JP2013545820A5 - - Google Patents
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- Publication number
- JP2013545820A5 JP2013545820A5 JP2013544824A JP2013544824A JP2013545820A5 JP 2013545820 A5 JP2013545820 A5 JP 2013545820A5 JP 2013544824 A JP2013544824 A JP 2013544824A JP 2013544824 A JP2013544824 A JP 2013544824A JP 2013545820 A5 JP2013545820 A5 JP 2013545820A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- occurrence
- alkyl
- phosphonoxy
- phosphono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 phosphonoxy Chemical group 0.000 claims 133
- 125000000623 heterocyclic group Chemical group 0.000 claims 64
- 125000004093 cyano group Chemical group *C#N 0.000 claims 56
- 229910052736 halogen Inorganic materials 0.000 claims 56
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 56
- 150000002367 halogens Chemical class 0.000 claims 55
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 48
- 125000001424 substituent group Chemical group 0.000 claims 40
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 38
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 36
- 125000004043 oxo group Chemical group O=* 0.000 claims 36
- 150000001875 compounds Chemical class 0.000 claims 35
- 150000003839 salts Chemical class 0.000 claims 34
- 125000004429 atom Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- 125000004452 carbocyclyl group Chemical group 0.000 claims 10
- 125000002837 carbocyclic group Chemical group 0.000 claims 9
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 8
- 125000006714 (C3-C10) heterocyclyl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940124683 HCV polymerase inhibitor Drugs 0.000 claims 1
- 229940122604 HCV protease inhibitor Drugs 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000232 haloalkynyl group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 0 CC(*1)=Nc2c1ccc(C)c2 Chemical compound CC(*1)=Nc2c1ccc(C)c2 0.000 description 14
- LLPKQRMDOFYSGZ-UHFFFAOYSA-N Cc1cnc(C)[nH]1 Chemical compound Cc1cnc(C)[nH]1 LLPKQRMDOFYSGZ-UHFFFAOYSA-N 0.000 description 3
- BMCNOECRVMTSHG-TWGQIWQCSA-N CCC(CI)N/C=C(/C(C)C)\N Chemical compound CCC(CI)N/C=C(/C(C)C)\N BMCNOECRVMTSHG-TWGQIWQCSA-N 0.000 description 1
- SEDSLMWYUQACGR-UHFFFAOYSA-N Cc1nc(I)c[nH]1 Chemical compound Cc1nc(I)c[nH]1 SEDSLMWYUQACGR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42390010P | 2010-12-16 | 2010-12-16 | |
| US61/423,900 | 2010-12-16 | ||
| PCT/US2011/065486 WO2012083164A1 (en) | 2010-12-16 | 2011-12-16 | Anti-viral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013545820A JP2013545820A (ja) | 2013-12-26 |
| JP2013545820A5 true JP2013545820A5 (enExample) | 2015-02-12 |
Family
ID=45478542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544824A Pending JP2013545820A (ja) | 2010-12-16 | 2011-12-16 | 抗ウイルス性化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20120115918A1 (enExample) |
| EP (1) | EP2651924A1 (enExample) |
| JP (1) | JP2013545820A (enExample) |
| CN (1) | CN103384664A (enExample) |
| CA (1) | CA2821973A1 (enExample) |
| MX (1) | MX2013006828A (enExample) |
| WO (1) | WO2012083164A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010075376A2 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| WO2010075380A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| EP2419404B1 (en) | 2009-04-15 | 2015-11-04 | AbbVie Inc. | Anti-viral compounds |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| CA2841095A1 (en) | 2011-07-09 | 2013-01-17 | Sunshine Lake Pharma Co., Ltd. | Spiro compounds as hepatitis c virus inhibitors |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TWI610916B (zh) | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| WO2014082380A1 (en) | 2012-11-29 | 2014-06-05 | Sunshine Lake Pharma Co., Ltd. | Fused ring compounds as hepatitis c virus inhibitors, pharmaceutical compositions and uses thereof |
| TWI585082B (zh) | 2012-11-29 | 2017-06-01 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的螺環化合物、藥物組合物及它們的用途 |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| CN105530933B (zh) | 2013-07-17 | 2018-12-11 | 百时美施贵宝公司 | 用于治疗hcv的包含联苯衍生物的组合产品 |
| DK3043803T3 (da) | 2013-09-11 | 2022-08-01 | Univ Emory | Nukleotid- og nucleosidsammensætninger og deres anvendelse |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| US9738629B2 (en) | 2014-01-23 | 2017-08-22 | Sunshine Lake Pharma Co., Ltd. | Bridged ring compounds as Hepatitis C virus inhibitors, pharmaceutical compositions and uses thereof |
| WO2017023631A1 (en) | 2015-08-06 | 2017-02-09 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US7906655B2 (en) * | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TWI438200B (zh) * | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| WO2010096777A1 (en) * | 2009-02-23 | 2010-08-26 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| US8796466B2 (en) * | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2419404B1 (en) * | 2009-04-15 | 2015-11-04 | AbbVie Inc. | Anti-viral compounds |
| US8138215B2 (en) * | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2454254A2 (en) * | 2009-07-16 | 2012-05-23 | Vertex Pharmaceuticals Incorporated | Benzimidazole analogues for the treatment or prevention of flavivirus infections |
-
2011
- 2011-12-16 MX MX2013006828A patent/MX2013006828A/es not_active Application Discontinuation
- 2011-12-16 JP JP2013544824A patent/JP2013545820A/ja active Pending
- 2011-12-16 US US13/328,767 patent/US20120115918A1/en not_active Abandoned
- 2011-12-16 CA CA2821973A patent/CA2821973A1/en not_active Abandoned
- 2011-12-16 CN CN2011800677647A patent/CN103384664A/zh active Pending
- 2011-12-16 EP EP11808486.2A patent/EP2651924A1/en not_active Withdrawn
- 2011-12-16 WO PCT/US2011/065486 patent/WO2012083164A1/en not_active Ceased
-
2013
- 2013-11-22 US US14/087,480 patent/US20140155382A1/en not_active Abandoned
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