CN102137836B - 用于治疗代谢疾病的化合物 - Google Patents
用于治疗代谢疾病的化合物 Download PDFInfo
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- CN102137836B CN102137836B CN200980133756.0A CN200980133756A CN102137836B CN 102137836 B CN102137836 B CN 102137836B CN 200980133756 A CN200980133756 A CN 200980133756A CN 102137836 B CN102137836 B CN 102137836B
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- phenyl
- ethynyl
- propionic acid
- etoac
- compound
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- FVUPYYYPUUMIAQ-UHFFFAOYSA-N C=CCOc1cccc(C#Cc2ccc(CCC(O)=O)cc2)c1 Chemical compound C=CCOc1cccc(C#Cc2ccc(CCC(O)=O)cc2)c1 FVUPYYYPUUMIAQ-UHFFFAOYSA-N 0.000 description 1
- 0 CC(C1C(C2)/C=C/C(/C#C[Al]*)=C\C=C2\*1)O* Chemical compound CC(C1C(C2)/C=C/C(/C#C[Al]*)=C\C=C2\*1)O* 0.000 description 1
- ZXYKHYHOPVRYNY-UHFFFAOYSA-N CCOC(COc(cc1)ccc1C#Cc1cccc(O)c1)=O Chemical compound CCOC(COc(cc1)ccc1C#Cc1cccc(O)c1)=O ZXYKHYHOPVRYNY-UHFFFAOYSA-N 0.000 description 1
- UEEATOJHRZBEGO-UHFFFAOYSA-N Cc(cc1)ccc1S(OCCc(cccc1)c1C#Cc1ccc(CCC(OC)=O)cc1)(=O)=O Chemical compound Cc(cc1)ccc1S(OCCc(cccc1)c1C#Cc1ccc(CCC(OC)=O)cc1)(=O)=O UEEATOJHRZBEGO-UHFFFAOYSA-N 0.000 description 1
- CFYHBPNTTQBMIV-UHFFFAOYSA-N Cc1nccc(C#Cc2ccc(CCC(OC)=O)cc2)c1 Chemical compound Cc1nccc(C#Cc2ccc(CCC(OC)=O)cc2)c1 CFYHBPNTTQBMIV-UHFFFAOYSA-N 0.000 description 1
- BGYHRAMMUCXREZ-UHFFFAOYSA-N OCc(cccc1)c1C#Cc1ccc(CCC(O)=O)cc1 Chemical compound OCc(cccc1)c1C#Cc1ccc(CCC(O)=O)cc1 BGYHRAMMUCXREZ-UHFFFAOYSA-N 0.000 description 1
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- C07D215/18—Halogen atoms or nitro radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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- C—CHEMISTRY; METALLURGY
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- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/04—1,2,3-Triazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510564913.0A CN105152919A (zh) | 2008-07-28 | 2009-07-23 | 用于治疗代谢疾病的化合物 |
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| US8409808P | 2008-07-28 | 2008-07-28 | |
| US61/084,098 | 2008-07-28 | ||
| PCT/EP2009/059527 WO2010012650A1 (en) | 2008-07-28 | 2009-07-23 | Compounds for the treatment of metabolic diseases |
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| CN201510564913.0A Pending CN105152919A (zh) | 2008-07-28 | 2009-07-23 | 用于治疗代谢疾病的化合物 |
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| EP (1) | EP2313360B1 (enExample) |
| JP (2) | JP2012503595A (enExample) |
| CN (2) | CN102137836B (enExample) |
| WO (1) | WO2010012650A1 (enExample) |
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| CN101835750B (zh) | 2007-08-22 | 2013-07-17 | 阿斯利康(瑞典)有限公司 | 环丙基酰胺衍生物 |
| WO2009067493A2 (en) * | 2007-11-19 | 2009-05-28 | Envivo Pharmaceuticals, Inc. | 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders |
| RU2527177C2 (ru) | 2007-12-20 | 2014-08-27 | Энвиво Фармасьютикалз, Инк. | Четырехзамещенные бензолы |
| WO2010012650A1 (en) * | 2008-07-28 | 2010-02-04 | Syddansk Universitet | Compounds for the treatment of metabolic diseases |
| TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| US20110201623A1 (en) | 2010-02-18 | 2011-08-18 | Uczynski Michael A | Crystalline Form Of A Cyclopropyl Benzamide Derivative |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| CN104470886A (zh) * | 2011-04-08 | 2015-03-25 | 赛丹思科大学 | 用于治疗代谢疾病的邻-氟取代的化合物 |
| SG10201603776RA (en) * | 2011-05-04 | 2016-07-28 | Univ Sydney | Prenylated hydroxystilbenes |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| RU2477726C1 (ru) * | 2011-10-18 | 2013-03-20 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение |
| US8633182B2 (en) * | 2012-05-30 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Indanyloxyphenylcyclopropanecarboxylic acids |
| HK1210825A1 (en) | 2012-07-11 | 2016-05-06 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
| EP3068788A1 (en) | 2013-11-14 | 2016-09-21 | Cadila Healthcare Limited | Novel heterocyclic compounds |
| US9839644B2 (en) | 2014-09-09 | 2017-12-12 | ARKAY Therapeutics, LLC | Formulations and methods for treatment of metabolic syndrome |
| EP3253745B1 (en) * | 2015-02-05 | 2021-09-29 | Piramal Enterprises Limited | Compounds containing carbon-carbon linker as gpr120 agonists |
| WO2016151018A1 (en) | 2015-03-24 | 2016-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| WO2019074241A1 (ko) * | 2017-10-11 | 2019-04-18 | 정원혁 | 페닐아세틸렌 유도체를 포함하는 pd-1과 pd-l1의 상호작용 억제제 |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| UA126421C2 (uk) | 2018-07-13 | 2022-09-28 | Гіліад Сайєнсіз, Інк. | Інгібітори pd-1/pd-l1 |
| MX2021003750A (es) * | 2018-10-11 | 2021-06-15 | Basf As | Compuestos aromaticos y usos farmaceuticos de los mismos. |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| US20240382465A1 (en) | 2021-08-05 | 2024-11-21 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Aromatic acetylene derivative, and preparation method therefor and use thereof |
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- 2009-07-23 WO PCT/EP2009/059527 patent/WO2010012650A1/en not_active Ceased
- 2009-07-23 US US13/056,484 patent/US8586607B2/en not_active Expired - Fee Related
- 2009-07-23 CN CN200980133756.0A patent/CN102137836B/zh active Active
- 2009-07-23 CN CN201510564913.0A patent/CN105152919A/zh active Pending
- 2009-07-23 JP JP2011520437A patent/JP2012503595A/ja active Pending
- 2009-07-23 EP EP09781005A patent/EP2313360B1/en not_active Not-in-force
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Also Published As
| Publication number | Publication date |
|---|---|
| US20110152315A1 (en) | 2011-06-23 |
| JP2015120698A (ja) | 2015-07-02 |
| CN105152919A (zh) | 2015-12-16 |
| WO2010012650A1 (en) | 2010-02-04 |
| JP2012503595A (ja) | 2012-02-09 |
| EP2313360B1 (en) | 2012-09-05 |
| JP6101675B2 (ja) | 2017-03-22 |
| EP2313360A1 (en) | 2011-04-27 |
| CN102137836A (zh) | 2011-07-27 |
| US8586607B2 (en) | 2013-11-19 |
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