JP2014514318A5 - - Google Patents
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- JP2014514318A5 JP2014514318A5 JP2014505775A JP2014505775A JP2014514318A5 JP 2014514318 A5 JP2014514318 A5 JP 2014514318A5 JP 2014505775 A JP2014505775 A JP 2014505775A JP 2014505775 A JP2014505775 A JP 2014505775A JP 2014514318 A5 JP2014514318 A5 JP 2014514318A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- composition
- side chain
- residue
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 113
- 108090000765 processed proteins & peptides Proteins 0.000 claims 113
- 102000004196 processed proteins & peptides Human genes 0.000 claims 113
- 239000000203 mixture Substances 0.000 claims 84
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 27
- 230000002163 immunogen Effects 0.000 claims 18
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 16
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 16
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 14
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 13
- 239000002671 adjuvant Substances 0.000 claims 9
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical group NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 6
- 238000002784 cytotoxicity assay Methods 0.000 claims 6
- 231100000263 cytotoxicity test Toxicity 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 6
- 241000193163 Clostridioides difficile Species 0.000 claims 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 4
- 229920000053 polysorbate 80 Polymers 0.000 claims 4
- 229940068968 polysorbate 80 Drugs 0.000 claims 4
- 241001112695 Clostridiales Species 0.000 claims 3
- 239000007983 Tris buffer Substances 0.000 claims 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- DPVHGFAJLZWDOC-PVXXTIHASA-N (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol;dihydrate Chemical compound O.O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DPVHGFAJLZWDOC-PVXXTIHASA-N 0.000 claims 2
- UQBOJOOOTLPNST-UHFFFAOYSA-N Dehydroalanine Chemical group NC(=C)C(O)=O UQBOJOOOTLPNST-UHFFFAOYSA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 229940074410 trehalose Drugs 0.000 claims 2
- 229940074409 trehalose dihydrate Drugs 0.000 claims 2
- 101710084578 Short neurotoxin 1 Proteins 0.000 claims 1
- 101710182223 Toxin B Proteins 0.000 claims 1
- 101710182532 Toxin a Proteins 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478474P | 2011-04-22 | 2011-04-22 | |
| US61/478,474 | 2011-04-22 | ||
| US201161478899P | 2011-04-25 | 2011-04-25 | |
| US61/478,899 | 2011-04-25 | ||
| PCT/IB2012/051999 WO2012143902A1 (en) | 2011-04-22 | 2012-04-20 | Compositions relating to a mutant clostridium difficile toxin and methods thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016009882A Division JP6097853B2 (ja) | 2011-04-22 | 2016-01-21 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014514318A JP2014514318A (ja) | 2014-06-19 |
| JP2014514318A5 true JP2014514318A5 (enExample) | 2016-01-28 |
| JP5917682B2 JP5917682B2 (ja) | 2016-05-18 |
Family
ID=46085103
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014505775A Active JP5917682B2 (ja) | 2011-04-22 | 2012-04-20 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2016009882A Active JP6097853B2 (ja) | 2011-04-22 | 2016-01-21 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2017027808A Active JP6321239B2 (ja) | 2011-04-22 | 2017-02-17 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2017198569A Pending JP2018052938A (ja) | 2011-04-22 | 2017-10-12 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2018071560A Active JP6735784B2 (ja) | 2011-04-22 | 2018-04-03 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2018192593A Active JP6892425B2 (ja) | 2011-04-22 | 2018-10-11 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2021088838A Active JP7097478B2 (ja) | 2011-04-22 | 2021-05-27 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2022102418A Pending JP2022126822A (ja) | 2011-04-22 | 2022-06-27 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016009882A Active JP6097853B2 (ja) | 2011-04-22 | 2016-01-21 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2017027808A Active JP6321239B2 (ja) | 2011-04-22 | 2017-02-17 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2017198569A Pending JP2018052938A (ja) | 2011-04-22 | 2017-10-12 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2018071560A Active JP6735784B2 (ja) | 2011-04-22 | 2018-04-03 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2018192593A Active JP6892425B2 (ja) | 2011-04-22 | 2018-10-11 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2021088838A Active JP7097478B2 (ja) | 2011-04-22 | 2021-05-27 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| JP2022102418A Pending JP2022126822A (ja) | 2011-04-22 | 2022-06-27 | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (13) | US8481692B2 (enExample) |
| EP (4) | EP3549949B1 (enExample) |
| JP (8) | JP5917682B2 (enExample) |
| KR (1) | KR101667837B1 (enExample) |
| CN (3) | CN103619871B (enExample) |
| AR (1) | AR086199A1 (enExample) |
| AU (6) | AU2012245904B2 (enExample) |
| BR (2) | BR122019017005B1 (enExample) |
| CA (1) | CA2832712C (enExample) |
| CO (1) | CO6801643A2 (enExample) |
| DK (2) | DK2699587T3 (enExample) |
| ES (3) | ES2968629T3 (enExample) |
| FI (1) | FI3549949T3 (enExample) |
| HR (2) | HRP20240042T1 (enExample) |
| HU (2) | HUE065594T2 (enExample) |
| IL (8) | IL270779B2 (enExample) |
| MX (3) | MX385834B (enExample) |
| MY (2) | MY168205A (enExample) |
| NZ (1) | NZ616035A (enExample) |
| PE (2) | PE20141029A1 (enExample) |
| PH (1) | PH12013502178B1 (enExample) |
| PL (3) | PL3505531T3 (enExample) |
| PT (2) | PT2699587T (enExample) |
| RU (2) | RU2754446C2 (enExample) |
| SA (3) | SA115360698B1 (enExample) |
| SG (3) | SG194132A1 (enExample) |
| SI (3) | SI3549949T1 (enExample) |
| TW (6) | TWI650329B (enExample) |
| WO (1) | WO2012143902A1 (enExample) |
| ZA (1) | ZA201307818B (enExample) |
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| ES2968629T3 (es) | 2011-04-22 | 2024-05-13 | Wyeth Llc | Composiciones relacionadas con una toxina mutante de Clostridium difficile y sus procedimientos |
| JP6084631B2 (ja) * | 2011-12-08 | 2017-02-22 | ノバルティス アーゲー | Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ毒素ベースのワクチン |
| AR089797A1 (es) | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| ES2992753T3 (en) | 2012-08-24 | 2024-12-17 | Univ California | Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis |
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| US11185555B2 (en) | 2016-04-11 | 2021-11-30 | Noah James Harrison | Method to kill pathogenic microbes in a patient |
| KR20240113990A (ko) | 2016-06-27 | 2024-07-23 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 암 치료 조합 |
| US20190211377A1 (en) * | 2016-12-22 | 2019-07-11 | Roche Molecular Systems, Inc. | Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile |
| CA3076961A1 (en) * | 2017-09-28 | 2019-04-04 | Pfizer Inc. | Compositions and methods for eliciting an immune response against clostridium difficile |
| EP3946444A1 (en) | 2019-04-01 | 2022-02-09 | Pfizer Inc. | Compositions and methods for eliciting an immune response against clostridium difficile |
| EP3965810A4 (en) * | 2019-05-10 | 2023-01-25 | The Board Of Regents Of The University Of Oklahoma | CLOSTRIDIOIDES DIFFICILE TCDB VARIANTS, VACCINES AND METHOD OF USE |
| WO2020231930A1 (en) * | 2019-05-11 | 2020-11-19 | The Texas A&M University System | Protein inhibitors of clostridium difficile toxin b |
| KR102376876B1 (ko) | 2020-04-09 | 2022-03-21 | 대진대학교 산학협력단 | 무독성의 클로스트리디움 디피실 독소단백질-단편 및 이의 용도 |
| CN115697330A (zh) * | 2020-05-06 | 2023-02-03 | 阿尔伯特·爱因斯坦医学院 | 通过抑制肠道损伤性细菌毒素TcdA和TcdB预防来自艰难梭菌感染的组织损伤的活性剂 |
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| CN111755068B (zh) * | 2020-06-19 | 2021-02-19 | 深圳吉因加医学检验实验室 | 基于测序数据识别肿瘤纯度和绝对拷贝数的方法及装置 |
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