BR112014007947A2 - método para monitoramento, diagnóstico e/ou prognóstico de distúrbios relacionados à hipoxia usando nfat5 - Google Patents

método para monitoramento, diagnóstico e/ou prognóstico de distúrbios relacionados à hipoxia usando nfat5

Info

Publication number
BR112014007947A2
BR112014007947A2 BR112014007947A BR112014007947A BR112014007947A2 BR 112014007947 A2 BR112014007947 A2 BR 112014007947A2 BR 112014007947 A BR112014007947 A BR 112014007947A BR 112014007947 A BR112014007947 A BR 112014007947A BR 112014007947 A2 BR112014007947 A2 BR 112014007947A2
Authority
BR
Brazil
Prior art keywords
nfat5
hypoxia
sample
prognosis
diagnosis
Prior art date
Application number
BR112014007947A
Other languages
English (en)
Inventor
Ernesto Irarrazabal Muñoz Carlos
Original Assignee
Univ Los Andes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48044247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014007947(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Los Andes filed Critical Univ Los Andes
Publication of BR112014007947A2 publication Critical patent/BR112014007947A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7038—Hypoxia

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

abstract: title method for monitoring, diagnosis and/or prognosis of hypoxia related disorders using nfat5 the present invention relates to a method for monitoring, diagnosis and/or prognosis of hypoxia related disorders using nfat5, the method comprising the steps of a) providing a body sample; b) concentrating the transcription factors present in the sample; c) detecting and/or quantifying nfat5 in the treated sample. the invention further comprises a diagnostic kit for determining the presence and/or level of nfat5, for simple determination of the onset of an hypoxia related disorder or condition in a subject, the kit comprising means for concentrating the transcription factors present in the sample and means for detecting nfat5. ______________________________________________________________ resumo traduzido resumo patente de invenção: "método para monitoramento, diagnóstico e/ou prognóstico de distúrbios relacionados à hipoxia usando nfat5". a presente invenção refere-se a um método para monitoramento, diagnóstico e/ou prognóstico e distúrbios relacionados à hipoxia usando nfat5, o método compreendendo as etapas de a) provisão de uma amostra corporal; b) concentração dos fatores de transcrição presentes na amostra; c) detecção e/ou quantificação de nfat5 na amostra tratada. a invenção compreende ainda um estojo de diagnóstico para determinação da presença e/ou nível de nfat5, para determinação simples do início de um distúrbio ou condição relacionado à hipoxia em um indivíduo, o estojo compreendendo meios para concentração dos fatores de transcrição presentes na amostra e meios para detecção de nfat5.
BR112014007947A 2011-10-03 2012-10-03 método para monitoramento, diagnóstico e/ou prognóstico de distúrbios relacionados à hipoxia usando nfat5 BR112014007947A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161542446P 2011-10-03 2011-10-03
PCT/IB2012/055311 WO2013050950A2 (en) 2011-10-03 2012-10-03 Method for monitoring, diagnosis and/or prognosis of hypoxia related disorders using nfat5

Publications (1)

Publication Number Publication Date
BR112014007947A2 true BR112014007947A2 (pt) 2017-04-18

Family

ID=48044247

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014007947A BR112014007947A2 (pt) 2011-10-03 2012-10-03 método para monitoramento, diagnóstico e/ou prognóstico de distúrbios relacionados à hipoxia usando nfat5

Country Status (8)

Country Link
US (1) US9631237B2 (pt)
EP (1) EP2764114A4 (pt)
BR (1) BR112014007947A2 (pt)
CL (1) CL2014000809A1 (pt)
CO (1) CO7020868A2 (pt)
HK (1) HK1200877A1 (pt)
PE (1) PE20141723A1 (pt)
WO (1) WO2013050950A2 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9687510B2 (en) * 2014-09-04 2017-06-27 The Johns Hopkins University Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
US20220243281A1 (en) * 2019-05-28 2022-08-04 Case Western Reserve University Compositions and methods for preserving dna methylation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL158010A0 (en) * 2003-09-18 2004-03-28 Hadasit Med Res Service Methods and kits for the detection of prion diseases
US20080039416A1 (en) * 2004-06-02 2008-02-14 Ho Steffan N Methods for Treating Disease by Modulating an Osmotic Stress Pathway
WO2007114449A1 (en) * 2006-03-28 2007-10-11 Oncorex, Inc. Low-glucose-inducible or low-glucose-and-hypoxia-inducible genes, proteins, and uses thereof
WO2008103202A2 (en) * 2006-11-21 2008-08-28 Beth Israel Deaconess Medical Center Hypoxia related genes and proteins for the treatment and diagnosis of pregnancy related complications
WO2010009474A1 (en) * 2008-07-18 2010-01-21 Hill's Pet Nutrition, Inc. Compositions and methods for treating osteoarthritis
JP2010187469A (ja) 2009-02-12 2010-08-26 Hitachi Consumer Marketing Inc 消費エネルギー積算値管理警報システム
WO2011057172A1 (en) * 2009-11-06 2011-05-12 University Of Miami Podocyte specific assays and uses thereof

Also Published As

Publication number Publication date
HK1200877A1 (en) 2015-08-14
CL2014000809A1 (es) 2014-11-28
EP2764114A4 (en) 2015-05-06
WO2013050950A2 (en) 2013-04-11
US9631237B2 (en) 2017-04-25
PE20141723A1 (es) 2014-11-26
US20140255947A1 (en) 2014-09-11
CO7020868A2 (es) 2014-08-11
EP2764114A2 (en) 2014-08-13
WO2013050950A3 (en) 2013-06-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]