JP6812564B2 - 肝疾患治療剤 - Google Patents
肝疾患治療剤 Download PDFInfo
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- JP6812564B2 JP6812564B2 JP2019540608A JP2019540608A JP6812564B2 JP 6812564 B2 JP6812564 B2 JP 6812564B2 JP 2019540608 A JP2019540608 A JP 2019540608A JP 2019540608 A JP2019540608 A JP 2019540608A JP 6812564 B2 JP6812564 B2 JP 6812564B2
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- Prior art keywords
- liver
- pyrazole
- pharmaceutically acceptable
- acid
- liver disease
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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Description
本発明の他の態様として、肝疾患患者の肝疾患を予防、改善又は治療するための方法であって、前記化学式1で表示されるピラゾール系化合物及びその薬学的に許容可能な塩から選ばれる少なくとも1種の化合物の有効量を、これを必要とする対象に投与することを含む方法を提供する。
本発明において、“脂肪肝疾患”とは、肝細胞に脂肪が蓄積して肝障害を起こす疾患を総称し、アルコール性肝障害、非アルコール性脂肪肝(NAFLD又はNASH)を含む。
3−フェニル−4−メチル−1−(ピリジン−2−イル)−1H−ピラゾール−5−オール又はその塩酸塩;
3−フェニル−4−エチル−1−(ピリジン−2−イル)−1H−ピラゾール−5−オール又はその塩酸塩;
3−フェニル−4−ノルマルプロピル−1−(ピリジン−2−イル)−1H−ピラゾール−5−オール又はその塩酸塩;
3−フェニル−4−イソプロピル−1−(ピリジン−2−イル)−1H−ピラゾール−5−オール又はその塩酸塩;
3−フェニル−4−ノルマルブチル−1−(ピリジン−2−イル)−1H−ピラゾール−5−オール又はその塩酸塩;
3−フェニル−4−tert−ブチル−1−(ピリジン−2−イル)−1H−ピラゾール−5−オール又はその塩酸塩;
3−フェニル−4−ノルマルペンチル−1−(ピリジン−2−イル)−1H−ピラゾール−5−オール又はその塩酸塩;
又は
3−フェニル−4−ノルマルヘキシル−1−(ピリジン−2−イル)−1H−ピラゾール−5−オール又はその塩酸塩。
本合成例では、肝疾患治療用の薬学組成物に有効成分として含まれるピラゾール系化合物を合成する代表的な製造方法を例示する。
本実施例では、肝疾患治療用の医薬組成物に有効成分として含まれるピラゾール誘体の薬理作用が詳細に特定される。
被検動物は、6週齢の雄のスプラーグドーリー(SD)ラットを購入した。ラットはいずれも標準条件で保存された。約6週間飼育して12週齢で試験物質がラットに投与された。試験群は、5週目に採取した血液のALT値を基準にして構成された。
正常対照群は陰性対照として用いられた。
被検動物は、6週齢のラットを購入した。ラットはいずれも標準条件で保存された。約6週間飼育して12週齢で試験物質がラットに投与された。試験群は、5週目に採取した血液のALT値を基準にして構成された。12週齢から5週間、試験物質はビヒクル投与群、陽性対照群であるオベチコール酸投与群、及び3-フェニル-4-ノルマルプロピル-1-(ピリジン-2-イル)-1H-ピラゾール-5-オール塩酸塩投与群対して別々に投与された。
被検動物は6週齢の雄糖尿病db/dbマウス(C57BLKS/J−leprdb/leprdb)をJackson Laboratory(Bar Harbor,ME,USA)から購入した。マウスはいずれも標準条件で保存された。約2週間飼育して8週齢で試験物質がマウスに投与された。8週齢から12週間、試験物質は、ビヒクル投与群と、3-フェニル-4-ノルマルプロピル-1-(ピリジン-2-イル)-1H-ピラゾール-5-オール塩酸塩投与群とに対して別々にされた。
正常対照群は陰性対照として使用された。
Claims (7)
- 3-フェニル-4-ノルマルプロピル-1-(ピリジン-2-イル)-1H-ピラゾール-5-オール及びその薬学的に許容可能な塩から選ばれる少なくとも1種以上の化合物が有効成分として含まれている、請求項1に記載の肝疾患の予防、改善又は治療用の薬学組成物。
- 前記薬学的に許容可能な塩は、アルカリ金属塩、アルカリ土金属塩、無機酸との塩、有機酸との塩及び酸性アミノ酸との塩からなる群から選ばれることを特徴とする、請求項1に記載の肝疾患の予防、改善又は治療用の薬学組成物。
- 前記薬学的に許容可能な塩は、塩酸塩であることを特徴とする、請求項1に記載の肝疾患の予防、改善又は治療用の薬学組成物。
- 前記薬学組成物は、注射剤、顆粒剤、錠剤、丸剤、カプセル剤、ゲル剤、シロップ剤、懸濁剤、乳剤、点滴剤及び液剤からなる群から選ばれる剤形に製剤化されたことを特徴とする、請求項1に記載の肝疾患の予防、改善又は治療用の薬学組成物。
- 3-フェニル-4-ノルマルプロピル-1-(ピリジン-2-イル)-1H-ピラゾール-5-オール及びその薬学的に許容可能な塩から選ばれる少なくとも1種が有効成分として含まれている、非アルコール性脂肪肝炎の予防又は治療剤。
- 3-フェニル-4-ノルマルプロピル-1-(ピリジン-2-イル)-1H-ピラゾール-5-オール及びその薬学的に許容可能な塩から選ばれる少なくとも1種が有効成分として含まれている、肝硬変の予防又は治療剤。
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CN115413239A (zh) * | 2020-04-08 | 2022-11-29 | 阿普塔生物治疗公司 | 用于治疗造影引起的急性肾脏损伤的试剂 |
US20230148365A1 (en) * | 2020-04-13 | 2023-05-11 | Aptabio Therapeutics Inc. | Pulmonary fibrosis medicine containing pyrazole derivative |
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