TWI523658B - 巨環脯胺酸衍生之ｈｃｖ絲胺酸蛋白酶抑制劑 - Google Patents

巨環脯胺酸衍生之ｈｃｖ絲胺酸蛋白酶抑制劑 Download PDF

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TWI523658B
TWI523658B TW100133824A TW100133824A TWI523658B TW I523658 B TWI523658 B TW I523658B TW 100133824 A TW100133824 A TW 100133824A TW 100133824 A TW100133824 A TW 100133824A TW I523658 B TWI523658 B TW I523658B
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substituted
group
compound
cycloalkyl
mmol
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TW100133824A
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TW201216979A (en
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柯日新
馬俊
王國強
龍江
王冰
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安塔製藥公司
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
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    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW100133824A 2010-09-21 2011-09-20 巨環脯胺酸衍生之ｈｃｖ絲胺酸蛋白酶抑制劑 TWI523658B (zh)

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US38505810P 2010-09-21 2010-09-21
US201161499994P 2011-06-22 2011-06-22
US201161504616P 2011-07-05 2011-07-05

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TW201216979A TW201216979A (en) 2012-05-01
TWI523658B true TWI523658B (zh) 2016-03-01

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