JP2015064362A5 - - Google Patents
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- JP2015064362A5 JP2015064362A5 JP2014218116A JP2014218116A JP2015064362A5 JP 2015064362 A5 JP2015064362 A5 JP 2015064362A5 JP 2014218116 A JP2014218116 A JP 2014218116A JP 2014218116 A JP2014218116 A JP 2014218116A JP 2015064362 A5 JP2015064362 A5 JP 2015064362A5
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- Japan
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 25
- 239000000090 biomarker Substances 0.000 claims 21
- 239000000523 sample Substances 0.000 claims 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 11
- 239000008103 glucose Substances 0.000 claims 11
- 208000002705 Glucose Intolerance Diseases 0.000 claims 10
- 201000009104 prediabetes syndrome Diseases 0.000 claims 10
- 206010022489 Insulin Resistance Diseases 0.000 claims 9
- WWNNZCOKKKDOPX-UHFFFAOYSA-N N-methylnicotinate Chemical compound C[N+]1=CC=CC(C([O-])=O)=C1 WWNNZCOKKKDOPX-UHFFFAOYSA-N 0.000 claims 9
- 239000012472 biological sample Substances 0.000 claims 9
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 9
- 239000008777 Glycerylphosphorylcholine Substances 0.000 claims 8
- SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 claims 8
- 229960004956 glycerylphosphorylcholine Drugs 0.000 claims 8
- 206010012601 diabetes mellitus Diseases 0.000 claims 7
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims 6
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 6
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims 6
- BKAJNAXTPSGJCU-UHFFFAOYSA-N 4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O BKAJNAXTPSGJCU-UHFFFAOYSA-N 0.000 claims 6
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 5
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 5
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 5
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 5
- 239000005642 Oleic acid Substances 0.000 claims 5
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 5
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 5
- AFENDNXGAFYKQO-VKHMYHEASA-N (S)-2-hydroxybutyric acid Chemical compound CC[C@H](O)C(O)=O AFENDNXGAFYKQO-VKHMYHEASA-N 0.000 claims 4
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 claims 4
- 235000021355 Stearic acid Nutrition 0.000 claims 4
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 4
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 4
- 229960004488 linolenic acid Drugs 0.000 claims 4
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 4
- 125000005645 linoleyl group Chemical group 0.000 claims 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 4
- 239000008117 stearic acid Substances 0.000 claims 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
- FPRKGXIOSIUDSE-SYACGTDESA-N (2z,4z,6z,8z)-docosa-2,4,6,8-tetraenoic acid Chemical compound CCCCCCCCCCCCC\C=C/C=C\C=C/C=C\C(O)=O FPRKGXIOSIUDSE-SYACGTDESA-N 0.000 claims 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 3
- MVJLYXCJBPXRCY-UHFFFAOYSA-N 2-methylbutyl propanoate Chemical compound CCC(C)COC(=O)CC MVJLYXCJBPXRCY-UHFFFAOYSA-N 0.000 claims 3
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 3
- 239000001142 4-methyl-2-oxopentanoic acid Substances 0.000 claims 3
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims 3
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 3
- 235000021292 Docosatetraenoic acid Nutrition 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 3
- HWXBTNAVRSUOJR-UHFFFAOYSA-N alpha-hydroxyglutaric acid Natural products OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 claims 3
- 229940009533 alpha-ketoglutaric acid Drugs 0.000 claims 3
- 229960003624 creatine Drugs 0.000 claims 3
- 239000006046 creatine Substances 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- 229940041290 mannose Drugs 0.000 claims 3
- 238000012544 monitoring process Methods 0.000 claims 3
- 229960002969 oleic acid Drugs 0.000 claims 3
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 229940055726 pantothenic acid Drugs 0.000 claims 3
- 235000019161 pantothenic acid Nutrition 0.000 claims 3
- 239000011713 pantothenic acid Substances 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 3
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- 206010056997 Impaired fasting glucose Diseases 0.000 claims 2
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
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- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 1
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- 108010075254 C-Peptide Proteins 0.000 claims 1
- 108010023302 HDL Cholesterol Proteins 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 238000008214 LDL Cholesterol Methods 0.000 claims 1
- 108010028554 LDL Cholesterol Proteins 0.000 claims 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- 108010088847 Peptide YY Proteins 0.000 claims 1
- 102100029909 Peptide YY Human genes 0.000 claims 1
- 108010076181 Proinsulin Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 235000021588 free fatty acids Nutrition 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- 238000013178 mathematical model Methods 0.000 claims 1
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- 235000021313 oleic acid Nutrition 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
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- 230000001225 therapeutic effect Effects 0.000 claims 1
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95028607P | 2007-07-17 | 2007-07-17 | |
| US60/950,286 | 2007-07-17 | ||
| US3762808P | 2008-03-18 | 2008-03-18 | |
| US61/037,628 | 2008-03-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517019A Division JP5701601B2 (ja) | 2007-07-17 | 2008-07-17 | 糖尿病前症、心血管疾患及びその他のメタボリックシンドローム関連障害のバイオマーカー並びにその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015236454A Division JP2016102797A (ja) | 2007-07-17 | 2015-12-03 | 糖尿病前症、心血管疾患及びその他のメタボリックシンドローム関連障害のバイオマーカー並びにその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015064362A JP2015064362A (ja) | 2015-04-09 |
| JP2015064362A5 true JP2015064362A5 (enExample) | 2015-05-28 |
| JP5876918B2 JP5876918B2 (ja) | 2016-03-02 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517019A Active JP5701601B2 (ja) | 2007-07-17 | 2008-07-17 | 糖尿病前症、心血管疾患及びその他のメタボリックシンドローム関連障害のバイオマーカー並びにその使用方法 |
| JP2014218116A Active JP5876918B2 (ja) | 2007-07-17 | 2014-10-27 | 糖尿病前症、心血管疾患及びその他のメタボリックシンドローム関連障害のバイオマーカー並びにその使用方法 |
| JP2015236454A Pending JP2016102797A (ja) | 2007-07-17 | 2015-12-03 | 糖尿病前症、心血管疾患及びその他のメタボリックシンドローム関連障害のバイオマーカー並びにその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517019A Active JP5701601B2 (ja) | 2007-07-17 | 2008-07-17 | 糖尿病前症、心血管疾患及びその他のメタボリックシンドローム関連障害のバイオマーカー並びにその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015236454A Pending JP2016102797A (ja) | 2007-07-17 | 2015-12-03 | 糖尿病前症、心血管疾患及びその他のメタボリックシンドローム関連障害のバイオマーカー並びにその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US8187830B2 (enExample) |
| EP (1) | EP2164977B1 (enExample) |
| JP (3) | JP5701601B2 (enExample) |
| AU (1) | AU2008279778B2 (enExample) |
| BR (1) | BRPI0815095B1 (enExample) |
| CA (1) | CA2690541A1 (enExample) |
| ES (1) | ES2443540T3 (enExample) |
| MX (3) | MX377928B (enExample) |
| WO (1) | WO2009014639A2 (enExample) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602007011592D1 (de) * | 2006-03-24 | 2011-02-10 | Metanomics Gmbh | MITTEL UND VERFAHREN ZUR PROGNOSE ODER DIAGNOSE VON DIABETES typ II |
| WO2008015929A1 (fr) * | 2006-08-04 | 2008-02-07 | Ajinomoto Co., Inc. | procédé d'évaluation de syndrome métabolique, appareil D'ÉVALUATION DE SYNDROME MÉTABOLIQUE, système D'ÉVALUATION DE SYNDROME MÉTABOLIQUE, programme d'évaluation de syndrome métabolique et support d'enregistrement, et proc& |
| US9867530B2 (en) | 2006-08-14 | 2018-01-16 | Volcano Corporation | Telescopic side port catheter device with imaging system and method for accessing side branch occlusions |
| EP2172775A4 (en) * | 2007-06-25 | 2010-12-01 | Ajinomoto Kk | METHOD OF EVALUATING VISCERAL GREASE ACCUMULATION |
| EP2178442B1 (en) | 2007-07-12 | 2017-09-06 | Volcano Corporation | Catheter for in vivo imaging |
| US9596993B2 (en) | 2007-07-12 | 2017-03-21 | Volcano Corporation | Automatic calibration systems and methods of use |
| US10219780B2 (en) | 2007-07-12 | 2019-03-05 | Volcano Corporation | OCT-IVUS catheter for concurrent luminal imaging |
| BRPI0815095B1 (pt) | 2007-07-17 | 2021-04-13 | Metabolon, Inc | Método de classificação de um indivíduo de acordo com a tolerância à glicose predita em tolerância à glicose normal (ngt), tolerância à glicose de jejum prejudicada (ifg), ou tolerância à glicose prejudicada (igt), para diabetes tipo 2, método de determinação da suscetibilidade de um indivíduo a diabetes tipo 2 e método de monitoramento da progressão ou regressão do pré- diabetes em um indivíduo |
| EP2209001A4 (en) * | 2007-10-25 | 2010-10-27 | Ajinomoto Kk | METHOD FOR ASSESSING STROKEN GLUCOSE TOLERANCE |
| EP2930512B1 (en) * | 2007-11-02 | 2018-01-31 | Metabolon, Inc. | Biomarkers for fatty liver disease and methods using the same |
| CA2878025C (en) | 2008-01-18 | 2018-12-11 | President And Fellows Of Harvard College | Methods of detecting signatures of disease or conditions in bodily fluids |
| EP2265957B1 (en) * | 2008-04-09 | 2013-07-24 | B.R.A.H.M.S GmbH | Pro-endothelin-1 for the prediction of impaired peak oxygen consumption |
| US20100222315A1 (en) * | 2008-09-24 | 2010-09-02 | Harbor BioSciencs, Inc. | Patient populations and treatment methods |
| EP2344890B1 (en) * | 2008-10-20 | 2021-08-11 | Liposcience, Inc. | Lipoprotein insulin resistance indexes and related methods |
| US20110318726A1 (en) | 2009-03-10 | 2011-12-29 | Shah Svati H | Predicting coronary artery disease and risk of cardiovascular events |
| WO2010114897A1 (en) * | 2009-03-31 | 2010-10-07 | Metabolon, Inc. | Biomarkers related to insulin resistance and methods using the same |
| US10519504B2 (en) | 2009-05-11 | 2019-12-31 | Berg Llc | Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| EP2476053A4 (en) * | 2009-09-08 | 2014-03-12 | Nodality Inc | ANALYSIS OF CELL NETWORKS |
| JP5787339B2 (ja) * | 2009-12-28 | 2015-09-30 | 学校法人福岡大学 | 糖尿病前症の検査方法 |
| JP2013522652A (ja) * | 2010-03-23 | 2013-06-13 | パーデュー・リサーチ・ファウンデーション | 代謝物プロファイリングを用いた再発乳癌の早期検出 |
| JP5801802B2 (ja) | 2010-06-08 | 2015-10-28 | カルピス株式会社 | 脂質代謝改善剤 |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| MX2013000917A (es) | 2010-07-23 | 2013-07-05 | Harvard College | Metodos para detectar las enfermedades o condiciones usando celulas fagociticas. |
| KR20130041961A (ko) | 2010-07-23 | 2013-04-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 체액에서 질환 또는 상태의 특징을 검출하는 방법 |
| CA2806301A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting cardiovascular diseases or conditions |
| WO2012012717A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting prenatal or pregnancy-related diseases or conditions |
| WO2012013667A1 (en) * | 2010-07-30 | 2012-02-02 | Technische Universität Graz | Analyses of analytes by mass spectrometry with values in at least 3 dimensions |
| WO2012058298A1 (en) * | 2010-10-26 | 2012-05-03 | Mayo Foundation For Medical Education And Research | Biomarkers of reduced insulin action |
| JP2014501926A (ja) * | 2010-12-23 | 2014-01-23 | メタノミクス ヘルス ゲーエムベーハー | 糖尿病を予測する手段及び方法 |
| US11141063B2 (en) | 2010-12-23 | 2021-10-12 | Philips Image Guided Therapy Corporation | Integrated system architectures and methods of use |
| US11040140B2 (en) | 2010-12-31 | 2021-06-22 | Philips Image Guided Therapy Corporation | Deep vein thrombosis therapeutic methods |
| WO2012116074A1 (en) * | 2011-02-22 | 2012-08-30 | Mayo Foundation For Medical Education And Research | Biomarkers of insulin sensitivity |
| EP2694463B8 (en) | 2011-04-04 | 2019-10-09 | Berg LLC | Treating central nervous system tumors with coenzyme q10 |
| JP6260275B2 (ja) | 2011-06-30 | 2018-01-17 | 味の素株式会社 | 脂肪肝の評価方法、脂肪肝評価装置、脂肪肝評価方法、脂肪肝評価プログラム、脂肪肝評価システム、および端末装置 |
| EP3527990A1 (en) * | 2011-07-28 | 2019-08-21 | metanomics GmbH | Use of sm_sphingomyelin (d18:1, c23:1) as a marker for heart failure |
| WO2013033592A1 (en) | 2011-08-31 | 2013-03-07 | Volcano Corporation | Optical-electrical rotary joint and methods of use |
| JP6158186B2 (ja) * | 2011-09-14 | 2017-07-05 | メタボロン，インコーポレイテッド | インスリン抵抗性に関連するバイオマーカーおよびそれを使用する方法 |
| WO2013122469A2 (en) * | 2012-02-17 | 2013-08-22 | Rijksuniversiteit Groningen | Prediction of the efficacy of a medicament on renal or cardiovascular clinical outcomes |
| EP2642296A1 (en) * | 2012-03-22 | 2013-09-25 | Nestec S.A. | p-Cresol sulphate as biomarker for healthy ageing |
| EP2642294A1 (en) * | 2012-03-22 | 2013-09-25 | Nestec S.A. | Phenylacetylglutamine as biomarker for healthy ageing |
| EP2642295A1 (en) | 2012-03-22 | 2013-09-25 | Nestec S.A. | 1-O-alkyl-2-acylglycerophosphocholine (PC-O) 40:1 as biomarker for healthy ageing |
| EP2642293A1 (en) | 2012-03-22 | 2013-09-25 | Nestec S.A. | 9-oxo-octadecadienoic acid (9-oxo-HODE)as as biomarker for healthy ageing |
| EP2642297A1 (en) * | 2012-03-22 | 2013-09-25 | Nestec S.A. | Hydroxy-sphingomyelin 22:1 as biomarker for healthy ageing |
| ES2687979T3 (es) * | 2012-06-05 | 2018-10-30 | Nestec S.A. | Métodos de diagnóstico de la enfermedad valvular crónica |
| US9928345B2 (en) | 2012-06-08 | 2018-03-27 | Liposciences, Inc. | Multiple-marker risk parameters predictive of conversion to diabetes |
| US9361429B2 (en) | 2012-06-08 | 2016-06-07 | Liposcience, Inc. | Multi-parameter diabetes risk evaluations |
| KR20150035818A (ko) | 2012-06-15 | 2015-04-07 | 해리 스타일리 | 순환 병든 세포를 사용하여 질환 또는 병태를 검출하는 방법 |
| JP2015522260A (ja) | 2012-06-15 | 2015-08-06 | ハリー スティリ， | 疾患または状態を検出する方法 |
| WO2014001451A1 (en) | 2012-06-27 | 2014-01-03 | Metanomics Health Gmbh | Methods for identifying diabetes drugs |
| WO2014026991A1 (en) * | 2012-08-13 | 2014-02-20 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Biomarkers for type 2 diabetes |
| US20140324460A1 (en) * | 2012-09-26 | 2014-10-30 | Health Diagnostic Laboratory, Inc. | Method for determining and managing total cardiodiabetes risk |
| US9286673B2 (en) | 2012-10-05 | 2016-03-15 | Volcano Corporation | Systems for correcting distortions in a medical image and methods of use thereof |
| US9292918B2 (en) | 2012-10-05 | 2016-03-22 | Volcano Corporation | Methods and systems for transforming luminal images |
| US9858668B2 (en) | 2012-10-05 | 2018-01-02 | Volcano Corporation | Guidewire artifact removal in images |
| US9307926B2 (en) | 2012-10-05 | 2016-04-12 | Volcano Corporation | Automatic stent detection |
| US9367965B2 (en) | 2012-10-05 | 2016-06-14 | Volcano Corporation | Systems and methods for generating images of tissue |
| US11272845B2 (en) | 2012-10-05 | 2022-03-15 | Philips Image Guided Therapy Corporation | System and method for instant and automatic border detection |
| US10070827B2 (en) | 2012-10-05 | 2018-09-11 | Volcano Corporation | Automatic image playback |
| US9324141B2 (en) | 2012-10-05 | 2016-04-26 | Volcano Corporation | Removal of A-scan streaking artifact |
| US9478940B2 (en) | 2012-10-05 | 2016-10-25 | Volcano Corporation | Systems and methods for amplifying light |
| US20140100454A1 (en) | 2012-10-05 | 2014-04-10 | Volcano Corporation | Methods and systems for establishing parameters for three-dimensional imaging |
| US10568586B2 (en) | 2012-10-05 | 2020-02-25 | Volcano Corporation | Systems for indicating parameters in an imaging data set and methods of use |
| US9840734B2 (en) | 2012-10-22 | 2017-12-12 | Raindance Technologies, Inc. | Methods for analyzing DNA |
| EP2931132B1 (en) | 2012-12-13 | 2023-07-05 | Philips Image Guided Therapy Corporation | System for targeted cannulation |
| CA2895502A1 (en) | 2012-12-20 | 2014-06-26 | Jeremy Stigall | Smooth transition catheters |
| CA2895989A1 (en) | 2012-12-20 | 2014-07-10 | Nathaniel J. Kemp | Optical coherence tomography system that is reconfigurable between different imaging modes |
| WO2014113188A2 (en) | 2012-12-20 | 2014-07-24 | Jeremy Stigall | Locating intravascular images |
| US10942022B2 (en) | 2012-12-20 | 2021-03-09 | Philips Image Guided Therapy Corporation | Manual calibration of imaging system |
| US11406498B2 (en) | 2012-12-20 | 2022-08-09 | Philips Image Guided Therapy Corporation | Implant delivery system and implants |
| US10939826B2 (en) | 2012-12-20 | 2021-03-09 | Philips Image Guided Therapy Corporation | Aspirating and removing biological material |
| JP2016501623A (ja) | 2012-12-21 | 2016-01-21 | アンドリュー ハンコック， | 画像信号のマルチ経路処理のためのシステムおよび方法 |
| US10058284B2 (en) | 2012-12-21 | 2018-08-28 | Volcano Corporation | Simultaneous imaging, monitoring, and therapy |
| US9612105B2 (en) | 2012-12-21 | 2017-04-04 | Volcano Corporation | Polarization sensitive optical coherence tomography system |
| CA2896004A1 (en) | 2012-12-21 | 2014-06-26 | Nathaniel J. Kemp | Power-efficient optical buffering using optical switch |
| US10413317B2 (en) | 2012-12-21 | 2019-09-17 | Volcano Corporation | System and method for catheter steering and operation |
| WO2014100606A1 (en) | 2012-12-21 | 2014-06-26 | Meyer, Douglas | Rotational ultrasound imaging catheter with extended catheter body telescope |
| US9486143B2 (en) | 2012-12-21 | 2016-11-08 | Volcano Corporation | Intravascular forward imaging device |
| CA2896006A1 (en) | 2012-12-21 | 2014-06-26 | David Welford | Systems and methods for narrowing a wavelength emission of light |
| JP2016501625A (ja) | 2012-12-21 | 2016-01-21 | ジェローム マイ， | 可変線密度での超音波撮像 |
| CA2895993A1 (en) | 2012-12-21 | 2014-06-26 | Jason Spencer | System and method for graphical processing of medical data |
| WO2014120449A1 (en) * | 2013-01-31 | 2014-08-07 | Metabolon, Inc. | Biomarkers related to insulin resistance progression and methods using the same |
| RU2015136673A (ru) * | 2013-01-31 | 2017-03-10 | Каприон Протеомикс Инк. | Биомаркеры сахарного диабета 2 типа и их применение |
| CN105120852A (zh) * | 2013-02-14 | 2015-12-02 | 梅坦诺米克斯保健有限公司 | 评估生物样品质量的工具和方法 |
| WO2014138555A1 (en) | 2013-03-07 | 2014-09-12 | Bernhard Sturm | Multimodal segmentation in intravascular images |
| US10226597B2 (en) | 2013-03-07 | 2019-03-12 | Volcano Corporation | Guidewire with centering mechanism |
| WO2014164362A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting prostate cancer |
| EP2965077B1 (en) | 2013-03-09 | 2022-07-13 | Harry Stylli | Methods of detecting cancer |
| US20140276923A1 (en) | 2013-03-12 | 2014-09-18 | Volcano Corporation | Vibrating catheter and methods of use |
| US10638939B2 (en) | 2013-03-12 | 2020-05-05 | Philips Image Guided Therapy Corporation | Systems and methods for diagnosing coronary microvascular disease |
| US9301687B2 (en) | 2013-03-13 | 2016-04-05 | Volcano Corporation | System and method for OCT depth calibration |
| EP2967488B1 (en) | 2013-03-13 | 2021-06-16 | Jinhyoung Park | System for producing an image from a rotational intravascular ultrasound device |
| US11026591B2 (en) | 2013-03-13 | 2021-06-08 | Philips Image Guided Therapy Corporation | Intravascular pressure sensor calibration |
| US20140278121A1 (en) * | 2013-03-13 | 2014-09-18 | Robust for Life, Inc. | Systems and methods for network-based calculation and reporting of metabolic risk |
| US10292677B2 (en) | 2013-03-14 | 2019-05-21 | Volcano Corporation | Endoluminal filter having enhanced echogenic properties |
| US10426590B2 (en) | 2013-03-14 | 2019-10-01 | Volcano Corporation | Filters with echogenic characteristics |
| US12343198B2 (en) | 2013-03-14 | 2025-07-01 | Philips Image Guided Therapy Corporation | Delivery catheter having imaging capabilities |
| US10219887B2 (en) | 2013-03-14 | 2019-03-05 | Volcano Corporation | Filters with echogenic characteristics |
| EA032775B1 (ru) | 2013-04-08 | 2019-07-31 | Берг Ллк | Способы лечения злокачественной опухоли с использованием комбинированной терапии с коферментом q10 |
| CA2921530A1 (en) | 2013-07-18 | 2015-01-22 | True Health Diagnostics, Llc | Method of determination of risk of 2 hour blood glucose equal to or greater than 140 mg/dl |
| WO2015035094A1 (en) | 2013-09-04 | 2015-03-12 | Berg Llc | Methods of treatment of cancer by continuous infusion of coenzyme q10 |
| GB2524230A (en) * | 2014-02-14 | 2015-09-23 | Asda Stores Ltd | Transaction processing system and transaction processing method |
| EP4428251A3 (en) | 2014-09-11 | 2024-12-18 | Immunis.AI, Inc. | Methods of detecting prostate cancer |
| WO2016103390A1 (ja) * | 2014-12-25 | 2016-06-30 | 株式会社日立製作所 | インスリン分泌能分析装置、当該装置を備えるインスリン分泌能分析システム及びインスリン分泌能分析方法 |
| CN113156096A (zh) * | 2015-01-09 | 2021-07-23 | 全球基因集团有限责任公司 | 用于诊断冠状动脉粥样硬化性疾病的基于血液的生物标志物 |
| US10451641B2 (en) | 2015-03-13 | 2019-10-22 | Duke University | Compositions and methods for metabolic profiling in subjects with heart failure with preserved ejection fraction |
| JP6051258B2 (ja) * | 2015-04-15 | 2016-12-27 | ライオン株式会社 | 脂質異常症への罹患しやすさを試験する方法 |
| KR101795689B1 (ko) * | 2015-04-30 | 2017-11-30 | 경희대학교 산학협력단 | 혈관 협착 질환 진단용 마커 및 이의 용도 |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| WO2018094204A1 (en) * | 2016-11-17 | 2018-05-24 | Arivale, Inc. | Determining relationships between risks for biological conditions and dynamic analytes |
| US11881311B1 (en) | 2017-02-17 | 2024-01-23 | BioAge Labs, Inc. | Survival prediction using metabolomic profiles |
| JP2018141728A (ja) * | 2017-02-28 | 2018-09-13 | トヨタ自動車株式会社 | 生活習慣病の診断方法 |
| US11740247B2 (en) * | 2017-11-22 | 2023-08-29 | Mayo Foundation For Medical Education And Research | Methods and materials for assessing and treating obesity |
| US20200041496A1 (en) * | 2018-08-01 | 2020-02-06 | Joshua Health Care LLC | Methods for Identifying and Treating Mammalian Subjects with Insulin Resistance |
| JP7189537B2 (ja) * | 2019-06-27 | 2022-12-14 | サンスター株式会社 | 血液試料の酸化ｈｄｌ量の反映値を測定する工程を含む、測定方法 |
| JP7665157B2 (ja) * | 2019-07-08 | 2025-04-21 | 株式会社島津製作所 | 移植用肝臓の機能評価方法、移植用肝臓の機能評価プログラムおよび移植用肝臓の機能評価装置 |
| WO2021072222A1 (en) * | 2019-10-11 | 2021-04-15 | The Regents Of The University Of California | Metabolic profile screening for gestational diabetes |
| CN115552025A (zh) * | 2020-02-05 | 2022-12-30 | 克利夫兰诊所基金会 | 基于苯乙酰谷氨酰胺水平的疾病检测和治疗 |
| CN113866284B (zh) * | 2020-06-30 | 2023-09-05 | 上海脉示生物技术有限公司 | 一组用于心力衰竭诊断的肠道微生物代谢标志物及其应用 |
| CN112684064B (zh) * | 2020-12-08 | 2022-05-17 | 安徽农业大学 | 用于筛选抗应激胁迫肉羊的血清代谢标志物及其应用 |
| EP4262814A4 (en) * | 2020-12-16 | 2025-02-26 | St. Jude Children's Research Hospital, Inc. | Methods of treating disorders associated with castor |
| CN113325117B (zh) * | 2021-06-25 | 2022-07-15 | 中国医学科学院北京协和医院 | 一组生物标记物在制备预测静脉内平滑肌瘤病进展的试剂盒中的应用 |
| CN115023608B (zh) * | 2021-11-30 | 2024-01-19 | 江苏品生医疗科技集团有限公司 | 预测受试者患有糖尿病的可能性的标记物及其应用 |
| JP2025504961A (ja) * | 2022-01-28 | 2025-02-19 | ジーエーティーシー ヘルス コーポレーション | 糖尿病の早期発見のためのバイオマーカー |
| CN114965733B (zh) * | 2022-04-07 | 2023-12-01 | 中国人民解放军总医院第一医学中心 | 结直肠进展期腺瘤诊断代谢标志物组合及其应用 |
| WO2025019706A1 (en) * | 2023-07-19 | 2025-01-23 | Ahara Corporation | Systems and methods for generating a nutrition program |
| CN119846232B (zh) * | 2025-01-21 | 2025-10-03 | 宁夏农林科学院动物科学研究所(宁夏草畜工程技术研究中心) | 一种早期诊断奶牛隐性乳房炎的生物标志物组合及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5367052A (en) * | 1987-04-27 | 1994-11-22 | Amylin Pharmaceuticals, Inc. | Amylin peptides |
| EP0825258A4 (en) * | 1996-02-20 | 2001-12-05 | Kyowa Hakko Kogyo Kk | METHOD OF DETERMINING 1,5-ANHYDROGLUCITOL |
| JP2938048B1 (ja) * | 1998-06-30 | 1999-08-23 | 技術研究組合医療福祉機器研究所 | 代謝機能測定装置 |
| US6140067A (en) * | 1999-04-30 | 2000-10-31 | Mitokor | Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus |
| JP3975279B2 (ja) * | 1999-11-01 | 2007-09-12 | 旭化成ファーマ株式会社 | 糖尿病予備群の検査方法 |
| WO2001078652A2 (en) * | 2000-04-14 | 2001-10-25 | Metabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| US7329489B2 (en) * | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| WO2002011716A2 (en) * | 2000-08-07 | 2002-02-14 | Ranbaxy Signature Llc | Liquid formulation of metformin |
| US20030092028A1 (en) * | 2001-06-01 | 2003-05-15 | Yuanhong Ma | Methods and Reagents For Diagnosis and Treatment of Insulin Resistance and Related Condition |
| US7425545B2 (en) * | 2001-07-25 | 2008-09-16 | Isis Pharmaceuticals, Inc. | Modulation of C-reactive protein expression |
| JP4100673B2 (ja) * | 2001-12-07 | 2008-06-11 | 日本化薬株式会社 | 肝糖放出の検査方法 |
| JP2003204800A (ja) * | 2002-01-15 | 2003-07-22 | Sumitomo Pharmaceut Co Ltd | 糖代謝異常疾患マーカーおよびその利用 |
| US20040101874A1 (en) * | 2002-04-12 | 2004-05-27 | Mitokor Inc. | Targets for therapeutic intervention identified in the mitochondrial proteome |
| US20060148690A1 (en) * | 2002-07-08 | 2006-07-06 | Lydie Bougueleret | Secreted peptides |
| JP2005006645A (ja) * | 2003-05-22 | 2005-01-13 | Sumitomo Chemical Co Ltd | インスリン応答性の評価方法 |
| WO2005094200A2 (en) * | 2003-06-20 | 2005-10-13 | University Of Florida | Biomarkers for differentiating between type 2 and type 2 diabetes |
| US7345142B2 (en) * | 2004-01-27 | 2008-03-18 | Compugen Ltd. | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease |
| JP4547173B2 (ja) * | 2004-03-17 | 2010-09-22 | シスメックス株式会社 | 糖尿病診療支援システム |
| JP4533042B2 (ja) * | 2004-08-25 | 2010-08-25 | 裕 笹川 | 糖尿病および糖代謝異常を判断する方法 |
| WO2006036476A2 (en) * | 2004-09-07 | 2006-04-06 | The General Hospital Corporation | Methods of detecting myocardial ischemia and myocardial infarction |
| JP4522222B2 (ja) * | 2004-10-22 | 2010-08-11 | 扶桑薬品工業株式会社 | 血中脂肪酸濃度測定による心疾患の早期診断方法 |
| WO2006063733A1 (en) * | 2004-12-14 | 2006-06-22 | F.Hoffmann-La Roche Ag | Cd99 as target/marker for insulin resistance |
| WO2006066263A1 (en) | 2004-12-17 | 2006-06-22 | Entelos, Inc. | Assessing insulin resistance using biomarkers |
| JPWO2006073195A1 (ja) * | 2005-01-07 | 2008-06-12 | 敏一 吉川 | 糖尿病の予知・診断方法および糖尿病予知・診断用キット |
| FR2890079B1 (fr) * | 2005-08-26 | 2007-11-30 | Alain Rambach | Detection des salmonelles lactose + |
| JP2009509539A (ja) * | 2005-09-30 | 2009-03-12 | パーレジェン サイエンシーズ， インコーポレイテッド | 血糖調節の障害のスクリーニングおよび処置のための方法および組成物 |
| US20070218519A1 (en) * | 2005-10-11 | 2007-09-20 | Tethys Bioscience, Inc. | Diabetes-associated markers and methods of use thereof |
| JP2007127423A (ja) * | 2005-10-31 | 2007-05-24 | Toray Ind Inc | ３−ヒドロキシ酪酸の測定方法およびキット |
| DE602007011592D1 (de) * | 2006-03-24 | 2011-02-10 | Metanomics Gmbh | MITTEL UND VERFAHREN ZUR PROGNOSE ODER DIAGNOSE VON DIABETES typ II |
| US8321154B2 (en) * | 2007-03-26 | 2012-11-27 | Bg Medicine, Inc. | Methods for detecting coronary artery disease |
| BRPI0815095B1 (pt) | 2007-07-17 | 2021-04-13 | Metabolon, Inc | Método de classificação de um indivíduo de acordo com a tolerância à glicose predita em tolerância à glicose normal (ngt), tolerância à glicose de jejum prejudicada (ifg), ou tolerância à glicose prejudicada (igt), para diabetes tipo 2, método de determinação da suscetibilidade de um indivíduo a diabetes tipo 2 e método de monitoramento da progressão ou regressão do pré- diabetes em um indivíduo |
| WO2010114897A1 (en) * | 2009-03-31 | 2010-10-07 | Metabolon, Inc. | Biomarkers related to insulin resistance and methods using the same |
| JP2014501926A (ja) * | 2010-12-23 | 2014-01-23 | メタノミクス ヘルス ゲーエムベーハー | 糖尿病を予測する手段及び方法 |
-
2008
- 2008-07-17 BR BRPI0815095-8A patent/BRPI0815095B1/pt active IP Right Grant
- 2008-07-17 WO PCT/US2008/008756 patent/WO2009014639A2/en not_active Ceased
- 2008-07-17 CA CA2690541A patent/CA2690541A1/en not_active Abandoned
- 2008-07-17 ES ES08780229.4T patent/ES2443540T3/es active Active
- 2008-07-17 MX MX2016009020A patent/MX377928B/es unknown
- 2008-07-17 EP EP08780229.4A patent/EP2164977B1/en active Active
- 2008-07-17 JP JP2010517019A patent/JP5701601B2/ja active Active
- 2008-07-17 AU AU2008279778A patent/AU2008279778B2/en active Active
- 2008-07-17 MX MX2010000414A patent/MX2010000414A/es active IP Right Grant
- 2008-07-17 MX MX2013008169A patent/MX341954B/es unknown
- 2008-07-17 US US12/218,980 patent/US8187830B2/en active Active
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2012
- 2012-04-27 US US13/457,620 patent/US8546098B2/en active Active
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2013
- 2013-08-14 US US13/966,475 patent/US8809008B2/en active Active
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- 2014-07-07 US US14/324,689 patent/US9250225B2/en active Active
- 2014-10-27 JP JP2014218116A patent/JP5876918B2/ja active Active
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- 2015-12-03 JP JP2015236454A patent/JP2016102797A/ja active Pending
- 2015-12-21 US US14/975,988 patent/US10175233B2/en active Active
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