JP2015506912A5 - - Google Patents

Info

Publication number

JP2015506912A5

JP2015506912A5 JP2014543533A JP2014543533A JP2015506912A5 JP 2015506912 A5 JP2015506912 A5 JP 2015506912A5 JP 2014543533 A JP2014543533 A JP 2014543533A JP 2014543533 A JP2014543533 A JP 2014543533A JP 2015506912 A5 JP2015506912 A5 JP 2015506912A5

Authority

JP

Japan

Prior art keywords

antibody

amino acid

seq

antigen

binding fragment

Prior art date

2012-11-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000012634 fragment Substances 0.000 claims 33
• 239000000427 antigen Substances 0.000 claims 30
• 102000036639 antigens Human genes 0.000 claims 30
• 108091007433 antigens Proteins 0.000 claims 30
• 125000003275 alpha amino acid group Chemical group 0.000 claims 25
• 235000001014 amino acid Nutrition 0.000 claims 14
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• 229940024606 amino acid Drugs 0.000 claims 12
• 238000006467 substitution reaction Methods 0.000 claims 12
• 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 7
• 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 7
• 125000000539 amino acid group Chemical group 0.000 claims 7
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• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 6
• 239000004473 Threonine Substances 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 6
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 5
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 5
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 5
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 5
• 239000004475 Arginine Substances 0.000 claims 4
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 4
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
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• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
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• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
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• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1