JP2014522718A - 多相エマルションおよび多相エマルション形成法 - Google Patents

多相エマルションおよび多相エマルション形成法 Download PDF

Info

Publication number
JP2014522718A
JP2014522718A JP2014519281A JP2014519281A JP2014522718A JP 2014522718 A JP2014522718 A JP 2014522718A JP 2014519281 A JP2014519281 A JP 2014519281A JP 2014519281 A JP2014519281 A JP 2014519281A JP 2014522718 A JP2014522718 A JP 2014522718A
Authority
JP
Japan
Prior art keywords
fluid
conduit
shell
droplet
droplets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014519281A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014522718A5 (enExample
Inventor
キム・シンヒン
アリレザ・アッバスポールラド
デイビッド・エイ・ウェイツ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of JP2014522718A publication Critical patent/JP2014522718A/ja
Publication of JP2014522718A5 publication Critical patent/JP2014522718A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/14—Mixing drops, droplets or bodies of liquid which flow together or contact each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4145—Emulsions of oils, e.g. fuel, and water
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/311—Injector mixers in conduits or tubes through which the main component flows for mixing more than two components; Devices specially adapted for generating foam
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F2025/91—Direction of flow or arrangement of feed and discharge openings
    • B01F2025/918—Counter current flow, i.e. flows moving in opposite direction and colliding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0404—Technical information in relation with mixing theories or general explanations of phenomena associated with mixing or generalizations of a concept by comparison of equivalent methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0454—Numerical frequency values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0486—Material property information
    • B01F2215/0495—Numerical values of viscosity of substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Colloid Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polymerisation Methods In General (AREA)
  • Lubricants (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
JP2014519281A 2011-07-06 2012-07-05 多相エマルションおよび多相エマルション形成法 Pending JP2014522718A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161505001P 2011-07-06 2011-07-06
US201161504990P 2011-07-06 2011-07-06
US61/504,990 2011-07-06
US61/505,001 2011-07-06
PCT/US2012/045481 WO2013006661A2 (en) 2011-07-06 2012-07-05 Multiple emulsions and techniques for the formation of multiple emulsions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016159526A Division JP2017024005A (ja) 2011-07-06 2016-08-16 多相エマルションおよび多相エマルション形成法

Publications (2)

Publication Number Publication Date
JP2014522718A true JP2014522718A (ja) 2014-09-08
JP2014522718A5 JP2014522718A5 (enExample) 2015-08-20

Family

ID=46516865

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014519281A Pending JP2014522718A (ja) 2011-07-06 2012-07-05 多相エマルションおよび多相エマルション形成法
JP2016159526A Pending JP2017024005A (ja) 2011-07-06 2016-08-16 多相エマルションおよび多相エマルション形成法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016159526A Pending JP2017024005A (ja) 2011-07-06 2016-08-16 多相エマルションおよび多相エマルション形成法

Country Status (6)

Country Link
US (2) US20140220350A1 (enExample)
EP (2) EP2729238A2 (enExample)
JP (2) JP2014522718A (enExample)
CN (2) CN106268389A (enExample)
BR (1) BR112014000141A2 (enExample)
WO (1) WO2013006661A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018141689A (ja) * 2017-02-27 2018-09-13 シスメックス株式会社 液体送液方法および液体送液装置
JP2018537414A (ja) * 2015-10-13 2018-12-20 プレジデント アンド フェローズ オブ ハーバード カレッジ ゲルマイクロスフェアの作製及び使用のためのシステム及び方法
JP2020014980A (ja) * 2018-07-23 2020-01-30 日本精工株式会社 マイクロ流路チップ、マイクロ流路デバイス、およびマイクロ流路チップの製造方法

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2248578B1 (en) 2005-03-04 2012-06-06 President and Fellows of Harvard College Method for forming multiple emulsions
WO2010033200A2 (en) 2008-09-19 2010-03-25 President And Fellows Of Harvard College Creation of libraries of droplets and related species
ES2533498T3 (es) * 2009-08-28 2015-04-10 Georgia Tech Research Corporation Método y dispositivo electro-fluídico para producir emulsiones y suspensión de partículas
CN102574078B (zh) 2009-09-02 2016-05-18 哈佛学院院长等 使用喷射和其它技术产生的多重乳液
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
CN106268389A (zh) 2011-07-06 2017-01-04 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
EP3065712A4 (en) 2013-11-08 2017-06-21 President and Fellows of Harvard College Microparticles, methods for their preparation and use
WO2015160919A1 (en) 2014-04-16 2015-10-22 President And Fellows Of Harvard College Systems and methods for producing droplet emulsions with relatively thin shells
ES2564893B2 (es) * 2014-08-25 2016-07-08 Universidad De Sevilla Procedimiento y dispositivo de generación de emulsiones micrométricas simples y compuestas
EP3224419A4 (en) * 2014-11-24 2018-06-27 President and Fellows of Harvard College Multiple emulsions comprising rigidified portions
CA2966914A1 (en) 2014-11-24 2016-06-02 The Procter & Gamble Company Systems for encapsulation of actives within droplets and other compartments
CA2972113C (en) 2014-12-24 2023-03-14 National Research Council Of Canada Microparticles and apparatus for smart ink production
WO2016164773A1 (en) 2015-04-09 2016-10-13 Saudi Arabian Oil Company Encapsulated nanocompositions for increasing hydrocarbon recovery
US10620428B1 (en) * 2015-09-28 2020-04-14 Amazon Technologies, Inc. Method for manufacturing an electrowetting device using a hardened fluid coating
US10125307B2 (en) 2016-01-13 2018-11-13 Saudi Arabian Oil Company Stabilization of petroleum surfactants for enhancing oil recovery
JP7039575B2 (ja) * 2016-09-30 2022-03-22 アモーレパシフィック コーポレーション マイクロ流体チャネルに基づいて瞬時に乳化された乳化物を含有する化粧品組成物調製装置
WO2018075069A1 (en) * 2016-10-21 2018-04-26 Hewlett-Packard Development Company, L.P. Droplet generator
DE102017105194A1 (de) * 2017-03-10 2018-09-13 Little Things Factory Gmbh Fokussiereinrichtung, Tropfengenerator und Verfahren zum Erzeugen einer Vielzahl von Tröpfchen
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
WO2018213643A1 (en) 2017-05-18 2018-11-22 10X Genomics, Inc. Methods and systems for sorting droplets and beads
US10610865B2 (en) 2017-08-22 2020-04-07 10X Genomics, Inc. Droplet forming devices and system with differential surface properties
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
EP3703662A4 (en) * 2017-11-03 2021-12-22 Mark A. Gray PRODUCTION AND DOSAGE OF QUANTS
WO2020009998A1 (en) 2018-07-03 2020-01-09 Chan Zuckerberg Biohub, Inc. Method to perform high-throughput single cell genomic and phenotypic analyses
US10731012B2 (en) * 2018-11-06 2020-08-04 President And Fellows Of Harvard College Anti-clogging microfluidic multichannel device
EP3902632A1 (en) * 2018-12-28 2021-11-03 Astraveus Device and method for handling a particle suspension
WO2020160152A1 (en) * 2019-01-31 2020-08-06 The Trustees Of The University Of Pennsylvania Silicon chip having multi-zone through silicon vias and method of manufacturing the same
WO2022159605A1 (en) * 2021-01-20 2022-07-28 Arizona Board Of Regents On Behalf Of Arizona State University Encapsulant-containing polymer capsules and fibers and composites including same
CN114316302A (zh) * 2021-12-29 2022-04-12 南通大学 一种用于油包水型小液滴制备的硅油及水溶液配方
ES2966288A1 (es) * 2022-09-22 2024-04-19 Univ Rovira I Virgili Reometro y procedimientos asociados
CN118454760A (zh) * 2023-02-09 2024-08-09 上海交通大学 一种单分散结构色双重乳液的制备方法
CN117123288B (zh) * 2023-09-15 2025-10-10 武汉科技大学 一种收缩型入口流聚焦高通量核-壳复合液滴可控生成装置及方法
CN118892786B (zh) * 2024-07-22 2025-11-18 华东理工大学 一种超分子水凝胶微胶囊及其制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS518875B2 (enExample) * 1972-10-14 1976-03-22
JPH10219222A (ja) * 1997-02-07 1998-08-18 Nissei Tekunika:Kk 液晶表示パネル基板の接着用のマイクロカプセル型接着性粒子
JPH11509768A (ja) * 1995-03-29 1999-08-31 ワーナー−ランバート・カンパニー 継ぎ目なしカプセル
WO2002068104A1 (fr) * 2001-02-23 2002-09-06 Japan Science And Technology Corporation Procede de preparation d'emulsion et de microcapsules et appareil a cet effet
JP2008535644A (ja) * 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 多重エマルジョンの形成のための方法および装置
JP2008238146A (ja) * 2007-03-29 2008-10-09 Okayama Prefecture Industrial Promotion Foundation マイクロリアクター
US7776927B2 (en) * 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
WO2011028764A2 (en) * 2009-09-02 2011-03-10 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques

Family Cites Families (245)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2379816A (en) 1939-07-17 1945-07-03 Gelatin Products Corp Capsulating process and apparatus
US2918263A (en) 1957-08-09 1959-12-22 Dow Chemical Co Mixing liquids and solids
NL6605917A (enExample) 1965-04-30 1966-10-31
US3980541A (en) 1967-06-05 1976-09-14 Aine Harry E Electrode structures for electric treatment of fluids and filters using same
US3675901A (en) 1970-12-09 1972-07-11 Phillips Petroleum Co Method and apparatus for mixing materials
FR2180722B1 (enExample) 1972-04-20 1975-12-26 Centre Rech Metallurgique
US3816331A (en) 1972-07-05 1974-06-11 Ncr Continuous encapsulation and device therefor
CH563807A5 (en) 1973-02-14 1975-07-15 Battelle Memorial Institute Fine granules and microcapsules mfrd. from liquid droplets - partic. of high viscosity requiring forced sepn. of droplets
CH564966A5 (enExample) 1974-02-25 1975-08-15 Sauter Fr Ag Fabrik Elektrisch
NL180807C (nl) 1975-12-26 1987-05-04 Morishita Jintan Co Inrichting voor het vervaardigen van naadloze, met materiaal gevulde capsules.
JPS5857973B2 (ja) 1978-02-13 1983-12-22 ぺんてる株式会社 無機質壁マイクロカプセルの製造方法
US4279345A (en) 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
JPS5933018B2 (ja) 1980-03-17 1984-08-13 森下仁丹株式会社 高融点物質のマイクロカプセル製造方法とその製造装置
JPS6057907B2 (ja) 1981-06-18 1985-12-17 工業技術院長 液体の混合噴霧化方法
US4422985A (en) 1982-09-24 1983-12-27 Morishita Jintan Co., Ltd. Method and apparatus for encapsulation of a liquid or meltable solid material
JPS59131355A (ja) 1983-01-17 1984-07-28 森下仁丹株式会社 多重軟カプセルの製法
US5100933A (en) 1986-03-31 1992-03-31 Massachusetts Institute Of Technology Collapsible gel compositions
JPS6046980B2 (ja) 1983-08-11 1985-10-18 森下仁丹株式会社 変形シ−ムレス軟カプセルの製法およびその製造装置
US4865444A (en) 1984-04-05 1989-09-12 Mobil Oil Corporation Apparatus and method for determining luminosity of hydrocarbon fuels
JPS6157236A (ja) 1984-08-29 1986-03-24 Agency Of Ind Science & Technol 含油無機質壁マイクロカプセル及びその製造方法
US4732930A (en) 1985-05-20 1988-03-22 Massachusetts Institute Of Technology Reversible, discontinuous volume changes of ionized isopropylacrylamide cells
US5209978A (en) 1985-12-26 1993-05-11 Taisho Pharmaceutical Co., Ltd. Seamless soft capsule and production thereof
US4916070A (en) 1986-04-14 1990-04-10 The General Hospital Corporation Fibrin-specific antibodies and method of screening for the antibodies
US5204112A (en) 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US4743507A (en) 1986-09-12 1988-05-10 Franses Elias I Nonspherical microparticles and method therefor
AT393633B (de) 1986-11-26 1991-11-25 Waagner Biro Ag Verfahren zum mischen von medien unterschiedlicher zaehigkeit
JPH075743B2 (ja) 1986-12-22 1995-01-25 ダイキン工業株式会社 テトラフルオロエチレン系共重合体粉末およびその製造法
US4888140A (en) 1987-02-11 1989-12-19 Chesebrough-Pond's Inc. Method of forming fluid filled microcapsules
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US4978483A (en) 1987-09-28 1990-12-18 Redding Bruce K Apparatus and method for making microcapsules
US5418154A (en) 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US4931225A (en) 1987-12-30 1990-06-05 Union Carbide Industrial Gases Technology Corporation Method and apparatus for dispersing a gas into a liquid
JPH0694483B2 (ja) 1988-01-29 1994-11-24 三田工業株式会社 粒径の増大した単分散重合体粒子の製造方法
US5227979A (en) 1989-10-13 1993-07-13 Hitachi Metals, Ltd. Method of designing cavity shape of mold
US5093602A (en) 1989-11-17 1992-03-03 Charged Injection Corporation Methods and apparatus for dispersing a fluent material utilizing an electron beam
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
GB9021061D0 (en) 1990-09-27 1990-11-07 Unilever Plc Encapsulating method and products containing encapsulated material
US6149789A (en) 1990-10-31 2000-11-21 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for manipulating microscopic, dielectric particles and a device therefor
US5232712A (en) 1991-06-28 1993-08-03 Brown University Research Foundation Extrusion apparatus and systems
DE4127405C2 (de) 1991-08-19 1996-02-29 Fraunhofer Ges Forschung Verfahren zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter dielektrischer Teilchen und Vorrichtung zur Durchführung des Verfahrens
US5216096A (en) 1991-09-24 1993-06-01 Japan Synthetic Rubber Co., Ltd. Process for the preparation of cross-linked polymer particles
SE500071C2 (sv) 1992-06-25 1994-04-11 Vattenfall Utveckling Ab Anordning för blandning av två fluider, i synnerhet vätskor med olika temperatur
FR2696658B1 (fr) 1992-10-14 1994-11-18 Hospal Ind Procédé et dispositif d'encapsulation d'une substance, ainsi que capsule obtenue.
DE4308839C2 (de) 1993-03-19 1997-04-30 Jordanow & Co Gmbh Vorrichtung zum Mischen von Strömungsmedien
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
CA2151541C (en) 1994-06-13 1999-06-08 William Thoru Kobayashi Narrow spray angle liquid fuel atomizers for combustion
US5935331A (en) 1994-09-09 1999-08-10 Matsushita Electric Industrial Co., Ltd. Apparatus and method for forming films
US5762775A (en) 1994-09-21 1998-06-09 Lockheed Martin Energy Systems, Inc. Method for electrically producing dispersions of a nonconductive fluid in a conductive medium
EP0812434B1 (en) 1995-03-01 2013-09-18 President and Fellows of Harvard College Microcontact printing on surfaces and derivative articles
US5888538A (en) * 1995-03-29 1999-03-30 Warner-Lambert Company Methods and apparatus for making seamless capsules
US6238690B1 (en) 1995-03-29 2001-05-29 Warner-Lambert Company Food products containing seamless capsules and methods of making the same
US5851769A (en) 1995-09-27 1998-12-22 The Regents Of The University Of California Quantitative DNA fiber mapping
JP3759986B2 (ja) 1995-12-07 2006-03-29 フロイント産業株式会社 シームレスカプセルおよびその製造方法
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
JP3765338B2 (ja) 1995-12-15 2006-04-12 武田薬品工業株式会社 注射用徐放性製剤の製造法
US5681600A (en) 1995-12-18 1997-10-28 Abbott Laboratories Stabilization of liquid nutritional products and method of making
US6355198B1 (en) 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
JP3633091B2 (ja) 1996-04-09 2005-03-30 旭硝子株式会社 微小無機質球状中実体の製造方法
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6299145B1 (en) 1996-05-13 2001-10-09 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6116516A (en) 1996-05-13 2000-09-12 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US6196525B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6187214B1 (en) 1996-05-13 2001-02-13 Universidad De Seville Method and device for production of components for microfabrication
US6189803B1 (en) 1996-05-13 2001-02-20 University Of Seville Fuel injection nozzle and method of use
US6405936B1 (en) 1996-05-13 2002-06-18 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
US6248378B1 (en) 1998-12-16 2001-06-19 Universidad De Sevilla Enhanced food products
US6386463B1 (en) 1996-05-13 2002-05-14 Universidad De Sevilla Fuel injection nozzle and method of use
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
AU4113297A (en) 1996-09-04 1998-03-26 Technical University Of Denmark A micro flow system for particle separation and analysis
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6120666A (en) 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
CA2289088C (en) 1997-04-30 2007-08-07 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream
JP4102459B2 (ja) 1997-05-14 2008-06-18 森下仁丹株式会社 生体高分子を合成するシームレスカプセルおよびその製造方法
WO1999002671A1 (en) 1997-07-07 1999-01-21 Medical Research Council In vitro sorting method
US5980936A (en) 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6004525A (en) 1997-10-06 1999-12-21 Kabushiki Kaisha Toyota Chuo Kenkyusho Hollow oxide particle and process for producing the same
US6614598B1 (en) 1998-11-12 2003-09-02 Institute Of Technology, California Microlensing particles and applications
US6450189B1 (en) 1998-11-13 2002-09-17 Universidad De Sevilla Method and device for production of components for microfabrication
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
CA2373347A1 (en) 1999-05-17 2000-11-23 Caliper Technologies Corporation Focusing of microparticles in microfluidic systems
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US20030124509A1 (en) 1999-06-03 2003-07-03 Kenis Paul J.A. Laminar flow patterning and articles made thereby
JP2003501257A (ja) 1999-06-11 2003-01-14 アラディジム コーポレーション エーロゾルを生成する方法
ATE215673T1 (de) 1999-06-28 2002-04-15 California Inst Of Techn Elastomerische mikropumpen- und mikroventilsysteme
US6380297B1 (en) 1999-08-12 2002-04-30 Nexpress Solutions Llc Polymer particles of controlled shape
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US6890487B1 (en) 1999-09-30 2005-05-10 Science & Technology Corporation ©UNM Flow cytometry for high throughput screening
US6916488B1 (en) 1999-11-05 2005-07-12 Biocure, Inc. Amphiphilic polymeric vesicles
JP2001234188A (ja) 1999-12-17 2001-08-28 Ricoh Co Ltd 加工液およびその製造方法ならびにその加工液を用いた加工方法
DE19961257C2 (de) 1999-12-18 2002-12-19 Inst Mikrotechnik Mainz Gmbh Mikrovermischer
AU2001232805A1 (en) 2000-01-12 2001-07-24 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
JP2003527299A (ja) 2000-03-10 2003-09-16 フロー・フォーカシング・インコーポレーテッド 高粘性液体を収束させることにより光ファイバを製作する方法
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
DE10015109A1 (de) 2000-03-28 2001-10-04 Peter Walzel Verfahren und Vorrichtungen zur Herstellung gleich großer Tropfen
US7758888B2 (en) 2000-04-21 2010-07-20 Sol-Gel Technologies Ltd. Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
CN1189159C (zh) 2000-05-05 2005-02-16 欧莱雅 含水溶性美容活性组分水性核的微胶囊及含其的组合物
US6413548B1 (en) 2000-05-10 2002-07-02 Aveka, Inc. Particulate encapsulation of liquid beads
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
US6777450B1 (en) 2000-05-26 2004-08-17 Color Access, Inc. Water-thin emulsions with low emulsifier levels
US20060263888A1 (en) 2000-06-02 2006-11-23 Honeywell International Inc. Differential white blood count on a disposable card
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
DE10035302C2 (de) 2000-07-18 2002-12-19 Deotexis Inc Mikrokapsel, Verfahren zu ihrer Herstellung und Verwendung derselben
US6623788B1 (en) 2000-07-25 2003-09-23 Seagate Technology Llc Defect-free patterning of sol-gel-coated substrates for magnetic recording media
US6301055B1 (en) 2000-08-16 2001-10-09 California Institute Of Technology Solid immersion lens structures and methods for producing solid immersion lens structures
WO2002013755A1 (en) 2000-08-17 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Method of manufacturing seamless capsule
DE10041823C2 (de) 2000-08-25 2002-12-19 Inst Mikrotechnik Mainz Gmbh Verfahren und statischer Mikrovermischer zum Mischen mindestens zweier Fluide
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US6508988B1 (en) 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US6887493B2 (en) 2000-10-25 2005-05-03 Adi Shefer Multi component controlled release system for oral care, food products, nutraceutical, and beverages
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US20040096515A1 (en) 2001-12-07 2004-05-20 Bausch Andreas R. Methods and compositions for encapsulating active agents
WO2002047665A2 (en) 2000-12-07 2002-06-20 President And Fellows Of Harvard College Methods and compositions for encapsulating active agents
US6767637B2 (en) * 2000-12-13 2004-07-27 Purdue Research Foundation Microencapsulation using ultrasonic atomizers
JP3860186B2 (ja) 2001-02-23 2006-12-20 独立行政法人科学技術振興機構 エマルションの製造装置
EP1741482B1 (en) 2001-02-23 2008-10-15 Japan Science and Technology Agency Process and apparatus for producing microcapsules
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
JP4194934B2 (ja) 2001-05-26 2008-12-10 ワン セル システムズ インコーポレイテッド カプセル化細胞によるタンパク質の分泌法
GB0114854D0 (en) 2001-06-18 2001-08-08 Medical Res Council Selective gene amplification
US20030015425A1 (en) 2001-06-20 2003-01-23 Coventor Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
EP1412065A2 (en) 2001-07-27 2004-04-28 President And Fellows Of Harvard College Laminar mixing apparatus and methods
DE60200822T2 (de) 2001-10-18 2005-09-15 Aida Engineering, Ltd., Sagamihara Mikrodosier- und Probennahmevorrichtung sowie Mikrochip mit dieser Vorrichtung
DE10206083B4 (de) 2002-02-13 2009-11-26 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren zum Erzeugen monodisperser Nanotropfen sowie mikrofluidischer Reaktor zum Durchführen des Verfahrens
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US7718099B2 (en) 2002-04-25 2010-05-18 Tosoh Corporation Fine channel device, fine particle producing method and solvent extraction method
EP2283918B1 (en) 2002-05-09 2022-10-05 The University of Chicago Device and method for pressure-driven plug transport and reaction
US20030227820A1 (en) 2002-06-05 2003-12-11 Parrent Kenneth Gaylord Apparatus for mixing, combining or dissolving fluids or fluidized components in each other
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
JP2006023322A (ja) 2002-09-12 2006-01-26 Ticona Gmbh 静電荷像現像用トナーの製造方法
JP5285201B2 (ja) 2002-09-25 2013-09-11 株式会社ナノエッグ レチノイン酸ナノカプセル
JP4186637B2 (ja) 2002-11-06 2008-11-26 東ソー株式会社 粒子製造方法及びそのための微小流路構造体
GB2395196B (en) 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
US7670627B2 (en) 2002-12-09 2010-03-02 Salvona Ip Llc pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients
TWI299101B (en) 2003-01-30 2008-07-21 Sipix Imaging Inc High performance capsules for electrophoretic displays
WO2004071638A2 (en) 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US7045040B2 (en) 2003-03-20 2006-05-16 Asm Nutool, Inc. Process and system for eliminating gas bubbles during electrochemical processing
WO2004087338A2 (de) 2003-03-31 2004-10-14 Behr Gmbh & Co. Kg Wärmetauscher und verfahren zur oberflächenbehandlung eines solchen
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
EP2266687A3 (en) 2003-04-10 2011-06-29 The President and Fellows of Harvard College Formation and control of fluidic species
US7115230B2 (en) 2003-06-26 2006-10-03 Intel Corporation Hydrodynamic focusing devices
GB0315438D0 (en) 2003-07-02 2003-08-06 Univ Manchester Analysis of mixed cell populations
US20050032238A1 (en) 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
WO2005021151A1 (en) 2003-08-27 2005-03-10 President And Fellows Of Harvard College Electronic control of fluidic species
JP4533382B2 (ja) 2003-08-28 2010-09-01 セルラ・インコーポレイテッド マイクロ流体分析およびソーティング用の一体化された構造物
JP4341372B2 (ja) 2003-10-30 2009-10-07 コニカミノルタホールディングス株式会社 液体の混合方法および混合装置ならびに混合システム
JP4042683B2 (ja) 2003-11-17 2008-02-06 東ソー株式会社 微小流路構造体及びこれを用いた微小粒子製造方法
EP1691792A4 (en) 2003-11-24 2008-05-28 Yeda Res & Dev COMPOSITIONS AND PROCESSES FOR SORTING IN VITRO OF MOLECULE AND CELL LIBRARIES
JP3777427B2 (ja) 2003-11-25 2006-05-24 独立行政法人食品総合研究所 エマルションの製造方法および製造装置
JP4305145B2 (ja) 2003-11-25 2009-07-29 東ソー株式会社 微小流路による粒子製造方法
KR101376715B1 (ko) 2003-12-19 2014-03-27 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 소프트 또는 임프린트 리소그래피를 이용하여 분리된 마이크로- 및 나노- 구조를 제작하는 방법
JP4575394B2 (ja) 2004-02-27 2010-11-04 ヒタチ ケミカル リサーチ センター インコーポレイテッド 多重検出プローブ
EP1757357B1 (en) 2004-03-23 2013-04-24 Japan Science and Technology Agency Method and device for producing micro-droplets
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
CA2563836C (en) 2004-04-23 2011-06-14 Eugenia Kumacheva Method of producing polymeric particles with selected size, shape, morphology and composition
JP4461900B2 (ja) 2004-05-10 2010-05-12 富士ゼロックス株式会社 微粒子分散液の送液方法、及び微粒子分散液の送液装置
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
WO2006002641A1 (en) 2004-07-02 2006-01-12 Versamatrix A/S Spherical radiofrequency-encoded beads
US7759111B2 (en) 2004-08-27 2010-07-20 The Regents Of The University Of California Cell encapsulation microfluidic device
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CN100464833C (zh) 2004-11-11 2009-03-04 中国科学院化学研究所 用模板法制备中空球和复合结构的中空球的方法
WO2006051552A2 (en) 2004-11-15 2006-05-18 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Directed evolution and selection using in vitro compartmentalization
US20070009668A1 (en) 2004-11-18 2007-01-11 Wyman Jason L Microencapsulation of particles in a polymer solution by selective withdrawal through a high viscosity low density fluid and subsequent crosslinking
WO2006078841A1 (en) 2005-01-21 2006-07-27 President And Fellows Of Harvard College Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles
JP2006257415A (ja) 2005-02-17 2006-09-28 Kobe Univ 蓄熱カプセル及びその利用
US20070054119A1 (en) 2005-03-04 2007-03-08 Piotr Garstecki Systems and methods of forming particles
RU2007139819A (ru) 2005-03-29 2009-05-10 МакНЕЙЛ-Пи-Пи-Си, ИНК. (US) Композиции с гидрофильными лекарствами в гидрофобной среде
JP2006349060A (ja) 2005-06-16 2006-12-28 Ntn Corp ボールねじ
US20070047388A1 (en) 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
US8734003B2 (en) 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
DE102005048259B4 (de) 2005-10-07 2007-09-13 Landesstiftung Baden-Württemberg Vorrichtung und Verfahren zur Erzeugung eines Gemenges von zwei ineinander unlösbaren Phasen
EP1968550A2 (en) 2005-12-16 2008-09-17 University Of Kansas Nanoclusters for delivery of therapeutics
GB2433448B (en) 2005-12-20 2011-03-02 Q Chip Ltd Method for the control of chemical processes
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
AU2007206582B2 (en) 2006-01-23 2011-09-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Microspheres comprising nanocapsules containing a lipophilic drug
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
EP2004316B8 (en) 2006-01-27 2011-04-13 President and Fellows of Harvard College Fluidic droplet coalescence
US20080014589A1 (en) 2006-05-11 2008-01-17 Link Darren R Microfluidic devices and methods of use thereof
US8367113B2 (en) 2006-05-15 2013-02-05 Massachusetts Institute Of Technology Polymers for functional particles
CA2606963A1 (en) 2006-10-17 2008-04-17 Emile Haddad Self healing composite material and method of manufacturing same
WO2008058297A2 (en) 2006-11-10 2008-05-15 Harvard University Non-spherical particles
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008109176A2 (en) * 2007-03-07 2008-09-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
TW200845197A (en) 2007-03-28 2008-11-16 Matsushita Electric Industrial Co Ltd Plasma etching apparatus
US20100130369A1 (en) 2007-04-23 2010-05-27 Advanced Liquid Logic, Inc. Bead-Based Multiplexed Analytical Methods and Instrumentation
CA2691597C (en) * 2007-06-25 2016-04-05 Otsuka Pharmaceutical Co., Ltd. Microspheres having core/shell structure
WO2009003105A1 (en) 2007-06-26 2008-12-31 University Of South Florida Hands-free powered mobility device
GB0712861D0 (en) 2007-07-03 2007-08-08 Eastman Kodak Co Continuous ink jet printing of encapsulated droplets
GB0712863D0 (en) 2007-07-03 2007-08-08 Eastman Kodak Co Monodisperse droplet generation
GB0712860D0 (en) 2007-07-03 2007-08-08 Eastman Kodak Co continuous inkjet drop generation device
US20090068170A1 (en) 2007-07-13 2009-03-12 President And Fellows Of Harvard College Droplet-based selection
WO2009020633A2 (en) 2007-08-07 2009-02-12 President And Fellows Of Harvard College Metal oxide coating on surfaces
US8685323B2 (en) 2007-09-19 2014-04-01 Massachusetts Institute Of Technology Virus/nanowire encapsulation within polymer microgels for 2D and 3D devices for energy and electronics
GB0718300D0 (en) 2007-09-20 2007-10-31 Univ Leeds Microcapsules and methods
WO2009048532A2 (en) 2007-10-05 2009-04-16 President And Fellows Of Harvard College Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation
WO2009061372A1 (en) 2007-11-02 2009-05-14 President And Fellows Of Harvard College Systems and methods for creating multi-phase entities, including particles and/or fluids
JP2011506077A (ja) 2007-12-11 2011-03-03 ナンヤン テクノロジカル ユニヴァーシティー 親水性活性化合物の送達のための中空多重層微小球
US20090191276A1 (en) 2008-01-24 2009-07-30 Fellows And President Of Harvard University Colloidosomes having tunable properties and methods for making colloidosomes having tunable properties
US9011777B2 (en) 2008-03-21 2015-04-21 Lawrence Livermore National Security, Llc Monodisperse microdroplet generation and stopping without coalescence
EP2271581A4 (en) 2008-03-28 2014-09-03 Harvard College MICROFLUID CHANNELS CONTAINING SURFACES WITH CONTROLLED WETTING CHARACTERISTICS
JP2009241044A (ja) 2008-03-31 2009-10-22 Fujifilm Corp マイクロカプセル及びその製造方法
EP2303246A1 (en) * 2008-06-05 2011-04-06 President and Fellows of Harvard College Polymersomes, colloidosomes, liposomes, and other species associated with fluidic droplets
JP2011529392A (ja) 2008-07-31 2011-12-08 ゾル−ゲル テクノロジー リミテッド 活性成分および金属酸化物シェルを含むマイクロカプセル、その製造方法およびその使用
US20100040696A1 (en) * 2008-08-12 2010-02-18 Ilse Sente Composite Particles Having An Antioxidant-Based Protective System, And Topical Compositions Comprising The Same
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
KR101132732B1 (ko) 2008-11-26 2012-04-06 한국과학기술연구원 인 시튜 조직재생용 지능형 다공성 생분해 고분자 지지체 및 이의 제조방법
CN102307654B (zh) 2009-02-09 2015-01-21 切卢科技公司 聚合物壳
EP2396070B1 (en) 2009-02-12 2024-12-04 Incept Llc Drug delivery through hydrogel plugs
US9056299B2 (en) 2009-03-13 2015-06-16 President And Fellows Of Harvard College Scale-up of flow-focusing microfluidic devices
WO2010104604A1 (en) 2009-03-13 2010-09-16 President And Fellows Of Harvard College Method for the controlled creation of emulsions, including multiple emulsions
EP2411133B1 (en) 2009-03-25 2013-12-18 Eastman Kodak Company Droplet generator
CN101856603A (zh) 2009-04-09 2010-10-13 美国吉姆迪生物科技有限公司 透明质酸的纳米/微封装和释放
WO2010121307A1 (en) 2009-04-21 2010-10-28 The University Of Queensland Complex emulsions
US9446360B2 (en) 2009-05-07 2016-09-20 Universite De Strasbourg Microfluidic system and methods for highly selective droplet fusion
WO2010148106A1 (en) * 2009-06-16 2010-12-23 Washington State University Research Foundation Systems and methods involving calcium phosphate based materials
GB2471522B (en) 2009-07-03 2014-01-08 Cambridge Entpr Ltd Microfluidic devices
JP5212313B2 (ja) 2009-08-24 2013-06-19 株式会社日立プラントテクノロジー 乳化装置
ES2533498T3 (es) 2009-08-28 2015-04-10 Georgia Tech Research Corporation Método y dispositivo electro-fluídico para producir emulsiones y suspensión de partículas
CA3106547C (en) 2009-09-02 2022-07-05 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
JP2013503742A (ja) 2009-09-02 2013-02-04 プレジデント アンド フェロウズ オブ ハーバード カレッジ ジャンクションを使用して生成された多重エマルジョン
JP5589347B2 (ja) 2009-10-29 2014-09-17 国立大学法人 新潟大学 複合膜シェルマイクロカプセルの製造方法
CN101721964A (zh) 2009-11-12 2010-06-09 同济大学 一种防功能性物质泄露的核壳微/纳米球的制备方法
JP5374343B2 (ja) 2009-12-07 2013-12-25 積水化学工業株式会社 コアシェル粒子及びコアシェル粒子の製造方法
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
AR080405A1 (es) 2010-03-17 2012-04-04 Basf Se Emulsificacion para fundir
US10500156B2 (en) 2010-03-24 2019-12-10 Northeastern University Multi-compartmental macrophage delivery
EP2399667B1 (en) 2010-06-25 2017-03-08 Cognis IP Management GmbH Process for producing microcapsules
ES2966040T3 (es) 2010-10-08 2024-04-18 Harvard College Alto rendimiento de células individuales con código de barra
EP3736281A1 (en) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
BR112013029422B1 (pt) 2011-06-07 2021-12-28 Firmenich Sa Cápsulas núcleo-revestimento
CN106268389A (zh) 2011-07-06 2017-01-04 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
BR112014004554A2 (pt) 2011-08-30 2017-04-04 Basf Se sistemas e processos para encapsulamento de cápsulas
KR20140098739A (ko) 2011-09-21 2014-08-08 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘, 엘티디. Ｓｉｒｎａ에 대한 나노 전달 시스템
WO2013163246A2 (en) 2012-04-25 2013-10-31 President And Fellows Of Harvard College Polymerization reactions within microfluidic devices
US20140378349A1 (en) 2012-08-14 2014-12-25 10X Technologies, Inc. Compositions and methods for sample processing
US20150005200A1 (en) 2012-08-14 2015-01-01 10X Technologies, Inc. Compositions and methods for sample processing
EP2934739B1 (en) 2012-12-19 2019-10-02 Johnson & Johnson Consumer Inc. Anhydrous powder-to-liquid particles
US20160000886A1 (en) 2013-02-22 2016-01-07 President And Fellows Of Harvard College Nanostructured active therapeutic vehicles and uses thereof
WO2016061095A1 (en) 2014-10-14 2016-04-21 President And Fellows Of Harvard College Microcapsules and uses thereof
CA2966914A1 (en) 2014-11-24 2016-06-02 The Procter & Gamble Company Systems for encapsulation of actives within droplets and other compartments
EP3224419A4 (en) 2014-11-24 2018-06-27 President and Fellows of Harvard College Multiple emulsions comprising rigidified portions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS518875B2 (enExample) * 1972-10-14 1976-03-22
JPH11509768A (ja) * 1995-03-29 1999-08-31 ワーナー−ランバート・カンパニー 継ぎ目なしカプセル
JPH10219222A (ja) * 1997-02-07 1998-08-18 Nissei Tekunika:Kk 液晶表示パネル基板の接着用のマイクロカプセル型接着性粒子
WO2002068104A1 (fr) * 2001-02-23 2002-09-06 Japan Science And Technology Corporation Procede de preparation d'emulsion et de microcapsules et appareil a cet effet
JP2008535644A (ja) * 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 多重エマルジョンの形成のための方法および装置
US7776927B2 (en) * 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
JP2008238146A (ja) * 2007-03-29 2008-10-09 Okayama Prefecture Industrial Promotion Foundation マイクロリアクター
WO2011028764A2 (en) * 2009-09-02 2011-03-10 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018537414A (ja) * 2015-10-13 2018-12-20 プレジデント アンド フェローズ オブ ハーバード カレッジ ゲルマイクロスフェアの作製及び使用のためのシステム及び方法
US11123297B2 (en) 2015-10-13 2021-09-21 President And Fellows Of Harvard College Systems and methods for making and using gel microspheres
JP2018141689A (ja) * 2017-02-27 2018-09-13 シスメックス株式会社 液体送液方法および液体送液装置
US11389803B2 (en) 2017-02-27 2022-07-19 Sysmex Corporation Liquid sending method and liquid sending apparatus
JP2020014980A (ja) * 2018-07-23 2020-01-30 日本精工株式会社 マイクロ流路チップ、マイクロ流路デバイス、およびマイクロ流路チップの製造方法
JP7255100B2 (ja) 2018-07-23 2023-04-11 日本精工株式会社 マイクロ流路デバイス、およびマイクロ流路チップの製造方法

Also Published As

Publication number Publication date
EP3120923A3 (en) 2017-03-01
US20160375413A1 (en) 2016-12-29
CN103764265A (zh) 2014-04-30
WO2013006661A2 (en) 2013-01-10
EP2729238A2 (en) 2014-05-14
US20140220350A1 (en) 2014-08-07
JP2017024005A (ja) 2017-02-02
US10195571B2 (en) 2019-02-05
EP3120923A2 (en) 2017-01-25
BR112014000141A2 (pt) 2017-06-13
WO2013006661A3 (en) 2013-04-18
CN106268389A (zh) 2017-01-04

Similar Documents

Publication Publication Date Title
JP2017024005A (ja) 多相エマルションおよび多相エマルション形成法
US12331287B1 (en) Assays and other reactions involving droplets
EP2248578B1 (en) Method for forming multiple emulsions
CN105050718B (zh) 形成相对单分散液滴的装置和方法
JP2018537414A (ja) ゲルマイクロスフェアの作製及び使用のためのシステム及び方法
JP2013525087A (ja) 融解乳化
WO2015160919A1 (en) Systems and methods for producing droplet emulsions with relatively thin shells
CN102014871A (zh) 乳液及其形成技术
JP2012531302A (ja) 流体注入
EP3224419A1 (en) Multiple emulsions comprising rigidified portions
US10731012B2 (en) Anti-clogging microfluidic multichannel device
CN101247884A (zh) 用于在微流控装置中执行界面反应的方法和系统
Utada Drop formation in multi-phase microfluidic flows

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150703

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150703

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160517

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160524

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170110