|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
US5149782A
(en)
|
1988-08-19 |
1992-09-22 |
Tanox Biosystems, Inc. |
Molecular conjugates containing cell membrane-blending agents
|
|
ATE159982T1
(de)
|
1988-09-15 |
1997-11-15 |
Univ Columbia |
Antikörper mit modifiziertem kohlenhydratgehalt und verfahren zur herstellung und verwendung
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
CA2018248A1
(en)
*
|
1989-06-07 |
1990-12-07 |
Clyde W. Shearman |
Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use
|
|
CA2089661C
(en)
|
1990-08-29 |
2007-04-03 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
EP1136556B1
(en)
|
1991-11-25 |
2005-06-08 |
Enzon, Inc. |
Method of producing multivalent antigen-binding proteins
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
WO1994009817A1
(en)
|
1992-11-04 |
1994-05-11 |
City Of Hope |
Novel antibody construct
|
|
WO1994026087A2
(en)
|
1993-05-14 |
1994-11-24 |
Connor Kim C O |
Recombinant protein production and insect cell culture and process
|
|
US5429746A
(en)
|
1994-02-22 |
1995-07-04 |
Smith Kline Beecham Corporation |
Antibody purification
|
|
US5792456A
(en)
|
1994-08-04 |
1998-08-11 |
Bristol-Myers Squibb Company |
Mutant BR96 antibodies reactive with human carcinomas
|
|
PT706799E
(pt)
|
1994-09-16 |
2002-05-31 |
Merck Patent Gmbh |
Imunoconjugados ii
|
|
GB9422383D0
(en)
|
1994-11-05 |
1995-01-04 |
Wellcome Found |
Antibodies
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
WO1996040662A2
(en)
|
1995-06-07 |
1996-12-19 |
Cellpro, Incorporated |
Aminooxy-containing linker compounds and their application in conjugates
|
|
EP0799244A1
(en)
|
1995-10-16 |
1997-10-08 |
Unilever N.V. |
A bifunctional or bivalent antibody fragment analogue
|
|
GB9524973D0
(en)
|
1995-12-06 |
1996-02-07 |
Lynxvale Ltd |
Viral vectors
|
|
SE9601245D0
(sv)
|
1996-03-29 |
1996-03-29 |
Pharmacia Ab |
Chimeric superantigens and their use
|
|
UA71889C2
(uk)
|
1996-04-02 |
2005-01-17 |
Йєда Рісерч Енд Дівелопмент Ко. Лтд. |
Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
|
|
CA2262405A1
(en)
|
1996-08-02 |
1998-02-12 |
Bristol-Myers Squibb Company |
A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
ATE419009T1
(de)
|
1997-10-31 |
2009-01-15 |
Genentech Inc |
Methoden und zusammensetzungen bestehend aus glykoprotein-glykoformen
|
|
US6953675B2
(en)
|
1997-11-06 |
2005-10-11 |
Immunomedics, Inc. |
Landscaped antibodies and antibody fragments for clinical use
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
DE69937291T2
(de)
|
1998-04-02 |
2008-07-10 |
Genentech, Inc., South San Francisco |
Antikörpervarianten und fragmente davon
|
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
WO2000009560A2
(en)
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
US6465612B1
(en)
|
1998-09-23 |
2002-10-15 |
The Regents Of The University Of California |
Synthetic peptides, conjugation reagents and methods
|
|
EP1006183A1
(en)
|
1998-12-03 |
2000-06-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Recombinant soluble Fc receptors
|
|
KR101155191B1
(ko)
|
1999-01-15 |
2012-06-13 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US20020102208A1
(en)
|
1999-03-01 |
2002-08-01 |
Paul Chinn |
Radiolabeling kit and binding assay
|
|
CN1110322C
(zh)
|
1999-07-21 |
2003-06-04 |
中国医学科学院医药生物技术研究所 |
单克隆抗体Fab'-平阳霉素偶联物及其抗肿瘤作用
|
|
AU2001270609A1
(en)
|
2000-06-30 |
2002-01-14 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Heterodimeric fusion proteins
|
|
GB0029407D0
(en)
|
2000-12-01 |
2001-01-17 |
Affitech As |
Product
|
|
DK1355919T3
(da)
|
2000-12-12 |
2011-03-14 |
Medimmune Llc |
Molekyler med længere halveringstider, sammensætninger og anvendelser deraf
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US20050107595A1
(en)
|
2001-06-20 |
2005-05-19 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
|
US6900292B2
(en)
|
2001-08-17 |
2005-05-31 |
Lee-Hwei K. Sun |
Fc fusion proteins of human erythropoietin with increased biological activities
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
EP1487879B1
(en)
|
2002-03-01 |
2012-12-26 |
Immunomedics, Inc. |
Bispecific antibody point mutations for enhancing rate of clearance
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
GB0216648D0
(en)
|
2002-07-18 |
2002-08-28 |
Lonza Biologics Plc |
Method of expressing recombinant protein in CHO cells
|
|
CA2495251C
(en)
|
2002-08-14 |
2018-03-06 |
Macrogenics, Inc. |
Fc.gamma.riib-specific antibodies and methods of use thereof
|
|
KR100980065B1
(ko)
|
2002-09-27 |
2010-09-03 |
젠코어 인코포레이티드 |
최적화된 Fc 변이체 및 그의 제조 방법
|
|
AU2003286467B2
(en)
|
2002-10-15 |
2009-10-01 |
Abbvie Biotherapeutics Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
WO2004063351A2
(en)
|
2003-01-09 |
2004-07-29 |
Macrogenics, Inc. |
IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
|
|
AU2004251145C1
(en)
|
2003-06-12 |
2011-04-14 |
Eli Lilly And Company |
GLP-1 analog fusion proteins
|
|
CN1871259A
(zh)
|
2003-08-22 |
2006-11-29 |
比奥根艾迪克Ma公司 |
具有改变的效应物功能的经改进的抗体和制备它的方法
|
|
RU2392324C2
(ru)
*
|
2003-09-18 |
2010-06-20 |
Симфоген А/С |
Способ связывания интересующих последовательностей
|
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
|
SG149815A1
(en)
|
2003-11-06 |
2009-02-27 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugation to ligands
|
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
|
US7001978B2
(en)
|
2003-11-19 |
2006-02-21 |
Xerox Corporation |
Unsaturated ester substituted polymers with reduced halogen content
|
|
EP2221315A1
(en)
|
2003-12-04 |
2010-08-25 |
Xencor, Inc. |
Methods of generating variant proteins with increased host string content and compositions thereof
|
|
EP1697520A2
(en)
|
2003-12-22 |
2006-09-06 |
Xencor, Inc. |
Fc polypeptides with novel fc ligand binding sites
|
|
PT1706424E
(pt)
|
2004-01-12 |
2009-10-01 |
Applied Molecular Evolution |
Variantes da região fc
|
|
US7276585B2
(en)
|
2004-03-24 |
2007-10-02 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
CA2565414A1
(en)
|
2004-05-04 |
2005-11-24 |
Novo Nordisk Health Care Ag |
O-linked glycoforms of polypeptides and method to manufacture them
|
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
|
EP2940043A1
(en)
|
2004-07-15 |
2015-11-04 |
Xencor, Inc. |
Optimized fc variants
|
|
TR201808537T4
(tr)
|
2004-09-23 |
2018-07-23 |
Genentech Inc |
Sistein değiştirilmiş antikorlar ve konjugatlar.
|
|
US20060084145A1
(en)
|
2004-09-27 |
2006-04-20 |
Anderson Glenn M |
sRAGE mimetibody, compositions, methods and uses
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
JP4829609B2
(ja)
*
|
2004-12-22 |
2011-12-07 |
独立行政法人科学技術振興機構 |
ヒト抗体酵素およびその生産方法
|
|
DK1866339T3
(da)
*
|
2005-03-25 |
2013-09-02 |
Gitr Inc |
GTR-bindende molekyler og anvendelser heraf
|
|
JP2008537941A
(ja)
|
2005-03-31 |
2008-10-02 |
ゼンコー・インコーポレイテッド |
最適化特性を有するFc変異体
|
|
AU2006230413B8
(en)
|
2005-03-31 |
2011-01-20 |
Xencor, Inc |
Fc variants with optimized properties
|
|
US8163881B2
(en)
|
2005-05-31 |
2012-04-24 |
The Board Of Regents Of The University Of Texas System |
Immunoglobulin molecules with improved characteristics
|
|
JP5372500B2
(ja)
|
2005-06-17 |
2013-12-18 |
トレラクス リクイデーティング トラスト |
Ilt3結合分子およびその使用
|
|
JP2009504569A
(ja)
|
2005-06-30 |
2009-02-05 |
セントカー・インコーポレーテツド |
向上した治療活性をもつ方法および組成物
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
CZ2005627A3
(cs)
|
2005-10-03 |
2006-09-13 |
Flek@Jaroslav |
Zubní kartácek
|
|
US7846724B2
(en)
|
2006-04-11 |
2010-12-07 |
Hoffmann-La Roche Inc. |
Method for selecting CHO cell for production of glycosylated antibodies
|
|
EP2041180B8
(en)
*
|
2006-06-19 |
2014-03-05 |
Liquidating Trust |
Ilt3 binding molecules and uses therefor
|
|
FI20060946A0
(fi)
|
2006-10-26 |
2006-10-26 |
Glykos Finland Oy |
Influenssaviruksen nukleiinihappoja ja peptidejä
|
|
JP2010512306A
(ja)
|
2006-10-27 |
2010-04-22 |
ザ ロックフェラー ユニバーシティー |
抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法
|
|
AR063975A1
(es)
|
2006-11-28 |
2009-03-04 |
Centelion |
Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada
|
|
SI2068887T1
(sl)
*
|
2007-01-09 |
2014-06-30 |
Biogen Idec Ma Inc. |
SP35 protitelesa in njihova uporaba
|
|
CA2669412A1
(en)
|
2007-01-23 |
2008-07-31 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
|
AU2008251608B2
(en)
|
2007-05-08 |
2014-03-27 |
Genentech, Inc. |
Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates
|
|
DK2205258T3
(en)
|
2007-09-28 |
2017-08-28 |
Janssen Biotech Inc |
Method and structural conformations of antibody preparations with increased resistance to proteases
|
|
EP2050764A1
(en)
|
2007-10-15 |
2009-04-22 |
sanofi-aventis |
Novel polyvalent bispecific antibody format and uses thereof
|
|
NZ584514A
(en)
|
2007-10-19 |
2012-07-27 |
Genentech Inc |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
|
CN102037004A
(zh)
|
2008-01-08 |
2011-04-27 |
生物种属学股份公司 |
使用寡糖基转移酶的多肽的糖缀合
|
|
EP2247620B1
(en)
|
2008-01-31 |
2016-05-18 |
Genentech, Inc. |
Anti-cd79b antibodies and immunoconjugates and methods of use
|
|
EP2444491B1
(en)
|
2008-04-21 |
2016-11-16 |
Novo Nordisk Healthcare Ag |
Hyperglycosylated human coagulation factor IX
|
|
UA40611U
(ru)
|
2008-05-26 |
2009-04-27 |
Владимир Семенович Живченко |
Способ десульфурации железоуглеродистого расплава в тигельной печи
|
|
CA2735193A1
(en)
*
|
2008-08-26 |
2010-03-11 |
Macrogenics, Inc. |
T-cell receptor antibodies and methods of use thereof
|
|
EP2233499A1
(en)
|
2009-03-26 |
2010-09-29 |
CSL Behring AG |
Antibody composition with altered Fab sialylation
|
|
US10087236B2
(en)
|
2009-12-02 |
2018-10-02 |
Academia Sinica |
Methods for modifying human antibodies by glycan engineering
|
|
PH12018501083A1
(en)
*
|
2010-03-04 |
2019-02-18 |
Macrogenics Inc |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
|
JP6334166B2
(ja)
|
2010-08-10 |
2018-05-30 |
グリコトープ ゲーエムベーハー |
Fabグリコシル化抗体
|
|
AR085302A1
(es)
|
2011-02-24 |
2013-09-18 |
Sanofi Sa |
Metodo de produccion de anticuerpos sialilados
|
|
SG10201604757RA
(en)
|
2011-03-11 |
2016-08-30 |
Amicus Therapeutics Inc |
Dosing regimens for the treatment of fabry disease
|
|
TWI743461B
(zh)
|
2011-03-28 |
2021-10-21 |
法商賽諾菲公司 |
具有交叉結合區定向之雙重可變區類抗體結合蛋白
|
|
UY34317A
(es)
|
2011-09-12 |
2013-02-28 |
Genzyme Corp |
Anticuerpo antireceptor de célula T (alfa)/ß
|
|
US9790268B2
(en)
|
2012-09-12 |
2017-10-17 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
|
EP2895513B1
(en)
|
2012-09-12 |
2018-05-23 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
|
AU2014249224B2
(en)
|
2013-03-11 |
2019-01-17 |
Genzyme Corporation |
Site-specific antibody-drug conjugation through glycoengineering
|
|
EP3129067B1
(en)
|
2014-03-19 |
2023-01-04 |
Genzyme Corporation |
Site-specific glycoengineering of targeting moieties
|
|
US10905678B2
(en)
|
2014-04-08 |
2021-02-02 |
University Of Georgia Research Foundation, Inc. |
Site-specific antibody-drug glycoconjugates and methods
|
|
ES2838680T3
(es)
|
2014-10-09 |
2021-07-02 |
Genzyme Corp |
Conjugados de anticuerpo-fármaco glucomodificados
|
|
US10280317B2
(en)
|
2016-07-07 |
2019-05-07 |
Northwestern University |
Enhanced conductivity, adhesion and environmental stability of printed graphene inks with nitrocellulose
|