|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5981216A
(en)
|
1985-04-01 |
1999-11-09 |
Alusuisse Holdings A.G. |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
WO1991000916A2
(en)
|
1989-07-06 |
1991-01-24 |
The Regents Of The University Of California |
Receptors for fibroblast growth factors
|
|
US5863888A
(en)
|
1990-07-06 |
1999-01-26 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Human Bek Fibroblast growth factor receptor
|
|
JP4124480B2
(ja)
|
1991-06-14 |
2008-07-23 |
ジェネンテック・インコーポレーテッド |
免疫グロブリン変異体
|
|
GB9603256D0
(en)
|
1996-02-16 |
1996-04-17 |
Wellcome Found |
Antibodies
|
|
AU3494397A
(en)
|
1996-06-18 |
1998-01-07 |
United States Of America, Represented By The Secretary, Department Of Health And Human Services, The |
Fibroblast growth factor receptor activating gene i and related compositions and methods
|
|
ES2244066T3
(es)
|
1997-06-24 |
2005-12-01 |
Genentech, Inc. |
Procedimiento y composiciones de glicoproteinas galactosiladas.
|
|
WO1999022764A1
(en)
|
1997-10-31 |
1999-05-14 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
|
WO1999029888A1
(en)
|
1997-12-05 |
1999-06-17 |
The Scripps Research Institute |
Humanization of murine antibody
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
ATE375365T1
(de)
|
1998-04-02 |
2007-10-15 |
Genentech Inc |
Antikörper varianten und fragmente davon
|
|
PT1071700E
(pt)
|
1998-04-20 |
2010-04-23 |
Glycart Biotechnology Ag |
Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos
|
|
EP1125584A4
(en)
|
1998-10-30 |
2005-01-12 |
Takeda Chemical Industries Ltd |
PREPARATIONS CONTAINING BETACELLULIN PROTEIN
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
ES2601882T5
(es)
|
1999-04-09 |
2021-06-07 |
Kyowa Kirin Co Ltd |
Procedimiento para controlar la actividad de una molécula inmunofuncional
|
|
HK1045700B
(zh)
|
1999-04-28 |
2007-07-27 |
德克萨斯大学董事会 |
用於通过选择性抑制vegf来治疗癌症的组合物和方法
|
|
CA2388245C
(en)
|
1999-10-19 |
2012-01-10 |
Tatsuya Ogawa |
The use of serum-free adapted rat cells for producing heterologous polypeptides
|
|
JP2001302699A
(ja)
|
2000-04-17 |
2001-10-31 |
Nichirei Corp |
ヒトkgfrに対する抗体
|
|
HU231090B1
(hu)
|
2000-10-06 |
2020-07-28 |
Kyowa Kirin Co., Ltd. |
Antitest-kompozíciót termelő sejt
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
|
AU2002329540A1
(en)
|
2001-06-20 |
2003-01-02 |
Morphosys Ag |
Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
|
|
EP1423510A4
(en)
|
2001-08-03 |
2005-06-01 |
Glycart Biotechnology Ag |
ANTIBODY GLYCOSYLATION VARIANTS WITH INCREASED ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY
|
|
HUP0600342A3
(en)
|
2001-10-25 |
2011-03-28 |
Genentech Inc |
Glycoprotein compositions
|
|
CN101357943A
(zh)
*
|
2001-10-25 |
2009-02-04 |
杰南技术公司 |
糖蛋白组合物
|
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
|
DK1469878T3
(da)
|
2002-01-31 |
2011-07-18 |
Max Planck Gesellschaft |
FGFR agonister
|
|
US20040132101A1
(en)
*
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US8093357B2
(en)
*
|
2002-03-01 |
2012-01-10 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
CN102911987B
(zh)
|
2002-04-09 |
2015-09-30 |
协和发酵麒麟株式会社 |
基因组被修饰的细胞
|
|
WO2003085119A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcϜ RECEPTOR IIIa
|
|
CA2481656A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells in which activity of the protein involved in transportation of gdp-fucose is reduced or lost
|
|
US20050031613A1
(en)
|
2002-04-09 |
2005-02-10 |
Kazuyasu Nakamura |
Therapeutic agent for patients having human FcgammaRIIIa
|
|
WO2003084569A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Drug containing antibody composition
|
|
CA2481837A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Production process for antibody composition
|
|
KR100493460B1
(ko)
|
2002-08-29 |
2005-06-07 |
재단법인서울대학교산학협력재단 |
암 세포에서 발현되는 fgfr2 이성체
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
DK2289936T3
(en)
|
2002-12-16 |
2017-07-31 |
Genentech Inc |
IMMUNGLOBULIN VARIATIONS AND APPLICATIONS THEREOF
|
|
RU2337107C2
(ru)
*
|
2003-05-02 |
2008-10-27 |
Ксенкор, Инк. |
ОПТИМИЗИРОВАННЫЕ Fc-ВАРИАНТЫ, ИМЕЮЩИЕ ИЗМЕНЕННОЕ СВЯЗЫВАНИЕ С FcγR, И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
|
|
WO2005035586A1
(ja)
|
2003-10-08 |
2005-04-21 |
Kyowa Hakko Kogyo Co., Ltd. |
融合蛋白質組成物
|
|
WO2005035778A1
(ja)
|
2003-10-09 |
2005-04-21 |
Kyowa Hakko Kogyo Co., Ltd. |
α1,6-フコシルトランスフェラーゼの機能を抑制するRNAを用いた抗体組成物の製造法
|
|
CA2762955A1
(en)
*
|
2003-10-16 |
2005-04-28 |
Imclone Llc |
Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof
|
|
US8268582B2
(en)
|
2003-10-22 |
2012-09-18 |
Keck Graduate Institute |
Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
|
|
DK2380910T3
(en)
|
2003-11-05 |
2015-10-19 |
Roche Glycart Ag |
Antigen binding molecules with increased Fc receptor binding affinity and effector function
|
|
WO2005053742A1
(ja)
|
2003-12-04 |
2005-06-16 |
Kyowa Hakko Kogyo Co., Ltd. |
抗体組成物を含有する医薬
|
|
WO2005066211A2
(en)
|
2003-12-19 |
2005-07-21 |
Five Prime Therapeutics, Inc. |
Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention
|
|
MXPA06011199A
(es)
|
2004-03-31 |
2007-04-16 |
Genentech Inc |
Anticuerpos anti-tgf-beta humanizados.
|
|
US7872016B2
(en)
|
2004-05-25 |
2011-01-18 |
Yale University |
Method for treating skeletal disorders resulting from FGFR malfunction
|
|
US20080286834A1
(en)
|
2005-01-27 |
2008-11-20 |
Robert Forgan Halenbeck |
Leader Sequences For Directing Secretion of Polypeptides and Methods For Production Thereof
|
|
US8207303B2
(en)
*
|
2005-02-18 |
2012-06-26 |
Medarex, Inc. |
Monoclonal antibodies against CD30 lacking in fucosyl residues
|
|
US7923538B2
(en)
|
2005-07-22 |
2011-04-12 |
Kyowa Hakko Kirin Co., Ltd |
Recombinant antibody composition
|
|
US7890267B2
(en)
|
2006-03-31 |
2011-02-15 |
Ordway Research Institute |
Prognostic and diagnostic method for cancer therapy
|
|
EP2018442A2
(en)
|
2006-05-12 |
2009-01-28 |
Genentech, Inc. |
Methods and compositions for the diagnosis and treatment of cancer
|
|
CA2655246A1
(en)
*
|
2006-06-09 |
2007-12-21 |
University Of Maryland, Baltimore |
Glycosylation engineered antibody therapy
|
|
EP2046384A4
(en)
|
2006-06-15 |
2009-12-02 |
Fibron Ltd |
ANTIBODIES BLOCKING FIBROBLAST GROWTH FACTOR RECEPTOR ACTIVATION AND METHODS OF USING THE SAME
|
|
AR062223A1
(es)
*
|
2006-08-09 |
2008-10-22 |
Glycart Biotechnology Ag |
Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
|
|
AU2007305443B2
(en)
|
2006-09-29 |
2012-08-23 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
|
JP5570218B2
(ja)
|
2006-11-03 |
2014-08-13 |
ユースリー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Fgfr4抗体
|
|
PE20081250A1
(es)
|
2006-11-28 |
2008-10-07 |
Centelion |
FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA
|
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
|
WO2008079849A2
(en)
|
2006-12-22 |
2008-07-03 |
Genentech, Inc. |
Antibodies to insulin-like growth factor receptor
|
|
KR101578940B1
(ko)
|
2007-01-24 |
2015-12-18 |
교와 핫꼬 기린 가부시키가이샤 |
이펙터 활성이 증강된 유전자 재조합 항체 조성물
|
|
AU2008230880B2
(en)
|
2007-03-23 |
2014-04-24 |
The Translational Genomics Research Institute |
Method of diagnosing, classifying and treating endometrial cancer and precancer
|
|
WO2008121876A2
(en)
*
|
2007-03-28 |
2008-10-09 |
Biogen Idec Inc. |
Non-fucosylated antibodies
|
|
EP2205277B1
(en)
|
2007-10-22 |
2017-07-26 |
Genmab A/S |
Novel antibody therapies
|
|
WO2012021841A2
(en)
|
2010-08-12 |
2012-02-16 |
Attogen Inc. |
Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof
|
|
US20110059091A1
(en)
|
2008-02-04 |
2011-03-10 |
Xiao-Jia Chang |
Inhibitors of oncogenic isoforms and uses thereof
|
|
US9260525B2
(en)
|
2008-02-04 |
2016-02-16 |
Xiao-Jia Chang |
Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof
|
|
EP2259636B1
(en)
|
2008-03-26 |
2018-11-14 |
NEC Corporation |
Radio resource control method, radio station device, recording medium containing radio station control program, and radio communication system
|
|
CA2727247A1
(en)
*
|
2008-06-10 |
2009-12-17 |
University Of Southern California |
Thymidylate synthase haplotype is associated with tumor recurrence in stage ii and stage iii colon cancer patients
|
|
EP2177615A1
(en)
|
2008-10-10 |
2010-04-21 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases
|
|
LT3290052T
(lt)
|
2008-11-07 |
2020-02-25 |
Galaxy Biotech, Llc |
Monokloniniai antikūnai fibroblastų augimo faktoriaus receptoriui 2
|
|
US20120301482A1
(en)
|
2009-08-25 |
2012-11-29 |
National Jewish Health |
Methods and compositions for treatment of lung injury
|
|
PL2486141T3
(pl)
*
|
2009-10-07 |
2018-07-31 |
Macrogenics, Inc. |
Polipeptydy zawierające regiony fc i mające w wyniku zmian w zakresie fukozylacji ulepszoną funkcję efektorową, i sposoby zastosowania tych polipeptydów
|
|
US8664365B2
(en)
*
|
2009-10-14 |
2014-03-04 |
Kalobios Pharmaceuticals, Inc. |
Antibodies to EphA3
|
|
CA2786276A1
(en)
|
2010-01-14 |
2011-07-21 |
Yale University |
Inhibitors of receptor tyrosine kinases (rtk) and methods of use thereof
|
|
US9140689B2
(en)
|
2010-03-14 |
2015-09-22 |
Translational Genomics Research Institute |
Methods of determining susceptibility of tumors to tyrosine kinase inhibitors
|
|
JP2013529076A
(ja)
|
2010-05-11 |
2013-07-18 |
アベオ ファーマシューティカルズ, インコーポレイテッド |
抗fgfr2抗体
|
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
US20120258496A1
(en)
*
|
2010-09-27 |
2012-10-11 |
Boehringer Ingelheim International Gmbh |
Production of low fucose antibodies in h4-ii-e rat cells
|
|
EP3219731A1
(en)
*
|
2010-10-01 |
2017-09-20 |
Oxford BioTherapeutics Ltd |
Anti-ror1 antibodies
|
|
EP2714738B1
(en)
|
2011-05-24 |
2018-10-10 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
|
AR088941A1
(es)
|
2011-11-23 |
2014-07-16 |
Bayer Ip Gmbh |
Anticuerpos anti-fgfr2 y sus usos
|
|
KR20140114826A
(ko)
|
2011-12-14 |
2014-09-29 |
시애틀 지네틱스, 인크. |
Fgfr 항체 약물 콘주게이트 (adcs) 및 그의 용도
|
|
PL2831110T3
(pl)
*
|
2012-03-30 |
2018-11-30 |
The Regents Of The University Of California |
Terapia anty-EMP2 zmniejsza ilość rakowych komórek macierzystych
|
|
CA2870126C
(en)
|
2012-04-09 |
2020-10-27 |
Daiichi Sankyo Company, Limited |
Anti-fgfr2 antibody
|
|
US9254288B2
(en)
|
2012-05-07 |
2016-02-09 |
The Translational Genomics Research Institute |
Susceptibility of tumors to tyrosine kinase inhibitors and treatment thereof
|
|
SG10201700698WA
(en)
|
2012-05-15 |
2017-02-27 |
Bristol Myers Squibb Co |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
|
EP2871236A4
(en)
|
2012-07-05 |
2016-03-09 |
Nat Cancer Ct |
FGFR2 fusion
|
|
WO2014089193A1
(en)
|
2012-12-04 |
2014-06-12 |
Aveo Pharmaceuticals, Inc. |
Anti-fgfr2 antibodies
|
|
CA3150658A1
(en)
|
2013-01-18 |
2014-07-24 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
|
US9498532B2
(en)
|
2013-03-13 |
2016-11-22 |
Novartis Ag |
Antibody drug conjugates
|
|
US9415118B2
(en)
|
2013-03-13 |
2016-08-16 |
Novartis Ag |
Antibody drug conjugates
|
|
SG11201508878WA
(en)
|
2013-05-01 |
2015-11-27 |
Five Prime Therapeutics Inc |
Methods of treating cancer
|
|
JP6696896B2
(ja)
|
2013-06-13 |
2020-05-20 |
ユニバーシティ オブ サウス オーストラリアUniversity of South Australia |
前立腺癌を検出する方法
|
|
NZ715201A
(en)
*
|
2013-08-01 |
2021-12-24 |
Five Prime Therapeutics Inc |
Afucosylated anti-fgfr2iiib antibodies
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
US20170175197A1
(en)
|
2014-01-29 |
2017-06-22 |
Caris Mpi, Inc. |
Molecular profiling of immune modulators
|
|
KR20170080675A
(ko)
|
2014-11-05 |
2017-07-10 |
제넨테크, 인크. |
항-fgfr2/3 항체 및 이의 이용 방법
|
|
WO2016100882A1
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Combination therapies
|
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
|
EP3380523A1
(en)
|
2015-11-23 |
2018-10-03 |
Five Prime Therapeutics, Inc. |
Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment
|
|
EP4650004A2
(en)
|
2017-05-16 |
2025-11-19 |
Five Prime Therapeutics, Inc. |
Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
|