JP2012524100A5 - - Google Patents

Info

Publication number

JP2012524100A5

JP2012524100A5 JP2012506183A JP2012506183A JP2012524100A5 JP 2012524100 A5 JP2012524100 A5 JP 2012524100A5 JP 2012506183 A JP2012506183 A JP 2012506183A JP 2012506183 A JP2012506183 A JP 2012506183A JP 2012524100 A5 JP2012524100 A5 JP 2012524100A5

Authority

JP

Japan

Prior art keywords

independently

case

phosphonoxy

thioxo

phosphono

Prior art date

2010-04-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• -1 phosphonoxy Chemical group 0.000 claims 101
• 125000000623 heterocyclic group Chemical group 0.000 claims 59
• 125000004093 cyano group Chemical group *C#N 0.000 claims 51
• 229910052736 halogen Inorganic materials 0.000 claims 51
• 150000002367 halogens Chemical class 0.000 claims 51
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 51
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 45
• 125000001424 substituent group Chemical group 0.000 claims 37
• 125000004043 oxo group Chemical group O=* 0.000 claims 34
• 150000001875 compounds Chemical class 0.000 claims 24
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 21
• 125000004429 atom Chemical group 0.000 claims 19
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 18
• 150000003839 salts Chemical class 0.000 claims 18
• 229910052739 hydrogen Inorganic materials 0.000 claims 16
• 239000001257 hydrogen Substances 0.000 claims 16
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 9
• 125000003627 8 membered carbocyclic group Chemical group 0.000 claims 8
• SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 8
• 125000002837 carbocyclic group Chemical group 0.000 claims 4
• 150000002431 hydrogen Chemical class 0.000 claims 4
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
• 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 claims 3
• 125000002619 bicyclic group Chemical group 0.000 claims 3
• 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 2
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
• 125000005843 halogen group Chemical group 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
• 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 125000000464 thioxo group Chemical group S=* 0.000 claims 1
• 0 ***C**(CCNC*N)C(C=C)O Chemical compound ***C**(CCNC*N)C(C=C)O 0.000 description 3