JP2013541503A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013541503A5 JP2013541503A5 JP2013523380A JP2013523380A JP2013541503A5 JP 2013541503 A5 JP2013541503 A5 JP 2013541503A5 JP 2013523380 A JP2013523380 A JP 2013523380A JP 2013523380 A JP2013523380 A JP 2013523380A JP 2013541503 A5 JP2013541503 A5 JP 2013541503A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- pharmaceutical composition
- heterocycle
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003118 aryl group Chemical group 0.000 claims 46
- 239000008194 pharmaceutical composition Substances 0.000 claims 42
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 125000000623 heterocyclic group Chemical group 0.000 claims 34
- 125000004450 alkenylene group Chemical group 0.000 claims 16
- 125000004419 alkynylene group Chemical group 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000002367 halogens Chemical group 0.000 claims 16
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 11
- 229910052731 fluorine Inorganic materials 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 229910052801 chlorine Inorganic materials 0.000 claims 9
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 8
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 8
- 229910052794 bromium Inorganic materials 0.000 claims 7
- 150000008267 fucoses Chemical class 0.000 claims 7
- 229910052740 iodine Inorganic materials 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 150000001323 aldoses Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- -1 benzyloxymethyl Chemical group 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000033581 fucosylation Effects 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 125000005103 alkyl silyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- ARYZCSRUUPFYMY-UHFFFAOYSA-N methoxysilane Chemical compound CO[SiH3] ARYZCSRUUPFYMY-UHFFFAOYSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 0 *C1[C@@](*)C(*)O[C@@](*)C1* Chemical compound *C1[C@@](*)C(*)O[C@@](*)C1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37111610P | 2010-08-05 | 2010-08-05 | |
| US61/371,116 | 2010-08-05 | ||
| PCT/US2011/046857 WO2012019165A2 (en) | 2010-08-05 | 2011-08-05 | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016076930A Division JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541503A JP2013541503A (ja) | 2013-11-14 |
| JP2013541503A5 true JP2013541503A5 (OSRAM) | 2014-09-25 |
| JP5918235B2 JP5918235B2 (ja) | 2016-05-18 |
Family
ID=45560106
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523380A Active JP5918235B2 (ja) | 2010-08-05 | 2011-08-05 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2016076930A Expired - Fee Related JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2017049534A Active JP6622238B2 (ja) | 2010-08-05 | 2017-03-15 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2019210313A Pending JP2020040974A (ja) | 2010-08-05 | 2019-11-21 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016076930A Expired - Fee Related JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2017049534A Active JP6622238B2 (ja) | 2010-08-05 | 2017-03-15 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2019210313A Pending JP2020040974A (ja) | 2010-08-05 | 2019-11-21 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9504702B2 (OSRAM) |
| EP (2) | EP2608796B1 (OSRAM) |
| JP (4) | JP5918235B2 (OSRAM) |
| KR (2) | KR20190022884A (OSRAM) |
| CN (2) | CN107007615A (OSRAM) |
| AU (3) | AU2011285490B2 (OSRAM) |
| CA (1) | CA2803388C (OSRAM) |
| CY (1) | CY1121419T1 (OSRAM) |
| DK (1) | DK2608796T3 (OSRAM) |
| ES (1) | ES2711622T3 (OSRAM) |
| HU (1) | HUE043370T2 (OSRAM) |
| IL (2) | IL224487A (OSRAM) |
| MX (1) | MX356671B (OSRAM) |
| NZ (1) | NZ606250A (OSRAM) |
| PL (1) | PL2608796T3 (OSRAM) |
| PT (1) | PT2608796T (OSRAM) |
| RU (2) | RU2625768C2 (OSRAM) |
| SI (1) | SI2608796T1 (OSRAM) |
| TR (1) | TR201902439T4 (OSRAM) |
| WO (1) | WO2012019165A2 (OSRAM) |
| ZA (1) | ZA201300653B (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2975228C (en) | 2008-05-02 | 2020-07-21 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| RU2625768C2 (ru) * | 2010-08-05 | 2017-07-18 | Сиэтл Дженетикс, Инк. | Способы ингибирования фукозилирования белков in vivo с использованием аналогов фукозы |
| WO2014031875A1 (en) | 2012-08-23 | 2014-02-27 | Seattle Genetics, Inc. | Treatment of sickle cell disease and inflammatory conditions |
| WO2014130613A2 (en) | 2013-02-22 | 2014-08-28 | Amgen Inc. | Carbohydrate phosphonate derivatives as modulators of glycosylation |
| CN106699886A (zh) * | 2015-07-13 | 2017-05-24 | 西藏海思科药业集团股份有限公司 | 抗体依赖性细胞介导的细胞毒性(adcc)增强的奥法木抗体 |
| WO2017096274A1 (en) * | 2015-12-04 | 2017-06-08 | Seattle Genetics, Inc. | Cancer treatment using 2-deoxy-2-fluoro-l-fucose in combination with a checkpoint inhibitor |
| JP6882339B2 (ja) * | 2016-05-10 | 2021-06-02 | アレス トレーディング ソシエテ アノニム | ペルアセチルガラクトースを使った組換えタンパク質のタンパク質ガラクトシル化プロファイルを改変する方法 |
| JP2018002666A (ja) * | 2016-07-04 | 2018-01-11 | 国立研究開発法人理化学研究所 | フコース類似体と糖を検出する方法 |
| EA201992875A1 (ru) * | 2017-06-07 | 2020-03-25 | Сиэтл Дженетикс, Инк. | T-клетки со сниженным поверхностным фукозилированием и способы их получения и применения |
| CN111615520A (zh) | 2017-12-01 | 2020-09-01 | 辉瑞大药厂 | 抗cxcr5抗体及其组合物和用途 |
| JP2021519758A (ja) | 2018-03-29 | 2021-08-12 | ファイザー インコーポレイティッド | Ｌｆａ３バリアントならびにその組成物および使用法 |
| EP3841123A2 (en) | 2018-08-23 | 2021-06-30 | Seagen Inc. | Anti-tigit antibodies |
| WO2020138447A1 (ja) * | 2018-12-27 | 2020-07-02 | 学校法人慶應義塾 | 抗ヒトノロウイルス剤 |
| ES2977318T3 (es) * | 2019-12-19 | 2024-08-21 | Merck Patent Gmbh | Métodos y composiciones para modular el perfil de glucosilación de proteínas |
| TWI877278B (zh) * | 2019-12-30 | 2025-03-21 | 美商思進公司 | 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法 |
| IL272389A (en) | 2020-01-30 | 2021-08-31 | Yeda Res & Dev | Kits containing antibodies to PD-L1 and their uses in therapy |
| JP2023528400A (ja) * | 2020-06-03 | 2023-07-04 | サイモン フレイザー ユニヴァーシティー | タンパク質フコシル化の阻害剤及びその用途 |
| US12036286B2 (en) | 2021-03-18 | 2024-07-16 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| WO2022261021A1 (en) | 2021-06-07 | 2022-12-15 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
| CN113413465B (zh) * | 2021-06-15 | 2022-06-03 | 北京大学 | 岩藻糖基化抑制剂在抗癌导致炎症中的应用 |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| WO2024191807A1 (en) | 2023-03-10 | 2024-09-19 | Seagen Inc. | Methods of treating cancer with anti-tigit antibodies |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440780A (en) | 1979-06-01 | 1984-04-03 | Chevron Research Company | Fungicidal 3-(N-acyl-N-arylamino)-and 3-(N-thionoacyl-N-arylamino)-gamma-butyrolactones and gamma-thiobutyrolactones |
| JPH0660189B2 (ja) | 1986-01-22 | 1994-08-10 | 財団法人微生物化学研究会 | ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノ−ス又はその誘導体とその製造法 |
| FR2630914A1 (fr) | 1988-05-04 | 1989-11-10 | Hoechst Sa Laboratoires | Nouveaux analogues du l-fucose, leur procede de preparation, application de ces analogues a la preparation de nouveaux glycals, anthracyclines obtenues a l'aide de ces glycals et utilisation desdites anthracyclines en tant que medicaments |
| KR100211417B1 (ko) | 1990-11-30 | 1999-10-01 | 유충식 | L-탈로피라노시드 유도체 및 그의 제조방법 |
| US5461143A (en) | 1991-03-18 | 1995-10-24 | The Scripps Research Institute | Oligosaccharide enzyme substrates and inhibitors: methods and compositions |
| US5210078A (en) * | 1991-04-30 | 1993-05-11 | The Biomembrane Institute | Trifluoromethyl analogs of fucose and uses thereof |
| ATE174925T1 (de) | 1991-10-15 | 1999-01-15 | Scripps Research Inst | Herstellung von fucosylierten kohlenhydraten durch enzymatische fucosylierungs-synthese der zuckernukleotide; und in situ regeneration von gdp-fucose |
| CA2172983A1 (en) | 1993-09-29 | 1995-04-06 | Kei Sugai | 21-substituted steroid compound |
| US5481143A (en) | 1993-11-15 | 1996-01-02 | Burdick; Brian K. | Self starting brushless d.c. motor |
| FR2723947B1 (fr) | 1994-08-31 | 1996-09-27 | Adir | Nouveaux composes tetrahydropyraniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19524515A1 (de) | 1995-07-05 | 1997-01-09 | Deutsches Krebsforsch | Saccharid-Konjugate |
| US6713287B1 (en) | 1995-10-24 | 2004-03-30 | The Scripps Research Institute | Enzymatic synthesis of L-fucose and L-fucose analogs |
| WO1998018805A2 (en) * | 1996-10-28 | 1998-05-07 | Novartis Ag | Sugar derivatives as sialyl lewis x mimetics |
| US5770407A (en) | 1996-12-10 | 1998-06-23 | The Scripps Research Institute | Process for preparing nucleotide inhibitors of glycosyltransferases |
| JP4451933B2 (ja) * | 1996-12-27 | 2010-04-14 | 住友化学株式会社 | 遺伝子操作による植物へのｐｐｏ阻害性除草剤耐性付与法 |
| US6075134A (en) | 1997-05-15 | 2000-06-13 | The Regents Of The University Of California | Glycoconjugates and methods |
| JPH1135593A (ja) | 1997-07-18 | 1999-02-09 | Daikin Ind Ltd | ２−フルオロフコシル−ｎ−アロイルグルコサミン誘導体及びその中間物、並びにそれらの製造方法 |
| US6670330B1 (en) | 2000-05-01 | 2003-12-30 | Theodore J. Lampidis | Cancer chemotherapy with 2-deoxy-D-glucose |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| JPWO2003085118A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | 抗体組成物の製造方法 |
| EP1587519A4 (en) | 2003-01-10 | 2006-05-31 | Threshold Pharmaceuticals Inc | Treatment of cancer with 2-deoxyglucose |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| EP1613261A4 (en) | 2003-04-09 | 2011-01-26 | Novo Nordisk As | INTRA-CELLULAR FORMATION OF PEPTIDE CONJUGATES |
| US7332334B2 (en) | 2003-04-18 | 2008-02-19 | Oklahoma Medical Research Foundation | Hematopoietic stem cells treated by in vitro fucosylation and methods of use |
| EP2228445A1 (en) | 2003-06-18 | 2010-09-15 | Chugai Seiyaku Kabushiki Kaisha | Fucose Transporter |
| AU2004280066A1 (en) | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kirin Co., Ltd. | Genomically modified cell |
| KR20060129296A (ko) | 2003-12-23 | 2006-12-15 | 프로젠 인더스트리즈 리미티드 | 글리코사미노글리칸(ｇａｇ) 모방체 |
| DE102004032421A1 (de) | 2004-07-05 | 2006-01-26 | Bayer Cropscience Ag | Phenylsubstituierte [1.2]-Oxazin-3,5-dion-und Dihydropyron-Derivate |
| US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
| US20090061485A1 (en) | 2004-12-22 | 2009-03-05 | Chugai Seiyaku Kabushiki Kaisha | Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited |
| CN101203241B (zh) | 2005-04-19 | 2012-02-22 | 西雅图基因公司 | 人源化抗-cd70结合物和其应用 |
| CA2626556C (en) | 2005-10-21 | 2016-05-10 | Genzyme Corporation | Antibody-based therapeutics with enhanced adcc activity |
| US8278349B2 (en) | 2005-11-28 | 2012-10-02 | Ramot At Tel-Aviv University Ltd. | Cancer treatment using FTS and 2-deoxyglucose |
| US7956162B2 (en) | 2005-12-21 | 2011-06-07 | Viventia Biotechnologies Inc. | Cancer-associated antigen |
| WO2007081031A1 (ja) | 2006-01-16 | 2007-07-19 | Hokkaido University | 糖転移酵素阻害剤 |
| EP1991273B2 (en) | 2006-02-10 | 2022-01-05 | Life Technologies Corporation | Labeling and detection of post translationally modified proteins |
| MX2008010833A (es) | 2006-02-24 | 2008-11-12 | Univ Texas | Compuestos de hexosa para tratar cancer. |
| WO2007100728A2 (en) | 2006-02-24 | 2007-09-07 | University Of Miami | Mannose derivatives for killing tumor cells |
| EP1996609B1 (en) | 2006-03-22 | 2016-08-03 | The Scripps Research Institute | Method of preparing glycopeptides |
| WO2009108926A1 (en) | 2008-02-29 | 2009-09-03 | Board Of Regents, The University Of Texas System | Inhibitors of glycolysis useful in the treatment of brain tumors |
| US9149489B2 (en) | 2006-04-27 | 2015-10-06 | Board Of Regents, University Of Texas System | Inhibitors of glycolysis useful in the treatment of brain tumors |
| JP2010507394A (ja) | 2006-10-24 | 2010-03-11 | トルービオン ファーマスーティカルズ インコーポレイテッド | 改良免疫糖タンパク質のための物質および方法 |
| CA2677747A1 (en) | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| WO2008131024A1 (en) | 2007-04-17 | 2008-10-30 | Board Of Regents, The University Of Texas System | Iodo-hexose compounds useful to treat cancer |
| CN101062939A (zh) | 2007-05-17 | 2007-10-31 | 北京热景生物技术有限公司 | 检测肝癌岩藻糖基化高尔基蛋白gp73的装置及试剂盒 |
| SI2211904T1 (sl) | 2007-10-19 | 2016-12-30 | Seattle Genetics, Inc. | CD19 vezavna sredstva in njihove uporabe |
| US20110003338A1 (en) | 2008-03-11 | 2011-01-06 | Robert Bayer | Antibodies with enhanced adcc function |
| CA2975228C (en) | 2008-05-02 | 2020-07-21 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| WO2009143078A2 (en) | 2008-05-19 | 2009-11-26 | Board Of Regents, The University Of Texas System | Methods of treating brain cancer using hexose compounds |
| US20110183926A1 (en) | 2008-05-23 | 2011-07-28 | University Of Miami | Treatment using continuous low dose application of sugar analogs |
| JP2011524375A (ja) * | 2008-06-16 | 2011-09-01 | アカデミア シニカ | ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用 |
| WO2010111713A2 (en) | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | N-linked glycan biosynthesis modulators |
| WO2011137528A1 (en) * | 2010-05-06 | 2011-11-10 | Simon Fraser University | Methods and compounds for inhibiting glycosyltransferases |
| US20110288880A1 (en) | 2010-05-07 | 2011-11-24 | Patient Care Automation Services, Inc. | Targeted health care messaging |
| RU2625768C2 (ru) * | 2010-08-05 | 2017-07-18 | Сиэтл Дженетикс, Инк. | Способы ингибирования фукозилирования белков in vivo с использованием аналогов фукозы |
| JP2014505058A (ja) | 2011-01-11 | 2014-02-27 | ザ・ユニバーシティ・オブ・テキサス・エム・ディー・アンダーソン・キャンサー | 増殖性および炎症性皮膚疾患の治療用単糖ベース化合物 |
| US8979675B2 (en) | 2012-04-25 | 2015-03-17 | Nike, Inc. | Golf ball core having radial appendages |
| WO2014031875A1 (en) | 2012-08-23 | 2014-02-27 | Seattle Genetics, Inc. | Treatment of sickle cell disease and inflammatory conditions |
| WO2017096274A1 (en) | 2015-12-04 | 2017-06-08 | Seattle Genetics, Inc. | Cancer treatment using 2-deoxy-2-fluoro-l-fucose in combination with a checkpoint inhibitor |
-
2011
- 2011-08-05 RU RU2013109415A patent/RU2625768C2/ru active
- 2011-08-05 AU AU2011285490A patent/AU2011285490B2/en active Active
- 2011-08-05 NZ NZ606250A patent/NZ606250A/en unknown
- 2011-08-05 US US13/814,083 patent/US9504702B2/en active Active
- 2011-08-05 EP EP11815404.6A patent/EP2608796B1/en active Active
- 2011-08-05 PT PT11815404T patent/PT2608796T/pt unknown
- 2011-08-05 HU HUE11815404A patent/HUE043370T2/hu unknown
- 2011-08-05 MX MX2013001303A patent/MX356671B/es active IP Right Grant
- 2011-08-05 SI SI201131673T patent/SI2608796T1/sl unknown
- 2011-08-05 TR TR2019/02439T patent/TR201902439T4/tr unknown
- 2011-08-05 JP JP2013523380A patent/JP5918235B2/ja active Active
- 2011-08-05 ES ES11815404T patent/ES2711622T3/es active Active
- 2011-08-05 WO PCT/US2011/046857 patent/WO2012019165A2/en not_active Ceased
- 2011-08-05 RU RU2017122482A patent/RU2017122482A/ru not_active Application Discontinuation
- 2011-08-05 PL PL11815404T patent/PL2608796T3/pl unknown
- 2011-08-05 EP EP18206850.2A patent/EP3513794A3/en not_active Withdrawn
- 2011-08-05 CN CN201710076003.7A patent/CN107007615A/zh active Pending
- 2011-08-05 CA CA2803388A patent/CA2803388C/en active Active
- 2011-08-05 CN CN201180038334.2A patent/CN103402525B/zh active Active
- 2011-08-05 KR KR1020197004266A patent/KR20190022884A/ko not_active Ceased
- 2011-08-05 DK DK11815404.6T patent/DK2608796T3/en active
- 2011-08-05 KR KR1020137005545A patent/KR101950520B1/ko not_active Expired - Fee Related
-
2013
- 2013-01-24 ZA ZA2013/00653A patent/ZA201300653B/en unknown
- 2013-01-30 IL IL224487A patent/IL224487A/en active IP Right Grant
-
2016
- 2016-02-08 IL IL244019A patent/IL244019B/en active IP Right Grant
- 2016-04-07 JP JP2016076930A patent/JP6113887B2/ja not_active Expired - Fee Related
- 2016-06-29 AU AU2016204495A patent/AU2016204495A1/en not_active Abandoned
- 2016-10-21 US US15/299,894 patent/US10342811B2/en active Active
-
2017
- 2017-03-15 JP JP2017049534A patent/JP6622238B2/ja active Active
- 2017-12-20 AU AU2017279653A patent/AU2017279653A1/en not_active Abandoned
-
2019
- 2019-02-20 CY CY20191100218T patent/CY1121419T1/el unknown
- 2019-06-25 US US16/452,160 patent/US11033561B2/en active Active
- 2019-11-21 JP JP2019210313A patent/JP2020040974A/ja active Pending
-
2021
- 2021-05-07 US US17/315,144 patent/US20210260086A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013541503A5 (OSRAM) | ||
| RU2013109415A (ru) | Способы ингибирования фукозилирования белков in vivo с использованием аналогов фукозы | |
| JP2018504437A5 (OSRAM) | ||
| JP6100439B2 (ja) | アンドロゲン受容体調節薬のエステル誘導体およびそれらの使用のための方法 | |
| RU2012110380A (ru) | Новое производное 5-фторурацила | |
| JP2018530549A5 (OSRAM) | ||
| JP2008511634A5 (OSRAM) | ||
| JP2012503621A5 (OSRAM) | ||
| JP2006524660A5 (OSRAM) | ||
| RU2015107733A (ru) | Терапевтические средства на основе производных диглицилиловых простых эфиров и способы их применения | |
| JP2007269797A5 (OSRAM) | ||
| RU2009107537A (ru) | Новые стероидные соединения, обладающие повышенной растворимостью в воде и устойчивостью к метаболизму, и способы их приготовления | |
| JP2012519691A5 (OSRAM) | ||
| RU2012117829A (ru) | Фосфорамидатные производные нуклеозидов | |
| RU2011133128A (ru) | Противоопухолевые соединения дигидропиран-2-она | |
| JP2019522055A5 (OSRAM) | ||
| JP2019510027A5 (OSRAM) | ||
| JP2017519754A5 (OSRAM) | ||
| JP2015508092A5 (OSRAM) | ||
| JP2014519488A5 (OSRAM) | ||
| RU2012150501A (ru) | Противораковые стероидные лактоны, ненасыщенные в положении 7(8) | |
| JP2017505785A5 (OSRAM) | ||
| RU2016133471A (ru) | Композиции и способы для лечения диабета и заболеваний печени | |
| JP2016500074A5 (OSRAM) | ||
| RU2013136895A (ru) | Новое бициклическое соединение или его соль |