JP2015231530A - バイオイメージングのための光コヒーレンストモグラフィ - Google Patents
バイオイメージングのための光コヒーレンストモグラフィ Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
Abstract
Description
本願は、米国特許出願第61/182061号(2009年5月28日出願)、米国特許出願第61/258064号(2009年11月4日出願)及び米国特許出願第61/222238号(2009年7月1日出願)の出願日の利益を請求するものであり、本願の開示内容は、参照により全体としてここに組み込まれる。
本明細書で言及されるすべての刊行物及び特許出願は、あたかも個々の刊行物又は特許出願が具体的にかつ個々に提示されて参照により組み込まれていると言える程度に、参照により本明細書に組み込まれる。
光源からターゲットまで弾性的に往来する。即ち、ターゲットでのたった一回の散乱により、有用な信号が減少する。散乱断面の大きさは、250〜2000nmの範囲に及ぶ波長の逆数のべき乗で変化する。該べき乗は、より短い波長で−4、より長い波長でより小さくなる。その値は、短い波長からより長い波長へ移行すると単調減少するので、ニーズが組織内をより深く見ることにあれば、光源の波長範囲は、より長い波長範囲へ偏ることが必要となる。この選択には、必ず妥協が伴う。より長い波長に移行することにより、より短い波長でのイメージングと同じ分解能を達成するためには、より高機能のレーザー光源が必要となるだろう。しかしながらこれは、解決可能な技術的課題である。
Claims (87)
- 光放射線源と、
参照界面及びターゲットから反射した光放射線のための共通光路を提供するコアを有する光ファイバと、
参照界面及びターゲットから反射した光放射線を受信するように構成された受信用電子機器と、
参照界面に存在し、光ファイバと光学接続した界面媒質と、
受信用電子機器によって受信された光放射線に基づいて、ターゲットの画像を作成する処理装置とを備え、
前記コアは、第1屈折率を有し、
前記界面媒質は、第2屈折率を有し、
第1屈折率と第2屈折率とは、受信用電子機器がショットノイズ限界から5dB内の総ノイズ範囲で動作するように不整合にされた、光コヒーレンストモグラフィのためのシステム。 - 第1屈折率と第2屈折率とは、受信用電子機器がショットノイズ限界から3dB内の総ノイズ範囲で動作するように不整合にされた請求項1記載のシステム。
- 第1屈折率と第2屈折率とは、受信用電子機器がショットノイズ限界から1dB内の総ノイズ範囲で動作するように不整合にされた請求項1記載のシステム。
- 光放射線源は、掃引周波数光源である請求項1記載のシステム。
- 界面媒質においてミラーをさらに備え、
該ミラーは、光ファイバからターゲットに向けて放射線を反射するように構成された請求項1記載のシステム。 - ミラーは、金被覆されたシリコンダイを有する請求項5記載のシステム。
- 界面媒質は、固体の透明媒質である請求項1記載のシステム。
- 界面媒質は、コアの遠位端と光学接触している請求項1記載のシステム。
- 光源からコアの遠位端へ光放射線を中継するように構成された方向エレメントをさらに備えた請求項1記載のシステム。
- 第1屈折率n1と第2屈折率n2とが、
Pinは、界面媒質に入射する前の光ファイバの遠位端での光放射線の出力であり、Poutは、受信用電子機器がショットノイズ限界から5dB内の総ノイズ範囲で動作するように界面媒質から反射した光放射線の出力である請求項1記載のシステム。 - 第1屈折率n1と第2屈折率n2とが、
Lは、プローブの遠位端から受信用電子機器までの全光学的損失の総和であり、Pdetは受信用電子機器での出力である請求項10記載のシステム。 - 伸長性カテーテル体と、
該伸長性カテーテル体内の光ファイバと、
参照界面に存在し、光ファイバと光学接触する界面媒質とを備え、
前記光ファイバは、参照界面及びターゲットから反射した光放射線のための共通光路を提供するコアを有し、
該コアは第1屈折率を有し、
前記界面媒質は第2屈折率を有し、
第1屈折率と第2屈折率とは、参照界面及びターゲットから反射した光放射線を受信するように構成された受信用電子機器がショットノイズ限界から5dB内の総ノイズ範囲で動作するように不整合にされた、光コヒーレンストモグラフィと一緒に使用するためのカテーテル。 - 第1屈折率と第2屈折率とは、受信用電子機器がショットノイズ限界から3dB内の総ノイズ範囲で動作するように不整合にされた請求項12記載のカテーテル。
- 第1屈折率と第2屈折率とは、受信用電子機器がショットノイズ限界から2dB内の総ノイズ範囲で動作するように不整合にされた請求項12記載のカテーテル。
- 界面媒質内にミラーをさらに備え、
該ミラーは、光ファイバからターゲットに向けて放射線を反射するように構成された請求項12記載のカテーテル。 - ミラーは、金被覆されたシリコンダイを有する請求項15記載のカテーテル。
- 界面媒質は、固体の透明媒質である請求項12記載のカテーテル。
- 界面媒質は、コアの遠位端と光学接触している請求項12記載のカテーテル。
- 第1屈折率n1と第2屈折率n2とが、
Pinは界面媒質に入射する前の光ファイバの遠位端での光放射線の出力であり、Poutは、受信用電子機器がショットノイズ限界から5dB内の総ノイズ範囲で動作するように界面媒質から反射した光放射線の出力である請求項12記載のカテーテル。 - 第1屈折率n1と第2屈折率n2とが、
Lは、プローブの遠位端から受信用電子機器までの全光学的損失の総和であり、Pdetは受信用電子機器での出力である請求項19記載のカテーテル。 - コアを有する光ファイバを通じて光源からの光放射線を伝送することと、
界面媒質を通じて光ファイバから光放射線を伝送することと、
ターゲットから反射した光放射線及び参照界面から反射した光放射線を、光ファイバ中の共通光路に沿って検出器まで伝送することと、
受信用電子機器で反射後の光放射線を受信することと、
受信用電子機器が受信する反射後の光放射線に基づいて、ターゲットの画像を作成することとを含み、
前記コアは第1屈折率を有し、
前記界面媒質は光ファイバと光学接触しており、
界面媒質は第2屈折率を有し、
第1屈折率と第2屈折率とは、受信用電子機器がショットノイズ限界から5dB内の総ノイズ範囲で動作するように不整合にされた、光コヒーレンストモグラフィを実施する方法。 - 第1屈折率と第2屈折率とは、受信用電子機器がショットノイズ限界から3dB内の総ノイズ範囲で動作するように不整合にされた請求項21記載の方法。
- 第1屈折率と第2屈折率とは、受信用電子機器がショットノイズ限界から2dB内の総ノイズ範囲で動作するように不整合にされた請求項21記載の方法。
- 光放射線を伝送することは、掃引光源放射線を伝送することを含む請求項21記載の方法。
- 界面媒質を通じて光ファイバからの光放射線を伝送することは、光ファイバから界面媒質内のミラーまで光放射線を伝送することを含む請求項21記載の方法。
- 光放射線源と、
参照部及びターゲットから反射した光放射線のための共通光路を提供する光ファイバと、
参照部及びターゲットから反射した光放射線を受信するための検出器と、
参照界面に存在し、光ファイバの遠位端と光学接触している界面媒質と、
包囲媒質内のミラーと、
検出器が受信する光放射線に基づいてターゲットの画像を作成するための処理装置とを含み、
前記ミラーは、反射被覆を有するシリコンダイを含む、光コヒーレンストモグラフィのためのシステム。 - 反射被覆は金属である請求項26記載のシステム。
- 金属被覆は金である請求項27記載のシステム。
- 反射被覆は、少なくともλmin/2πの厚さを有し、λminは、光ファイバ内での光の波長である請求項26記載のシステム。
- 金属被覆の厚さは、少なくとも2800Åである請求項29記載のシステム。
- シリコンダイと反射被覆との間に、接着層をさらに含む請求項26記載のシステム。
- 接着層は、ニッケル、チタン又はクロムを含む請求項31記載のシステム。
- 接着層の厚さは50Å〜200Åの範囲内である請求項30記載のシステム。
- 接着層の厚さは約100Åである請求項33記載のシステム。
- 界面媒質は接着剤を含む請求項26記載のシステム。
- ミラーは、少なくとも95%を反射する請求項26記載のシステム。
- ミラーは、少なくとも98%を反射する請求項36記載のシステム。
- 界面媒質は、固体の透明媒質である請求項26記載のシステム。
- 光放射線源は、掃引光源放射線を供給するように構成された請求項26記載のシステム。
- 伸長性カテーテル体と、
該伸長性カテーテル体中の光ファイバと、
参照界面に存在し、光ファイバの遠位端と光学接触している界面媒質と、
該界面媒質内のミラーとを含み、
前記光ファイバは、参照界面及びターゲットから反射した光放射線のための共通光路を提供し、
前記ミラーは、反射被覆を有するシリコンダイを含む、光コヒーレンストモグラフィと一緒に使用するためのカテーテル。 - 界面媒質は接着剤を含む請求項40記載のカテーテル。
- 反射被覆は金属である請求項40記載のカテーテル。
- 金属被覆は金である請求項42記載のカテーテル。
- 反射被覆は、少なくともλmin/2πの厚さを有し、λminは、光ファイバ内での光の波長である請求項40記載のシステム。
- 金属被覆の厚さは、少なくとも2800Åである請求項44記載のシステム。
- シリコンダイと反射被覆との間に、接着層をさらに含む請求項40記載のカテーテル。
- 接着層は、ニッケル、チタン又はクロムを含む請求項46記載のカテーテル。
- 接着層の厚さは50Å〜200Åの範囲内である請求項46記載のカテーテル。
- 接着層の厚さは約100Åである請求項48記載のカテーテル。
- ミラーは、少なくとも95%を反射する請求項41記載のカテーテル。
- ミラーは、少なくとも98%を反射する請求項50記載のカテーテル。
- 光ファイバを通じて光源からの光放射線を伝送することと、
光放射線から界面媒質に埋め込まれたミラーまで光放射線を伝送することと、
ミラーからターゲットに向けて光放射線を反射することと、
参照界面からの光放射線を反射することと、
ターゲットから反射した光放射線及び参照界面から反射した光放射線を、光ファイバ内の共通光路に沿って検出器まで伝送することと、
反射後の光放射線を検出器で受信することと、
検出器が受信した反射後の光放射線に基づいて、ターゲットの画像を作成することとを含み、
前記ミラーは、反射被覆を有するシリコンダイを含み、
前記界面媒質は、光ファイバのコアの遠位端と光学接触しており、
前記参照界面は、光ファイバと界面媒質との間に存在する、光コヒーレンストモグラフィを実施する方法。 - 光放射線を伝送することは、掃引光源放射線を伝送することを含む請求項52記載の方法。
- 反射被覆は金属である請求項52記載の方法。
- 金属被覆は金である請求項54記載の方法。
- 反射被覆は、少なくともλmin/2πの厚さを有し、λminは、光ファイバ内での光の波長である請求項52記載のシステム。
- 金属被覆の厚さは、少なくとも2800Åである請求項56記載のシステム。
- シリコンダイと反射被覆との間に、接着層をさらに含む請求項52記載の方法。
- 接着層は、ニッケル、チタン又はクロムを含む請求項58記載の方法。
- 接着層の厚さは50Å〜200Åの範囲内である請求項58記載の方法。
- 接着層の厚さは約100Åである請求項59記載の方法。
- ミラーは、少なくとも95%を反射する請求項52記載の方法。
- ミラーは、少なくとも98%を反射する請求項62記載の方法。
- 光放射線源と、
伸長性カテーテル体と、
伸長性カテーテル体の近位端から遠位端まで及ぶ光ファイバと、
伸長性カテーテル体の近位端に取り付けられたハンドルと、
参照部及びターゲットから反射した光放射線を受信するための検出器と、
検出器が受信した光放射線に基づいてターゲットの画像を作成するための処理装置とを備え、
前記光ファイバは、カテーテル体の遠位端に取り付けられ、参照部及びターゲットから反射した光放射線のための共通光路を提供し、
前記ハンドルは、伸長性カテーテル体の長手軸周りの、ハンドルに対するカテーテル体及び光ファイバの回転を可能にするように構成されている、光コヒーレンストモグラフィのためのシステム。 - 光ファイバは、カテーテル体の遠位端の近くでのみ該カテーテル体に固定されている請求項64記載のシステム。
- 光ファイバの遠位端は、固体の透明媒質中に埋め込まれている請求項64記載のシステム。
- 光ファイバは、伸長性カテーテル体と同軸ではない請求項64記載のシステム。
- ハンドルは巻取り機構を有し、該巻取り機構は、回転時に光ファイバを巻き取るように構成されている請求項64記載のシステム。
- ハンドルは回転機構を有し、該回転機構の1回転により、カテーテル体及び光ファイバが長手軸周りに1回以上回転する請求項64記載のシステム。
- 回転機構の1回転により、カテーテル体及び光ファイバが長手軸周りに少なくとも2回転する請求項69記載のシステム。
- 回転機構の1回転により、カテーテル体及び光ファイバが長手軸周りに約4回転する請求項70記載のシステム。
- 伸長性カテーテル体と、
該伸長性カテーテル体の近位端から遠位端まで及ぶ光ファイバと、
伸長性カテーテル体の近位端に取り付けられたハンドルとを備え、
前記光ファイバは、カテーテル体の遠位端近くで該カテーテル体に固定され、参照部及びターゲットから反射した光放射線のための共通光路を提供し、
前記ハンドルは、伸長性カテーテル体の長手軸周りの、ハンドルに対するカテーテル体及び光ファイバの回転を可能にするように構成されている、光コヒーレンストモグラフィと一緒に使用するためのカテーテル。 - 光ファイバは、カテーテル体の遠位端の近くでのみ該カテーテル体に固定されている請求項72記載のカテーテル。
- 光ファイバの遠位端は、固体の透明媒質中に埋め込まれている請求項72記載のカテーテル。
- 光ファイバは、伸長性カテーテル体と同軸ではない請求項72記載のカテーテル。
- ハンドルは巻取り機構を有し、該巻取り機構は、回転時に光ファイバを巻き取るように構成されている請求項72記載のカテーテル。
- ハンドルは回転機構を有し、該回転機構の1回転により、カテーテル体及び光ファイバが長手軸周りに1回以上回転する請求項72記載のカテーテル。
- 回転機構の1回転により、カテーテル体及び光ファイバが長手軸周りに少なくとも2回転する請求項77記載のカテーテル。
- 回転機構の1回転により、カテーテル体及び光ファイバが長手軸周りに約4回転する請求項78記載のカテーテル。
- 光ファイバを通じて光源からの光放射線を伝送することと、
光ファイバからターゲットの第1位置まで光放射線を伝送することと、
ターゲットから反射した光放射線及び参照部から反射した光放射線を、光ファイバ内の共通光路に沿って検出器まで伝送することと、
反射後の光放射線を検出器で受信することと、
検出器が受信した反射後の光放射線に基づいて、ターゲットの第1位置の第1画像を作成することと、
ターゲットの第2位置から第2画像を取得できるように、カテーテル体及び光ファイバを、カテーテル体の長手軸周りに手動で回転させることとを含み、
前記光ファイバは、伸長性カテーテル体の近位端から遠位端まで延びており、カテーテル体の遠位端の近くで該カテーテル体に固定される、光コヒーレンストモグラフィを導く方法。 - 光放射線を伝送することは、掃引光源放射線を伝送することを含む請求項17記載の方法。
- 伸長性カテーテル体及び光ファイバを回転させることは、カテーテル体の遠位端と光ファイバの遠位端とを一緒に回転させることを含む請求項17記載の方法。
- 光ファイバを回転させることは、カテーテル体の近位端に取り付けられたハンドルの巻取り機構の周囲に光ファイバを巻き取ることを含む請求項17記載の方法。
- 伸長性体及び光ファイバを回転させることは、伸長性体及び光ファイバがハンドルに対して回転するように、カテーテル体の近位端に取り付けられたハンドルの回転機構を回転させることを含む請求項17記載の方法。
- 回転機構を1回転させることにより、カテーテル体及び光ファイバが長手軸周りに1回以上回転する請求項84記載の方法。
- 回転機構を1回転させることにより、カテーテル体及び光ファイバが長手軸周りに少なくとも2回転する請求項85記載の方法。
- 回転機構を1回転させることにより、カテーテル体及び光ファイバが長手軸周りに約4回転する請求項86記載の方法。
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WO2010138927A9 (en) | 2012-02-02 |
AU2010253912B2 (en) | 2015-03-05 |
JP2012528342A (ja) | 2012-11-12 |
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CN102460118B (zh) | 2015-03-25 |
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WO2010138927A8 (en) | 2011-02-24 |
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WO2010138927A2 (en) | 2010-12-02 |
EP2435815A2 (en) | 2012-04-04 |
EP4145111A1 (en) | 2023-03-08 |
JP6177278B2 (ja) | 2017-08-09 |
CN102460118A (zh) | 2012-05-16 |
AU2010253912A1 (en) | 2011-12-22 |
US20200069253A1 (en) | 2020-03-05 |
JP6101078B2 (ja) | 2017-03-29 |
US10342491B2 (en) | 2019-07-09 |
US11839493B2 (en) | 2023-12-12 |
US11284839B2 (en) | 2022-03-29 |
US20220240860A1 (en) | 2022-08-04 |
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