B2 (ja) | 2014-09-11 | 2021-09-29 | ブイエルピー・セラピューティクス・インコーポレイテッドＶＬＰ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | フラビウイルスウイルス様粒子 |
| GB2535753A (en) * | 2015-02-26 | 2016-08-31 | The Native Antigen Company | Particles comprising fusion proteins |
| US10166281B2 (en) * | 2015-09-04 | 2019-01-01 | Vlp Therapeutics, Llc | Method and composition for modulating immune response |
| CN105176936B (zh) * | 2015-10-23 | 2019-01-11 | 中国科学院武汉物理与数学研究所 | 复制耐受型的西门利克森林病毒的亚克隆及制备方法和应用 |
| WO2017120222A1 (en) * | 2016-01-04 | 2017-07-13 | Cour Pharmaceuticals Development Company Inc. | Particles encapsulating fusion proteins containing linked epitopes |
| AU2017297610B2 (en) * | 2016-07-15 | 2020-03-12 | Etubics Corporation | Compositions and methods for alphavirus vaccination |
| KR101875055B1 (ko) * | 2016-10-19 | 2018-07-06 | 연세대학교 원주산학협력단 | 융합 단백질 및 그의 용도 |
| EP3589312A1 (en) * | 2017-03-03 | 2020-01-08 | New York University | Induction and enhancement of antitumor immunity involving virus vectors expressing multiple epitopes of tumor associated antigens and immune checkpoint inhibitors or proteins |
| JP2020518648A (ja) | 2017-05-08 | 2020-06-25 | グリットストーン オンコロジー インコーポレイテッド | アルファウイルス新生抗原ベクター |
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| WO2019156223A1 (ja) * | 2018-02-09 | 2019-08-15 | 国立大学法人大阪大学 | チクングニアウイルスに対する抗体またはその抗原結合断片、およびその用途 |
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| CN112852852B (zh) * | 2019-11-27 | 2023-07-25 | 中国医学科学院医学生物学研究所 | 一种ox40抗原表位重组病毒样颗粒及其制备方法和应用 |
| CN115867658A (zh) | 2020-04-17 | 2023-03-28 | Vlp治疗公司 | 冠状病毒疫苗 |
| EP4141110A4 (en) | 2020-04-24 | 2025-04-09 | Sf Biotech Laboratuvar Danismanlik Anonim Sirketi | Method for producing particles of bacteriophages of the genus levivirus |
| AU2021264216A1 (en) | 2020-04-30 | 2022-11-10 | Vlp Therapeutics, Inc. | Cytokine immunotherapy |
| WO2022032196A2 (en) | 2020-08-06 | 2022-02-10 | Gritstone Bio, Inc. | Multiepitope vaccine cassettes |
| US20220193225A1 (en) * | 2020-08-31 | 2022-06-23 | Bruce Lyday | Compositions and methods for sars-2 vaccine with virus replicative particles and recombinant glycoproteins |
| EP4554617A1 (en) | 2022-07-13 | 2025-05-21 | ModernaTX, Inc. | Norovirus mrna vaccines |
| WO2025029700A1 (en) | 2023-07-28 | 2025-02-06 | Modernatx, Inc. | Vlp enteroviral vaccines |
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-
2013
- 2013-02-15 NZ NZ628206A patent/NZ628206A/en not_active IP Right Cessation
- 2013-02-15 KR KR1020147025267A patent/KR102181258B1/ko active Active
- 2013-02-15 CN CN202110434277.5A patent/CN113248626A/zh active Pending
- 2013-02-15 BR BR112014020052A patent/BR112014020052B8/pt active IP Right Grant
- 2013-02-15 NZ NZ717682A patent/NZ717682A/en unknown
- 2013-02-15 CA CA2863695A patent/CA2863695C/en active Active
- 2013-02-15 EP EP13749307.8A patent/EP2814847B1/en active Active
- 2013-02-15 AU AU2013221187A patent/AU2013221187B9/en active Active
- 2013-02-15 JP JP2014557308A patent/JP6306518B2/ja active Active
- 2013-02-15 CN CN201380020165.9A patent/CN104220462A/zh active Pending
- 2013-02-15 WO PCT/JP2013/054422 patent/WO2013122262A1/en not_active Ceased
- 2013-02-15 MX MX2014009916A patent/MX357202B/es active IP Right Grant
- 2013-02-15 SG SG10201606635SA patent/SG10201606635SA/en unknown
- 2013-02-15 US US13/768,801 patent/US9249191B2/en active Active
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- 2013-02-18 TW TW102105497A patent/TWI695844B/zh active
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2014
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2015
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2017
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