JP2013538235A5 - - Google Patents
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- JP2013538235A5 JP2013538235A5 JP2013529408A JP2013529408A JP2013538235A5 JP 2013538235 A5 JP2013538235 A5 JP 2013538235A5 JP 2013529408 A JP2013529408 A JP 2013529408A JP 2013529408 A JP2013529408 A JP 2013529408A JP 2013538235 A5 JP2013538235 A5 JP 2013538235A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- cycloalkenyl
- cycloalkyl
- alkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*(C*(C)IC(C(OC(*)(CC1C(NC2(C(*)C2)C(*)=O)=O)CN1C(C(*)N*N=C)=O)=NC(*)=C(C)*)=*)*C(C=C*)=C Chemical compound C*(C*(C)IC(C(OC(*)(CC1C(NC2(C(*)C2)C(*)=O)=O)CN1C(C(*)N*N=C)=O)=NC(*)=C(C)*)=*)*C(C=C*)=C 0.000 description 7
- UAEPNZWRGJTJPN-UHFFFAOYSA-N CC1CCCCC1 Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 1
- OVRKATYHWPCGPZ-UHFFFAOYSA-N CC1CCOCC1 Chemical compound CC1CCOCC1 OVRKATYHWPCGPZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38505810P | 2010-09-21 | 2010-09-21 | |
| US61/385,058 | 2010-09-21 | ||
| US201161499994P | 2011-06-22 | 2011-06-22 | |
| US61/499,994 | 2011-06-22 | ||
| US201161504616P | 2011-07-05 | 2011-07-05 | |
| US61/504,616 | 2011-07-05 | ||
| PCT/US2011/052304 WO2012040167A1 (en) | 2010-09-21 | 2011-09-20 | Macrocyclic proline derived hcv serine protease inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015241811A Division JP6352238B2 (ja) | 2010-09-21 | 2015-12-11 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013538235A JP2013538235A (ja) | 2013-10-10 |
| JP2013538235A5 true JP2013538235A5 (enExample) | 2014-04-10 |
| JP5857053B2 JP5857053B2 (ja) | 2016-02-10 |
Family
ID=45817947
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013529408A Active JP5857053B2 (ja) | 2010-09-21 | 2011-09-20 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
| JP2015241811A Active JP6352238B2 (ja) | 2010-09-21 | 2015-12-11 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
| JP2018107455A Active JP6574023B2 (ja) | 2010-09-21 | 2018-06-05 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
| JP2019148420A Pending JP2020015730A (ja) | 2010-09-21 | 2019-08-13 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
| JP2021004680A Ceased JP2021063130A (ja) | 2010-09-21 | 2021-01-15 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015241811A Active JP6352238B2 (ja) | 2010-09-21 | 2015-12-11 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
| JP2018107455A Active JP6574023B2 (ja) | 2010-09-21 | 2018-06-05 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
| JP2019148420A Pending JP2020015730A (ja) | 2010-09-21 | 2019-08-13 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
| JP2021004680A Ceased JP2021063130A (ja) | 2010-09-21 | 2021-01-15 | 大環式プロリン由来ｈｃｖセリンプロテアーゼ阻害剤 |
Country Status (43)
Families Citing this family (49)
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| US20200368229A9 (en) * | 2013-03-14 | 2020-11-26 | Abbvie Inc. | Methods for Treating HCV |
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| CA2925328A1 (en) * | 2013-10-25 | 2015-04-30 | Abbvie, Inc. | Methods for treating hcv |
| TR201906413T4 (tr) | 2013-12-23 | 2019-05-21 | Gilead Sciences Inc | Bir makrosiklik hcv ns3 inhibe edici tripeptidin sentezi. |
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| TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
| US9809576B1 (en) | 2014-07-18 | 2017-11-07 | Abbvie Inc. | Synthetic route to anti-viral agents |
| US9809534B1 (en) | 2014-07-21 | 2017-11-07 | Abbvie Inc. | Difluoroalkylcyclopropyl amino acids and esters, and syntheses thereof |
| US10059969B1 (en) | 2014-10-03 | 2018-08-28 | Abbvie Inc. | Process for the preparation of (S)-2-amino-non-8-enoic acid |
| US10316338B1 (en) | 2015-01-30 | 2019-06-11 | Abb Vie Inc. | Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid |
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| US20160375017A1 (en) | 2015-06-26 | 2016-12-29 | Abbvie Inc. | Solid Pharmaceutical Compositions for Treating HCV |
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| JP7133466B2 (ja) * | 2015-07-17 | 2022-09-08 | アッヴィ・インコーポレイテッド | Ｈｃｖを処置するための固体医薬組成物 |
| KR101726567B1 (ko) | 2016-07-08 | 2017-04-13 | 박공영 | 수직형 식물 재배장치 |
| TWI693286B (zh) | 2017-02-01 | 2020-05-11 | 美商艾伯維有限公司 | (±)-2-(二氟甲基)-1-(烷氧羰基)-環丙烷甲酸及(±)-2-(乙烯基)-1-(烷氧羰基)-環丙烷甲酸之酶催化製法 |
| JP2018131439A (ja) | 2017-02-14 | 2018-08-23 | アッヴィ・インコーポレイテッド | Ｈｃｖを処置する方法 |
| CA2981993A1 (en) * | 2017-08-02 | 2019-02-02 | Abbvie Inc. | Methods for treating hcv |
| WO2019046569A1 (en) * | 2017-09-01 | 2019-03-07 | Abbvie Inc. | METHODS FOR THE TREATMENT OF HCV |
| WO2019074507A1 (en) | 2017-10-12 | 2019-04-18 | Abbvie Inc. | METHODS FOR THE TREATMENT OF HCV |
| CN107739319A (zh) * | 2017-10-31 | 2018-02-27 | 上海同昌生物医药科技有限公司 | 一种Glecaprevir合成中间体及其胺盐的制备方法 |
| WO2019084740A1 (zh) * | 2017-10-31 | 2019-05-09 | 上海同昌生物医药科技有限公司 | 一种Glecaprevir合成中间体及其胺盐的制备方法 |
| CN108329332A (zh) * | 2018-03-16 | 2018-07-27 | 安徽华昌高科药业有限公司 | 一种制备Glecaprevir的方法 |
| MX2021012320A (es) | 2019-04-08 | 2022-01-18 | Abbvie Inc | Composiciones farmaceuticas solidas para el tratamiento del hcv. |
| KR102681664B1 (ko) | 2019-06-12 | 2024-07-05 | 엘지디스플레이 주식회사 | 폴더블 디스플레이와 그 구동 방법 |
| WO2021137256A1 (en) | 2020-01-03 | 2021-07-08 | Mylan Laboratories Limited | Polymorphic forms of glecaprevir |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
| CN114085458A (zh) * | 2021-12-08 | 2022-02-25 | 宁波塑之华塑化有限公司 | 一种高强度高韧性阻燃聚丙烯复合材料及其制备方法 |
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