JP2015518904A5 - - Google Patents
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- JP2015518904A5 JP2015518904A5 JP2015516260A JP2015516260A JP2015518904A5 JP 2015518904 A5 JP2015518904 A5 JP 2015518904A5 JP 2015516260 A JP2015516260 A JP 2015516260A JP 2015516260 A JP2015516260 A JP 2015516260A JP 2015518904 A5 JP2015518904 A5 JP 2015518904A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- alkoxy
- halo
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 66
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 56
- 125000003118 aryl group Chemical group 0.000 claims description 56
- 125000000217 alkyl group Chemical group 0.000 claims description 54
- 125000003282 alkyl amino group Chemical group 0.000 claims description 50
- 125000005843 halogen group Chemical group 0.000 claims description 45
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 42
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 40
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 35
- 125000001424 substituent group Chemical group 0.000 claims description 35
- 125000003545 alkoxy group Chemical group 0.000 claims description 32
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 32
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 24
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 23
- 125000001589 carboacyl group Chemical group 0.000 claims description 20
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 18
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 18
- 230000009385 viral infection Effects 0.000 claims description 17
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 16
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- 208000036142 Viral infection Diseases 0.000 claims description 12
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 12
- 125000001072 heteroaryl group Chemical group 0.000 claims description 12
- 125000003003 spiro group Chemical group 0.000 claims description 10
- 125000005549 heteroarylene group Chemical group 0.000 claims description 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
- 239000003112 inhibitor Substances 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- -1 cyano, hydroxy Chemical group 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 239000001301 oxygen Substances 0.000 claims description 6
- 125000006413 ring segment Chemical group 0.000 claims description 6
- 125000004434 sulfur atom Chemical group 0.000 claims description 6
- 208000030507 AIDS Diseases 0.000 claims description 4
- 241000711573 Coronaviridae Species 0.000 claims description 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 4
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims description 4
- 125000000732 arylene group Chemical group 0.000 claims description 4
- 150000001540 azides Chemical class 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 claims description 4
- 108700008776 hepatitis C virus NS-5 Proteins 0.000 claims description 4
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 239000002777 nucleoside Substances 0.000 claims description 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 4
- 229960000329 ribavirin Drugs 0.000 claims description 4
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 208000001490 Dengue Diseases 0.000 claims description 2
- 206010012310 Dengue fever Diseases 0.000 claims description 2
- 206010014596 Encephalitis Japanese B Diseases 0.000 claims description 2
- 206010016654 Fibrosis Diseases 0.000 claims description 2
- 229940124771 HCV-NS3 protease inhibitor Drugs 0.000 claims description 2
- 241000711549 Hepacivirus C Species 0.000 claims description 2
- 241000700721 Hepatitis B virus Species 0.000 claims description 2
- 208000005176 Hepatitis C Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 102000014150 Interferons Human genes 0.000 claims description 2
- 108010050904 Interferons Proteins 0.000 claims description 2
- 201000005807 Japanese encephalitis Diseases 0.000 claims description 2
- 241000710842 Japanese encephalitis virus Species 0.000 claims description 2
- 201000005805 Murray valley encephalitis Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 241000315672 SARS coronavirus Species 0.000 claims description 2
- 206010041896 St. Louis Encephalitis Diseases 0.000 claims description 2
- 229940124615 TLR 7 agonist Drugs 0.000 claims description 2
- 208000004006 Tick-borne encephalitis Diseases 0.000 claims description 2
- 201000006449 West Nile encephalitis Diseases 0.000 claims description 2
- 208000003152 Yellow Fever Diseases 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 2
- 229960000517 boceprevir Drugs 0.000 claims description 2
- LHHCSNFAOIFYRV-DOVBMPENSA-N boceprevir Chemical compound O=C([C@@H]1[C@@H]2[C@@H](C2(C)C)CN1C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)NC(C(=O)C(N)=O)CC1CCC1 LHHCSNFAOIFYRV-DOVBMPENSA-N 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000007882 cirrhosis Effects 0.000 claims description 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
- 208000025729 dengue disease Diseases 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 229940079322 interferon Drugs 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 2
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims description 2
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims description 2
- 229960002063 sofosbuvir Drugs 0.000 claims description 2
- TTZHDVOVKQGIBA-IQWMDFIBSA-N sofosbuvir Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@]2(F)C)O)CO[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC=2C=CC=CC=2)C=CC(=O)NC1=O TTZHDVOVKQGIBA-IQWMDFIBSA-N 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 229960002935 telaprevir Drugs 0.000 claims description 2
- BBAWEDCPNXPBQM-GDEBMMAJSA-N telaprevir Chemical compound N([C@H](C(=O)N[C@H](C(=O)N1C[C@@H]2CCC[C@@H]2[C@H]1C(=O)N[C@@H](CCC)C(=O)C(=O)NC1CC1)C(C)(C)C)C1CCCCC1)C(=O)C1=CN=CC=N1 BBAWEDCPNXPBQM-GDEBMMAJSA-N 0.000 claims description 2
- 108010017101 telaprevir Proteins 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims 1
- 241000907316 Zika virus Species 0.000 claims 1
- 0 CC(CCCC(NC(C(C(C)[C@](C)C(N1N[C@]2CCC1)=O)=O)=C(C)C)=O)C=C*(C(C1)N)=CC=C1[C@@](C)*C2=O Chemical compound CC(CCCC(NC(C(C(C)[C@](C)C(N1N[C@]2CCC1)=O)=O)=C(C)C)=O)C=C*(C(C1)N)=CC=C1[C@@](C)*C2=O 0.000 description 23
- 150000002148 esters Chemical class 0.000 description 14
- 229940002612 prodrug Drugs 0.000 description 14
- 239000000651 prodrug Substances 0.000 description 14
- 238000000034 method Methods 0.000 description 9
- LURLDFUOIKEELM-NPKGIASISA-N CC(C)[C@@H](C(N[C@@H](C)C(N(CCC1)N[C@@H]1C(N[C@H](C)c(cc1)nc2c1ccc(/C=C/CCC(CC1)(F)F)c2)=O)=O)=O)NC1=O Chemical compound CC(C)[C@@H](C(N[C@@H](C)C(N(CCC1)N[C@@H]1C(N[C@H](C)c(cc1)nc2c1ccc(/C=C/CCC(CC1)(F)F)c2)=O)=O)=O)NC1=O LURLDFUOIKEELM-NPKGIASISA-N 0.000 description 2
- QTYULVDUFLCFOF-NLCONRCSSA-N CC(C)[C@@H](C(N[C@@H](C)C(N(CCC1)N[C@@H]1C(O[C@H](C)c1nc2cc(/C=C/C3(CC4)CCN4C(OC(C)(C)C)=O)ccc2cc1)=O)=O)=O)NC3=O Chemical compound CC(C)[C@@H](C(N[C@@H](C)C(N(CCC1)N[C@@H]1C(O[C@H](C)c1nc2cc(/C=C/C3(CC4)CCN4C(OC(C)(C)C)=O)ccc2cc1)=O)=O)=O)NC3=O QTYULVDUFLCFOF-NLCONRCSSA-N 0.000 description 2
- VLMXFTVJDLZBJC-OMCJITFHSA-N CC(C)[C@@H](C(N[C@@H](C)C(N(CCC1)N[C@@H]1C(O[C@H](C)c1nc2cc(/C=C/C34CCNCC3)ccc2cc1)=O)=O)=O)NC4=O Chemical compound CC(C)[C@@H](C(N[C@@H](C)C(N(CCC1)N[C@@H]1C(O[C@H](C)c1nc2cc(/C=C/C34CCNCC3)ccc2cc1)=O)=O)=O)NC4=O VLMXFTVJDLZBJC-OMCJITFHSA-N 0.000 description 2
- ZCXNIEBUCYJLPK-AOLLOGBZSA-N CCC[C@](CCOCC)(/C=C/c1ccc(ccc([C@@H](C)OC([C@H](CCC2)NN2C([C@H](C)NC([C@H](C(C)C)N2)=O)=O)=O)n3)c3c1)C2=O Chemical compound CCC[C@](CCOCC)(/C=C/c1ccc(ccc([C@@H](C)OC([C@H](CCC2)NN2C([C@H](C)NC([C@H](C(C)C)N2)=O)=O)=O)n3)c3c1)C2=O ZCXNIEBUCYJLPK-AOLLOGBZSA-N 0.000 description 2
- CHEQYRNYWVIYEI-KGCYQTSASA-N C[C@H](c1nc2cc(/C=C/C(C)(C)C(N[C@@H](/C(/C)=C/C)C(N[C@@H](C)C(N3N[C@H]4CCC3)=O)=O)=O)ccc2cc1)OC4=O Chemical compound C[C@H](c1nc2cc(/C=C/C(C)(C)C(N[C@@H](/C(/C)=C/C)C(N[C@@H](C)C(N3N[C@H]4CCC3)=O)=O)=O)ccc2cc1)OC4=O CHEQYRNYWVIYEI-KGCYQTSASA-N 0.000 description 2
- 241000710781 Flaviviridae Species 0.000 description 2
- 230000002519 immonomodulatory effect Effects 0.000 description 2
- QBNHNFSXZUANPX-PFZJTCDASA-N CC([C@@H](C(N[C@@H](C)C(N(CCC1)NC1C(O[C@H](C)C1C=C(C=C(/C=C/C2)N=C3)C3=CC1)=O)=O)=O)NC2=O)O Chemical compound CC([C@@H](C(N[C@@H](C)C(N(CCC1)NC1C(O[C@H](C)C1C=C(C=C(/C=C/C2)N=C3)C3=CC1)=O)=O)=O)NC2=O)O QBNHNFSXZUANPX-PFZJTCDASA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 125000005576 pyrimidinylene group Chemical group 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657550P | 2012-06-08 | 2012-06-08 | |
| US61/657,550 | 2012-06-08 | ||
| PCT/US2013/044826 WO2013185103A1 (en) | 2012-06-08 | 2013-06-07 | Macrocyclic inhibitors of flaviviridae viruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518904A JP2015518904A (ja) | 2015-07-06 |
| JP2015518904A5 true JP2015518904A5 (enExample) | 2016-07-28 |
| JP6209601B2 JP6209601B2 (ja) | 2017-10-04 |
Family
ID=48692655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516260A Expired - Fee Related JP6209601B2 (ja) | 2012-06-08 | 2013-06-07 | フラビウイルス科ウイルスの大環状阻害剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9145441B2 (enExample) |
| EP (1) | EP2861604B1 (enExample) |
| JP (1) | JP6209601B2 (enExample) |
| KR (1) | KR20150040265A (enExample) |
| CN (1) | CN104703991B (enExample) |
| AU (1) | AU2013270672B2 (enExample) |
| BR (1) | BR112014030630A2 (enExample) |
| CA (1) | CA2875692A1 (enExample) |
| EA (1) | EA026235B1 (enExample) |
| ES (1) | ES2624223T3 (enExample) |
| HK (1) | HK1211285A1 (enExample) |
| IL (1) | IL236005A0 (enExample) |
| IN (1) | IN2014MN02652A (enExample) |
| MX (1) | MX2014014766A (enExample) |
| NZ (2) | NZ724503A (enExample) |
| PL (1) | PL2861604T3 (enExample) |
| PT (1) | PT2861604T (enExample) |
| SG (1) | SG11201408047XA (enExample) |
| SI (1) | SI2861604T1 (enExample) |
| WO (1) | WO2013185103A1 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2859009T1 (sl) * | 2012-06-08 | 2017-12-29 | Gilead Sciences, Inc. | Makrociklični inhibitorji flaviviridae virusov |
| AR091279A1 (es) * | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| IN2014MN02652A (enExample) | 2012-06-08 | 2015-08-21 | Gilead Sciences Inc | |
| WO2016106050A1 (en) | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| SG11201606876RA (en) | 2015-03-04 | 2016-10-28 | Gilead Sciences Inc | Toll like receptor modulator compounds |
| US20170008785A1 (en) * | 2015-07-07 | 2017-01-12 | Nch Corporation | System and Method for Treating Water with a Biological Based Biocide |
| MA42684A (fr) | 2015-08-26 | 2018-07-04 | Gilead Sciences Inc | Modulateurs deutérés du récepteur toll |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| CN121974842A (zh) | 2016-05-10 | 2026-05-05 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| ES2969239T3 (es) | 2016-05-27 | 2024-05-17 | Gilead Sciences Inc | Combinación de ledipasvir y sofosbuvir para su uso en el tratamiento de infecciones por el virus de la hepatitis B en humanos |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| SI3507276T1 (sl) | 2016-09-02 | 2022-01-31 | Gilead Sciences, Inc. | Spojine modulatorja toličnih receptorjev |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| KR20230010826A (ko) | 2016-10-14 | 2023-01-19 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| US10961213B2 (en) | 2017-01-25 | 2021-03-30 | Basf Se | Process for preparation of benzylic amides |
| TWI714820B (zh) | 2017-01-31 | 2021-01-01 | 美商基利科學股份有限公司 | 替諾福韋艾拉酚胺(tenofovir alafenamide)之晶型 |
| UY37581A (es) | 2017-02-02 | 2018-08-31 | Gilead Sciences Inc | Compuestos para el tratamiento de la infección por virus de la hepatitis b |
| CA3056970A1 (en) | 2017-03-21 | 2018-09-27 | Bayer Pharma Aktiengesellschaft | 2-methyl-quinazolines |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| EP4717317A3 (en) | 2017-06-20 | 2026-06-03 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| CN109384727B (zh) * | 2017-08-10 | 2023-07-28 | 中国科学院上海药物研究所 | 酞嗪酮类化合物、其制备方法、药物组合物及用途 |
| KR102891807B1 (ko) | 2017-08-22 | 2025-12-01 | 길리애드 사이언시즈, 인코포레이티드 | 치료 헤테로시클릭 화합물 |
| RU2020116571A (ru) | 2017-12-07 | 2021-11-22 | Эмори Юниверсити | N4-гидроксицитидин и производные и связанные с этим противовирусные применения |
| CR20200263A (es) | 2017-12-13 | 2020-07-26 | Lupin Ltd | Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5 |
| JP7037667B2 (ja) | 2017-12-20 | 2022-03-16 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． | Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する３’３’環状ジヌクレオチド |
| US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| EP3781565A1 (en) | 2018-04-18 | 2021-02-24 | Bayer Pharma Aktiengesellschaft | 2-methyl-aza-quinazolines |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| CN112384505B (zh) | 2018-07-06 | 2025-05-27 | 吉利德科学公司 | 治疗性的杂环化合物 |
| AU2019297428C1 (en) | 2018-07-06 | 2023-03-23 | Gilead Sciences, Inc. | Therapeutic heterocyclic compounds |
| PE20210642A1 (es) | 2018-07-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores de pd-1/pd-l1 |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| EP3873608A1 (en) | 2018-10-31 | 2021-09-08 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
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-
2013
- 2013-06-07 IN IN2652MUN2014 patent/IN2014MN02652A/en unknown
- 2013-06-07 AU AU2013270672A patent/AU2013270672B2/en not_active Ceased
- 2013-06-07 WO PCT/US2013/044826 patent/WO2013185103A1/en not_active Ceased
- 2013-06-07 HK HK15111999.1A patent/HK1211285A1/xx unknown
- 2013-06-07 MX MX2014014766A patent/MX2014014766A/es unknown
- 2013-06-07 PT PT137312039T patent/PT2861604T/pt unknown
- 2013-06-07 CN CN201380039194.XA patent/CN104703991B/zh not_active Expired - Fee Related
- 2013-06-07 JP JP2015516260A patent/JP6209601B2/ja not_active Expired - Fee Related
- 2013-06-07 PL PL13731203T patent/PL2861604T3/pl unknown
- 2013-06-07 KR KR1020157000171A patent/KR20150040265A/ko not_active Withdrawn
- 2013-06-07 BR BR112014030630A patent/BR112014030630A2/pt not_active Application Discontinuation
- 2013-06-07 SG SG11201408047XA patent/SG11201408047XA/en unknown
- 2013-06-07 NZ NZ724503A patent/NZ724503A/en not_active IP Right Cessation
- 2013-06-07 CA CA2875692A patent/CA2875692A1/en not_active Abandoned
- 2013-06-07 EP EP13731203.9A patent/EP2861604B1/en not_active Not-in-force
- 2013-06-07 US US13/913,259 patent/US9145441B2/en not_active Ceased
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- 2013-06-07 EA EA201492209A patent/EA026235B1/ru not_active IP Right Cessation
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