JP2014528485A5 - - Google Patents
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- Publication number
- JP2014528485A5 JP2014528485A5 JP2014535962A JP2014535962A JP2014528485A5 JP 2014528485 A5 JP2014528485 A5 JP 2014528485A5 JP 2014535962 A JP2014535962 A JP 2014535962A JP 2014535962 A JP2014535962 A JP 2014535962A JP 2014528485 A5 JP2014528485 A5 JP 2014528485A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- WEMSTZGSMUKWJC-UHFFFAOYSA-O CC(CC1)(C(CC2)C(CC3)C1C(CC1)C3CC1(C)O)C2C(C[NH2+]N=CC=N)=O Chemical compound CC(CC1)(C(CC2)C(CC3)C1C(CC1)C3CC1(C)O)C2C(C[NH2+]N=CC=N)=O WEMSTZGSMUKWJC-UHFFFAOYSA-O 0.000 description 1
- OLMPCBGYIZOSPC-ZISZBIOLSA-N CC(CC1)([C@@H](CC2)[C@H](CC3)[C@H]1C(CCC1C(C)=C4CC4)C3(C)C[C@H]1O)[C@H]2C(C[n]1cncc1)=O Chemical compound CC(CC1)([C@@H](CC2)[C@H](CC3)[C@H]1C(CCC1C(C)=C4CC4)C3(C)C[C@H]1O)[C@H]2C(C[n]1cncc1)=O OLMPCBGYIZOSPC-ZISZBIOLSA-N 0.000 description 1
- ZOGQGFCHOXYIRA-YBLSGOOYSA-N CCN(CC([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2CC[C@H](C[C@](CCC=N)(COC)O)CC1)=O)/C=C\N Chemical compound CCN(CC([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2CC[C@H](C[C@](CCC=N)(COC)O)CC1)=O)/C=C\N ZOGQGFCHOXYIRA-YBLSGOOYSA-N 0.000 description 1
- QMEKUHVFZNKVKW-SWKGGFOOSA-N C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1C(CC1)C3C[C@]1(COC)O)[C@H]2C(C[n]1nccc1)=O Chemical compound C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1C(CC1)C3C[C@]1(COC)O)[C@H]2C(C[n]1nccc1)=O QMEKUHVFZNKVKW-SWKGGFOOSA-N 0.000 description 1
- GLMMXZCVUUYNKR-RGBBFSEBSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@H](CC1)C3C[C@]1(CF)O)[C@H]2C(C[n]1nccn1)=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@H](CC1)C3C[C@]1(CF)O)[C@H]2C(C[n]1nccn1)=O GLMMXZCVUUYNKR-RGBBFSEBSA-N 0.000 description 1
- 0 C[C@](CC1)([C@](CC2)[C@@](CC3)[C@]1C(CC1)C3(C)C[C@]1(C(F)F)O)[C@]2C(CS*)=O Chemical compound C[C@](CC1)([C@](CC2)[C@@](CC3)[C@]1C(CC1)C3(C)C[C@]1(C(F)F)O)[C@]2C(CS*)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547291P | 2011-10-14 | 2011-10-14 | |
| US61/547,291 | 2011-10-14 | ||
| US201261698204P | 2012-09-07 | 2012-09-07 | |
| US61/698,204 | 2012-09-07 | ||
| PCT/US2012/060136 WO2013056181A1 (en) | 2011-10-14 | 2012-10-12 | 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235371A Division JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014528485A JP2014528485A (ja) | 2014-10-27 |
| JP2014528485A5 true JP2014528485A5 (https=) | 2015-11-12 |
Family
ID=47143295
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535962A Withdrawn JP2014528485A (ja) | 2011-10-14 | 2012-10-12 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2017235371A Active JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2020132282A Active JP7096864B2 (ja) | 2011-10-14 | 2020-08-04 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2022101881A Active JP7617057B2 (ja) | 2011-10-14 | 2022-06-24 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2025001804A Pending JP2025061026A (ja) | 2011-10-14 | 2025-01-06 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235371A Active JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2020132282A Active JP7096864B2 (ja) | 2011-10-14 | 2020-08-04 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2022101881A Active JP7617057B2 (ja) | 2011-10-14 | 2022-06-24 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2025001804A Pending JP2025061026A (ja) | 2011-10-14 | 2025-01-06 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20150291654A1 (https=) |
| EP (3) | EP4717314A2 (https=) |
| JP (5) | JP2014528485A (https=) |
| CN (4) | CN119192266A (https=) |
| AU (6) | AU2012323888A1 (https=) |
| CA (2) | CA3152410A1 (https=) |
| ES (1) | ES2738526T3 (https=) |
| PT (1) | PT2766380T (https=) |
| WO (1) | WO2013056181A1 (https=) |
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| CN101583620B (zh) | 2005-11-28 | 2016-08-17 | 马里纳斯医药公司 | 加奈索酮组合物及其制备和使用方法 |
| HRP20230747T1 (hr) | 2011-09-08 | 2024-01-05 | Sage Therapeutics, Inc. | Neuroaktivni steroidi, pripravci i njihova uporaba |
| CN119192266A (zh) | 2011-10-14 | 2024-12-27 | 萨奇治疗股份有限公司 | 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途 |
| SG10201606063RA (en) | 2012-01-23 | 2016-09-29 | Sage Therapeutics Inc | Neuroactive steroid formulations and methods of treating cns disorders |
| MX2015002252A (es) | 2012-08-21 | 2015-07-21 | Sage Therapeutics Inc | Metodos para tratar epilepsia o estado de epilepsia. |
| DK2925327T3 (da) | 2012-11-30 | 2024-03-25 | Univ California | Allopregnanolon til behandling, reduktion eller lindring af symptomer på fødselsdepression |
| SMT201800657T1 (it) | 2013-03-13 | 2019-01-11 | Sage Therapeutics Inc | Steroidi neuroattivi e loro metodi di utilizzo |
| ES2807264T3 (es) * | 2013-04-17 | 2021-02-22 | Sage Therapeutics Inc | Esteroides neuroactivos 19-nor para métodos de tratamiento |
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| JP6470258B2 (ja) * | 2013-04-17 | 2019-02-13 | セージ セラピューティクス， インコーポレイテッド | １９−ノルｃ３，３−ジ置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法 |
| WO2014169831A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof |
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| ES2848823T3 (es) | 2013-08-23 | 2021-08-12 | Sage Therapeutics Inc | Esteroides neuroactivos, composiciones y usos de los mismos |
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| EP4155314A1 (en) * | 2015-02-20 | 2023-03-29 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| US20180311258A1 (en) * | 2015-04-10 | 2018-11-01 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| AR105044A1 (es) | 2015-06-18 | 2017-08-30 | Sage Therapeutics Inc | Soluciones de esteroides neuroactivos y sus métodos de uso, recipiente |
| AU2016289965B2 (en) | 2015-07-06 | 2021-09-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| PL3319611T3 (pl) | 2015-07-06 | 2021-07-12 | Sage Therapeutics, Inc. | Oksysterole i sposoby ich stosowania |
| MX382122B (es) | 2015-07-06 | 2025-03-13 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos. |
| EA036155B1 (ru) | 2015-10-16 | 2020-10-06 | Маринус Фармасьютикалс, Инк. | Инъекционные составы нейростероида, содержащие наночастицы |
| HK1258616A1 (zh) | 2016-03-08 | 2019-11-15 | Sage Therapeutics, Inc. | 神经活性类固醇、组合物、及其用途 |
| EP3436022B1 (en) * | 2016-04-01 | 2022-03-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
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