JP2013536803A5 - - Google Patents
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- Publication number
- JP2013536803A5 JP2013536803A5 JP2013526210A JP2013526210A JP2013536803A5 JP 2013536803 A5 JP2013536803 A5 JP 2013536803A5 JP 2013526210 A JP2013526210 A JP 2013526210A JP 2013526210 A JP2013526210 A JP 2013526210A JP 2013536803 A5 JP2013536803 A5 JP 2013536803A5
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- polyethylene glycol
- poly
- rna
- immunogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002502 liposome Substances 0.000 claims description 44
- 150000002632 lipids Chemical class 0.000 claims description 20
- 229920001223 polyethylene glycol Polymers 0.000 claims description 20
- 239000002202 Polyethylene glycol Substances 0.000 claims description 15
- 230000002163 immunogen Effects 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 10
- 125000003827 glycol group Chemical group 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 108700026244 Open Reading Frames Proteins 0.000 claims description 6
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- 125000002947 alkylene group Chemical group 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- 125000005842 heteroatom Chemical group 0.000 claims description 5
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 4
- 150000001721 carbon Chemical group 0.000 claims description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 150000002466 imines Chemical class 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 150000004713 phosphodiesters Chemical class 0.000 claims description 4
- 238000006116 polymerization reaction Methods 0.000 claims description 4
- 150000003431 steroids Chemical class 0.000 claims description 4
- 150000003568 thioethers Chemical class 0.000 claims description 4
- 239000012991 xanthate Substances 0.000 claims description 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- ZOOODBUHSVUZEM-UHFFFAOYSA-N ethoxymethanedithioic acid Chemical compound CCOC(S)=S ZOOODBUHSVUZEM-UHFFFAOYSA-N 0.000 claims description 3
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims description 3
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims description 3
- 229920000223 polyglycerol Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 3
- 241000710929 Alphavirus Species 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- 108060004795 Methyltransferase Proteins 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 235000012000 cholesterol Nutrition 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 244000045947 parasite Species 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- NFQBIAXADRDUGK-KWXKLSQISA-N n,n-dimethyl-2,3-bis[(9z,12z)-octadeca-9,12-dienoxy]propan-1-amine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/C\C=C/CCCCC NFQBIAXADRDUGK-KWXKLSQISA-N 0.000 claims 2
- XLPHMKQBBCKEFO-UHFFFAOYSA-N 2-azaniumylethyl 2,3-bis(3,7,11,15-tetramethylhexadecanoyloxy)propyl phosphate Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CC(C)CCCC(C)CCCC(C)CCCC(C)C XLPHMKQBBCKEFO-UHFFFAOYSA-N 0.000 claims 1
- XLPHMKQBBCKEFO-DHYROEPTSA-N 2-azaniumylethyl [(2r)-2,3-bis(3,7,11,15-tetramethylhexadecanoyloxy)propyl] phosphate Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CC(C)CCCC(C)CCCC(C)CCCC(C)C XLPHMKQBBCKEFO-DHYROEPTSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- SUHOQUVVVLNYQR-MRVPVSSYSA-O glycerylphosphorylcholine Chemical compound C[N+](C)(C)CCO[P@](O)(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-O 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229920002187 poly[N-2-(hydroxypropyl) methacrylamide] polymer Polymers 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- 235000013877 carbamide Nutrition 0.000 description 3
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 description 2
- 229920001308 poly(aminoacid) Polymers 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 0 CC(C)(*CC*C(C*)CN)N Chemical compound CC(C)(*CC*C(C*)CN)N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37882610P | 2010-08-31 | 2010-08-31 | |
| US61/378,826 | 2010-08-31 | ||
| PCT/US2011/050095 WO2012031043A1 (en) | 2010-08-31 | 2011-08-31 | Pegylated liposomes for delivery of immunogen-encoding rna |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536803A JP2013536803A (ja) | 2013-09-26 |
| JP2013536803A5 true JP2013536803A5 (enExample) | 2014-10-16 |
| JP5911870B2 JP5911870B2 (ja) | 2016-04-27 |
Family
ID=44653554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526210A Active JP5911870B2 (ja) | 2010-08-31 | 2011-08-31 | 免疫原をコードするｒｎａの送達のためのｐｅｇ化リポソーム |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20130202684A1 (enExample) |
| EP (11) | EP2611461B1 (enExample) |
| JP (1) | JP5911870B2 (enExample) |
| CN (1) | CN103179984A (enExample) |
| AU (1) | AU2011295935B2 (enExample) |
| BR (1) | BR112013004866A2 (enExample) |
| CA (1) | CA2809851A1 (enExample) |
| CY (3) | CY1125209T1 (enExample) |
| DK (7) | DK4066855T3 (enExample) |
| ES (7) | ES2938327T3 (enExample) |
| FI (3) | FI4066855T3 (enExample) |
| HR (7) | HRP20220835T8 (enExample) |
| HU (7) | HUE058666T2 (enExample) |
| LT (7) | LT4066857T (enExample) |
| MX (1) | MX2013002336A (enExample) |
| PL (7) | PL3981427T3 (enExample) |
| PT (7) | PT4066857T (enExample) |
| RS (6) | RS63315B1 (enExample) |
| RU (1) | RU2013114362A (enExample) |
| SI (7) | SI3981427T1 (enExample) |
| SM (6) | SMT202300075T1 (enExample) |
| WO (1) | WO2012031043A1 (enExample) |
Families Citing this family (262)
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| BR112013000244A2 (pt) | 2010-07-06 | 2016-05-17 | Novartis Ag | lipossomas com lipídeos apresentando pka vantajoso para administração de rna |
| PL2590676T3 (pl) | 2010-07-06 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Wirionopodobne cząstki dostarczające dla autoreplikujących się cząsteczek rna |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
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2022
- 2022-05-31 CY CY20221100375T patent/CY1125209T1/el unknown
- 2022-06-29 CY CY20221100448T patent/CY1125575T1/el unknown
- 2022-07-19 CY CY20221100491T patent/CY1125492T1/el unknown
-
2023
- 2023-07-25 US US18/225,749 patent/US20240216276A1/en active Pending
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