JP2015501814A5 - - Google Patents
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- JP2015501814A5 JP2015501814A5 JP2014546016A JP2014546016A JP2015501814A5 JP 2015501814 A5 JP2015501814 A5 JP 2015501814A5 JP 2014546016 A JP2014546016 A JP 2014546016A JP 2014546016 A JP2014546016 A JP 2014546016A JP 2015501814 A5 JP2015501814 A5 JP 2015501814A5
- Authority
- JP
- Japan
- Prior art keywords
- binding polypeptide
- amino acid
- acid sequence
- domain
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims 33
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims 13
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 9
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 230000003042 antagnostic effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 101100519721 Homo sapiens PDGFRB gene Proteins 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 101100519722 Mus musculus Pdgfrb gene Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000006471 dimerization reaction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 210000003668 pericyte Anatomy 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161566778P | 2011-12-05 | 2011-12-05 | |
| US61/566,778 | 2011-12-05 | ||
| US201261610905P | 2012-03-14 | 2012-03-14 | |
| US61/610,905 | 2012-03-14 | ||
| PCT/US2012/067909 WO2013085972A1 (en) | 2011-12-05 | 2012-12-05 | Pdgf receptor beta binding polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018216510A Division JP6843816B2 (ja) | 2011-12-05 | 2018-11-19 | Ｐｄｇｆ受容体ベータ結合ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501814A JP2015501814A (ja) | 2015-01-19 |
| JP2015501814A5 true JP2015501814A5 (enExample) | 2016-01-14 |
| JP6483442B2 JP6483442B2 (ja) | 2019-03-13 |
Family
ID=48574820
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546016A Active JP6483442B2 (ja) | 2011-12-05 | 2012-12-05 | Ｐｄｇｆ受容体ベータ結合ポリペプチド |
| JP2018216510A Expired - Fee Related JP6843816B2 (ja) | 2011-12-05 | 2018-11-19 | Ｐｄｇｆ受容体ベータ結合ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018216510A Expired - Fee Related JP6843816B2 (ja) | 2011-12-05 | 2018-11-19 | Ｐｄｇｆ受容体ベータ結合ポリペプチド |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9416179B2 (enExample) |
| EP (2) | EP2788379B1 (enExample) |
| JP (2) | JP6483442B2 (enExample) |
| CN (2) | CN107353342B (enExample) |
| AU (1) | AU2012347972B2 (enExample) |
| CA (1) | CA2857721C (enExample) |
| ES (1) | ES2784131T3 (enExample) |
| TW (2) | TWI591074B (enExample) |
| WO (1) | WO2013085972A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2609106T5 (es) | 2010-01-28 | 2020-11-10 | Eagle Pharmaceuticals Inc | Formulaciones de bendamustina |
| US9880160B2 (en) | 2011-03-15 | 2018-01-30 | X-Body, Inc. | Antibody screening methods |
| WO2013085972A1 (en) * | 2011-12-05 | 2013-06-13 | X-Body, Inc. | Pdgf receptor beta binding polypeptides |
| DK3533447T3 (da) | 2012-03-20 | 2023-04-24 | Eagle Pharmaceuticals Inc | Flydende bendamustinsammensætninger til anvendelse i fremgangsmåde til behandling af bendamustin-responsive tilstande hos patienter som kræver reducerede volumener til indgivelse |
| FI2827862T3 (fi) | 2012-03-20 | 2024-02-13 | Eagle Pharmaceuticals Inc | Bendamustiinin formulaatioita |
| WO2015109898A1 (zh) * | 2014-01-24 | 2015-07-30 | 上海恒瑞医药有限公司 | VEGF与PDGFRβ双特异性融合蛋白及其用途 |
| KR102399028B1 (ko) | 2014-03-21 | 2022-05-17 | 엑스-바디 인코포레이티드 | 이중-특이적 항원-결합 폴리펩티드 |
| PE20242042A1 (es) | 2017-06-02 | 2024-10-10 | Pfizer | Anticuerpos especificos para flt3 y sus usos |
| BR112021006352A2 (pt) * | 2018-10-05 | 2021-07-06 | Univ Ewha Ind Collaboration | anticorpo receptor de pdgf e uso do mesmo |
| JP2020146318A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146298A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146307A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146314A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146297A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146302A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146305A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146308A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146303A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146311A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146317A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146309A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146300A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146310A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146312A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| US11725058B2 (en) * | 2019-06-26 | 2023-08-15 | Ap Biosciences, Inc. | CD137 antibodies for T-cell activation |
| JP7774293B2 (ja) * | 2019-07-24 | 2025-11-21 | 国立研究開発法人科学技術振興機構 | 抗体酵素の革新的製造技術 |
| WO2021174127A1 (en) * | 2020-02-28 | 2021-09-02 | Apexigen, Inc. | Anti-sirpa antibodies and methods of use |
| CN114369163B (zh) * | 2022-02-18 | 2024-02-23 | 中国科学技术大学 | 与人血小板衍生生长因子受体β结合的羊驼源纳米抗体 |
| CN117986337B (zh) * | 2024-02-02 | 2024-08-16 | 杭州御寿生物科技有限公司 | 一种提高免疫力的益生菌组合物以及在治疗疾病中的应用 |
| CN121378405A (zh) * | 2025-11-28 | 2026-01-23 | 首都医科大学附属北京口腔医院 | 一种pdgfd衍生肽及其制备方法和应用 |
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-
2012
- 2012-12-05 WO PCT/US2012/067909 patent/WO2013085972A1/en not_active Ceased
- 2012-12-05 ES ES12856569T patent/ES2784131T3/es active Active
- 2012-12-05 TW TW101145785A patent/TWI591074B/zh active
- 2012-12-05 TW TW106112237A patent/TWI640537B/zh not_active IP Right Cessation
- 2012-12-05 EP EP12856569.4A patent/EP2788379B1/en active Active
- 2012-12-05 AU AU2012347972A patent/AU2012347972B2/en not_active Ceased
- 2012-12-05 CN CN201710700723.6A patent/CN107353342B/zh not_active Expired - Fee Related
- 2012-12-05 CA CA2857721A patent/CA2857721C/en active Active
- 2012-12-05 JP JP2014546016A patent/JP6483442B2/ja active Active
- 2012-12-05 US US13/705,978 patent/US9416179B2/en active Active
- 2012-12-05 CN CN201280068404.3A patent/CN104105708B/zh active Active
- 2012-12-05 EP EP20154280.0A patent/EP3712173B1/en active Active
-
2016
- 2016-07-11 US US15/207,188 patent/US10604578B2/en active Active
-
2018
- 2018-11-19 JP JP2018216510A patent/JP6843816B2/ja not_active Expired - Fee Related
-
2020
- 2020-02-17 US US16/792,728 patent/US11136398B2/en not_active Expired - Fee Related
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2021
- 2021-08-24 US US17/410,324 patent/US20220089748A1/en not_active Abandoned
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