ES2711622T3 - Inhibición de la fucosilación in vivo usando análogos de fucosa - Google Patents
Inhibición de la fucosilación in vivo usando análogos de fucosa Download PDFInfo
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- ES2711622T3 ES2711622T3 ES11815404T ES11815404T ES2711622T3 ES 2711622 T3 ES2711622 T3 ES 2711622T3 ES 11815404 T ES11815404 T ES 11815404T ES 11815404 T ES11815404 T ES 11815404T ES 2711622 T3 ES2711622 T3 ES 2711622T3
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- Prior art keywords
- fucose
- cancer
- treatment
- fucose analogue
- prophylaxis
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- 125000003118 aryl group Chemical group 0.000 claims abstract description 94
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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| US37111610P | 2010-08-05 | 2010-08-05 | |
| PCT/US2011/046857 WO2012019165A2 (en) | 2010-08-05 | 2011-08-05 | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
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| ES2711622T3 true ES2711622T3 (es) | 2019-05-06 |
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| EP2282773B2 (en) | 2008-05-02 | 2025-03-05 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| US9504702B2 (en) | 2010-08-05 | 2016-11-29 | Seattle Genetics, Inc. | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
| CA2882725C (en) | 2012-08-23 | 2021-03-09 | Regents Of The University Of Minnesota | Treatment of sickle cell disease and inflammatory conditions |
| US9328134B2 (en) | 2013-02-22 | 2016-05-03 | Amgen Inc. | Carbohydrate phosphonate derivatives as modulators of glycosylation |
| CN106699886A (zh) * | 2015-07-13 | 2017-05-24 | 西藏海思科药业集团股份有限公司 | 抗体依赖性细胞介导的细胞毒性(adcc)增强的奥法木抗体 |
| JP6906520B2 (ja) * | 2015-12-04 | 2021-07-21 | シージェン インコーポレイテッド | チェックポイント阻害剤と組みわせて２−デオキシ−２−フルオロ−ｌ−フコースを用いる癌治療 |
| ES2908067T3 (es) | 2016-05-10 | 2022-04-27 | Ares Trading Sa | Métodos para modular los perfiles de galactosilación proteicos de proteínas recombinantes empleando peracetil galactosa |
| JP2018002666A (ja) * | 2016-07-04 | 2018-01-11 | 国立研究開発法人理化学研究所 | フコース類似体と糖を検出する方法 |
| JP7245177B2 (ja) * | 2017-06-07 | 2023-03-23 | シージェン インコーポレイテッド | 低減した表面フコシル化を有するｔ細胞、及びそれを作製及び使用する方法 |
| MX2020005662A (es) | 2017-12-01 | 2020-08-20 | Pfizer | Anticuerpos anti-cxcr5 y composiciones y usos de los mismos. |
| PE20211235A1 (es) | 2018-03-29 | 2021-07-08 | Univ California | Variantes de lfa3 y composiciones y usos de las mismas |
| US11401339B2 (en) | 2018-08-23 | 2022-08-02 | Seagen Inc. | Anti-TIGIT antibodies |
| WO2020138447A1 (ja) * | 2018-12-27 | 2020-07-02 | 学校法人慶應義塾 | 抗ヒトノロウイルス剤 |
| KR20220115998A (ko) * | 2019-12-19 | 2022-08-19 | 메르크 파텐트 게엠베하 | 단백질의 글리코실화 프로파일을 조절하기 위한 방법 및 조성물 |
| TWI877278B (zh) * | 2019-12-30 | 2025-03-21 | 美商思進公司 | 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法 |
| IL272389A (en) | 2020-01-30 | 2021-08-31 | Yeda Res & Dev | Kits containing antibodies to PD-L1 and their uses in therapy |
| CN116194089A (zh) * | 2020-06-03 | 2023-05-30 | 西蒙弗雷泽大学 | 蛋白质岩藻糖基化抑制剂及其用途 |
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| CN113413465B (zh) * | 2021-06-15 | 2022-06-03 | 北京大学 | 岩藻糖基化抑制剂在抗癌导致炎症中的应用 |
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