JP2016527273A5 - - Google Patents

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JP2016527273A5
JP2016527273A5 JP2016531878A JP2016531878A JP2016527273A5 JP 2016527273 A5 JP2016527273 A5 JP 2016527273A5 JP 2016531878 A JP2016531878 A JP 2016531878A JP 2016531878 A JP2016531878 A JP 2016531878A JP 2016527273 A5 JP2016527273 A5 JP 2016527273A5
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cancer
antibody
fgfr2iiib
composition
amino acid
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JP2016531878A
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JP2016527273A (ja
JP6860342B2 (ja
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Priority claimed from PCT/US2014/049008 external-priority patent/WO2015017600A1/en
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JP2016531878A 2013-08-01 2014-07-31 アフコシル化された抗fgfr2iiib抗体 Active JP6860342B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361861198P 2013-08-01 2013-08-01
US61/861,198 2013-08-01
US201361901732P 2013-11-08 2013-11-08
US61/901,732 2013-11-08
US201461933632P 2014-01-30 2014-01-30
US61/933,632 2014-01-30
PCT/US2014/049008 WO2015017600A1 (en) 2013-08-01 2014-07-31 Afucosylated anti-fgfr2iiib antibodies

Related Child Applications (1)

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JP2019194319A Division JP7183136B2 (ja) 2013-08-01 2019-10-25 アフコシル化された抗fgfr2iiib抗体

Publications (3)

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JP2016527273A JP2016527273A (ja) 2016-09-08
JP2016527273A5 true JP2016527273A5 (enExample) 2017-09-07
JP6860342B2 JP6860342B2 (ja) 2021-04-14

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JP2016531878A Active JP6860342B2 (ja) 2013-08-01 2014-07-31 アフコシル化された抗fgfr2iiib抗体
JP2019194319A Active JP7183136B2 (ja) 2013-08-01 2019-10-25 アフコシル化された抗fgfr2iiib抗体
JP2022020496A Pending JP2022078080A (ja) 2013-08-01 2022-02-14 アフコシル化された抗fgfr2iiib抗体
JP2022185432A Pending JP2023018049A (ja) 2013-08-01 2022-11-21 アフコシル化された抗fgfr2iiib抗体
JP2025061908A Pending JP2025118617A (ja) 2013-08-01 2025-04-03 アフコシル化された抗fgfr2iiib抗体

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JP2019194319A Active JP7183136B2 (ja) 2013-08-01 2019-10-25 アフコシル化された抗fgfr2iiib抗体
JP2022020496A Pending JP2022078080A (ja) 2013-08-01 2022-02-14 アフコシル化された抗fgfr2iiib抗体
JP2022185432A Pending JP2023018049A (ja) 2013-08-01 2022-11-21 アフコシル化された抗fgfr2iiib抗体
JP2025061908A Pending JP2025118617A (ja) 2013-08-01 2025-04-03 アフコシル化された抗fgfr2iiib抗体

Country Status (30)

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US (5) US20150050273A1 (enExample)
EP (3) EP3027651B1 (enExample)
JP (5) JP6860342B2 (enExample)
KR (3) KR102516152B1 (enExample)
CN (2) CN105452296B (enExample)
AU (4) AU2014296174B2 (enExample)
CA (1) CA2915665C (enExample)
CL (2) CL2016000221A1 (enExample)
CY (2) CY1121517T1 (enExample)
DK (2) DK3027651T3 (enExample)
ES (2) ES2913291T3 (enExample)
HR (1) HRP20190502T1 (enExample)
HU (2) HUE058243T2 (enExample)
IL (1) IL243409B (enExample)
LT (2) LT3708583T (enExample)
ME (1) ME03476B (enExample)
MX (2) MX374785B (enExample)
MY (1) MY184628A (enExample)
NZ (1) NZ715201A (enExample)
PE (2) PE20160190A1 (enExample)
PH (3) PH12021552742A1 (enExample)
PL (2) PL3027651T3 (enExample)
PT (2) PT3708583T (enExample)
RS (1) RS58719B1 (enExample)
RU (2) RU2698061C2 (enExample)
SG (1) SG11201600767UA (enExample)
SI (2) SI3708583T1 (enExample)
TW (2) TWI633120B (enExample)
WO (1) WO2015017600A1 (enExample)
ZA (1) ZA201603218B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2915665C (en) 2013-08-01 2020-07-28 Five Prime Therapeutics, Inc. Afucosylated anti-fgfr2iiib antibodies
JP6446044B2 (ja) * 2013-11-05 2018-12-26 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 結合分子の存在下で被検体の総量および/または総濃度を決定するための方法、ならびにそれに関係するキット、組成物および使用
JPWO2016171107A1 (ja) 2015-04-20 2018-03-22 第一三共株式会社 Fgfr2の検出
WO2017091580A1 (en) 2015-11-23 2017-06-01 Five Prime Therapeutics, Inc. Predicting response to cancer treatment with fgfr2 inhibitors
LT3624837T (lt) * 2017-05-16 2025-10-10 Anti-fgfr2 antikūnai derinyje su chemoterapijos agentais vėžio gydymui
US11389480B2 (en) 2017-05-19 2022-07-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibody targeting TNFR2 for cancer immunotherapy
WO2019040780A1 (en) 2017-08-25 2019-02-28 Five Prime Therapeutics Inc. ANTI-B7-H4 ANTIBODIES AND METHODS OF USE
AU2019226011B2 (en) 2018-02-21 2025-11-27 Five Prime Therapeutics, Inc. B7-H4 antibody formulations
EP3755719A1 (en) 2018-02-21 2020-12-30 Five Prime Therapeutics, Inc. B7-h4 antibody dosing regimens
CN111971308A (zh) 2018-03-02 2020-11-20 戊瑞治疗有限公司 B7-h4抗体及其使用方法
MY208925A (en) * 2018-10-05 2025-06-11 Five Prime Therapeutics Inc Anti-fgfr2 antibody formulations
MX2021004226A (es) 2018-10-15 2021-07-15 Five Prime Therapeutics Inc Terapia combinada contra el cáncer.
CN114901692A (zh) * 2019-12-24 2022-08-12 迪哲(江苏)医药股份有限公司 新颖抗fgfr2b抗体
AR120886A1 (es) * 2019-12-24 2022-03-30 Dizal Jiangsu Pharmaceutical Co Ltd Anticuerpos anti-fgfr2b
CN114901687A (zh) * 2019-12-24 2022-08-12 迪哲(江苏)医药股份有限公司 新颖抗fgfr2b抗体
CN115768465A (zh) 2020-03-06 2023-03-07 Ona疗法有限公司 抗cd36抗体及其治疗癌症的用途
AU2021366691B2 (en) * 2020-10-22 2024-06-06 Regeneron Pharmaceuticals, Inc. Anti-FGFR2 antibodies and methods of use thereof
JP2024501565A (ja) * 2020-12-29 2024-01-12 深▲せん▼福沃薬業有限公司 抗fgfr2抗体およびその使用
JP2024529502A (ja) 2021-07-30 2024-08-06 オーエヌエー セラピューティクス エセ.エレ. 抗cd36抗体及び癌を治療するためのそれらの使用
EP4414387A4 (en) * 2021-10-08 2025-10-29 Shenzhen Forward Pharmaceuticals Co Ltd ANTI-FGFR2 ANTIBODY WITH IMPROVED ADCC AND ITS USE
TW202342527A (zh) 2022-02-25 2023-11-01 美商安進公司 鱗狀非小細胞肺癌之治療
WO2024067876A1 (en) * 2022-09-30 2024-04-04 3H Pharmaceuticals Co., Ltd. Anti-fgfr2b antibodies and uses thereof
CN117917435A (zh) * 2022-10-21 2024-04-23 北京天广实生物技术股份有限公司 结合fgfr2b的抗体及其用途
AU2023416563A1 (en) * 2022-12-28 2025-07-17 Suzhou Transcenta Therapeutics Co., Ltd. Anti-fgfr2b antibody and uses thereof
WO2024222912A1 (zh) * 2023-04-28 2024-10-31 武汉人福创新药物研发中心有限公司 抗FGFR2b单抗
WO2025103358A1 (en) * 2023-11-14 2025-05-22 Suzhou Transcenta Therapeutics Co., Ltd. Anti-fgfr2b immunoconjugates and their use in the treatment of cancer
WO2025130860A1 (zh) * 2023-12-18 2025-06-26 山东先声生物制药有限公司 抗FGFR2b抗体及其应用
WO2025232811A1 (zh) * 2024-05-09 2025-11-13 正大天晴药业集团股份有限公司 靶向成纤维细胞生长因子受体2IIIb的抗体及其应用

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5981216A (en) 1985-04-01 1999-11-09 Alusuisse Holdings A.G. Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
ATE179862T1 (de) 1989-07-06 1999-05-15 Univ California Rezeptoren für fibroblasten-wachstumsfaktoren
US5863888A (en) 1990-07-06 1999-01-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Human Bek Fibroblast growth factor receptor
AU675916B2 (en) 1991-06-14 1997-02-27 Genentech Inc. Method for making humanized antibodies
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
US6323316B1 (en) 1996-06-18 2001-11-27 The United States Of America As Represented By The Secretary Of The Department Of And Human Services Fibroblast growth factor receptor activating gene 1 and related compositions and methods
ES2244066T3 (es) 1997-06-24 2005-12-01 Genentech, Inc. Procedimiento y composiciones de glicoproteinas galactosiladas.
DE69840412D1 (de) 1997-10-31 2009-02-12 Genentech Inc Methoden und zusammensetzungen bestehend aus glykoprotein-glykoformen
ES2375931T3 (es) 1997-12-05 2012-03-07 The Scripps Research Institute Humanización de anticuerpo murino.
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
AU3369999A (en) 1998-04-02 1999-10-25 Genentech Inc. Antibody variants and fragments thereof
AU3657899A (en) 1998-04-20 1999-11-08 James E. Bailey Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
WO2000025803A1 (en) 1998-10-30 2000-05-11 Takeda Chemical Industries, Ltd. Betacellulin protein-containing preparations
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP2275540B1 (en) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
EP1185559A2 (en) 1999-04-28 2002-03-13 Board Of Regents, The University Of Texas System Compositions and methods for cancer treatment by selectively inhibiting vegf
AU7950400A (en) 1999-10-19 2001-04-30 Kyowa Hakko Kogyo Co. Ltd. Process for producing polypeptide
JP2001302699A (ja) 2000-04-17 2001-10-31 Nichirei Corp ヒトkgfrに対する抗体
US7064191B2 (en) 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
CA2424602C (en) 2000-10-06 2012-09-18 Kyowa Hakko Kogyo Co., Ltd. Antibody composition-producing cell
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
AU2002314495A1 (en) 2001-06-20 2003-01-02 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
EP2180044A1 (en) 2001-08-03 2010-04-28 GlycArt Biotechnology AG Antibody glycosylation variants having increased anti-body-dependent cellular cytotoxicity
MXPA04003798A (es) 2001-10-25 2004-07-30 Genentech Inc Composiciones de glicoproteina.
CN101357943A (zh) * 2001-10-25 2009-02-04 杰南技术公司 糖蛋白组合物
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
WO2003063893A2 (en) 2002-01-31 2003-08-07 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Fgfr agonists
US7662925B2 (en) * 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
JPWO2003085118A1 (ja) 2002-04-09 2005-08-11 協和醗酵工業株式会社 抗体組成物の製造方法
AU2003236019A1 (en) 2002-04-09 2003-10-20 Kyowa Hakko Kirin Co., Ltd. Drug containing antibody composition appropriate for patient suffering from Fc Gamma RIIIa polymorphism
PL373256A1 (en) 2002-04-09 2005-08-22 Kyowa Hakko Kogyo Co, Ltd. Cells with modified genome
JPWO2003085119A1 (ja) 2002-04-09 2005-08-11 協和醗酵工業株式会社 抗体組成物のFcγ受容体IIIaに対する結合活性を高める方法
ATE503829T1 (de) 2002-04-09 2011-04-15 Kyowa Hakko Kirin Co Ltd Zelle mit erniedrigter oder deletierter aktivität eines am gdp-fucosetransport beteiligten proteins
AU2003236017B2 (en) 2002-04-09 2009-03-26 Kyowa Kirin Co., Ltd. Drug containing antibody composition
KR100493460B1 (ko) 2002-08-29 2005-06-07 재단법인서울대학교산학협력재단 암 세포에서 발현되는 fgfr2 이성체
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
TWI335821B (en) 2002-12-16 2011-01-11 Genentech Inc Immunoglobulin variants and uses thereof
KR100973564B1 (ko) * 2003-05-02 2010-08-03 젠코어 인코포레이티드 최적화된 Fc 변이체 및 그의 제조 방법
JPWO2005035586A1 (ja) 2003-10-08 2007-11-22 協和醗酵工業株式会社 融合蛋白質組成物
EP1705251A4 (en) 2003-10-09 2009-10-28 Kyowa Hakko Kirin Co Ltd PROCESS FOR PRODUCING ANTIBODY COMPOSITION BY RNA INHIBITION OF FUNCTION OF $ G (A) 1,6-FUCOSYLTRANSFERASE
SI1680140T1 (sl) * 2003-10-16 2011-08-31 Imclone Llc Inhibitorji receptorja-1 za fibroblastni rastni faktor in metode za zdravljenje z le-temi
DK2330201T3 (en) 2003-10-22 2017-07-24 Keck Graduate Inst PROCEDURES FOR SYNTHESIS OF HEATER-MULTIMATE POLYPEPTIDES WHEN USING A HAPLOID COUPLE STRATEGY
NO347530B1 (no) 2003-11-05 2023-12-11 Roche Glycart Ag Et humanisert type II anti-CD20 antistoff og vertscelle som produserer et humanisert type II anti-CD20 antistoff samt en fremgangsmåte for fremstilling og en farmasøytisk sammensetning.
WO2005053742A1 (ja) 2003-12-04 2005-06-16 Kyowa Hakko Kogyo Co., Ltd. 抗体組成物を含有する医薬
EP1697420A2 (en) 2003-12-19 2006-09-06 Five Prime Therapeutics, Inc. Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention
RU2386638C2 (ru) 2004-03-31 2010-04-20 Дженентек, Инк. Гуманизированные анти-тфр-бета-антитела
EP1773305A2 (en) 2004-05-25 2007-04-18 Yale University Corporation Method for treating skeletal disorders resulting from fgfr malfunction
ATE454455T1 (de) 2005-01-27 2010-01-15 Five Prime Therapeutics Inc Leitsequenzen zur anleitung von polypeptidsekretion und verfahren zur herstellung
SG170006A1 (en) * 2005-02-18 2011-04-29 Medarex Inc Monoclonal antibodies against cd30 lacking fucosyl residues
US7923538B2 (en) 2005-07-22 2011-04-12 Kyowa Hakko Kirin Co., Ltd Recombinant antibody composition
US7890267B2 (en) 2006-03-31 2011-02-15 Ordway Research Institute Prognostic and diagnostic method for cancer therapy
WO2007134210A2 (en) 2006-05-12 2007-11-22 Genentech, Inc. Methods and compositions for the diagnosis and treatment of cancer
CA2655246A1 (en) * 2006-06-09 2007-12-21 University Of Maryland, Baltimore Glycosylation engineered antibody therapy
EP2046384A4 (en) 2006-06-15 2009-12-02 Fibron Ltd ANTIBODIES BLOCKING FIBROBLAST GROWTH FACTOR RECEPTOR ACTIVATION AND METHODS OF USING THE SAME
AR062223A1 (es) 2006-08-09 2008-10-22 Glycart Biotechnology Ag Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
EP2066694B1 (en) 2006-09-29 2015-11-04 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
US8394927B2 (en) 2006-11-03 2013-03-12 U3 Pharma Gmbh FGFR4 antibodies
CL2007003411A1 (es) 2006-11-28 2008-07-04 Centelion Proteina fusion que consiste en una region fc de una inmunoglobulina con un fragmento o dominio soluble de un receptor para fgf; polinucleotido que la codifica y vector y celula que lo comprenden; composicion farmaceutica que comprende la proteina fu
US20090068110A1 (en) 2006-12-22 2009-03-12 Genentech, Inc. Antibodies to insulin-like growth factor receptor
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
JP5071942B2 (ja) 2007-01-24 2012-11-14 協和発酵キリン株式会社 エフェクター活性が増強された遺伝子組換え抗体組成物
BRPI0809137A2 (pt) 2007-03-23 2016-07-26 Translational Genomics Res Inst métodos de diagnosticar, câncer endometrial e pré-câncer classificar e tratar
WO2008121876A2 (en) * 2007-03-28 2008-10-09 Biogen Idec Inc. Non-fucosylated antibodies
WO2009052830A1 (en) 2007-10-22 2009-04-30 Genmab A/S Novel antibody therapies
US9260525B2 (en) 2008-02-04 2016-02-16 Xiao-Jia Chang Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof
US20110059091A1 (en) 2008-02-04 2011-03-10 Xiao-Jia Chang Inhibitors of oncogenic isoforms and uses thereof
US8688158B2 (en) 2008-03-26 2014-04-01 Nec Corporation Radio resource control method, radio station apparatus, recording medium storing radio station control program, and radio communication system
CA2727247A1 (en) * 2008-06-10 2009-12-17 University Of Southern California Thymidylate synthase haplotype is associated with tumor recurrence in stage ii and stage iii colon cancer patients
EP2177615A1 (en) 2008-10-10 2010-04-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases
LT2842573T (lt) 2008-11-07 2017-12-11 Galaxy Biotech, Llc Monokloniniai antikūnai prieš fibroblastų augimo faktoriaus receptorių-2
WO2011025814A1 (en) 2009-08-25 2011-03-03 National Jewish Health Methods and compositions for treatment of lung injury
CN102666874B (zh) * 2009-10-07 2016-06-01 宏观基因有限公司 由于岩藻糖基化程度的改变而表现出改善的效应子功能的含Fc区的多肽及其使用方法
EP2488554B1 (en) * 2009-10-14 2019-07-24 Humanigen, Inc. Antibodies to epha3
CN102762221A (zh) 2010-01-14 2012-10-31 耶鲁大学 受体酪氨酸激酶(rtk)的抑制剂及其使用方法
US9140689B2 (en) 2010-03-14 2015-09-22 Translational Genomics Research Institute Methods of determining susceptibility of tumors to tyrosine kinase inhibitors
BR112012028764A2 (pt) 2010-05-11 2017-03-14 Aveo Pharmaceuticals Inc anticor-pos antifgfr2
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
EP2603521A4 (en) 2010-08-12 2014-10-01 Attogen Inc ANTIBODY MOLECULARS FOR ONGOGEN FIBROBLAST GROWTH RECEPTOR 2 ISOFORMS AND ITS USES
US20120258496A1 (en) * 2010-09-27 2012-10-11 Boehringer Ingelheim International Gmbh Production of low fucose antibodies in h4-ii-e rat cells
EP3828205A1 (en) * 2010-10-01 2021-06-02 Oxford BioTherapeutics Ltd Anti-ror1 antibodies
CN103857699B (zh) 2011-05-24 2016-08-31 泽恩格尼亚股份有限公司 多价和单价多特异性复合物及其用途
AR088941A1 (es) 2011-11-23 2014-07-16 Bayer Ip Gmbh Anticuerpos anti-fgfr2 y sus usos
US20150023989A1 (en) 2011-12-14 2015-01-22 Seattle Genetics, Inc. New antibody drug conjugates (adcs) and the use thereof
DK2831110T3 (en) * 2012-03-30 2018-08-06 Univ California Anti-EMP2 therapy to reduce cancer stem cells
JP6188681B2 (ja) 2012-04-09 2017-08-30 第一三共株式会社 抗fgfr2抗体
US9254288B2 (en) 2012-05-07 2016-02-09 The Translational Genomics Research Institute Susceptibility of tumors to tyrosine kinase inhibitors and treatment thereof
KR102418979B1 (ko) 2012-05-15 2022-07-11 브리스톨-마이어스 스큅 컴퍼니 Pd-1/pd-l1 신호전달을 방해하는 것에 의한 암 면역요법
CN104619840A (zh) 2012-07-05 2015-05-13 日本国立癌症研究中心 Fgfr2融合基因
WO2014089193A1 (en) 2012-12-04 2014-06-12 Aveo Pharmaceuticals, Inc. Anti-fgfr2 antibodies
AU2014207342C1 (en) 2013-01-18 2019-04-04 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
US9415118B2 (en) 2013-03-13 2016-08-16 Novartis Ag Antibody drug conjugates
US9498532B2 (en) 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
HK1213817A1 (zh) 2013-05-01 2016-07-15 戊瑞治疗有限公司 治療癌症的方法
EP3800266A1 (en) 2013-06-13 2021-04-07 University Of South Australia Methods for detecting prostate cancer
CA2915665C (en) 2013-08-01 2020-07-28 Five Prime Therapeutics, Inc. Afucosylated anti-fgfr2iiib antibodies
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
US20170175197A1 (en) 2014-01-29 2017-06-22 Caris Mpi, Inc. Molecular profiling of immune modulators
KR20170080675A (ko) 2014-11-05 2017-07-10 제넨테크, 인크. 항-fgfr2/3 항체 및 이의 이용 방법
WO2016100882A1 (en) 2014-12-19 2016-06-23 Novartis Ag Combination therapies
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
WO2017091580A1 (en) 2015-11-23 2017-06-01 Five Prime Therapeutics, Inc. Predicting response to cancer treatment with fgfr2 inhibitors
LT3624837T (lt) 2017-05-16 2025-10-10 Anti-fgfr2 antikūnai derinyje su chemoterapijos agentais vėžio gydymui

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