JP2019510027A5 - - Google Patents
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- Publication number
- JP2019510027A5 JP2019510027A5 JP2018550333A JP2018550333A JP2019510027A5 JP 2019510027 A5 JP2019510027 A5 JP 2019510027A5 JP 2018550333 A JP2018550333 A JP 2018550333A JP 2018550333 A JP2018550333 A JP 2018550333A JP 2019510027 A5 JP2019510027 A5 JP 2019510027A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- pharmaceutically acceptable
- compound
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 16
- 239000012453 solvate Substances 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 12
- 208000001490 Dengue Diseases 0.000 claims description 8
- 206010012310 Dengue fever Diseases 0.000 claims description 8
- 208000025729 dengue disease Diseases 0.000 claims description 8
- 229940124597 therapeutic agent Drugs 0.000 claims description 8
- 241000725619 Dengue virus Species 0.000 claims description 4
- 239000003443 antiviral agent Substances 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 3
- 239000000969 carrier Substances 0.000 claims description 3
- 230000010076 replication Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163281.5 | 2016-03-31 | ||
| EP16163281 | 2016-03-31 | ||
| PCT/EP2017/057663 WO2017167953A1 (en) | 2016-03-31 | 2017-03-31 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510027A JP2019510027A (ja) | 2019-04-11 |
| JP2019510027A5 true JP2019510027A5 (OSRAM) | 2019-05-23 |
| JP6931357B2 JP6931357B2 (ja) | 2021-09-01 |
Family
ID=55646444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550333A Active JP6931357B2 (ja) | 2016-03-31 | 2017-03-31 | デングウイルス複製阻害剤としての置換インドリン誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10913716B2 (OSRAM) |
| EP (1) | EP3436436B1 (OSRAM) |
| JP (1) | JP6931357B2 (OSRAM) |
| KR (1) | KR102359735B1 (OSRAM) |
| CN (1) | CN109195949B (OSRAM) |
| AU (1) | AU2017240077A1 (OSRAM) |
| BR (1) | BR112018069601A2 (OSRAM) |
| CA (1) | CA3013407A1 (OSRAM) |
| CL (1) | CL2018002718A1 (OSRAM) |
| CO (1) | CO2018008421A2 (OSRAM) |
| CR (1) | CR20180496A (OSRAM) |
| EA (1) | EA201892216A1 (OSRAM) |
| EC (1) | ECSP18073366A (OSRAM) |
| ES (1) | ES2923771T3 (OSRAM) |
| IL (1) | IL261943A (OSRAM) |
| MA (1) | MA44498A (OSRAM) |
| MX (1) | MX2018011788A (OSRAM) |
| PH (1) | PH12018502016A1 (OSRAM) |
| SG (1) | SG11201808270PA (OSRAM) |
| WO (1) | WO2017167953A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2017242893A1 (en) | 2016-03-31 | 2018-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| CA3013407A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| KR102359766B1 (ko) | 2016-04-01 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JP7203764B2 (ja) * | 2017-05-22 | 2023-01-13 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | デングウイルス複製阻害剤としての置換インドリン誘導体 |
| DK3630724T3 (da) | 2017-05-22 | 2021-07-26 | Janssen Pharmaceuticals Inc | Substituerede indolinderivater som inhibitorer af virusreplikation af denguevirus |
| CN109485596A (zh) * | 2018-12-19 | 2019-03-19 | 山东理工职业学院 | 一种含吲哚啉的登革病毒抑制剂的制备方法 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69830335T2 (de) | 1997-10-27 | 2006-02-02 | Eli Lilly And Co., Indianapolis | MORPHOLINO-N-ETHYL ESTER PRODROGEN VON INDOL sPLA 2 HEMMER |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| CA2468202A1 (en) | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| WO2006076529A1 (en) | 2005-01-14 | 2006-07-20 | Genelabs Technologies, Inc. | Indole derivatives for treating viral infections |
| CA2597213A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| AP2010005480A0 (en) | 2008-06-03 | 2010-12-31 | Siga Technologies Inc | Small molecule inhibitors for the treatment or prevention of denque virus infection. |
| TWI614024B (zh) * | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| ES2612731T3 (es) * | 2008-08-19 | 2017-05-18 | Janssen Pharmaceutica Nv | Antagonistas de receptores al frío de mentol |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| EP2393359A4 (en) | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | COMPOUND DIBENZIMIDAZOLE DERIVATIVES |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| UA108221C2 (uk) | 2010-01-15 | 2015-04-10 | Похідні тіофен-2-карбонової кислоти як інгібітори вірусів flaviviridae | |
| US20130023532A1 (en) | 2010-03-26 | 2013-01-24 | Casillas Linda N | Indazolyl-pyrimidines as kinase inhibitors |
| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| AU2014338947B2 (en) | 2013-10-23 | 2018-02-22 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| UY35971A (es) | 2014-01-31 | 2015-07-31 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Macrociclos con grupos p2? aromáticos como inhibidores del factor xia |
| HUE042628T2 (hu) | 2014-10-01 | 2019-07-29 | Janssen Pharmaceuticals Inc | Mono- vagy diszubsztituált indolok mint dengue vírus replikáció inhibitorok |
| NO2721243T3 (OSRAM) | 2014-10-01 | 2018-10-20 | ||
| KR102478311B1 (ko) | 2014-10-01 | 2022-12-15 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 １치환 또는 ２치환 인돌 유도체 |
| PH12017501272B1 (en) | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JP6864001B2 (ja) | 2015-11-03 | 2021-04-21 | ゾエティス・サービシーズ・エルエルシー | ゾル−ゲルポリマー組成物及びそれらの使用 |
| AU2017242893A1 (en) | 2016-03-31 | 2018-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| CA3013407A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| KR102388440B1 (ko) | 2016-03-31 | 2022-04-19 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 |
| MX379513B (es) | 2016-04-01 | 2025-03-11 | Signal Pharm Llc | Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos. |
| PE20190356A1 (es) | 2016-04-01 | 2019-03-07 | Kite Pharma Inc | Receptores quimericos y metodos de uso de los mismos |
| PE20190201A1 (es) | 2016-04-01 | 2019-02-05 | Amgen Inc | Receptores quimericos de flt3 y metodos de uso de los mismos |
| JOP20170069B1 (ar) * | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR102359766B1 (ko) | 2016-04-01 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체 |
| PL3436079T3 (pl) | 2016-04-01 | 2021-12-20 | Kite Pharma, Inc. | Antygen chimeryczny i receptory komórek t oraz sposoby ich stosowania |
| PE20181898A1 (es) | 2016-04-01 | 2018-12-11 | Basf Se | Compuestos biciclicos |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| DK3630724T3 (da) | 2017-05-22 | 2021-07-26 | Janssen Pharmaceuticals Inc | Substituerede indolinderivater som inhibitorer af virusreplikation af denguevirus |
| JP7203764B2 (ja) | 2017-05-22 | 2023-01-13 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | デングウイルス複製阻害剤としての置換インドリン誘導体 |
| CN109485596A (zh) * | 2018-12-19 | 2019-03-19 | 山东理工职业学院 | 一种含吲哚啉的登革病毒抑制剂的制备方法 |
-
2017
- 2017-03-31 CA CA3013407A patent/CA3013407A1/en not_active Abandoned
- 2017-03-31 US US16/088,459 patent/US10913716B2/en active Active
- 2017-03-31 JP JP2018550333A patent/JP6931357B2/ja active Active
- 2017-03-31 MX MX2018011788A patent/MX2018011788A/es unknown
- 2017-03-31 CN CN201780021312.2A patent/CN109195949B/zh active Active
- 2017-03-31 KR KR1020187026918A patent/KR102359735B1/ko active Active
- 2017-03-31 CR CR20180496A patent/CR20180496A/es unknown
- 2017-03-31 EA EA201892216A patent/EA201892216A1/ru unknown
- 2017-03-31 BR BR112018069601A patent/BR112018069601A2/pt not_active Application Discontinuation
- 2017-03-31 EP EP17714475.5A patent/EP3436436B1/en active Active
- 2017-03-31 MA MA044498A patent/MA44498A/fr unknown
- 2017-03-31 ES ES17714475T patent/ES2923771T3/es active Active
- 2017-03-31 WO PCT/EP2017/057663 patent/WO2017167953A1/en not_active Ceased
- 2017-03-31 SG SG11201808270PA patent/SG11201808270PA/en unknown
- 2017-03-31 AU AU2017240077A patent/AU2017240077A1/en not_active Abandoned
-
2018
- 2018-08-10 CO CONC2018/0008421A patent/CO2018008421A2/es unknown
- 2018-09-20 PH PH12018502016A patent/PH12018502016A1/en unknown
- 2018-09-25 CL CL2018002718A patent/CL2018002718A1/es unknown
- 2018-09-26 IL IL261943A patent/IL261943A/en unknown
- 2018-09-28 EC ECSENADI201873366A patent/ECSP18073366A/es unknown