AU2011326395B2 - Spiro-oxindole MDM2 antagonists - Google Patents

Spiro-oxindole MDM2 antagonists Download PDF

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Publication number
AU2011326395B2
AU2011326395B2 AU2011326395A AU2011326395A AU2011326395B2 AU 2011326395 B2 AU2011326395 B2 AU 2011326395B2 AU 2011326395 A AU2011326395 A AU 2011326395A AU 2011326395 A AU2011326395 A AU 2011326395A AU 2011326395 B2 AU2011326395 B2 AU 2011326395B2
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Australia
Prior art keywords
optionally substituted
group
compound
compounds
pharmaceutically acceptable
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Ceased
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AU2011326395A
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AU2011326395A1 (en
Inventor
Kwame Amaning
Cedric Barriere
Jean-Christophe Carry
Laurent Debussche
Ming Guo
Sanjeev Kumar
Lance Leopold
Wei Sun
Shaomeng Wang
Yujun Zhao
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Sanofi SA
University of Michigan System
Ascenta Licensing Corp
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Sanofi SA
University of Michigan System
Ascenta Licensing Corp
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Publication of AU2011326395A1 publication Critical patent/AU2011326395A1/en
Assigned to THE REGENTS OF THE UNIVERSITY OF MICHIGAN, SANOFI, ASCENTA LICENSING CORPORATION reassignment THE REGENTS OF THE UNIVERSITY OF MICHIGAN Request for Assignment Assignors: ASCENTA THERAPEUTICS, INC., SANOFI, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2011326395A 2010-11-12 2011-11-11 Spiro-oxindole MDM2 antagonists Ceased AU2011326395B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US41309410P 2010-11-12 2010-11-12
US61/413,094 2010-11-12
US201161451958P 2011-03-11 2011-03-11
US201161451968P 2011-03-11 2011-03-11
US61/451,968 2011-03-11
US61/451,958 2011-03-11
US201161470992P 2011-04-01 2011-04-01
US61/470,992 2011-04-01
PCT/US2011/060300 WO2012065022A2 (en) 2010-11-12 2011-11-11 Spiro-oxindole mdm2 antagonists

Publications (2)

Publication Number Publication Date
AU2011326395A1 AU2011326395A1 (en) 2013-05-09
AU2011326395B2 true AU2011326395B2 (en) 2016-01-07

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Application Number Title Priority Date Filing Date
AU2011326395A Ceased AU2011326395B2 (en) 2010-11-12 2011-11-11 Spiro-oxindole MDM2 antagonists

Country Status (27)

Country Link
US (2) US8680132B2 (enExample)
EP (1) EP2638046A4 (enExample)
JP (1) JP2014500870A (enExample)
KR (1) KR101929188B1 (enExample)
CN (1) CN103298818B (enExample)
AR (1) AR083849A1 (enExample)
AU (1) AU2011326395B2 (enExample)
CA (1) CA2817585A1 (enExample)
CO (1) CO6721010A2 (enExample)
CR (1) CR20130271A (enExample)
DO (1) DOP2013000104A (enExample)
EA (1) EA201390682A1 (enExample)
EC (1) ECSP13012678A (enExample)
GT (1) GT201300118A (enExample)
IL (1) IL226275A0 (enExample)
MA (1) MA34732B1 (enExample)
MX (1) MX2013005238A (enExample)
NI (1) NI201300041A (enExample)
NZ (1) NZ611866A (enExample)
PE (1) PE20140408A1 (enExample)
PH (1) PH12013500955A1 (enExample)
SG (1) SG190230A1 (enExample)
TW (1) TWI535723B (enExample)
UA (1) UA109464C2 (enExample)
UY (1) UY33725A (enExample)
WO (1) WO2012065022A2 (enExample)
ZA (1) ZA201304042B (enExample)

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