JP2011503118A5 - - Google Patents
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- Publication number
- JP2011503118A5 JP2011503118A5 JP2010533395A JP2010533395A JP2011503118A5 JP 2011503118 A5 JP2011503118 A5 JP 2011503118A5 JP 2010533395 A JP2010533395 A JP 2010533395A JP 2010533395 A JP2010533395 A JP 2010533395A JP 2011503118 A5 JP2011503118 A5 JP 2011503118A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- haloalkyl
- het
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 118
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 32
- 125000003118 aryl group Chemical group 0.000 claims 30
- 125000005843 halogen group Chemical group 0.000 claims 28
- 125000000753 cycloalkyl group Chemical group 0.000 claims 25
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 16
- 125000000304 alkynyl group Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000001424 substituent group Chemical group 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 125000004043 oxo group Chemical group O=* 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 125000000464 thioxo group Chemical group S=* 0.000 claims 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- -1 Het Chemical group 0.000 claims 2
- 125000001118 alkylidene group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000000815 N-oxide group Chemical group 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- HWYHDWGGACRVEH-UHFFFAOYSA-N n-methyl-n-(4-pyrrolidin-1-ylbut-2-ynyl)acetamide Chemical group CC(=O)N(C)CC#CCN1CCCC1 HWYHDWGGACRVEH-UHFFFAOYSA-N 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98832707P | 2007-11-15 | 2007-11-15 | |
| US60/988,327 | 2007-11-15 | ||
| PCT/CA2008/001941 WO2009062289A1 (en) | 2007-11-15 | 2008-11-03 | Inhibitors of human immunodeficiency virus replication |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503118A JP2011503118A (ja) | 2011-01-27 |
| JP2011503118A5 true JP2011503118A5 (enExample) | 2011-12-22 |
| JP5269086B2 JP5269086B2 (ja) | 2013-08-21 |
Family
ID=40638278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533395A Active JP5269086B2 (ja) | 2007-11-15 | 2008-11-03 | ヒト免疫不全ウイルスの複製阻害薬 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8377960B2 (enExample) |
| EP (1) | EP2220076B1 (enExample) |
| JP (1) | JP5269086B2 (enExample) |
| AR (1) | AR069544A1 (enExample) |
| AT (1) | ATE541841T1 (enExample) |
| CA (1) | CA2705318C (enExample) |
| CY (1) | CY1112691T1 (enExample) |
| DK (1) | DK2220076T5 (enExample) |
| ES (1) | ES2381234T3 (enExample) |
| HR (1) | HRP20120328T2 (enExample) |
| PL (1) | PL2220076T3 (enExample) |
| PT (1) | PT2220076E (enExample) |
| SI (1) | SI2220076T1 (enExample) |
| TW (1) | TW200920744A (enExample) |
| WO (1) | WO2009062289A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5269086B2 (ja) | 2007-11-15 | 2013-08-21 | ギリアード サイエンシス インコーポレーテッド | ヒト免疫不全ウイルスの複製阻害薬 |
| NZ585226A (en) | 2007-11-16 | 2012-08-31 | Gilead Sciences Inc | Inhibitors of human immunodeficiency virus replication |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| TW201116212A (en) | 2009-10-29 | 2011-05-16 | Du Pont | Heterobicycle-substituted azolyl benzene fungicides |
| AP2013006706A0 (en) | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | Napht-2-ylacetic acid derivatives to treat AIDS |
| SG186821A1 (en) * | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
| US8633200B2 (en) | 2010-09-08 | 2014-01-21 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| NZ610315A (en) * | 2010-11-15 | 2015-08-28 | Univ Leuven Kath | Antiviral condensed heterocyclic compounds |
| EP2662357B1 (en) * | 2011-01-07 | 2016-08-03 | Taiho Pharmaceutical Co., Ltd. | Bicyclic compounds or salts thereof for use in the treatment of cancer |
| ES2589557T3 (es) | 2011-01-07 | 2016-11-15 | Taiho Pharmaceutical Co., Ltd. | Nuevos derivados de indol o indazol y sales de los mismos |
| JP2014511859A (ja) * | 2011-04-04 | 2014-05-19 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖインテグラーゼ阻害剤の調製のためのプロセス |
| EP2508511A1 (en) | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2511273B8 (en) | 2011-04-15 | 2019-06-26 | Hivih | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| SG194512A1 (en) | 2011-04-21 | 2013-12-30 | Gilead Sciences Inc | Benzothiazole compounds and their pharmaceutical use |
| US8791108B2 (en) | 2011-08-18 | 2014-07-29 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9199959B2 (en) | 2011-10-25 | 2015-12-01 | Shionogi & Co., Ltd. | HIV replication inhibitor |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US8629276B2 (en) | 2012-02-15 | 2014-01-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9034882B2 (en) | 2012-03-05 | 2015-05-19 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| CN105121418A (zh) | 2012-04-20 | 2015-12-02 | 吉利德科学公司 | 苯并噻唑-6-基乙酸衍生物及其治疗hiv感染的用途 |
| US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2716639A1 (en) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2716632A1 (en) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2719685A1 (en) | 2012-10-11 | 2014-04-16 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| TW201441197A (zh) | 2013-01-31 | 2014-11-01 | Shionogi & Co | Ｈｉｖ複製抑制劑 |
| EP2970298A1 (en) | 2013-03-13 | 2016-01-20 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| ES2619708T3 (es) | 2013-03-13 | 2017-06-26 | VIIV Healthcare UK (No.5) Limited | Inhibidores de la replicación del virus de inmunodeficiencia humana |
| JP2016512507A (ja) | 2013-03-13 | 2016-04-28 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヒト免疫不全ウイルス複製の阻害剤 |
| WO2014159959A1 (en) | 2013-03-14 | 2014-10-02 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| CN105008369B (zh) | 2013-03-14 | 2017-07-11 | 百时美施贵宝公司 | 人类免疫缺陷病毒复制抑制剂 |
| EP2821082A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use |
| EP2821104A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| US9897981B2 (en) * | 2013-10-01 | 2018-02-20 | Linear Technology Corporation | Detection and classification scheme for power over ethernet system |
| CN103788020B (zh) * | 2014-01-22 | 2015-11-04 | 苏州明锐医药科技有限公司 | 沃替西汀的制备方法 |
| ES2654242T3 (es) | 2014-02-12 | 2018-02-12 | Viiv Healthcare (No.5) Limited | Macrociclos de benzotiazol como inhibidores de la réplica del virus de la inmunodeficiencia humana |
| EP3116879A1 (en) | 2014-02-18 | 2017-01-18 | VIIV Healthcare UK (No.5) Limited | Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9409922B2 (en) | 2014-02-18 | 2016-08-09 | Bristol-Myers Squibb Company | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication |
| EP3152215A1 (en) | 2014-02-18 | 2017-04-12 | ViiV Healthcare UK (No.5) Limited | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| WO2015126765A1 (en) | 2014-02-19 | 2015-08-27 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9273067B2 (en) | 2014-02-19 | 2016-03-01 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9193720B2 (en) | 2014-02-20 | 2015-11-24 | Bristol-Myers Squibb Company | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| ES2670010T3 (es) | 2014-02-20 | 2018-05-29 | VIIV Healthcare UK (No.5) Limited | Macrociclos de ácido piridin-3-il acético como inhibidores de replicación del virus de inmunodeficiencia humana |
| WO2015147247A1 (ja) * | 2014-03-28 | 2015-10-01 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害作用を有する３環性誘導体 |
| WO2015174511A1 (ja) | 2014-05-16 | 2015-11-19 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害作用を有する３環性複素環誘導体 |
| SG11201709634QA (en) | 2015-05-29 | 2017-12-28 | Shionogi & Co | Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity |
| US20180170903A1 (en) | 2015-07-06 | 2018-06-21 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| EP3319957A1 (en) | 2015-07-08 | 2018-05-16 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| RU2018103031A (ru) | 2015-07-09 | 2019-08-09 | ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД | Производные пиридин-3-ил уксусной кислоты в качестве ингибиторов репликации вируса иммунодефицита человека |
| AU2016290986A1 (en) | 2015-07-09 | 2018-01-18 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| KR20180035910A (ko) | 2015-08-07 | 2018-04-06 | 비브 헬스케어 유케이 (넘버5) 리미티드 | 인간 면역결핍 바이러스 복제의 억제제로서 피리딘-3-일 아세트산 유도체 |
| CN108026113A (zh) | 2015-08-10 | 2018-05-11 | Viiv保健英国第五有限公司 | 作为人免疫缺陷病毒复制的抑制剂的咪唑并吡啶大环类化合物 |
| TWI657086B (zh) | 2015-08-11 | 2019-04-21 | 英商Viiv醫療保健英國(No.5)有限公司 | 做為人類免疫缺陷病毒複製抑制劑之５－（ｎ－苯甲基四氫異喹啉－６－基）吡啶－３－基乙酸衍生物 |
| TW201718537A (zh) | 2015-08-12 | 2017-06-01 | Ｖｉｉｖ醫療保健英國（Ｎｏ．５）有限公司 | 做為人類免疫缺陷病毒複製抑制劑之吡啶－３－基乙酸衍生物 |
| CA2995087A1 (en) | 2015-08-12 | 2017-02-16 | John F. Kadow | 5-(n-fused tricyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| CN108137553A (zh) | 2015-08-12 | 2018-06-08 | Viiv保健英国第五有限公司 | 作为人免疫缺陷病毒复制的抑制剂的5-(n-[6,5]-稠合双环芳基四氢异喹啉-6-基)吡啶-3-基乙酸衍生物 |
| US10106504B2 (en) | 2015-08-20 | 2018-10-23 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| US10407410B2 (en) | 2016-05-11 | 2019-09-10 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| WO2017195112A1 (en) | 2016-05-11 | 2017-11-16 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| JP2019515939A (ja) | 2016-05-11 | 2019-06-13 | ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド | ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−３−イル酢酸誘導体 |
| CN106316998B (zh) * | 2016-08-23 | 2019-01-29 | 阜新峰成化工科技发展有限公司 | 一种普卡必利中间体的制备方法 |
| US20200016136A1 (en) | 2017-01-03 | 2020-01-16 | Viiv Healthcare Uk (No. 5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| US20200055839A1 (en) | 2017-01-03 | 2020-02-20 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| WO2019244066A2 (en) | 2018-06-19 | 2019-12-26 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| WO2020003093A1 (en) | 2018-06-25 | 2020-01-02 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| CN110498739A (zh) * | 2019-09-12 | 2019-11-26 | 南华大学 | 一种合成6-羟基-2,3,4-三甲氧基-α-氯代苯乙酮的方法 |
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| JPS6463518A (en) | 1987-09-02 | 1989-03-09 | Otsuka Pharma Co Ltd | Antiarrhythmic agent |
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| DK1874117T3 (da) | 2005-04-28 | 2013-09-23 | Viiv Healthcare Co | Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet |
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| JP5131689B2 (ja) | 2005-10-27 | 2013-01-30 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体 |
| US7939545B2 (en) * | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| CA2705831C (en) | 2007-11-13 | 2015-04-07 | Artex Picture Frames Ltd. | Canvas stretching system with corner clamps |
| JP5269086B2 (ja) | 2007-11-15 | 2013-08-21 | ギリアード サイエンシス インコーポレーテッド | ヒト免疫不全ウイルスの複製阻害薬 |
| NZ585226A (en) * | 2007-11-16 | 2012-08-31 | Gilead Sciences Inc | Inhibitors of human immunodeficiency virus replication |
-
2008
- 2008-11-03 JP JP2010533395A patent/JP5269086B2/ja active Active
- 2008-11-03 HR HRP20120328AT patent/HRP20120328T2/hr unknown
- 2008-11-03 DK DK08848765.7T patent/DK2220076T5/da active
- 2008-11-03 CA CA2705318A patent/CA2705318C/en not_active Expired - Fee Related
- 2008-11-03 US US12/743,138 patent/US8377960B2/en not_active Expired - Fee Related
- 2008-11-03 PL PL08848765T patent/PL2220076T3/pl unknown
- 2008-11-03 SI SI200830600T patent/SI2220076T1/sl unknown
- 2008-11-03 WO PCT/CA2008/001941 patent/WO2009062289A1/en not_active Ceased
- 2008-11-03 ES ES08848765T patent/ES2381234T3/es active Active
- 2008-11-03 AT AT08848765T patent/ATE541841T1/de active
- 2008-11-03 PT PT08848765T patent/PT2220076E/pt unknown
- 2008-11-03 EP EP08848765A patent/EP2220076B1/en active Active
- 2008-11-14 TW TW097144271A patent/TW200920744A/zh unknown
- 2008-11-14 AR ARP080104988A patent/AR069544A1/es unknown
-
2012
- 2012-04-18 CY CY20121100365T patent/CY1112691T1/el unknown
-
2013
- 2013-01-11 US US13/739,937 patent/US20130190491A1/en not_active Abandoned
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