JP2006511474A5 - - Google Patents
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- Publication number
- JP2006511474A5 JP2006511474A5 JP2004537682A JP2004537682A JP2006511474A5 JP 2006511474 A5 JP2006511474 A5 JP 2006511474A5 JP 2004537682 A JP2004537682 A JP 2004537682A JP 2004537682 A JP2004537682 A JP 2004537682A JP 2006511474 A5 JP2006511474 A5 JP 2006511474A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenoxy
- butylamino
- nicotinamide
- pyrazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ADXBHKREPBWTDP-UHFFFAOYSA-N CC(C)CCNCc(cc1)ccc1Oc(cc1)ncc1C(N)=O Chemical compound CC(C)CCNCc(cc1)ccc1Oc(cc1)ncc1C(N)=O ADXBHKREPBWTDP-UHFFFAOYSA-N 0.000 description 4
- QWNDOCKIKKQJNN-UHFFFAOYSA-N NC(c(cc1)cnc1Oc1ccc(CNCCC2CCOCC2)cc1F)=O Chemical compound NC(c(cc1)cnc1Oc1ccc(CNCCC2CCOCC2)cc1F)=O QWNDOCKIKKQJNN-UHFFFAOYSA-N 0.000 description 3
- WSTRRHWTLHPFLJ-UHFFFAOYSA-N CC(C)(C)CCNCc(cc1F)ccc1Oc1ncc(C(N)=O)nc1 Chemical compound CC(C)(C)CCNCc(cc1F)ccc1Oc1ncc(C(N)=O)nc1 WSTRRHWTLHPFLJ-UHFFFAOYSA-N 0.000 description 2
- QWVMKVCQRJKDNE-UHFFFAOYSA-N CC(C)CCNCc(c(F)c1F)cc(F)c1Oc(cc1)ncc1C(N)=O Chemical compound CC(C)CCNCc(c(F)c1F)cc(F)c1Oc(cc1)ncc1C(N)=O QWVMKVCQRJKDNE-UHFFFAOYSA-N 0.000 description 2
- KXIFIKGCMNZIRR-UHFFFAOYSA-N CCCCCNCc(cc1OC)ccc1Oc(nc1)cnc1C(N)=O Chemical compound CCCCCNCc(cc1OC)ccc1Oc(nc1)cnc1C(N)=O KXIFIKGCMNZIRR-UHFFFAOYSA-N 0.000 description 2
- ZGCYVRNZWGUXNQ-UHFFFAOYSA-N COc1cc(CNCCC2CCOCC2)ccc1Oc(nc1)cnc1C(N)=O Chemical compound COc1cc(CNCCC2CCOCC2)ccc1Oc(nc1)cnc1C(N)=O ZGCYVRNZWGUXNQ-UHFFFAOYSA-N 0.000 description 2
- ORJMHMIAJUKSME-UHFFFAOYSA-N COc1cc(CNCCc(cc2)ccc2F)ccc1Oc(nc1)cnc1C(N)=O Chemical compound COc1cc(CNCCc(cc2)ccc2F)ccc1Oc(nc1)cnc1C(N)=O ORJMHMIAJUKSME-UHFFFAOYSA-N 0.000 description 2
- SRTJWEAYPLHPFJ-UHFFFAOYSA-N CC(C)(C)CCCNCc(cc1OC)ccc1Oc(nc1)cnc1C(N)=O Chemical compound CC(C)(C)CCCNCc(cc1OC)ccc1Oc(nc1)cnc1C(N)=O SRTJWEAYPLHPFJ-UHFFFAOYSA-N 0.000 description 1
- MPAAEZPHTFLIIG-UHFFFAOYSA-N CC(C)(C)CCNCCc(cc1F)cc(F)c1Oc(nc1)ccc1C(N)=O Chemical compound CC(C)(C)CCNCCc(cc1F)cc(F)c1Oc(nc1)ccc1C(N)=O MPAAEZPHTFLIIG-UHFFFAOYSA-N 0.000 description 1
- RTJRBLXYTFNKGI-UHFFFAOYSA-N CC(C)(C)CCNCc(cc1)ccc1Oc(ccc(C(N)=O)c1)c1Cl Chemical compound CC(C)(C)CCNCc(cc1)ccc1Oc(ccc(C(N)=O)c1)c1Cl RTJRBLXYTFNKGI-UHFFFAOYSA-N 0.000 description 1
- WGCYEUMXKPHFPH-UHFFFAOYSA-N CC(C)(C)CCNCc(cc1F)cc(OC)c1Oc(cc1)ncc1C(N)=O Chemical compound CC(C)(C)CCNCc(cc1F)cc(OC)c1Oc(cc1)ncc1C(N)=O WGCYEUMXKPHFPH-UHFFFAOYSA-N 0.000 description 1
- MXOQKGNZONURBF-UHFFFAOYSA-N CC(C)CCNCc(cc1)ccc1Oc(c(F)cc(C(N)=O)c1)c1F Chemical compound CC(C)CCNCc(cc1)ccc1Oc(c(F)cc(C(N)=O)c1)c1F MXOQKGNZONURBF-UHFFFAOYSA-N 0.000 description 1
- IBNFHMRDGWKDCH-UHFFFAOYSA-N CC(C)CCNCc(cc1)ccc1Oc(ccc(C(N)=O)c1)c1F Chemical compound CC(C)CCNCc(cc1)ccc1Oc(ccc(C(N)=O)c1)c1F IBNFHMRDGWKDCH-UHFFFAOYSA-N 0.000 description 1
- HLCRMSMJGHCCGN-UHFFFAOYSA-N CC(C)CCNCc(cc1C)ccc1Oc(nc1)ccc1C(N)=O Chemical compound CC(C)CCNCc(cc1C)ccc1Oc(nc1)ccc1C(N)=O HLCRMSMJGHCCGN-UHFFFAOYSA-N 0.000 description 1
- WKJOLNYSGNKXFN-UHFFFAOYSA-N CC(C)CCNCc(cc1Cl)ccc1Oc(cc1)ncc1C(N)=O Chemical compound CC(C)CCNCc(cc1Cl)ccc1Oc(cc1)ncc1C(N)=O WKJOLNYSGNKXFN-UHFFFAOYSA-N 0.000 description 1
- DZZIJHPOQGYOHW-UHFFFAOYSA-N CC(C)CCNCc(cc1F)cc(F)c1Oc(cc1)ncc1C(N)=O Chemical compound CC(C)CCNCc(cc1F)cc(F)c1Oc(cc1)ncc1C(N)=O DZZIJHPOQGYOHW-UHFFFAOYSA-N 0.000 description 1
- KBJFPTRVYNXNLR-UHFFFAOYSA-N CC(C)CCNCc(cc1F)ccc1Oc(nc1)cnc1C(N)=O Chemical compound CC(C)CCNCc(cc1F)ccc1Oc(nc1)cnc1C(N)=O KBJFPTRVYNXNLR-UHFFFAOYSA-N 0.000 description 1
- COOCONHDRCJRDK-UHFFFAOYSA-N CCCCCNCc(c(F)c1F)ccc1Oc(nc1)ccc1C(N)=O Chemical compound CCCCCNCc(c(F)c1F)ccc1Oc(nc1)ccc1C(N)=O COOCONHDRCJRDK-UHFFFAOYSA-N 0.000 description 1
- NYFIRDWZRSBSFQ-UHFFFAOYSA-N CCCCCNCc(cc1F)ccc1Oc(nc1)cnc1C(N)=O Chemical compound CCCCCNCc(cc1F)ccc1Oc(nc1)cnc1C(N)=O NYFIRDWZRSBSFQ-UHFFFAOYSA-N 0.000 description 1
- IHCVJFPPZBMWNV-UHFFFAOYSA-N Cc(cc(CNCCC1CCOCC1)cc1)c1Oc(nc1)cnc1C(N)=O Chemical compound Cc(cc(CNCCC1CCOCC1)cc1)c1Oc(nc1)cnc1C(N)=O IHCVJFPPZBMWNV-UHFFFAOYSA-N 0.000 description 1
- ORWSVYPVMAOKOR-UHFFFAOYSA-N NC(c(cn1)ccc1Oc1ccc(CNCCC2CCOCC2)cc1)=O Chemical compound NC(c(cn1)ccc1Oc1ccc(CNCCC2CCOCC2)cc1)=O ORWSVYPVMAOKOR-UHFFFAOYSA-N 0.000 description 1
- FESNRGIEUHAIML-UHFFFAOYSA-N NC(c(cn1)ncc1Oc1ccc(CNCCC2CCOCC2)cc1F)=O Chemical compound NC(c(cn1)ncc1Oc1ccc(CNCCC2CCOCC2)cc1F)=O FESNRGIEUHAIML-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41215802P | 2002-09-19 | 2002-09-19 | |
| PCT/US2003/026300 WO2004026305A1 (en) | 2002-09-19 | 2003-09-17 | Diaryl ethers as opioid receptor antagonist |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006511474A JP2006511474A (ja) | 2006-04-06 |
| JP2006511474A5 true JP2006511474A5 (enExample) | 2006-10-19 |
| JP4646628B2 JP4646628B2 (ja) | 2011-03-09 |
Family
ID=32030816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004537682A Expired - Lifetime JP4646628B2 (ja) | 2002-09-19 | 2003-09-17 | オピオイド受容体アンタゴニストとしてのジアリールエーテル類 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US7381719B2 (enExample) |
| EP (2) | EP2208727B1 (enExample) |
| JP (1) | JP4646628B2 (enExample) |
| KR (1) | KR101025633B1 (enExample) |
| CN (1) | CN1305852C (enExample) |
| AR (1) | AR042423A1 (enExample) |
| AT (1) | ATE395915T1 (enExample) |
| AU (1) | AU2008246245B2 (enExample) |
| BR (1) | BRPI0314308B8 (enExample) |
| CA (1) | CA2499690C (enExample) |
| CY (2) | CY1108228T1 (enExample) |
| DE (1) | DE60321207D1 (enExample) |
| DK (2) | DK1562595T3 (enExample) |
| EA (1) | EA008861B1 (enExample) |
| EC (1) | ECSP055684A (enExample) |
| ES (2) | ES2305491T3 (enExample) |
| HR (1) | HRP20050253B1 (enExample) |
| MX (1) | MXPA05003093A (enExample) |
| MY (1) | MY140236A (enExample) |
| NO (1) | NO330740B1 (enExample) |
| NZ (1) | NZ538459A (enExample) |
| PE (1) | PE20050080A1 (enExample) |
| PL (1) | PL212616B1 (enExample) |
| PT (2) | PT1562595E (enExample) |
| SI (2) | SI2208727T1 (enExample) |
| TW (1) | TWI287012B (enExample) |
| UA (1) | UA80437C2 (enExample) |
| WO (1) | WO2004026305A1 (enExample) |
| ZA (1) | ZA200502276B (enExample) |
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| ES2527117T3 (es) * | 2003-08-29 | 2015-01-20 | Ono Pharmaceutical Co., Ltd. | Compuesto capaz de unirse a receptor SIP y uso farmacéutico del mismo |
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| EP1697307B1 (en) * | 2003-12-12 | 2014-03-12 | Eli Lilly & Company | Opioid receptor antagonists |
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| ATE329901T1 (de) | 2000-11-10 | 2006-07-15 | Lilly Co Eli | 3-substituierte oxindolderivate als beta-3- agonisten |
| US7507767B2 (en) * | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| PL220721B1 (pl) | 2001-03-29 | 2015-12-31 | Lilly Co Eli | Związki będące pochodnymi N-(indolilo-2-etylo) benzyloaminy, kompozycja farmaceutyczna oraz zastosowanie |
| GB0109103D0 (en) * | 2001-04-11 | 2001-05-30 | Pfizer Ltd | Novel compounds |
| US7381719B2 (en) * | 2002-09-19 | 2008-06-03 | Eli Lilly And Company | Diaryl ethers as opioid receptor antagonist |
| BRPI0407616A (pt) | 2003-03-07 | 2006-02-14 | Lilly Co Eli | composto, composição farmacêutica, método para bloquear uma combinação de receptor de mu, capa, delta (heterodìmero) deste em mamìferos, método para tratar ou prevenir obesidade e doenças relacionadas, uso de um composto, e método de suprimir o apetite em um paciente em necessidade deste" |
| US7396943B2 (en) | 2003-03-07 | 2008-07-08 | Eli Lilly And Company | Opioid receptor antagonists |
| US6767015B1 (en) * | 2003-06-05 | 2004-07-27 | The United States Of America As Represented By The Secretary Of The Navy | Thermal target |
| EP1697307B1 (en) | 2003-12-12 | 2014-03-12 | Eli Lilly & Company | Opioid receptor antagonists |
| US7414132B2 (en) | 2003-12-22 | 2008-08-19 | Eli Lilly And Company | Opioid receptor antagonists |
| ES2308471T3 (es) | 2004-03-12 | 2008-12-01 | Eli Lilly And Company | Antagonistas de receptores de opioides. |
| US7381750B2 (en) | 2004-03-12 | 2008-06-03 | Eli Lilly And Company | Amino-phenoxymethyl-benzamide opioid receptor antagonists |
| CA2557794A1 (en) | 2004-03-15 | 2005-10-06 | Eli Lilly And Company | Opioid receptor antagonists |
| EP1751103B1 (en) | 2004-03-15 | 2009-01-14 | Eli Lilly And Company | 4-(5-(aminomethyl)-indole-1-ylmethyl)-benzamide derivatives and related compounds as opioid receptor antagonists for the treatment of obesity |
-
2003
- 2003-09-17 US US10/526,960 patent/US7381719B2/en not_active Expired - Lifetime
- 2003-09-17 PT PT03751877T patent/PT1562595E/pt unknown
- 2003-09-17 DE DE60321207T patent/DE60321207D1/de not_active Expired - Lifetime
- 2003-09-17 MY MYPI20033546A patent/MY140236A/en unknown
- 2003-09-17 MX MXPA05003093A patent/MXPA05003093A/es active IP Right Grant
- 2003-09-17 CA CA2499690A patent/CA2499690C/en not_active Expired - Lifetime
- 2003-09-17 HR HRP20050253AA patent/HRP20050253B1/hr not_active IP Right Cessation
- 2003-09-17 KR KR1020057004628A patent/KR101025633B1/ko not_active Expired - Lifetime
- 2003-09-17 AR ARP030103376A patent/AR042423A1/es active IP Right Grant
- 2003-09-17 NZ NZ538459A patent/NZ538459A/en not_active IP Right Cessation
- 2003-09-17 EA EA200500508A patent/EA008861B1/ru unknown
- 2003-09-17 ES ES03751877T patent/ES2305491T3/es not_active Expired - Lifetime
- 2003-09-17 EP EP08153866A patent/EP2208727B1/en not_active Expired - Lifetime
- 2003-09-17 AT AT03751877T patent/ATE395915T1/de active
- 2003-09-17 CN CNB038222418A patent/CN1305852C/zh not_active Expired - Lifetime
- 2003-09-17 DK DK03751877T patent/DK1562595T3/da active
- 2003-09-17 UA UAA200502384A patent/UA80437C2/uk unknown
- 2003-09-17 ES ES08153866T patent/ES2392200T3/es not_active Expired - Lifetime
- 2003-09-17 PL PL376057A patent/PL212616B1/pl unknown
- 2003-09-17 SI SI200332196T patent/SI2208727T1/sl unknown
- 2003-09-17 PT PT08153866T patent/PT2208727E/pt unknown
- 2003-09-17 DK DK08153866.2T patent/DK2208727T3/da active
- 2003-09-17 BR BRPI0314308A patent/BRPI0314308B8/pt not_active IP Right Cessation
- 2003-09-17 JP JP2004537682A patent/JP4646628B2/ja not_active Expired - Lifetime
- 2003-09-17 SI SI200331282T patent/SI1562595T1/sl unknown
- 2003-09-17 WO PCT/US2003/026300 patent/WO2004026305A1/en not_active Ceased
- 2003-09-17 EP EP03751877A patent/EP1562595B1/en not_active Expired - Lifetime
- 2003-09-18 PE PE2003000959A patent/PE20050080A1/es active IP Right Grant
- 2003-09-18 TW TW092125729A patent/TWI287012B/zh not_active IP Right Cessation
-
2005
- 2005-03-17 ZA ZA200502276A patent/ZA200502276B/en unknown
- 2005-03-17 EC EC2005005684A patent/ECSP055684A/es unknown
- 2005-04-18 NO NO20051871A patent/NO330740B1/no not_active IP Right Cessation
-
2008
- 2008-03-21 US US12/052,972 patent/US7531557B2/en not_active Expired - Lifetime
- 2008-03-21 US US12/052,994 patent/US7560463B2/en not_active Expired - Lifetime
- 2008-07-30 CY CY20081100798T patent/CY1108228T1/el unknown
- 2008-11-19 AU AU2008246245A patent/AU2008246245B2/en not_active Expired
-
2012
- 2012-10-25 CY CY20121101016T patent/CY1113362T1/el unknown
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