JP2014508927A - 熱支援脱離イオン化システムのための装置および方法 - Google Patents
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Abstract
【選択図】図9A
Description
本出願は、以下の米国出願に対する優先権を主張する。
(1)2011年2月5日に出願された、発明者Jordan KrechmerおよびBrian D.Musselmanによる「APPARATUS FOR THERMAL ASSISTED DESORPTION IONIZATION」という名称の米国仮特許出願第61/439,866号、
(2)2011年12月30日に出願された、発明者Jordan KrechmerおよびBrian D.Musselmanによる「APPARATUS AND METHOD FOR THERMAL ASSISTED DESORPTION IONIZATION SYSTEMS」という名称の米国仮特許出願第61/582,204号、
(3)2011年1月17日に出願された、発明者Jordan KrechmerおよびBrian D.Musselmanによる「APPARATUS AND METHOD FOR THERMAL ASSISTED DESORPTION IONIZATION SYSTEMS」という名称の米国仮特許出願第61/587,218号、および、
(4)2012年2月2日に出願された、発明者Jordan KrechmerおよびBrian D.Musselmanによる「APPARATUS AND METHOD FOR THERMAL ASSISTED DESORPTION IONIZATION SYSTEMS」という名称の米国仮特許出願第61/587,218号。
である。これらの出願((1)〜(4))は、参照によりその全体が本明細書に明示的に組込まれる。
、または、レーザ、マスターまたは他の周波数の光源で分析物を照射する)ことによって脱離されうる。
トリアシルグリセリドの脂肪酸含量(content)の決定
Claims (24)
- 分析物を分析するためのデバイスであって、
分析物イオンを受取るための入口および分析される分析物イオンを検出するための検出器を有する分光計と、
大気圧ソースと、
熱を生成することおよび熱を伝達することの一方または両方を行うための供給部と、
前記大気圧ソースと前記分光計との間に配置された1つまたは複数のメッシュとを備え、前記分析物は前記1つまたは複数のメッシュ上にまたはその近くに導入され、前記供給部は熱を前記分析物に伝達し、分析物分子は、前記大気圧ソースによって生成されたイオン化種と相互作用して、前記分光計に入り分析される複数の分析物イオンを形成するデバイス。 - 前記1つまたは複数のメッシュと前記分光計入口との間に配置されたガスイオン分離器をさらに備える請求項1に記載のデバイス。
- 前記大気圧ソースは、実時間直接分析(DART)ソース、プラズマ支援脱離/イオン化(PADI)ソース、誘電体バリア放電イオン化(DBDIまたはDCBI)ソース、脱離大気圧化学イオン化(DAPCI)ソース、脱離ソニックスプレーイオン化(DeSSI)ソース、脱離大気圧光イオン化(DAPPI)ソース、および流動大気圧アフターグロー(FAPA)ソースおよび脱離エレクトロスプレーイオン化(DESI)ソース、大気レーザ脱離イオン化ソース、コロナ放電ソース、誘導結合プラズマ(ICP)ソース、およびグロー放電ソースからなるソースの群から選択される請求項1に記載のデバイス。
- 前記供給部は、
約10−2ワットの下限と
約103ワットの上限との間の
前記1つまたは複数のメッシュのうちの1つのメッシュに電力を送出するようになっている(adapted)請求項1に記載のデバイス。 - 前記分光計の前記入口と前記検出器との間の領域はほぼ大気圧である請求項1に記載のデバイス。
- 前記供給部は、前記分析物を含む第1のメッシュに第1の電位を印加するように構成されることができる請求項1に記載のデバイス。
- 前記第1の電位は、前記分光計の前記入口に印加される電位とほぼ同じである請求項6に記載のデバイス。
- 前記供給部は、第1のメッシュに第2の電位を印加するように構成されることができ、前記第2の電位は前記第1の電位と異なる請求項6に記載のデバイス。
- 前記第1のメッシュから脱離される前記分析物イオンの運動エネルギーは、前記第2の電位を調整することによって調整されることができる請求項8に記載のデバイス。
- 前記供給部は、前記1つまたは複数のメッシュの少なくとも1つのメッシュ上の第1および第2の場所を独立に加熱するように構成され、前記第1の場所は前記第2の場所と異なる請求項1に記載のデバイス。
- 第1のメッシュは、第2のメッシュに対して配向し、前記イオン化種は、前記第2のメッシュに接触する前に、前記第1のメッシュに接触する請求項1に記載のデバイス。
- 前記第1のワイヤメッシュ上にまたはその近くに分析物を含む溶液を送出するためにチューブが使用される請求項11に記載のデバイス。
- 分析物を誘導体化しイオン化するためのデバイスであって、
イオン化種を生成するためのソースと、
大気圧領域内に配置される1つまたは複数のメッシュとを備え、前記分析物は第1のメッシュ上に塗布され、誘導体化試薬は第2のメッシュに塗布され、前記ソースによって生成される前記イオン化種は、前記分析物および前記誘導体化試薬の一方または両方と相互作用して、複数の分析物イオンおよび複数の誘導体化分析物イオンの一方または両方を形成するデバイス。 - 前記1つまたは複数のメッシュは加熱されることができる請求項13に記載のデバイス。
- 前記メッシュは、2つ以上の接続されたフィラメントを備え、前記フィラメントの1つまたは複数は、金属、動物ストリング、紙、穿孔された紙、ファイバ、布、シリカ、プラスチック、プラスチックフォーム、ポリマー、テフロン(登録商標)、ポリマー含浸テフロン(登録商標)、セルロース、疎水性支持材料被覆フィラメント、および疎水性支持材料含浸フィラメントからなる群から選択される請求項13に記載のデバイス。
- 分析物を分析するためのデバイスであって、
入口および検出器を含むイオン移動度分光計と、
イオン化種を生成するためのソースと、
熱を生成すること、熱を伝達すること、熱を伝導させること、熱を放射すること、および電位を印加することの1つまたは複数を行うための供給部と、
前記ソースと前記イオン移動度分光計との間に配置された2つ以上のメッシュとを備え、前記分析物は第1のメッシュ上にまたはその近くに塗布され、前記供給部は、前記第1のメッシュに対して熱を生成すること、熱を伝達すること、熱を伝導させること、および熱を放射することの1つまたは複数を行うことができ、前記第1のメッシュから脱離される分析物分子は、イオン化種と相互作用して、分析物イオンを形成するデバイス。 - 前記イオン移動度分光計は、ほぼ大気圧で動作する請求項16に記載のデバイス。
- 前記2つ以上のメッシュの少なくとも1つのメッシュは、前記イオン移動度分光計に印加される電位と同じ電位を有する請求項16に記載のデバイス。
- 電位は第2のメッシュに印加され、前記分析物イオンの運動エネルギーは、前記第2のメッシュに印加される電位によって変更(alter)される請求項16に記載のデバイス。
- サンプルを分析する方法であって、
(a)メッシュの小片上に前記サンプルを塗布するステップと、
(b)前記メッシュの小片を、イオン化ソースと分光計への入口との間に配置するステップと、
(c)前記サンプルを加熱することができる供給部を前記メッシュの小片に接続するステップと、
(d)前記サンプルを加熱するステップであって、それにより、前記メッシュの小片から中性サンプル分子を脱離する、加熱するステップと、
(e)前記イオン化ソースによって形成されるイオン化種を前記メッシュに送るステップであって、前記イオン化種は、前記中性サンプル分子と相互作用して、前記分光計に入るサンプルイオンを形成する、送るステップと
(f)前記サンプルイオンを分析するステップとを含む方法。 - 複数の分析物を生成するためにソースであって、
大気圧ソースと、
熱を生成することおよび熱を伝達することの一方または両方を行うための供給部と、
1つまたは複数のメッシュとを備え、前記分析物は前記1つまたは複数のメッシュ上にまたはその近くに導入され、前記供給部は、前記分析物に熱を伝達することができ、分析物分子は、前記大気圧ソースによって生成されたイオン化種と相互作用して、複数の分析物イオンを形成するソース。 - サンプルを分析するための装置であって、
分光計と、
請求項21に記載のソースとを備え、前記1つまたは複数のメッシュは、前記大気圧ソースと前記分光計との間に配置され、前記複数の分析物イオンの1つまたは複数は、前記分光計内に送られ分析される装置。 - 複数の分析物イオンを生成することを実施するためのキットであって、
(a)メッシュの小片と、
(b)前記メッシュの小片に前記分析物を塗布する手段と、
(c)前記メッシュの小片を配置するためのホルダと、
(d)前記メッシュの小片に塗布された前記分析物を加熱するためのソースと、
(e)イオン化種を生成するための大気圧イオン化ソースとを備え、前記イオン化種は、前記分析物分子と相互作用して、分析物イオンを形成するキット。 - 質量分光計によってサンプルの大気圧分析を実施するためのキットであって、
(a)メッシュの小片と、
(b)前記メッシュの小片に前記分析物を塗布する手段と、
(c)前記メッシュの小片を前記質量分光計の入口アパーチャの前に配置するためのホルダと、
(d)前記メッシュの小片に塗布された前記分析物を加熱するためのソースと、
(e)イオン化種を生成するための大気圧イオン化ソースとを備え、前記イオン化種は、前記サンプル分子を相互作用して、サンプルイオンを形成し、前記サンプルイオンは、分析のために前記質量分光計の前記入口アパーチャに入るキット。
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US201161439866P | 2011-02-05 | 2011-02-05 | |
US61/439,866 | 2011-02-05 | ||
US201161582204P | 2011-12-30 | 2011-12-30 | |
US61/582,204 | 2011-12-30 | ||
US13/364,322 | 2012-01-02 | ||
US201261587218P | 2012-01-17 | 2012-01-17 | |
US61/587,218 | 2012-01-17 | ||
US13/364,322 US8822949B2 (en) | 2011-02-05 | 2012-02-02 | Apparatus and method for thermal assisted desorption ionization systems |
PCT/US2012/000061 WO2012106054A2 (en) | 2011-02-05 | 2012-02-06 | Apparatus and method for thermal assisted desorption ionization systems |
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