JP2020502111A5 - - Google Patents
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- Publication number
- JP2020502111A5 JP2020502111A5 JP2019531649A JP2019531649A JP2020502111A5 JP 2020502111 A5 JP2020502111 A5 JP 2020502111A5 JP 2019531649 A JP2019531649 A JP 2019531649A JP 2019531649 A JP2019531649 A JP 2019531649A JP 2020502111 A5 JP2020502111 A5 JP 2020502111A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- hydrogen
- indene
- hex
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 239000001257 hydrogen Substances 0.000 claims 36
- -1 cyano, hydroxy Chemical group 0.000 claims 32
- 239000002253 acid Substances 0.000 claims 27
- 150000002431 hydrogen Chemical class 0.000 claims 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 239000000126 substance Substances 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 208000016097 disease of metabolism Diseases 0.000 claims 4
- 208000030159 metabolic disease Diseases 0.000 claims 4
- 125000004970 halomethyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102100026148 Free fatty acid receptor 1 Human genes 0.000 claims 2
- 101710142060 Free fatty acid receptor 1 Proteins 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000008196 pharmacological composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160171541 | 2016-12-15 | ||
| KR10-2016-0171541 | 2016-12-15 | ||
| KR1020170171228A KR102007633B1 (ko) | 2016-12-15 | 2017-12-13 | 신규 페닐 프로피온 산 유도체 및 이의 용도 |
| KR10-2017-0171228 | 2017-12-13 | ||
| PCT/KR2017/014757 WO2018111012A1 (en) | 2016-12-15 | 2017-12-14 | Novel phenyl propionic acid derivatives and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502111A JP2020502111A (ja) | 2020-01-23 |
| JP2020502111A5 true JP2020502111A5 (enExample) | 2020-11-12 |
| JP6892922B2 JP6892922B2 (ja) | 2021-06-23 |
Family
ID=62559593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531649A Active JP6892922B2 (ja) | 2016-12-15 | 2017-12-14 | 新規フェニルプロピオン酸誘導体及びその用途 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11225472B2 (enExample) |
| EP (1) | EP3555076B1 (enExample) |
| JP (1) | JP6892922B2 (enExample) |
| KR (1) | KR102007633B1 (enExample) |
| CN (1) | CN110049984B (enExample) |
| AU (1) | AU2017374460B2 (enExample) |
| BR (1) | BR112019012433A2 (enExample) |
| CA (1) | CA3042528C (enExample) |
| DK (1) | DK3555076T3 (enExample) |
| ES (1) | ES2948485T3 (enExample) |
| FI (1) | FI3555076T3 (enExample) |
| HU (1) | HUE062468T2 (enExample) |
| IL (1) | IL267239B (enExample) |
| MX (1) | MX2019007071A (enExample) |
| MY (1) | MY198292A (enExample) |
| PH (1) | PH12019501251A1 (enExample) |
| PL (1) | PL3555076T3 (enExample) |
| PT (1) | PT3555076T (enExample) |
| RS (1) | RS64259B1 (enExample) |
| RU (1) | RU2760266C2 (enExample) |
| SI (1) | SI3555076T1 (enExample) |
| WO (1) | WO2018111012A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220112185A1 (en) * | 2016-12-15 | 2022-04-14 | Ildong Pharmaceutical Co., Ltd. | Novel phenyl propionic acid derivatives and uses thereof |
| KR102007633B1 (ko) * | 2016-12-15 | 2019-08-06 | 일동제약(주) | 신규 페닐 프로피온 산 유도체 및 이의 용도 |
| MY196582A (en) | 2018-02-13 | 2023-04-19 | Gilead Sciences Inc | PD-1/PD-L1 Inhibitors |
| CA3093851A1 (en) | 2018-03-29 | 2019-10-03 | Arbutus Biopharma Corporation | Substituted 1,1'-biphenyl compounds, analogues thereof, and methods using same |
| WO2019204609A1 (en) | 2018-04-19 | 2019-10-24 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| PT3820572T (pt) | 2018-07-13 | 2023-11-10 | Gilead Sciences Inc | Inibidores pd-1/pd-l1 |
| EP3870566A1 (en) | 2018-10-24 | 2021-09-01 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
| JP7745559B2 (ja) | 2020-02-28 | 2025-09-29 | キャリーオペ，インク． | Ｇｐｒ４０アゴニスト |
| BR112022023359A2 (pt) | 2020-05-19 | 2023-04-18 | Kallyope Inc | Ativadores de ampk |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| MX2023012835A (es) * | 2021-04-29 | 2023-11-08 | Ildong Pharmaceutical Co Ltd | Composicion farmaceutica que comprende un agonista de gpr40 y un inhibidor de sglt-2. |
| CN117835981A (zh) * | 2021-06-21 | 2024-04-05 | 尹诺卫医药有限公司 | 控制血糖水平和治疗糖尿病及相关疾患的方法 |
| WO2023080299A1 (ko) * | 2021-11-08 | 2023-05-11 | 일동제약(주) | 페닐 프로피온 산 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물 |
| KR20240084229A (ko) * | 2022-12-06 | 2024-06-13 | 유노비아 주식회사 | 안정성이 향상된 gpr40 효현제를 유효성분으로 포함하는 약제학적 조성물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4594611B2 (ja) * | 2002-11-08 | 2010-12-08 | 武田薬品工業株式会社 | 受容体機能調節剤 |
| KR20070004769A (ko) * | 2004-02-27 | 2007-01-09 | 암젠 인코포레이션 | 대사 장애의 치료에 사용되는 화합물, 약제학적 조성물 및그 사용방법 |
| JP4875978B2 (ja) * | 2004-03-15 | 2012-02-15 | 武田薬品工業株式会社 | アミノフェニルプロパン酸誘導体 |
| CA2620476A1 (en) | 2005-06-02 | 2006-12-07 | Jenrin Discovery | Mao-b inhibitors useful for treating obesity |
| EP1924546A1 (en) * | 2005-09-14 | 2008-05-28 | Amgen, Inc | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| JP5055852B2 (ja) | 2006-06-21 | 2012-10-24 | 住友大阪セメント株式会社 | 鉄資源の回収方法 |
| ES2546154T3 (es) * | 2010-12-01 | 2015-09-21 | Boehringer Ingelheim International Gmbh | Ácidos indaniloxidihidrobenzofuranilacéticos, útiles para el tratamiento del síndrome metabólico |
| JP2013147443A (ja) * | 2012-01-18 | 2013-08-01 | Daiichi Sankyo Co Ltd | β置換カルボン酸誘導体 |
| US8633182B2 (en) * | 2012-05-30 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Indanyloxyphenylcyclopropanecarboxylic acids |
| EP3049396B1 (en) * | 2013-09-26 | 2017-11-15 | Boehringer Ingelheim International GmbH | Process and intermediates for preparing indanyloxydihydrobenzofuranyl acetic acid derivatives as gpr40 agonists |
| US10195178B2 (en) | 2016-04-11 | 2019-02-05 | Janssen Pharmaceutica Nv | GPR40 agonists in anti-diabetic drug combinations |
| KR102007633B1 (ko) * | 2016-12-15 | 2019-08-06 | 일동제약(주) | 신규 페닐 프로피온 산 유도체 및 이의 용도 |
| US20220112185A1 (en) * | 2016-12-15 | 2022-04-14 | Ildong Pharmaceutical Co., Ltd. | Novel phenyl propionic acid derivatives and uses thereof |
| MX2023012835A (es) * | 2021-04-29 | 2023-11-08 | Ildong Pharmaceutical Co Ltd | Composicion farmaceutica que comprende un agonista de gpr40 y un inhibidor de sglt-2. |
| CN117835981A (zh) * | 2021-06-21 | 2024-04-05 | 尹诺卫医药有限公司 | 控制血糖水平和治疗糖尿病及相关疾患的方法 |
| US20230022803A1 (en) * | 2021-06-25 | 2023-01-26 | Ildong Pharmaceutical Co., Ltd. | Novel crystalline form of gpr40 agonist |
-
2017
- 2017-12-13 KR KR1020170171228A patent/KR102007633B1/ko active Active
- 2017-12-14 RU RU2019121871A patent/RU2760266C2/ru active
- 2017-12-14 RS RS20230456A patent/RS64259B1/sr unknown
- 2017-12-14 MX MX2019007071A patent/MX2019007071A/es unknown
- 2017-12-14 PL PL17880872.1T patent/PL3555076T3/pl unknown
- 2017-12-14 CN CN201780074801.4A patent/CN110049984B/zh not_active Expired - Fee Related
- 2017-12-14 JP JP2019531649A patent/JP6892922B2/ja active Active
- 2017-12-14 BR BR112019012433A patent/BR112019012433A2/pt not_active Application Discontinuation
- 2017-12-14 FI FIEP17880872.1T patent/FI3555076T3/fi active
- 2017-12-14 AU AU2017374460A patent/AU2017374460B2/en not_active Ceased
- 2017-12-14 EP EP17880872.1A patent/EP3555076B1/en active Active
- 2017-12-14 HU HUE17880872A patent/HUE062468T2/hu unknown
- 2017-12-14 ES ES17880872T patent/ES2948485T3/es active Active
- 2017-12-14 MY MYPI2019003388A patent/MY198292A/en unknown
- 2017-12-14 DK DK17880872.1T patent/DK3555076T3/da active
- 2017-12-14 PT PT178808721T patent/PT3555076T/pt unknown
- 2017-12-14 SI SI201731367T patent/SI3555076T1/sl unknown
- 2017-12-14 US US16/467,654 patent/US11225472B2/en active Active
- 2017-12-14 CA CA3042528A patent/CA3042528C/en active Active
- 2017-12-14 WO PCT/KR2017/014757 patent/WO2018111012A1/en not_active Ceased
- 2017-12-14 IL IL267239A patent/IL267239B/en unknown
-
2019
- 2019-06-06 PH PH12019501251A patent/PH12019501251A1/en unknown
-
2021
- 2021-11-10 US US17/523,652 patent/US11731961B2/en active Active
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