JP2015120698A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015120698A5 JP2015120698A5 JP2014262319A JP2014262319A JP2015120698A5 JP 2015120698 A5 JP2015120698 A5 JP 2015120698A5 JP 2014262319 A JP2014262319 A JP 2014262319A JP 2014262319 A JP2014262319 A JP 2014262319A JP 2015120698 A5 JP2015120698 A5 JP 2015120698A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- propanoic acid
- ethynyl
- optionally substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8409808P | 2008-07-28 | 2008-07-28 | |
| US61/084,098 | 2008-07-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520437A Division JP2012503595A (ja) | 2008-07-28 | 2009-07-23 | 代謝病の治療用の化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015120698A JP2015120698A (ja) | 2015-07-02 |
| JP2015120698A5 true JP2015120698A5 (enExample) | 2017-01-05 |
| JP6101675B2 JP6101675B2 (ja) | 2017-03-22 |
Family
ID=41076693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520437A Pending JP2012503595A (ja) | 2008-07-28 | 2009-07-23 | 代謝病の治療用の化合物 |
| JP2014262319A Expired - Fee Related JP6101675B2 (ja) | 2008-07-28 | 2014-12-25 | 代謝病の治療用の化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520437A Pending JP2012503595A (ja) | 2008-07-28 | 2009-07-23 | 代謝病の治療用の化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8586607B2 (enExample) |
| EP (1) | EP2313360B1 (enExample) |
| JP (2) | JP2012503595A (enExample) |
| CN (2) | CN102137836B (enExample) |
| WO (1) | WO2010012650A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101835750B (zh) | 2007-08-22 | 2013-07-17 | 阿斯利康(瑞典)有限公司 | 环丙基酰胺衍生物 |
| WO2009067493A2 (en) * | 2007-11-19 | 2009-05-28 | Envivo Pharmaceuticals, Inc. | 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders |
| RU2527177C2 (ru) | 2007-12-20 | 2014-08-27 | Энвиво Фармасьютикалз, Инк. | Четырехзамещенные бензолы |
| WO2010012650A1 (en) * | 2008-07-28 | 2010-02-04 | Syddansk Universitet | Compounds for the treatment of metabolic diseases |
| TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| US20110201623A1 (en) | 2010-02-18 | 2011-08-18 | Uczynski Michael A | Crystalline Form Of A Cyclopropyl Benzamide Derivative |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| CN104470886A (zh) * | 2011-04-08 | 2015-03-25 | 赛丹思科大学 | 用于治疗代谢疾病的邻-氟取代的化合物 |
| SG10201603776RA (en) * | 2011-05-04 | 2016-07-28 | Univ Sydney | Prenylated hydroxystilbenes |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| RU2477726C1 (ru) * | 2011-10-18 | 2013-03-20 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение |
| US8633182B2 (en) * | 2012-05-30 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Indanyloxyphenylcyclopropanecarboxylic acids |
| HK1210825A1 (en) | 2012-07-11 | 2016-05-06 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
| EP3068788A1 (en) | 2013-11-14 | 2016-09-21 | Cadila Healthcare Limited | Novel heterocyclic compounds |
| US9839644B2 (en) | 2014-09-09 | 2017-12-12 | ARKAY Therapeutics, LLC | Formulations and methods for treatment of metabolic syndrome |
| EP3253745B1 (en) * | 2015-02-05 | 2021-09-29 | Piramal Enterprises Limited | Compounds containing carbon-carbon linker as gpr120 agonists |
| WO2016151018A1 (en) | 2015-03-24 | 2016-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| WO2019074241A1 (ko) * | 2017-10-11 | 2019-04-18 | 정원혁 | 페닐아세틸렌 유도체를 포함하는 pd-1과 pd-l1의 상호작용 억제제 |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| UA126421C2 (uk) | 2018-07-13 | 2022-09-28 | Гіліад Сайєнсіз, Інк. | Інгібітори pd-1/pd-l1 |
| MX2021003750A (es) * | 2018-10-11 | 2021-06-15 | Basf As | Compuestos aromaticos y usos farmaceuticos de los mismos. |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| US20240382465A1 (en) | 2021-08-05 | 2024-11-21 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Aromatic acetylene derivative, and preparation method therefor and use thereof |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| JPH10265452A (ja) | 1996-05-24 | 1998-10-06 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
| EP1787646A3 (en) * | 1997-06-18 | 2007-10-03 | Smithkline Beecham Plc | Novel method of treatment |
| US6492421B1 (en) * | 1997-07-31 | 2002-12-10 | Athena Neurosciences, Inc. | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| NZ502582A (en) * | 1997-07-31 | 2002-07-26 | American Home Prod | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| WO1999029640A2 (en) * | 1997-12-05 | 1999-06-17 | Eisai Co., Ltd. | Compositions and methods for modulating the activity of fibroblast growth factor |
| US6284796B1 (en) * | 1998-08-06 | 2001-09-04 | Abbott Laboratories | Ukokinase inhibitors |
| US6518283B1 (en) * | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| JP5046466B2 (ja) * | 2000-08-11 | 2012-10-10 | 科研製薬株式会社 | 2,3−ジフェニルプロピオン酸誘導体またはその塩、それを用いた医薬および細胞接着阻害剤ならびにその使用方法 |
| US6313107B1 (en) * | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
| EP1559422B1 (en) * | 2002-11-08 | 2014-04-30 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| JP2006518738A (ja) * | 2003-02-12 | 2006-08-17 | トランス テック ファーマ,インコーポレイテッド | 治療薬としての置換アゾール誘導体 |
| WO2005051890A1 (en) | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
| CN1914173A (zh) * | 2003-12-12 | 2007-02-14 | 惠氏公司 | 用于治疗心血管疾病的喹啉化合物 |
| PE20050676A1 (es) * | 2003-12-12 | 2005-11-02 | Wyeth Corp | Quinolinas referidas a enfermedades cardiovasculares |
| EA011010B1 (ru) | 2004-02-27 | 2008-12-30 | Эмджен, Инк. | Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина |
| WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| CA2583326A1 (en) * | 2004-10-08 | 2006-04-13 | Takeda Pharmaceutical Company Limited | Receptor function regulating agent |
| EP1924546A1 (en) * | 2005-09-14 | 2008-05-28 | Amgen, Inc | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| WO2007049050A2 (en) | 2005-10-27 | 2007-05-03 | Heptahelix Ab | Modulators of gpr40 for the treatment of diabetes |
| AU2007214709A1 (en) | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
| CA2646430A1 (en) * | 2006-03-14 | 2007-09-20 | Amgen Inc. | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders |
| CL2007001873A1 (es) | 2006-06-27 | 2008-01-04 | Takeda Pharmaceutical | Acido((3s))-6-((¨2,6-dimetil-4-(3-(metilsulfonil)-propoxi)bifenil-3-il)metoxi-2,3-dihidro-1-benzofuran-3-il)acetico o una sal del mismo |
| US7687526B2 (en) | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| WO2008054675A2 (en) | 2006-10-31 | 2008-05-08 | Merck & Co., Inc. | Antidiabetic bicyclic compounds |
| US20080221195A1 (en) | 2006-12-13 | 2008-09-11 | Lars Wortmann | 1,2-diarylacetylene derivatives of acyltryptophanols |
| WO2010012650A1 (en) * | 2008-07-28 | 2010-02-04 | Syddansk Universitet | Compounds for the treatment of metabolic diseases |
-
2009
- 2009-07-23 WO PCT/EP2009/059527 patent/WO2010012650A1/en not_active Ceased
- 2009-07-23 US US13/056,484 patent/US8586607B2/en not_active Expired - Fee Related
- 2009-07-23 CN CN200980133756.0A patent/CN102137836B/zh active Active
- 2009-07-23 CN CN201510564913.0A patent/CN105152919A/zh active Pending
- 2009-07-23 JP JP2011520437A patent/JP2012503595A/ja active Pending
- 2009-07-23 EP EP09781005A patent/EP2313360B1/en not_active Not-in-force
-
2014
- 2014-12-25 JP JP2014262319A patent/JP6101675B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015508749A5 (enExample) | ||
| JP2016028068A5 (enExample) | ||
| JP2006511474A5 (enExample) | ||
| FI3555076T3 (fi) | Uusia fenyylipropionihappojohdannaisia ja niiden käyttötapoja | |
| JP2016500063A5 (enExample) | ||
| JP2007504284A5 (enExample) | ||
| JP2019513804A5 (enExample) | ||
| JP2012532112A5 (enExample) | ||
| JP2012255002A5 (enExample) | ||
| JP6812564B2 (ja) | 肝疾患治療剤 | |
| JP2012504141A5 (enExample) | ||
| CN102348689A (zh) | 含有羟基和/或羧基的胺与作为dhodh抑制剂的胺基烟碱酸衍生物的加成盐 | |
| JP2004504301A5 (enExample) | ||
| JP2020502111A5 (enExample) | ||
| JP2010529203A5 (enExample) | ||
| JP2004506718A5 (enExample) | ||
| JP2004529161A5 (enExample) | ||
| AU2005220728A1 (en) | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders | |
| JP2015517525A5 (enExample) | ||
| JP2013529637A5 (enExample) | ||
| RU2015113746A (ru) | Замещенные сульфонамиды | |
| JP2016510741A5 (enExample) | ||
| JP2019531346A (ja) | 甲状腺関連副作用を低下させる方法 | |
| JP2007532511A5 (enExample) | ||
| JP2013510077A5 (enExample) |