CN110612292A - 奥扎莫德加成盐晶型、制备方法及药物组合物和用途 - Google Patents
奥扎莫德加成盐晶型、制备方法及药物组合物和用途 Download PDFInfo
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
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Abstract
公开了奥扎莫德加成盐晶型,与已知的奥扎莫德固体形态相比,其具有一种或多种改进的特性。还公开了奥扎莫德加成盐晶型的制备方法、其药物组合物、及其用于制备在医学上需要选择性鞘氨醇‑1‑磷酸酯受体的调节、活化、激动、抑制或拮抗的病症或不良状况的药物中的用途。
Description
PCT国内申请,说明书已公开。
Claims (56)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/CN2017/079654 WO2018184185A1 (zh) | 2017-04-07 | 2017-04-07 | 奥扎莫德加成盐晶型、制备方法及药物组合物和用途 |
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CN110612292A true CN110612292A (zh) | 2019-12-24 |
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CN201780090485.XA Pending CN110612292A (zh) | 2017-04-07 | 2017-04-07 | 奥扎莫德加成盐晶型、制备方法及药物组合物和用途 |
Country Status (3)
Country | Link |
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US (1) | US20200031784A1 (zh) |
CN (1) | CN110612292A (zh) |
WO (1) | WO2018184185A1 (zh) |
Families Citing this family (8)
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US11111223B2 (en) * | 2016-06-14 | 2021-09-07 | Receptos Llc | Crystalline forms of ozanimod and ozanimod hydrochloride, and processes for preparation thereof |
EP3502100A4 (en) | 2016-08-19 | 2019-06-26 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | CRYSTAL FORMS OF OZANIMOD AND MANUFACTURING METHOD THEREFOR |
US10882830B2 (en) * | 2016-09-14 | 2021-01-05 | Receptos Llc | Crystal form of ozanimod hydrochloride and processes for preparation therefor |
WO2019042219A1 (zh) | 2017-08-31 | 2019-03-07 | 苏州科睿思制药有限公司 | 奥扎莫德盐酸盐的晶型及其制备方法 |
WO2021009306A1 (en) | 2019-07-16 | 2021-01-21 | Synthon B.V. | Improved process for preparing ozanimod |
WO2021084068A1 (en) | 2019-10-31 | 2021-05-06 | Idorsia Pharmaceuticals Ltd | Combination of a cxcr7 antagonist with an s1p1 receptor modulator |
EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
WO2023152767A1 (en) * | 2022-02-11 | 2023-08-17 | Mylan Laboratories Limited | Polymorphic forms of ozanimod hydrochloride |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102762100A (zh) * | 2009-11-13 | 2012-10-31 | 瑞塞普托斯公司 | 选择性的1-磷酸鞘氨醇受体调节剂及手性合成方法 |
CN102887829A (zh) * | 2012-09-05 | 2013-01-23 | 中国科学院上海药物研究所 | 芬戈莫德粘酸盐及其晶体的制备方法和用途 |
WO2015066515A1 (en) * | 2013-11-01 | 2015-05-07 | Receptos, Inc. | Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith |
-
2017
- 2017-04-07 CN CN201780090485.XA patent/CN110612292A/zh active Pending
- 2017-04-07 US US16/603,416 patent/US20200031784A1/en not_active Abandoned
- 2017-04-07 WO PCT/CN2017/079654 patent/WO2018184185A1/zh active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102762100A (zh) * | 2009-11-13 | 2012-10-31 | 瑞塞普托斯公司 | 选择性的1-磷酸鞘氨醇受体调节剂及手性合成方法 |
CN102887829A (zh) * | 2012-09-05 | 2013-01-23 | 中国科学院上海药物研究所 | 芬戈莫德粘酸盐及其晶体的制备方法和用途 |
WO2015066515A1 (en) * | 2013-11-01 | 2015-05-07 | Receptos, Inc. | Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith |
Non-Patent Citations (2)
Title |
---|
SCOTT F L等: ""Ozanimod(PRC1063) is a potent sphingosine-1-phosphate receptor-1(S1P1) and receptor-5(S1P5) agonist with autoimmune disease-modifying activity"", 《BRITISH JOURNAL OF PHARMACOLOGY》 * |
潘卫三: "《工业药剂学》", 31 August 2015 * |
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US20200031784A1 (en) | 2020-01-30 |
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