CN110612292A - 奥扎莫德加成盐晶型、制备方法及药物组合物和用途 - Google Patents
奥扎莫德加成盐晶型、制备方法及药物组合物和用途 Download PDFInfo
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- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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Abstract
公开了奥扎莫德加成盐晶型，与已知的奥扎莫德固体形态相比，其具有一种或多种改进的特性。还公开了奥扎莫德加成盐晶型的制备方法、其药物组合物、及其用于制备在医学上需要选择性鞘氨醇‑1‑磷酸酯受体的调节、活化、激动、抑制或拮抗的病症或不良状况的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (56)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/079654 WO2018184185A1 (zh) | 2017-04-07 | 2017-04-07 | 奥扎莫德加成盐晶型、制备方法及药物组合物和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110612292A true CN110612292A (zh) | 2019-12-24 |
Family
ID=63712314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780090485.XA Pending CN110612292A (zh) | 2017-04-07 | 2017-04-07 | 奥扎莫德加成盐晶型、制备方法及药物组合物和用途 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20200031784A1 (zh) |
| CN (1) | CN110612292A (zh) |
| WO (1) | WO2018184185A1 (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111223B2 (en) * | 2016-06-14 | 2021-09-07 | Receptos Llc | Crystalline forms of ozanimod and ozanimod hydrochloride, and processes for preparation thereof |
| WO2018033149A1 (zh) | 2016-08-19 | 2018-02-22 | 苏州科睿思制药有限公司 | 奥扎莫德的晶型及其制备方法 |
| CN109640982A (zh) * | 2016-09-14 | 2019-04-16 | 苏州科睿思制药有限公司 | 奥扎莫德盐酸盐的晶型及其制备方法 |
| US11117876B2 (en) | 2017-08-31 | 2021-09-14 | Receptos Llc | Crystalline form of ozanimod hydrochloride, and processes for preparation thereof |
| MX2022000651A (es) | 2019-07-16 | 2022-03-11 | Synthon Bv | Proceso mejorado para preparar ozanimod. |
| CN114599363A (zh) | 2019-10-31 | 2022-06-07 | 爱杜西亚药品有限公司 | Cxcr7拮抗剂与s1p1受体调节剂的组合 |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| WO2023152767A1 (en) * | 2022-02-11 | 2023-08-17 | Mylan Laboratories Limited | Polymorphic forms of ozanimod hydrochloride |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102762100A (zh) * | 2009-11-13 | 2012-10-31 | 瑞塞普托斯公司 | 选择性的1-磷酸鞘氨醇受体调节剂及手性合成方法 |
| CN102887829A (zh) * | 2012-09-05 | 2013-01-23 | 中国科学院上海药物研究所 | 芬戈莫德粘酸盐及其晶体的制备方法和用途 |
| WO2015066515A1 (en) * | 2013-11-01 | 2015-05-07 | Receptos, Inc. | Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith |
-
2017
- 2017-04-07 CN CN201780090485.XA patent/CN110612292A/zh active Pending
- 2017-04-07 US US16/603,416 patent/US20200031784A1/en not_active Abandoned
- 2017-04-07 WO PCT/CN2017/079654 patent/WO2018184185A1/zh active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102762100A (zh) * | 2009-11-13 | 2012-10-31 | 瑞塞普托斯公司 | 选择性的1-磷酸鞘氨醇受体调节剂及手性合成方法 |
| CN102887829A (zh) * | 2012-09-05 | 2013-01-23 | 中国科学院上海药物研究所 | 芬戈莫德粘酸盐及其晶体的制备方法和用途 |
| WO2015066515A1 (en) * | 2013-11-01 | 2015-05-07 | Receptos, Inc. | Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith |
Non-Patent Citations (2)
| Title |
|---|
| SCOTT F L等: ""Ozanimod（PRC1063） is a potent sphingosine-1-phosphate receptor-1（S1P1） and receptor-5（S1P5） agonist with autoimmune disease-modifying activity"", 《BRITISH JOURNAL OF PHARMACOLOGY》 * |
| 潘卫三: "《工业药剂学》", 31 August 2015 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018184185A1 (zh) | 2018-10-11 |
| US20200031784A1 (en) | 2020-01-30 |
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