EP1492613A4 - Ionization apparatus and method for mass spectrometer system - Google Patents

Ionization apparatus and method for mass spectrometer system

Info

Publication number
EP1492613A4
EP1492613A4 EP03716618A EP03716618A EP1492613A4 EP 1492613 A4 EP1492613 A4 EP 1492613A4 EP 03716618 A EP03716618 A EP 03716618A EP 03716618 A EP03716618 A EP 03716618A EP 1492613 A4 EP1492613 A4 EP 1492613A4
Authority
EP
European Patent Office
Prior art keywords
mass spectrometer
spectrometer system
ionization apparatus
ionization
mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03716618A
Other languages
German (de)
French (fr)
Other versions
EP1492613A2 (en
Inventor
Alexander A Makarov
Pavel V Bondarenko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Finnigan LLC
Original Assignee
Thermo Finnigan LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/105,172 external-priority patent/US6707036B2/en
Application filed by Thermo Finnigan LLC filed Critical Thermo Finnigan LLC
Publication of EP1492613A2 publication Critical patent/EP1492613A2/en
Publication of EP1492613A4 publication Critical patent/EP1492613A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/067—Ion lenses, apertures, skimmers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
EP03716618A 2002-03-21 2003-03-14 Ionization apparatus and method for mass spectrometer system Withdrawn EP1492613A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US341621 1994-11-17
US105172 2002-03-21
US10/105,172 US6707036B2 (en) 2002-03-21 2002-03-21 Ionization apparatus and method for mass spectrometer system
US10/341,621 US6707040B2 (en) 2002-03-21 2003-01-13 Ionization apparatus and method for mass spectrometer system
PCT/US2003/008041 WO2003081205A2 (en) 2002-03-21 2003-03-14 Ionization apparatus and method for mass spectrometer system

Publications (2)

Publication Number Publication Date
EP1492613A2 EP1492613A2 (en) 2005-01-05
EP1492613A4 true EP1492613A4 (en) 2009-12-16

Family

ID=29738740

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03716618A Withdrawn EP1492613A4 (en) 2002-03-21 2003-03-14 Ionization apparatus and method for mass spectrometer system

Country Status (4)

Country Link
EP (1) EP1492613A4 (en)
AU (1) AU2003220320A1 (en)
CA (1) CA2479872C (en)
WO (1) WO2003081205A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135674B2 (en) * 2004-01-22 2006-11-14 Thermo Finnigan Llc Method and apparatus for FAIMS with a laser-based ionization source
US7700913B2 (en) * 2006-03-03 2010-04-20 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
JP2009539115A (en) * 2006-05-26 2009-11-12 イオンセンス インコーポレイテッド Flexible open tube collection system for use in surface ionization technology
CA2726072A1 (en) 2008-05-29 2009-12-23 Universitaetsklinikum Muenster Ion source means for desorption / ionisation of analyte substances an d method of desorbing / ionising of analyte substances
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
US8822949B2 (en) 2011-02-05 2014-09-02 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
US8901488B1 (en) 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
CA2841752A1 (en) * 2011-07-14 2013-06-13 The George Washington University Plume collimation for laser ablation electrospray ionization mass spectrometry
GB2493179B (en) * 2011-07-26 2018-09-05 Kratos Analytical Ltd MALDI sample preparation methods and targets
US9337007B2 (en) 2014-06-15 2016-05-10 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US9899196B1 (en) 2016-01-12 2018-02-20 Jeol Usa, Inc. Dopant-assisted direct analysis in real time mass spectrometry
GB201705981D0 (en) 2017-04-13 2017-05-31 Micromass Ltd MALDI target plate
US10636640B2 (en) 2017-07-06 2020-04-28 Ionsense, Inc. Apparatus and method for chemical phase sampling analysis
WO2019231859A1 (en) 2018-06-01 2019-12-05 Ionsense Inc. Apparatus and method for reducing matrix effects when ionizing a sample
GB201815676D0 (en) 2018-09-26 2018-11-07 Micromass Ltd MALDI nozzle
WO2021086778A1 (en) 2019-10-28 2021-05-06 Ionsense Inc. Pulsatile flow atmospheric real time ionization
US11913861B2 (en) 2020-05-26 2024-02-27 Bruker Scientific Llc Electrostatic loading of powder samples for ionization

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3796872A (en) * 1970-12-18 1974-03-12 Ass Elect Ind Mass spectrometry
WO1999030350A1 (en) * 1997-12-05 1999-06-17 University Of British Columbia Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap
WO2000077822A2 (en) * 1999-06-11 2000-12-21 Perseptive Biosystems, Inc. Method and apparatus for determining molecular weight of labile molecules
US6331702B1 (en) * 1999-01-25 2001-12-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US20020070345A1 (en) * 2000-12-08 2002-06-13 Hitachi, Ltd. Evacuation use sample chamber and circuit pattern forming apparatus using the same
WO2002097857A1 (en) * 2001-05-25 2002-12-05 Analytica Of Branford, Inc. Atmospheric and vacuum pressure maldi ion source

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106583A (en) * 1989-03-08 1992-04-21 Applied Biosystems, Inc. Automated protein hydrolysis system
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
CA2227806C (en) 1998-01-23 2006-07-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US5965884A (en) * 1998-06-04 1999-10-12 The Regents Of The University Of California Atmospheric pressure matrix assisted laser desorption
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
CA2400644C (en) * 2000-02-18 2009-07-14 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
JP4772212B2 (en) 2001-05-31 2011-09-14 浜松ホトニクス株式会社 X-ray generator
US6683300B2 (en) * 2001-09-17 2004-01-27 Science & Engineering Services, Inc. Method and apparatus for mass spectrometry analysis of common analyte solutions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3796872A (en) * 1970-12-18 1974-03-12 Ass Elect Ind Mass spectrometry
WO1999030350A1 (en) * 1997-12-05 1999-06-17 University Of British Columbia Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap
US6331702B1 (en) * 1999-01-25 2001-12-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
WO2000077822A2 (en) * 1999-06-11 2000-12-21 Perseptive Biosystems, Inc. Method and apparatus for determining molecular weight of labile molecules
US20020070345A1 (en) * 2000-12-08 2002-06-13 Hitachi, Ltd. Evacuation use sample chamber and circuit pattern forming apparatus using the same
WO2002097857A1 (en) * 2001-05-25 2002-12-05 Analytica Of Branford, Inc. Atmospheric and vacuum pressure maldi ion source

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO03081205A2 *

Also Published As

Publication number Publication date
EP1492613A2 (en) 2005-01-05
CA2479872A1 (en) 2003-10-02
WO2003081205A2 (en) 2003-10-02
AU2003220320A1 (en) 2003-10-08
WO2003081205A3 (en) 2003-12-18
CA2479872C (en) 2009-06-23
AU2003220320A8 (en) 2003-10-08

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20041014

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MAKAROV, ALEXANDER, A.

Inventor name: BONDARENKO, PAVEL, V.

A4 Supplementary search report drawn up and despatched

Effective date: 20091113

RIC1 Information provided on ipc code assigned before grant

Ipc: H01J 49/04 20060101AFI20091110BHEP

Ipc: H01J 49/06 20060101ALI20091110BHEP

Ipc: H01J 49/16 20060101ALI20091110BHEP

17Q First examination report despatched

Effective date: 20100427

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20161001