JP2014523412A5 - - Google Patents
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- JP2014523412A5 JP2014523412A5 JP2014514932A JP2014514932A JP2014523412A5 JP 2014523412 A5 JP2014523412 A5 JP 2014523412A5 JP 2014514932 A JP2014514932 A JP 2014514932A JP 2014514932 A JP2014514932 A JP 2014514932A JP 2014523412 A5 JP2014523412 A5 JP 2014523412A5
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- 125000005647 linker group Chemical group 0.000 claims 29
- 125000000524 functional group Chemical group 0.000 claims 13
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- 125000002837 carbocyclic group Chemical group 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 8
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- -1 heteroaliphatic Chemical group 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 229940122803 Vinca alkaloid Drugs 0.000 claims 2
- 108010044540 auristatin Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 claims 2
- 229960005501 duocarmycin Drugs 0.000 claims 2
- 229930184221 duocarmycin Natural products 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 2
- 210000003739 neck Anatomy 0.000 claims 2
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- DLKUYSQUHXBYPB-NSSHGSRYSA-N (2s,4r)-4-[[2-[(1r,3r)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2s,3s)-3-methyl-2-[[(2r)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-2-methyl-5-(4-methylphenyl)pentanoic acid Chemical compound N([C@@H]([C@@H](C)CC)C(=O)N(COC(=O)CC(C)C)[C@H](C[C@@H](OC(C)=O)C=1SC=C(N=1)C(=O)N[C@H](C[C@H](C)C(O)=O)CC=1C=CC(C)=CC=1)C(C)C)C(=O)[C@H]1CCCCN1C DLKUYSQUHXBYPB-NSSHGSRYSA-N 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 229940124647 MEK inhibitor Drugs 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 229940116355 PI3 kinase inhibitor Drugs 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 102000004243 Tubulin Human genes 0.000 claims 1
- 108090000704 Tubulin Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000000867 larynx Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 201000001514 prostate carcinoma Diseases 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 201000000498 stomach carcinoma Diseases 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 229930184737 tubulysin Natural products 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 0 CC*C(CC(N1C(C)C)=O)C1=O Chemical compound CC*C(CC(N1C(C)C)=O)C1=O 0.000 description 5
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161495771P | 2011-06-10 | 2011-06-10 | |
| US61/495,771 | 2011-06-10 | ||
| US201161501000P | 2011-06-24 | 2011-06-24 | |
| US61/501,000 | 2011-06-24 | ||
| US201161513234P | 2011-07-29 | 2011-07-29 | |
| US61/513,234 | 2011-07-29 | ||
| US201161566935P | 2011-12-05 | 2011-12-05 | |
| US61/566,935 | 2011-12-05 | ||
| US201261605618P | 2012-03-01 | 2012-03-01 | |
| US61/605,618 | 2012-03-01 | ||
| US201261618499P | 2012-03-30 | 2012-03-30 | |
| US61/618,499 | 2012-03-30 | ||
| PCT/US2012/041931 WO2012171020A1 (en) | 2011-06-10 | 2012-06-11 | Protein-polymer-drug conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016083700A Division JP6034525B2 (ja) | 2011-06-10 | 2016-04-19 | タンパク質−高分子−薬剤コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014523412A JP2014523412A (ja) | 2014-09-11 |
| JP2014523412A5 true JP2014523412A5 (enExample) | 2015-11-12 |
| JP5926374B2 JP5926374B2 (ja) | 2016-05-25 |
Family
ID=46317544
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514932A Active JP5926374B2 (ja) | 2011-06-10 | 2012-06-11 | タンパク質−高分子−薬剤コンジュゲート |
| JP2016083700A Active JP6034525B2 (ja) | 2011-06-10 | 2016-04-19 | タンパク質−高分子−薬剤コンジュゲート |
| JP2016207699A Active JP6212194B2 (ja) | 2011-06-10 | 2016-10-24 | タンパク質−高分子−薬剤コンジュゲート |
| JP2017177008A Expired - Fee Related JP6467009B2 (ja) | 2011-06-10 | 2017-09-14 | タンパク質−高分子−薬剤コンジュゲート |
| JP2019002870A Expired - Fee Related JP6788045B2 (ja) | 2011-06-10 | 2019-01-10 | タンパク質−高分子−薬剤コンジュゲート |
| JP2020180205A Active JP7305604B2 (ja) | 2011-06-10 | 2020-10-28 | タンパク質－高分子－薬剤コンジュゲート |
| JP2023106308A Pending JP2023120427A (ja) | 2011-06-10 | 2023-06-28 | タンパク質－高分子－薬剤コンジュゲート |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016083700A Active JP6034525B2 (ja) | 2011-06-10 | 2016-04-19 | タンパク質−高分子−薬剤コンジュゲート |
| JP2016207699A Active JP6212194B2 (ja) | 2011-06-10 | 2016-10-24 | タンパク質−高分子−薬剤コンジュゲート |
| JP2017177008A Expired - Fee Related JP6467009B2 (ja) | 2011-06-10 | 2017-09-14 | タンパク質−高分子−薬剤コンジュゲート |
| JP2019002870A Expired - Fee Related JP6788045B2 (ja) | 2011-06-10 | 2019-01-10 | タンパク質−高分子−薬剤コンジュゲート |
| JP2020180205A Active JP7305604B2 (ja) | 2011-06-10 | 2020-10-28 | タンパク質－高分子－薬剤コンジュゲート |
| JP2023106308A Pending JP2023120427A (ja) | 2011-06-10 | 2023-06-28 | タンパク質－高分子－薬剤コンジュゲート |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US8685383B2 (enExample) |
| EP (2) | EP2717916B1 (enExample) |
| JP (7) | JP5926374B2 (enExample) |
| KR (2) | KR101972303B1 (enExample) |
| CN (2) | CN106110332B (enExample) |
| AU (2) | AU2012267447B2 (enExample) |
| BR (1) | BR112013031819B1 (enExample) |
| CA (1) | CA2837840C (enExample) |
| DK (1) | DK2717916T3 (enExample) |
| ES (1) | ES2622578T3 (enExample) |
| IL (2) | IL229695B (enExample) |
| MX (2) | MX368966B (enExample) |
| RU (1) | RU2617402C2 (enExample) |
| TW (2) | TWI603741B (enExample) |
| WO (1) | WO2012171020A1 (enExample) |
Families Citing this family (84)
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| EP2717916B1 (en) * | 2011-06-10 | 2017-03-08 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| PT3210627T (pt) * | 2012-07-12 | 2023-03-23 | Hangzhou Dac Biotech Co Ltd | Conjugados de moléculas de ligação celular com agentes citotóxicos |
| US11873281B2 (en) | 2012-07-12 | 2024-01-16 | Hangzhou Dac Biotech Co., Ltd. | Conjugates of cell binding molecules with cytotoxic agents |
| US10226535B2 (en) | 2012-12-10 | 2019-03-12 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
| AU2013359506B2 (en) * | 2012-12-10 | 2018-05-24 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| EP2931316B1 (en) * | 2012-12-12 | 2019-02-20 | Mersana Therapeutics, Inc. | Hydroxyl-polymer-drug-protein conjugates |
| US20160022829A1 (en) * | 2013-03-14 | 2016-01-28 | Mersana Therapeutics, Inc. | Tubulysin compounds and conjugates thereof |
| KR102178606B1 (ko) | 2013-03-15 | 2020-11-13 | 자임워크스 인코포레이티드 | 세포독성 및 유사분열-억제 화합물, 및 이를 사용하는 방법 |
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| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| SG11201510740YA (en) | 2013-09-17 | 2016-01-28 | Obi Pharma Inc | Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment |
| EA032231B1 (ru) | 2013-10-11 | 2019-04-30 | Мерсана Терапьютикс, Инк. | Конъюгаты белок-полимер-лекарственное средство |
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| JP6971858B2 (ja) | 2015-06-22 | 2021-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | 酵素開裂性基を有する抗体薬物複合体（ａｄｃ）および抗体プロドラッグ複合体（ａｐｄｃ） |
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