MX2021003750A - Compuestos aromaticos y usos farmaceuticos de los mismos. - Google Patents
Compuestos aromaticos y usos farmaceuticos de los mismos.Info
- Publication number
- MX2021003750A MX2021003750A MX2021003750A MX2021003750A MX2021003750A MX 2021003750 A MX2021003750 A MX 2021003750A MX 2021003750 A MX2021003750 A MX 2021003750A MX 2021003750 A MX2021003750 A MX 2021003750A MX 2021003750 A MX2021003750 A MX 2021003750A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- diseases
- present disclosure
- compounds
- phospholipid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/04—Monocyclic monocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/64—Monocyclic acids with unsaturation outside the aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente descripción se refiere a compuestos de la fórmula general (I): (ver Fórmula) (I) R1, R2, R3, R4, R5, R6, y R7 se pueden elegir de diferentes sustituyentes; n es 0, 1, o 2; y X es un hidroximetilo o un ácido carboxílico o un derivado del mismo, tal como un carboxilato, tal como un éster carboxílico, un glicérido, un anhídrido, un fosfolípido, una carboxamida, un fosfolípido, o un profármaco del mismo; o una sal farmacéuticamente aceptable, solvato, solvato de tal sal o un profármaco de la misma. La presente descripción también se refiere a composiciones farmacéuticas y composiciones lipídicas que comprenden al menos un compuesto de acuerdo con la presente descripción, y a tales compuestos para su uso como medicamentos o para su uso en terapia, en particular para el tratamiento de enfermedades relacionadas con enfermedades metabólicas y enfermedades hepáticas, tal como la enfermedad del hígado graso no alcohólico y enfermedades de colestasis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862744461P | 2018-10-11 | 2018-10-11 | |
PCT/IB2019/001139 WO2020074964A1 (en) | 2018-10-11 | 2019-10-10 | Romatic compounds and pharmaceutical uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021003750A true MX2021003750A (es) | 2021-06-15 |
Family
ID=68655570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021003750A MX2021003750A (es) | 2018-10-11 | 2019-10-10 | Compuestos aromaticos y usos farmaceuticos de los mismos. |
Country Status (17)
Country | Link |
---|---|
US (1) | US20210380521A1 (es) |
EP (1) | EP3864001A1 (es) |
JP (1) | JP2022504707A (es) |
KR (1) | KR20210091150A (es) |
CN (1) | CN113166024A (es) |
AU (1) | AU2019358595A1 (es) |
BR (1) | BR112021006907A2 (es) |
CA (1) | CA3112073A1 (es) |
CL (1) | CL2021000846A1 (es) |
CO (1) | CO2021006087A2 (es) |
EA (1) | EA202190890A1 (es) |
IL (1) | IL282134A (es) |
MA (1) | MA53188A1 (es) |
MX (1) | MX2021003750A (es) |
PH (1) | PH12021550744A1 (es) |
SG (1) | SG11202103011YA (es) |
WO (1) | WO2020074964A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023065200A1 (en) * | 2021-10-21 | 2023-04-27 | Givaudan Sa | Organic compounds |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ20033394A3 (cs) * | 2001-06-12 | 2005-03-16 | Wellstat Therapeutics Corporation | Sloučeniny pro léčení metabolických poruch a způsob jejich přípravy |
WO2004022551A1 (ja) * | 2002-09-06 | 2004-03-18 | Takeda Pharmaceutical Company Limited | フランまたはチオフェン誘導体およびその医薬用途 |
ES2530235T3 (es) * | 2003-02-13 | 2015-02-27 | Wellstat Therapeutics Corporation | Compuestos para el tratamiento de trastornos metabólicos |
AU2004282219C1 (en) * | 2003-10-15 | 2009-12-17 | Osi Pharmaceuticals, Inc. | Imidazo [1, 5 - a] pyrazine tyrosine kinase inhibitors |
EP1692133A1 (en) * | 2003-12-05 | 2006-08-23 | Actelion Pharmaceuticals Ltd. | Diazabicyclononene derivatives and their use as renin inhibitors |
EP1836160A1 (en) * | 2004-12-24 | 2007-09-26 | CTG Pharma S.r.l. | Compounds for treating metabolic syndrome |
TW200724138A (en) * | 2005-03-29 | 2007-07-01 | Sk Corp | Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use |
JP2008543741A (ja) * | 2005-05-09 | 2008-12-04 | アストラゼネカ・アクチエボラーグ | 新規な化合物 |
GB0522433D0 (en) * | 2005-11-03 | 2005-12-14 | Astrazeneca Ab | Therapeutic agents |
WO2007093364A1 (en) * | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
CL2008001632A1 (es) * | 2007-06-05 | 2009-10-16 | Sanofi Aventis | Compuestos derivados de acidos benzoilamino-indan-2-carboxilicos sustituidos, inhibidores del receptor cxcr5; composicion farmaceutica; y su uso en el tratamiento de efecciones fisiologicas inflamatorias, tales como artritis reumatoidea y asma. |
JP2011517321A (ja) * | 2008-03-13 | 2011-06-02 | ビーエーエスエフ ソシエタス・ヨーロピア | 二量体ベンジリデンマロネート類 |
EP2291182A1 (en) * | 2008-05-13 | 2011-03-09 | Genmedica Therapeutics SL | Salicylate conjugates useful for treating metabolic disorders |
WO2010012650A1 (en) * | 2008-07-28 | 2010-02-04 | Syddansk Universitet | Compounds for the treatment of metabolic diseases |
PT2427415T (pt) * | 2009-05-08 | 2019-05-31 | Basf As | Ácidos gordos polinsaturados para o tratamento de doenças relacionadas com as áreas cardiovascular, metabólica e de doença inflamatória |
EP2491039A1 (en) * | 2009-10-20 | 2012-08-29 | Cellzome Limited | Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors |
TR201810393T4 (tr) * | 2009-11-26 | 2018-08-27 | Genfit | Karaciğer rahatıszlıklarının tedavisi için 1,3-difenilprop-2-en-1-on türevlerinin kullanımı. |
US9562041B2 (en) * | 2012-05-16 | 2017-02-07 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
US20170305943A1 (en) * | 2014-05-21 | 2017-10-26 | Taxis Pharmaceuticals, Inc. | Compounds for the treatment of bacterial infections |
GB2543478A (en) * | 2015-09-07 | 2017-04-26 | Manchester Metropolitan Univ | Glycomimetics |
-
2019
- 2019-10-10 US US17/284,022 patent/US20210380521A1/en active Pending
- 2019-10-10 CA CA3112073A patent/CA3112073A1/en active Pending
- 2019-10-10 AU AU2019358595A patent/AU2019358595A1/en active Pending
- 2019-10-10 JP JP2021519840A patent/JP2022504707A/ja active Pending
- 2019-10-10 BR BR112021006907-0A patent/BR112021006907A2/pt unknown
- 2019-10-10 EP EP19809143.1A patent/EP3864001A1/en active Pending
- 2019-10-10 WO PCT/IB2019/001139 patent/WO2020074964A1/en unknown
- 2019-10-10 CN CN201980067283.2A patent/CN113166024A/zh active Pending
- 2019-10-10 KR KR1020217014095A patent/KR20210091150A/ko unknown
- 2019-10-10 MX MX2021003750A patent/MX2021003750A/es unknown
- 2019-10-10 MA MA53188A patent/MA53188A1/fr unknown
- 2019-10-10 SG SG11202103011YA patent/SG11202103011YA/en unknown
- 2019-10-10 EA EA202190890A patent/EA202190890A1/ru unknown
-
2021
- 2021-04-05 CL CL2021000846A patent/CL2021000846A1/es unknown
- 2021-04-05 PH PH12021550744A patent/PH12021550744A1/en unknown
- 2021-04-07 IL IL282134A patent/IL282134A/en unknown
- 2021-05-11 CO CONC2021/0006087A patent/CO2021006087A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN113166024A (zh) | 2021-07-23 |
SG11202103011YA (en) | 2021-04-29 |
IL282134A (en) | 2021-05-31 |
EA202190890A1 (ru) | 2021-09-10 |
CL2021000846A1 (es) | 2021-11-12 |
BR112021006907A2 (pt) | 2021-09-08 |
US20210380521A1 (en) | 2021-12-09 |
MA53188A1 (fr) | 2021-12-31 |
EP3864001A1 (en) | 2021-08-18 |
PH12021550744A1 (en) | 2022-02-21 |
KR20210091150A (ko) | 2021-07-21 |
JP2022504707A (ja) | 2022-01-13 |
WO2020074964A1 (en) | 2020-04-16 |
CO2021006087A2 (es) | 2021-08-09 |
AU2019358595A1 (en) | 2021-05-27 |
CA3112073A1 (en) | 2020-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12015500930A1 (en) | Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas | |
MY153620A (en) | Novel sulphur containing lipids for use as food supplementor as medicament | |
EP3157936B1 (en) | Mineral amino-acid complexes of active agents | |
MX2009004336A (es) | Lipidos omega-3 alfa-sustituidos que son activadores o moduladores del receptor activado por proliferadores de peroxisoma (ppar). | |
JP2016506941A (ja) | 慢性炎症及び炎症性疾患を治療する組成物と方法 | |
EA200301204A1 (ru) | Фармацевтически активные производные нуклеозида, способ их получения, их применение (варианты) и содержащая их фармацевтическая композиция, способ профилактики и/или лечения заболеваний и нарушений млекопитающих (варианты), комбинация лекарственных средств и ее применение (варианты) | |
MX2011010827A (es) | Composiciones y metodos para el tratamiento de la inflamacion. | |
JP2017513824A5 (es) | ||
JP2016511753A5 (es) | ||
MY177702A (en) | Derivatives of dolastatin 10 and auristatins | |
ZA202206481B (en) | Amide derivative and preparation method therefore and use thereof in medicine | |
RU2020122008A (ru) | Структурно усиленные жирные кислоты, содержащие кислород, для лечения неалкогольного стеатогепатита | |
JP2023116579A (ja) | 硫黄を含有する構造的に強化された脂肪酸の非アルコール性脂肪性肝炎の予防及び/又は治療のための使用 | |
PH12021550744A1 (en) | Aromatic compounds and pharmaceutical uses thereof | |
PH12019500618A1 (en) | Pharmaceutical composition and method for treatment of non-alcoholic fatty liver disease | |
JP5587333B2 (ja) | 抗アクネ剤としての多価不飽和脂肪酸およびジオールエステル | |
ES2560220T3 (es) | Agente terapéutico y agente preventivo para la enfermedad de Alzheimer | |
IL58065A (en) | Furyl substituted polyene carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them | |
CA3101144A1 (en) | Composition having improved voluntary acceptance | |
NO20076251L (no) | Nye DHA derivater og deres anvendelse som medikamenter | |
US3835131A (en) | 2-acyl-5-nitrothiazole derivatives | |
HU216156B (hu) | Eljárás indozilidinszármazékok előállítására, és a kiindulási vegyület | |
WO2024059664A3 (en) | Salts and esters of apx3330 and therapeutic uses thereof | |
JPS61204124A (ja) | 冠血管拡張剤 | |
RU94028194A (ru) | 4-ацетил-5-n-иодфенил-1-карбоксиметил-3-гидрокси-2,5-дигидропиррол-2-он, проявляющий анальгетическую активность |