MX2014003422A - Método para la monitorización, el diagnostico y/o el pronostico de lesión renal aguda en fase temprana. - Google Patents

Método para la monitorización, el diagnostico y/o el pronostico de lesión renal aguda en fase temprana.

Info

Publication number
MX2014003422A
MX2014003422A MX2014003422A MX2014003422A MX2014003422A MX 2014003422 A MX2014003422 A MX 2014003422A MX 2014003422 A MX2014003422 A MX 2014003422A MX 2014003422 A MX2014003422 A MX 2014003422A MX 2014003422 A MX2014003422 A MX 2014003422A
Authority
MX
Mexico
Prior art keywords
kidney injury
acute kidney
prognosis
diagnosis
monitoring
Prior art date
Application number
MX2014003422A
Other languages
English (en)
Inventor
Carlos Ernesto Irarrazabal Muñoz
Original Assignee
Univ Los Andes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47913944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2014003422(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Los Andes filed Critical Univ Los Andes
Publication of MX2014003422A publication Critical patent/MX2014003422A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a un método y un Kit para la monitorización, el diagnóstico, el pronóstico de lesión renal aguda en fase temprana y la determinación del tratamiento en sujetos que padecen la misma. El método comprende las etapas de a) proporcionar una muestra de orina; b) enriquecer la muestra de orina en exosomas presentes en la muestra de orina usando al menos una etapa de inmunopurificación; c) detectar un marcador de lesión renal aguda (LRA) en el exosoma. La invención también se refiere a un Kit para determinar la presencia y/o el nivel de un marcador de lesión renal específico, para la determinación sencilla y temprana de la aparición de LRA en un sujeto, comprendido el Kit medios para enriquecer la muestra de orina en exoxomas usando al menos una etapa de inmunopurificación, y medios para detectar un marcador de lesión renal predeterminado de un estado. El método y el Kit de la invención tienen la ventaja de proporcionar la detección específica, sencilla y temprana de marcadores de lesión renal, lo que no es posible con los métodos convencionales aplicados hasta ahora. El método y el Kit de la invención también proporcionan la ventaja de identificar la estructura específica que presenta la lesión en el riñon, puesto que usa anticuerpos específicos para proteínas específicas presentes en estructuras específicas del riñon.
MX2014003422A 2011-09-22 2011-09-22 Método para la monitorización, el diagnostico y/o el pronostico de lesión renal aguda en fase temprana. MX2014003422A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2011/054187 WO2013041913A1 (en) 2011-09-22 2011-09-22 Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage

Publications (1)

Publication Number Publication Date
MX2014003422A true MX2014003422A (es) 2014-10-13

Family

ID=47913944

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003422A MX2014003422A (es) 2011-09-22 2011-09-22 Método para la monitorización, el diagnostico y/o el pronostico de lesión renal aguda en fase temprana.

Country Status (14)

Country Link
US (1) US20140329334A1 (es)
EP (1) EP2758774A4 (es)
JP (1) JP5893742B2 (es)
KR (1) KR20140076571A (es)
CN (1) CN103917869A (es)
AU (1) AU2011377379A1 (es)
BR (1) BR112014006741A2 (es)
CA (1) CA2849577A1 (es)
HK (1) HK1199754A1 (es)
IL (1) IL231626A0 (es)
IN (1) IN2014DN03194A (es)
MX (1) MX2014003422A (es)
RU (1) RU2014115999A (es)
WO (1) WO2013041913A1 (es)

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RU2765678C1 (ru) * 2020-12-21 2022-02-01 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ прогнозирования риска развития острого повреждения почек у больных с острым коронарным синдромом

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WO2014182330A1 (en) 2013-05-06 2014-11-13 Hitachi Chemical Company Ltd Devices and methods for capturing target molecules
FR3014198B1 (fr) * 2013-12-03 2017-03-03 Biomerieux Sa Procede d'isolement d'exosomes
EP3169691B1 (en) * 2014-07-17 2020-09-02 The Trustees Of The University Of Pennsylvania Methods for using exosomes to monitor transplanted organ status
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
US20170315134A1 (en) * 2014-11-11 2017-11-02 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2016077537A1 (en) * 2014-11-12 2016-05-19 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
WO2016140388A1 (ko) * 2015-03-05 2016-09-09 경북대학교 산학협력단 엑소좀 또는 이의 단백질을 포함하는 장기 독성 진단용 바이오마커 조성물 및 이를 이용한 진단 방법
US20160320390A1 (en) * 2015-05-01 2016-11-03 Morehouse School Of Medicine Compositions and methods for capturing exosomes
EP3334498B1 (en) 2015-08-12 2023-06-07 The Trustees of Columbia University in the City of New York Methods of treating volume depletion and kidney injury
WO2017040520A1 (en) 2015-08-31 2017-03-09 Hitachi Chemical Co., Ltd. Molecular methods for assessing urothelial disease
JP6531987B2 (ja) * 2015-10-01 2019-06-19 国立大学法人名古屋大学 腎疾患診断のためのエクソソーム回収法
CN105441578B (zh) * 2016-01-19 2018-08-31 中南大学湘雅二医院 尿液外泌体microRNA分子标志物的应用及制备的试剂盒
EP3427060A4 (en) 2016-03-07 2019-12-18 CFGenome, LLC NON-INVASIVE MOLECULAR WITNESSES
CN106053811A (zh) * 2016-06-05 2016-10-26 浙江大学 一种尿液外泌体elisa的检测方法及其应用
RU2647327C2 (ru) * 2016-07-05 2018-03-15 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО КубГМУ Минздрава России) Способ ранней диагностики хронической болезни почек у пациентов с хронической обструктивной болезнью легких
JP2019168223A (ja) * 2016-08-12 2019-10-03 公立大学法人和歌山県立医科大学 エクソソームの膜に存在するタンパク質の検出方法
CN109425742A (zh) * 2017-08-23 2019-03-05 迪亚莱博（张家港）生物科技有限公司 一种化学发光法快速检测水通道蛋白1的试剂盒
JPWO2019045049A1 (ja) * 2017-09-01 2020-12-03 学校法人帝京大学 腎尿細管細胞特異的発現ベクター
RU2702023C1 (ru) * 2018-08-17 2019-10-04 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ диагностики острого повреждения почек после органосохраняющего хирургического лечения локализованного рака почки
EP3748362B1 (en) * 2019-06-06 2023-10-11 Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz In vitro method for detecting renal disease
EP3904883A1 (en) * 2020-04-07 2021-11-03 Sciomics GmbH Prediction and early diagnosis of acute kidney injury
CN113189321A (zh) * 2021-04-12 2021-07-30 攸太科技(台州)有限公司 一种尿液检测方法
WO2024085722A1 (ko) * 2022-10-20 2024-04-25 건국대학교 산학협력단 신장 질환의 조기 진단을 위한 바이오마커 조성물 및 이를 이용한 신장 질환의 조기 진단에 필요한 정보를 제공하는 방법

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
RU2765678C1 (ru) * 2020-12-21 2022-02-01 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ прогнозирования риска развития острого повреждения почек у больных с острым коронарным синдромом

Also Published As

Publication number Publication date
EP2758774A1 (en) 2014-07-30
JP2014528076A (ja) 2014-10-23
CN103917869A (zh) 2014-07-09
EP2758774A4 (en) 2015-04-29
US20140329334A1 (en) 2014-11-06
AU2011377379A1 (en) 2014-04-10
BR112014006741A2 (pt) 2017-03-28
HK1199754A1 (en) 2015-07-17
CA2849577A1 (en) 2013-03-28
WO2013041913A1 (en) 2013-03-28
RU2014115999A (ru) 2015-10-27
JP5893742B2 (ja) 2016-03-23
KR20140076571A (ko) 2014-06-20
IL231626A0 (en) 2014-05-28
IN2014DN03194A (es) 2015-05-22

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