JP2013533885A5 - - Google Patents
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- Publication number
- JP2013533885A5 JP2013533885A5 JP2013518779A JP2013518779A JP2013533885A5 JP 2013533885 A5 JP2013533885 A5 JP 2013533885A5 JP 2013518779 A JP2013518779 A JP 2013518779A JP 2013518779 A JP2013518779 A JP 2013518779A JP 2013533885 A5 JP2013533885 A5 JP 2013533885A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- carbocycle
- aryl
- heteroaryl
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 439
- 125000000623 heterocyclic group Chemical group 0.000 claims description 294
- 125000001072 heteroaryl group Chemical group 0.000 claims description 262
- 125000003118 aryl group Chemical group 0.000 claims description 252
- 125000001188 haloalkyl group Chemical group 0.000 claims description 201
- 125000003342 alkenyl group Chemical group 0.000 claims description 185
- 125000000304 alkynyl group Chemical group 0.000 claims description 181
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 64
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 56
- 150000001875 compounds Chemical class 0.000 claims description 49
- 125000002619 bicyclic group Chemical group 0.000 claims description 46
- 125000005843 halogen group Chemical group 0.000 claims description 45
- 150000003839 salts Chemical class 0.000 claims description 31
- 125000004429 atom Chemical group 0.000 claims description 28
- 125000002837 carbocyclic group Chemical group 0.000 claims description 24
- 125000001475 halogen functional group Chemical group 0.000 claims description 23
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- 150000002367 halogens Chemical class 0.000 claims description 14
- 208000030507 AIDS Diseases 0.000 claims description 13
- 125000005217 alkenylheteroaryl group Chemical group 0.000 claims description 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 13
- 125000004043 oxo group Chemical group O=* 0.000 claims description 12
- -1 -OH Chemical group 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 125000000464 thioxo group Chemical group S=* 0.000 claims description 8
- 125000001963 4 membered heterocyclic group Chemical group 0.000 claims description 6
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 6
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 6
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims description 6
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 6
- 230000012010 growth Effects 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims description 5
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000000069 prophylactic effect Effects 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 35
- 125000006736 (C6-C20) aryl group Chemical group 0.000 claims 29
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 16
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 13
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 12
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 11
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052717 sulfur Chemical group 0.000 claims 2
- 239000011593 sulfur Chemical group 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 125000005025 alkynylaryl group Chemical group 0.000 description 10
- 125000005024 alkenyl aryl group Chemical group 0.000 description 8
- 241000124008 Mammalia Species 0.000 description 3
- 125000002877 alkyl aryl group Chemical group 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 0 C*(C)Cc1nc2cc(C)c([C@@](C(C=O)=O)OC(C)(C)C)c(-c(cc3)c4nccc5c4c3OCC5)c2cc1 Chemical compound C*(C)Cc1nc2cc(C)c([C@@](C(C=O)=O)OC(C)(C)C)c(-c(cc3)c4nccc5c4c3OCC5)c2cc1 0.000 description 1
- AFBJHLBWIKNGAZ-MUUNZHRXSA-N CC(C)(C)O[C@H](C(C=O)=O)c(c(C)cc1nc(C)ccc11)c1-c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)O[C@H](C(C=O)=O)c(c(C)cc1nc(C)ccc11)c1-c(cc1)c2nccc3c2c1OCC3 AFBJHLBWIKNGAZ-MUUNZHRXSA-N 0.000 description 1
- IYLQLCOPSLTWQK-RUZDIDTESA-N CC(C)(C)O[C@H](C(C=O)=O)c1c(C)cc2nc(C3CC3)ccc2c1-c(cc1)ccc1Cl Chemical compound CC(C)(C)O[C@H](C(C=O)=O)c1c(C)cc2nc(C3CC3)ccc2c1-c(cc1)ccc1Cl IYLQLCOPSLTWQK-RUZDIDTESA-N 0.000 description 1
- RBXJIHNVSYSXDY-MUUNZHRXSA-N CC(C)(C)O[C@H](C(C=O)=O)c1c(C)cc2nc(CO)ccc2c1-c(cc1)c2nccc3c2c1OCC3 Chemical compound CC(C)(C)O[C@H](C(C=O)=O)c1c(C)cc2nc(CO)ccc2c1-c(cc1)c2nccc3c2c1OCC3 RBXJIHNVSYSXDY-MUUNZHRXSA-N 0.000 description 1
- SSVTZMSLDASXIF-SANMLTNESA-N CC(C)(C)O[C@H](C(O)=O)c(c(-c(cc1)ccc1Cl)c1cc2)c(C)cc1nc2-c(cc1)ccc1Cl Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(-c(cc1)ccc1Cl)c1cc2)c(C)cc1nc2-c(cc1)ccc1Cl SSVTZMSLDASXIF-SANMLTNESA-N 0.000 description 1
- KFRFCFKOQQJYSG-QFIPXVFZSA-N CC(C)(C)O[C@H](C(O)=O)c(c(-c(cc1)ccc1Cl)c1cc2)c(C)cc1nc2C(N(C)C)=O Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(-c(cc1)ccc1Cl)c1cc2)c(C)cc1nc2C(N(C)C)=O KFRFCFKOQQJYSG-QFIPXVFZSA-N 0.000 description 1
- LQDRGHYZERBNGN-FQEVSTJZSA-N CC(C)(C)O[C@H](C(O)=O)c(c(-c(cc1)ccc1Cl)c1cc2)c(C)cc1nc2C(O)=O Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(-c(cc1)ccc1Cl)c1cc2)c(C)cc1nc2C(O)=O LQDRGHYZERBNGN-FQEVSTJZSA-N 0.000 description 1
- LPZBDJPIJJTEKX-DEOSSOPVSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c(cc2)c1nc2N1CCOCC1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)c1)c(-c(cc2)ccc2Cl)c(cc2)c1nc2N1CCOCC1 LPZBDJPIJJTEKX-DEOSSOPVSA-N 0.000 description 1
- OWWOGEAVFSEGSB-QHCPKHFHSA-N CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c2ccc(NC3CC3)nc2cc1C Chemical compound CC(C)(C)O[C@H](C(O)=O)c1c(-c(cc2)ccc2Cl)c2ccc(NC3CC3)nc2cc1C OWWOGEAVFSEGSB-QHCPKHFHSA-N 0.000 description 1
- DSNONLCGUJYAQZ-XMMPIXPASA-N CCOC(c1nc2cc(C)c([C@@H](C(CO)=O)OC(C)(C)C)c(-c(cc3)ccc3Cl)c2cc1)=O Chemical compound CCOC(c1nc2cc(C)c([C@@H](C(CO)=O)OC(C)(C)C)c(-c(cc3)ccc3Cl)c2cc1)=O DSNONLCGUJYAQZ-XMMPIXPASA-N 0.000 description 1
- RDEURQJNIGNEBG-QHCPKHFHSA-N CCOCc1nc2cc(C)c([C@@H](C(O)=O)OC(C)(C)C)c(-c(cc3)ccc3Cl)c2cc1 Chemical compound CCOCc1nc2cc(C)c([C@@H](C(O)=O)OC(C)(C)C)c(-c(cc3)ccc3Cl)c2cc1 RDEURQJNIGNEBG-QHCPKHFHSA-N 0.000 description 1
- XCSVJZXYCMFNMZ-QFIPXVFZSA-N CCc1nc2cc(C)c([C@@H](C(O)=O)OC(C)(C)C)c(-c(cc3)ccc3Cl)c2cc1 Chemical compound CCc1nc2cc(C)c([C@@H](C(O)=O)OC(C)(C)C)c(-c(cc3)ccc3Cl)c2cc1 XCSVJZXYCMFNMZ-QFIPXVFZSA-N 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36133510P | 2010-07-02 | 2010-07-02 | |
| US61/361,335 | 2010-07-02 | ||
| PCT/US2011/042881 WO2012003498A1 (en) | 2010-07-02 | 2011-07-01 | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015138380A Division JP2015180696A (ja) | 2010-07-02 | 2015-07-10 | Ｈｉｖ抗ウイルス化合物としての２−キノリニル−酢酸誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533885A JP2013533885A (ja) | 2013-08-29 |
| JP2013533885A5 true JP2013533885A5 (enExample) | 2014-08-14 |
| JP5806735B2 JP5806735B2 (ja) | 2015-11-10 |
Family
ID=44508471
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518779A Active JP5806735B2 (ja) | 2010-07-02 | 2011-07-01 | Ｈｉｖ抗ウイルス化合物としての２−キノリニル−酢酸誘導体 |
| JP2015138380A Withdrawn JP2015180696A (ja) | 2010-07-02 | 2015-07-10 | Ｈｉｖ抗ウイルス化合物としての２−キノリニル−酢酸誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015138380A Withdrawn JP2015180696A (ja) | 2010-07-02 | 2015-07-10 | Ｈｉｖ抗ウイルス化合物としての２−キノリニル−酢酸誘導体 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9296758B2 (enExample) |
| EP (1) | EP2588455B1 (enExample) |
| JP (2) | JP5806735B2 (enExample) |
| KR (1) | KR20130124291A (enExample) |
| CN (1) | CN103209963A (enExample) |
| AP (1) | AP2013006707A0 (enExample) |
| AR (1) | AR082080A1 (enExample) |
| AU (1) | AU2011274323B2 (enExample) |
| BR (1) | BR112012033689A2 (enExample) |
| CA (1) | CA2802492C (enExample) |
| CL (1) | CL2012003723A1 (enExample) |
| CO (1) | CO6660514A2 (enExample) |
| CR (1) | CR20130043A (enExample) |
| EA (1) | EA201291301A1 (enExample) |
| EC (1) | ECSP13012418A (enExample) |
| ES (1) | ES2669793T3 (enExample) |
| MA (1) | MA34400B1 (enExample) |
| MX (1) | MX2012015293A (enExample) |
| NZ (1) | NZ604716A (enExample) |
| PE (1) | PE20130525A1 (enExample) |
| PH (1) | PH12013500015A1 (enExample) |
| PT (1) | PT2588455T (enExample) |
| SG (1) | SG186821A1 (enExample) |
| TW (1) | TWI458711B (enExample) |
| UY (1) | UY33479A (enExample) |
| WO (1) | WO2012003498A1 (enExample) |
| ZA (1) | ZA201209602B (enExample) |
Families Citing this family (161)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ593110A (en) | 2008-12-09 | 2013-06-28 | Gilead Sciences Inc | pteridinone derivatives as MODULATORS OF TOLL-LIKE RECEPTORS |
| WO2012003498A1 (en) | 2010-07-02 | 2012-01-05 | Gilead Sciences, Inc. | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
| MA34397B1 (fr) | 2010-07-02 | 2013-07-03 | Gilead Sciences Inc | Dérivés d'acide napht-2-ylacétique dans le traitement du sida |
| EP2511273B8 (en) * | 2011-04-15 | 2019-06-26 | Hivih | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| WO2012145728A1 (en) | 2011-04-21 | 2012-10-26 | Gilead Sciences, Inc. | Benzothiazole compounds and their pharmaceutical use |
| PT2729448E (pt) | 2011-07-06 | 2015-12-02 | Gilead Sciences Inc | Compostos para o tratamento de vih |
| US8791108B2 (en) | 2011-08-18 | 2014-07-29 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| JP6099149B2 (ja) | 2011-10-25 | 2017-03-22 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害剤 |
| CA2860015C (en) | 2011-12-22 | 2020-07-07 | Universite Laval | Three-dimensional cavities of dendritic cell immunoreceptor (dcir), compounds binding thereto and therapeutic applications related to inhibition of human immunodeficiency virus type-1 (hiv-1) |
| WO2013103738A1 (en) * | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| WO2013103724A1 (en) * | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
| US8629276B2 (en) | 2012-02-15 | 2014-01-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9034882B2 (en) | 2012-03-05 | 2015-05-19 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP3070081B1 (en) | 2012-04-20 | 2018-02-28 | Gilead Sciences, Inc. | Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection |
| EP2662379A1 (en) * | 2012-05-07 | 2013-11-13 | Universiteit Antwerpen | Recycling of organotin compounds |
| US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2719685A1 (en) | 2012-10-11 | 2014-04-16 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| DK3067358T3 (da) | 2012-12-21 | 2019-11-04 | Gilead Sciences Inc | Polycykliske carbamoylpyridon-forbindelser og deres farmaceutiske anvendelse |
| NZ727792A (en) | 2013-01-09 | 2018-04-27 | Gilead Sciences Inc | Therapeutic compounds |
| JP5941598B2 (ja) | 2013-01-09 | 2016-06-29 | ギリアード サイエンシーズ， インコーポレイテッド | ５員ヘテロアリールおよびそれらの抗ウイルス剤としての使用 |
| TW201443037A (zh) | 2013-01-09 | 2014-11-16 | Gilead Sciences Inc | 治療用化合物 |
| TW201441197A (zh) * | 2013-01-31 | 2014-11-01 | Shionogi & Co | Ｈｉｖ複製抑制劑 |
| TWI694071B (zh) | 2013-03-01 | 2020-05-21 | 美商基利科學股份有限公司 | 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物 |
| ES2623777T3 (es) | 2013-03-13 | 2017-07-12 | VIIV Healthcare UK (No.5) Limited | Inhibidores de la replicación del virus de la inmunodeficiencia humana |
| WO2014164467A1 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| WO2014164428A1 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| CN105189503B (zh) | 2013-03-14 | 2017-03-22 | 百时美施贵宝公司 | 人免疫缺陷病毒复制的抑制剂 |
| EP2970297A1 (en) | 2013-03-14 | 2016-01-20 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2821082A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use |
| EP2821104A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| PL3019503T3 (pl) | 2013-07-12 | 2018-01-31 | Gilead Sciences Inc | Policykliczne związki karbamoilopirydonowe i ich zastosowanie do leczenia infekcji hiv |
| NO2865735T3 (enExample) | 2013-07-12 | 2018-07-21 | ||
| US9944656B2 (en) | 2014-02-12 | 2018-04-17 | VIIV Healthcare UK (No.5) Limited | Benzothiazole macrocycles as inhibitors of human immunodeficiency virus replication |
| WO2015126743A1 (en) | 2014-02-18 | 2015-08-27 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9409922B2 (en) | 2014-02-18 | 2016-08-09 | Bristol-Myers Squibb Company | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication |
| EP3116879A1 (en) | 2014-02-18 | 2017-01-18 | VIIV Healthcare UK (No.5) Limited | Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9273067B2 (en) | 2014-02-19 | 2016-03-01 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| PT3107913T (pt) | 2014-02-19 | 2018-09-28 | Viiv Healthcare Uk No 5 Ltd | Inibidores da replicação do vírus da imunodeficiência humana |
| US10202353B2 (en) | 2014-02-28 | 2019-02-12 | Gilead Sciences, Inc. | Therapeutic compounds |
| WO2015147247A1 (ja) * | 2014-03-28 | 2015-10-01 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害作用を有する３環性誘導体 |
| JP6579549B2 (ja) * | 2014-05-16 | 2019-09-25 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害作用を有する３環性複素環誘導体 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (enExample) | 2014-06-20 | 2018-06-23 | ||
| EA201790024A1 (ru) | 2014-07-11 | 2017-07-31 | Джилид Сайэнс, Инк. | Модуляторы toll-подобных рецепторов для лечения вич |
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| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
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| ES2705709T3 (es) | 2014-12-24 | 2019-03-26 | Gilead Sciences Inc | Compuestos de isoquinolina para el tratamiento del VIH |
| TWI770552B (zh) | 2014-12-24 | 2022-07-11 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
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2011
- 2011-07-01 WO PCT/US2011/042881 patent/WO2012003498A1/en not_active Ceased
- 2011-07-01 UY UY0001033479A patent/UY33479A/es not_active Application Discontinuation
- 2011-07-01 AR ARP110102377A patent/AR082080A1/es not_active Application Discontinuation
- 2011-07-01 JP JP2013518779A patent/JP5806735B2/ja active Active
- 2011-07-01 CN CN2011800384434A patent/CN103209963A/zh active Pending
- 2011-07-01 PH PH1/2013/500015A patent/PH12013500015A1/en unknown
- 2011-07-01 ES ES11738339.8T patent/ES2669793T3/es active Active
- 2011-07-01 EA EA201291301A patent/EA201291301A1/ru unknown
- 2011-07-01 PT PT117383398T patent/PT2588455T/pt unknown
- 2011-07-01 PE PE2012002650A patent/PE20130525A1/es not_active Application Discontinuation
- 2011-07-01 KR KR1020137002776A patent/KR20130124291A/ko not_active Withdrawn
- 2011-07-01 MX MX2012015293A patent/MX2012015293A/es not_active Application Discontinuation
- 2011-07-01 EP EP11738339.8A patent/EP2588455B1/en active Active
- 2011-07-01 MA MA35610A patent/MA34400B1/fr unknown
- 2011-07-01 US US13/806,048 patent/US9296758B2/en active Active
- 2011-07-01 SG SG2012095428A patent/SG186821A1/en unknown
- 2011-07-01 CA CA2802492A patent/CA2802492C/en active Active
- 2011-07-01 TW TW100123358A patent/TWI458711B/zh not_active IP Right Cessation
- 2011-07-01 AP AP2013006707A patent/AP2013006707A0/xx unknown
- 2011-07-01 BR BR112012033689A patent/BR112012033689A2/pt not_active IP Right Cessation
- 2011-07-01 AU AU2011274323A patent/AU2011274323B2/en active Active
- 2011-07-01 NZ NZ604716A patent/NZ604716A/en unknown
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2012
- 2012-12-18 ZA ZA2012/09602A patent/ZA201209602B/en unknown
- 2012-12-28 CL CL2012003723A patent/CL2012003723A1/es unknown
- 2012-12-28 CO CO12236158A patent/CO6660514A2/es not_active Application Discontinuation
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2013
- 2013-01-29 CR CR20130043A patent/CR20130043A/es unknown
- 2013-02-04 EC ECSP13012418 patent/ECSP13012418A/es unknown
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2015
- 2015-07-10 JP JP2015138380A patent/JP2015180696A/ja not_active Withdrawn
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