JP2018512443A5 - - Google Patents
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- JP2018512443A5 JP2018512443A5 JP2017562952A JP2017562952A JP2018512443A5 JP 2018512443 A5 JP2018512443 A5 JP 2018512443A5 JP 2017562952 A JP2017562952 A JP 2017562952A JP 2017562952 A JP2017562952 A JP 2017562952A JP 2018512443 A5 JP2018512443 A5 JP 2018512443A5
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- Prior art keywords
- seq
- cdr2
- cdr3
- cdr1
- cancer
- Prior art date
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- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 239000013604 expression vector Substances 0.000 claims 14
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 230000003213 activating effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000032320 Germ cell tumor of testis Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 101001102797 Homo sapiens Transmembrane protein PVRIG Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000009052 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000017414 Precursor T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 102100039630 Transmembrane protein PVRIG Human genes 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 229940124622 immune-modulator drug Drugs 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 230000014828 interferon-gamma production Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 201000008261 skin carcinoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 208000002918 testicular germ cell tumor Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022067066A JP2022106783A (ja) | 2015-02-19 | 2022-04-14 | 抗ｐｖｒｉｇ抗体及び使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562118208P | 2015-02-19 | 2015-02-19 | |
| US62/118,208 | 2015-02-19 | ||
| US201562141120P | 2015-03-31 | 2015-03-31 | |
| US62/141,120 | 2015-03-31 | ||
| US201562235823P | 2015-10-01 | 2015-10-01 | |
| US62/235,823 | 2015-10-01 | ||
| PCT/US2016/018809 WO2016134333A1 (en) | 2015-02-19 | 2016-02-19 | Anti-pvrig antibodies and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022067066A Division JP2022106783A (ja) | 2015-02-19 | 2022-04-14 | 抗ｐｖｒｉｇ抗体及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512443A JP2018512443A (ja) | 2018-05-17 |
| JP2018512443A5 true JP2018512443A5 (enExample) | 2019-07-04 |
| JP7115856B2 JP7115856B2 (ja) | 2022-08-09 |
Family
ID=55453315
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562952A Active JP7115856B2 (ja) | 2015-02-19 | 2016-02-19 | 抗ｐｖｒｉｇ抗体及び使用方法 |
| JP2022067066A Pending JP2022106783A (ja) | 2015-02-19 | 2022-04-14 | 抗ｐｖｒｉｇ抗体及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022067066A Pending JP2022106783A (ja) | 2015-02-19 | 2022-04-14 | 抗ｐｖｒｉｇ抗体及び使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (8) | US10227408B2 (enExample) |
| EP (4) | EP3653221B1 (enExample) |
| JP (2) | JP7115856B2 (enExample) |
| KR (2) | KR20240090732A (enExample) |
| CN (2) | CN115350275A (enExample) |
| AU (3) | AU2016219835B2 (enExample) |
| CA (1) | CA2976926A1 (enExample) |
| CY (2) | CY1122970T1 (enExample) |
| DK (3) | DK3653221T5 (enExample) |
| ES (3) | ES2806800T3 (enExample) |
| HR (3) | HRP20200572T1 (enExample) |
| HU (3) | HUE061084T2 (enExample) |
| IL (2) | IL254039B2 (enExample) |
| LT (3) | LT3653221T (enExample) |
| MX (2) | MX374853B (enExample) |
| PL (3) | PL3653221T3 (enExample) |
| PT (3) | PT3653221T (enExample) |
| RU (1) | RU2732042C2 (enExample) |
| SG (1) | SG11201706583PA (enExample) |
| SI (2) | SI3258951T1 (enExample) |
| WO (1) | WO2016134333A1 (enExample) |
| ZA (1) | ZA201706323B (enExample) |
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| JP5641508B2 (ja) * | 2010-02-23 | 2014-12-17 | 国立大学法人 東京大学 | 樹状細胞免疫受容体刺激剤 |
| MY178233A (en) | 2013-12-20 | 2020-10-07 | Hutchinson Fred Cancer Res | Tagged chimeric effector molecules and receptors thereof |
| PL3653221T3 (pl) | 2015-02-19 | 2022-12-19 | Compugen Ltd. | Przeciwciała anty-pvrig i sposoby ich zastosowania |
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| US11827904B2 (en) | 2015-04-29 | 2023-11-28 | Fred Hutchinson Cancer Center | Modified stem cells and uses thereof |
| KR101997241B1 (ko) | 2015-05-21 | 2019-07-09 | 하푼 테라퓨틱스, 인크. | 삼중특이성 결합 단백질 및 사용 방법 |
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| BR112020024249A2 (pt) * | 2018-06-01 | 2021-03-02 | Compugen Ltd. | anticorpo biespecífico anti-pvrig/anti-tigit, composição, composição de ácido nucleico, composição de vetor de expressão, célula hospedeira, métodos para produzir um anticorpo biespecífico anti-pvrig/anti-tigit, para ativação de células t de um paciente, para ativação de células t citotóxicas de um paciente, para ativação de células nk de um paciente, para ativação de células t gama delta de um paciente, para ativação de células th1 de um paciente, para diminuir ou eliminar o número de células e/ou a atividade de pelo menos uma das células t reguladoras em um paciente, para aumentar a produção de interferon-gama e/ou a secreção de citocinas pró-inflamatórias em um paciente e para tratamento de câncer em um paciente, anticorpo anti-pvrig, anticorpo anti-tigit, e, vetor de expressão. |
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