JP2014500870A - スピロ−オキシインドールｍｄｍ２アンタゴニスト - Google Patents

スピロ−オキシインドールｍｄｍ２アンタゴニスト Download PDF

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JP2014500870A
JP2014500870A JP2013538923A JP2013538923A JP2014500870A JP 2014500870 A JP2014500870 A JP 2014500870A JP 2013538923 A JP2013538923 A JP 2013538923A JP 2013538923 A JP2013538923 A JP 2013538923A JP 2014500870 A JP2014500870 A JP 2014500870A
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optionally substituted
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cancer
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JP2014500870A5 (enExample
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シャオムオン・ワーン
ユジュイン・ジャオ
ウェイ・スゥン
サンジーヴ・クマ
ランス・レオポルド
ローラン・デビュッシュ
セドリック・バリエー
ジャン−クリストフ・カリー
クウェム・アメイニング
ミーン・グオ
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University of Michigan System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2013538923A 2010-11-12 2011-11-11 スピロ−オキシインドールｍｄｍ２アンタゴニスト Ceased JP2014500870A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US41309410P 2010-11-12 2010-11-12
US61/413,094 2010-11-12
US201161451968P 2011-03-11 2011-03-11
US201161451958P 2011-03-11 2011-03-11
US61/451,968 2011-03-11
US61/451,958 2011-03-11
US201161470992P 2011-04-01 2011-04-01
US61/470,992 2011-04-01
PCT/US2011/060300 WO2012065022A2 (en) 2010-11-12 2011-11-11 Spiro-oxindole mdm2 antagonists

Publications (2)

Publication Number Publication Date
JP2014500870A true JP2014500870A (ja) 2014-01-16
JP2014500870A5 JP2014500870A5 (enExample) 2014-12-25

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JP2013538923A Ceased JP2014500870A (ja) 2010-11-12 2011-11-11 スピロ−オキシインドールｍｄｍ２アンタゴニスト

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US (2) US8680132B2 (enExample)
EP (1) EP2638046A4 (enExample)
JP (1) JP2014500870A (enExample)
KR (1) KR101929188B1 (enExample)
CN (1) CN103298818B (enExample)
AR (1) AR083849A1 (enExample)
AU (1) AU2011326395B2 (enExample)
CA (1) CA2817585A1 (enExample)
CO (1) CO6721010A2 (enExample)
CR (1) CR20130271A (enExample)
DO (1) DOP2013000104A (enExample)
EA (1) EA201390682A1 (enExample)
EC (1) ECSP13012678A (enExample)
GT (1) GT201300118A (enExample)
IL (1) IL226275A0 (enExample)
MA (1) MA34732B1 (enExample)
MX (1) MX2013005238A (enExample)
NI (1) NI201300041A (enExample)
NZ (1) NZ611866A (enExample)
PE (1) PE20140408A1 (enExample)
PH (1) PH12013500955A1 (enExample)
SG (1) SG190230A1 (enExample)
TW (1) TWI535723B (enExample)
UA (1) UA109464C2 (enExample)
UY (1) UY33725A (enExample)
WO (1) WO2012065022A2 (enExample)
ZA (1) ZA201304042B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021508727A (ja) * 2017-12-29 2021-03-11 甘李薬業股▲フン▼有限公司Ｇａｎ＆Ｌｅｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ 腫瘍阻害剤として使用できる化合物およびその調製方法と応用

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CN104812384B (zh) 2012-11-01 2020-09-18 爱勒让治疗公司 二取代的氨基酸及其制备和使用方法
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