JP5269086B2 - ヒト免疫不全ウイルスの複製阻害薬 - Google Patents
ヒト免疫不全ウイルスの複製阻害薬 Download PDFInfo
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- JP5269086B2 JP5269086B2 JP2010533395A JP2010533395A JP5269086B2 JP 5269086 B2 JP5269086 B2 JP 5269086B2 JP 2010533395 A JP2010533395 A JP 2010533395A JP 2010533395 A JP2010533395 A JP 2010533395A JP 5269086 B2 JP5269086 B2 JP 5269086B2
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- alkyl
- alkylene
- haloalkyl
- het
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- 0 COc1c(*)c(OCC2)c2cc1 Chemical compound COc1c(*)c(OCC2)c2cc1 0.000 description 31
- HQXIOTIMHNJCRD-UHFFFAOYSA-N Oc(ccc1c2OCC1)c2Cl Chemical compound Oc(ccc1c2OCC1)c2Cl HQXIOTIMHNJCRD-UHFFFAOYSA-N 0.000 description 2
- HFXBATJCENGPKN-UHFFFAOYSA-N CC(C(C1Cl)OC2)(C=CC1(C)OC)C2=O Chemical compound CC(C(C1Cl)OC2)(C=CC1(C)OC)C2=O HFXBATJCENGPKN-UHFFFAOYSA-N 0.000 description 1
- RXZJIPVEFYOKDZ-UHFFFAOYSA-N CC(C)(C)[O-]c(c(-c(c(ccc(N1CCN(C)CC1)c1)c1nc1C)c1[BrH]C(O)=O)c1Cl)cc2c1NCCO2 Chemical compound CC(C)(C)[O-]c(c(-c(c(ccc(N1CCN(C)CC1)c1)c1nc1C)c1[BrH]C(O)=O)c1Cl)cc2c1NCCO2 RXZJIPVEFYOKDZ-UHFFFAOYSA-N 0.000 description 1
- KZPGMBLUJVSZNX-UHFFFAOYSA-N CC(C)(C)[O-]c(c(-c1c(CC(OC)=O)c(C)nc2c1ccc(Br)c2)c1Cl)cc2c1NCCO2 Chemical compound CC(C)(C)[O-]c(c(-c1c(CC(OC)=O)c(C)nc2c1ccc(Br)c2)c1Cl)cc2c1NCCO2 KZPGMBLUJVSZNX-UHFFFAOYSA-N 0.000 description 1
- YBJIBHBLLLPERD-UHFFFAOYSA-N CC(C)c(cc1)c(C)c2c1OCCC2 Chemical compound CC(C)c(cc1)c(C)c2c1OCCC2 YBJIBHBLLLPERD-UHFFFAOYSA-N 0.000 description 1
- WSWDKRJNGDTLCQ-UHFFFAOYSA-N CC(C)c(ccc(O)c1N)c1Cl Chemical compound CC(C)c(ccc(O)c1N)c1Cl WSWDKRJNGDTLCQ-UHFFFAOYSA-N 0.000 description 1
- OZZZRMLTFZSOAZ-UHFFFAOYSA-N CC(C)c(ccc1c2OCCC1)c2Cl Chemical compound CC(C)c(ccc1c2OCCC1)c2Cl OZZZRMLTFZSOAZ-UHFFFAOYSA-N 0.000 description 1
- LDFGSXFYXWGDJB-UHFFFAOYSA-N CC(C1Cl)(C=CC2=C1OCC2=O)OC Chemical compound CC(C1Cl)(C=CC2=C1OCC2=O)OC LDFGSXFYXWGDJB-UHFFFAOYSA-N 0.000 description 1
- PZFPICYZKDKGQE-UHFFFAOYSA-N CC(CC1)C=C2C1OCCC2 Chemical compound CC(CC1)C=C2C1OCCC2 PZFPICYZKDKGQE-UHFFFAOYSA-N 0.000 description 1
- WWIDGPAIPCKOMP-UHFFFAOYSA-N CC1(C)OB(c(ccc2c3[o]cc2)c3Cl)OC1(C)C Chemical compound CC1(C)OB(c(ccc2c3[o]cc2)c3Cl)OC1(C)C WWIDGPAIPCKOMP-UHFFFAOYSA-N 0.000 description 1
- PVOAHINGSUIXLS-UHFFFAOYSA-N CN1CCNCC1 Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
- BKPSCWWOIHVFHA-UHFFFAOYSA-N COc1ccc(C(CO2)O)c2c1Cl Chemical compound COc1ccc(C(CO2)O)c2c1Cl BKPSCWWOIHVFHA-UHFFFAOYSA-N 0.000 description 1
- FBAWHDJDOTWYMV-OLZOCXBDSA-N C[C@H](CC=C(C(OC(C)(C)O1)=O)C1=O)[C@H](C)c(cc(cc1)OC)c1OC Chemical compound C[C@H](CC=C(C(OC(C)(C)O1)=O)C1=O)[C@H](C)c(cc(cc1)OC)c1OC FBAWHDJDOTWYMV-OLZOCXBDSA-N 0.000 description 1
- SIRZAUFJHUZRTI-UHFFFAOYSA-N Cc(c(OC)ccc1)c1O Chemical compound Cc(c(OC)ccc1)c1O SIRZAUFJHUZRTI-UHFFFAOYSA-N 0.000 description 1
- DEYZAVIODZYUKE-UHFFFAOYSA-N Cc1c(CC(OC)=O)c(-c(ccc2c3NCCO2)c3Cl)c(ccc(CO)c2)c2n1 Chemical compound Cc1c(CC(OC)=O)c(-c(ccc2c3NCCO2)c3Cl)c(ccc(CO)c2)c2n1 DEYZAVIODZYUKE-UHFFFAOYSA-N 0.000 description 1
- CCRIXVBKXIFKPA-UHFFFAOYSA-N Cc1ccc2OCCCc2c1Cl Chemical compound Cc1ccc2OCCCc2c1Cl CCRIXVBKXIFKPA-UHFFFAOYSA-N 0.000 description 1
- LZYWWOLTQXGHOP-UHFFFAOYSA-N O=C(CCO1)C2C1=CC=CC2 Chemical compound O=C(CCO1)C2C1=CC=CC2 LZYWWOLTQXGHOP-UHFFFAOYSA-N 0.000 description 1
- BPBAMMDJAACWRW-UHFFFAOYSA-N O=S(C(F)(F)F)(Oc1ccc(CCO2)c2c1Cl)=O Chemical compound O=S(C(F)(F)F)(Oc1ccc(CCO2)c2c1Cl)=O BPBAMMDJAACWRW-UHFFFAOYSA-N 0.000 description 1
- DWAREJYMJKAABQ-UHFFFAOYSA-N OB(c1ccc2OCCc3ccnc1c23)O Chemical compound OB(c1ccc2OCCc3ccnc1c23)O DWAREJYMJKAABQ-UHFFFAOYSA-N 0.000 description 1
- ABJVCVSZRKYGPJ-UHFFFAOYSA-N Oc1ccc2OC=Cc3ccnc1c23 Chemical compound Oc1ccc2OC=Cc3ccnc1c23 ABJVCVSZRKYGPJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98832707P | 2007-11-15 | 2007-11-15 | |
| US60/988,327 | 2007-11-15 | ||
| PCT/CA2008/001941 WO2009062289A1 (en) | 2007-11-15 | 2008-11-03 | Inhibitors of human immunodeficiency virus replication |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503118A JP2011503118A (ja) | 2011-01-27 |
| JP2011503118A5 JP2011503118A5 (enExample) | 2011-12-22 |
| JP5269086B2 true JP5269086B2 (ja) | 2013-08-21 |
Family
ID=40638278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533395A Active JP5269086B2 (ja) | 2007-11-15 | 2008-11-03 | ヒト免疫不全ウイルスの複製阻害薬 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8377960B2 (enExample) |
| EP (1) | EP2220076B1 (enExample) |
| JP (1) | JP5269086B2 (enExample) |
| AR (1) | AR069544A1 (enExample) |
| AT (1) | ATE541841T1 (enExample) |
| CA (1) | CA2705318C (enExample) |
| CY (1) | CY1112691T1 (enExample) |
| DK (1) | DK2220076T5 (enExample) |
| ES (1) | ES2381234T3 (enExample) |
| HR (1) | HRP20120328T2 (enExample) |
| PL (1) | PL2220076T3 (enExample) |
| PT (1) | PT2220076E (enExample) |
| SI (1) | SI2220076T1 (enExample) |
| TW (1) | TW200920744A (enExample) |
| WO (1) | WO2009062289A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20120328T2 (hr) | 2007-11-15 | 2012-09-30 | Gilead Sciences | Inhibitori replikacije virusa humane imunodeficijencije |
| WO2009062285A1 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| TW201116212A (en) | 2009-10-29 | 2011-05-16 | Du Pont | Heterobicycle-substituted azolyl benzene fungicides |
| AP2013006706A0 (en) * | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | Napht-2-ylacetic acid derivatives to treat AIDS |
| PH12013500015A1 (en) * | 2010-07-02 | 2013-02-18 | Gilead Sciences Inc | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
| US8633200B2 (en) | 2010-09-08 | 2014-01-21 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| BR112013011737A2 (pt) * | 2010-11-15 | 2016-08-09 | Univ Leuven Kath | composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv |
| KR20140025326A (ko) | 2011-01-07 | 2014-03-04 | 다이호야쿠힌고교 가부시키가이샤 | 신규 인돌, 인다졸 유도체 또는 그 염 |
| WO2012093708A1 (ja) * | 2011-01-07 | 2012-07-12 | 大鵬薬品工業株式会社 | 新規二環式化合物又はその塩 |
| JP2014511859A (ja) * | 2011-04-04 | 2014-05-19 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖインテグラーゼ阻害剤の調製のためのプロセス |
| EP2508511A1 (en) | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2511273B8 (en) | 2011-04-15 | 2019-06-26 | Hivih | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| UA111841C2 (uk) | 2011-04-21 | 2016-06-24 | Гіліад Сайєнсіз, Інк. | Сполуки бензотіазолу та їх фармацевтичне застосування |
| US8791108B2 (en) | 2011-08-18 | 2014-07-29 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| WO2013062028A1 (ja) | 2011-10-25 | 2013-05-02 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害剤 |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US8629276B2 (en) | 2012-02-15 | 2014-01-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9034882B2 (en) | 2012-03-05 | 2015-05-19 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9096586B2 (en) | 2012-04-20 | 2015-08-04 | Gilead Sciences, Inc. | Therapeutic compounds |
| US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2716639A1 (en) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2716632A1 (en) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2719685A1 (en) | 2012-10-11 | 2014-04-16 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| TW201441197A (zh) | 2013-01-31 | 2014-11-01 | Shionogi & Co | Ｈｉｖ複製抑制劑 |
| US9663536B2 (en) | 2013-03-13 | 2017-05-30 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
| JP2016512507A (ja) | 2013-03-13 | 2016-04-28 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヒト免疫不全ウイルス複製の阻害剤 |
| US9580431B2 (en) | 2013-03-13 | 2017-02-28 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
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| ES2381234T3 (es) | 2012-05-24 |
| EP2220076A1 (en) | 2010-08-25 |
| CY1112691T1 (el) | 2016-02-10 |
| CA2705318C (en) | 2013-12-31 |
| ATE541841T1 (de) | 2012-02-15 |
| WO2009062289A1 (en) | 2009-05-22 |
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