JP2017519802A5 - - Google Patents
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- Publication number
- JP2017519802A5 JP2017519802A5 JP2017500886A JP2017500886A JP2017519802A5 JP 2017519802 A5 JP2017519802 A5 JP 2017519802A5 JP 2017500886 A JP2017500886 A JP 2017500886A JP 2017500886 A JP2017500886 A JP 2017500886A JP 2017519802 A5 JP2017519802 A5 JP 2017519802A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- substituted
- alkoxy
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000001424 substituent group Chemical group 0.000 claims 52
- 229910052736 halogen Inorganic materials 0.000 claims 41
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 28
- 150000002367 halogens Chemical class 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 25
- 125000004093 cyano group Chemical group *C#N 0.000 claims 22
- 125000005647 linker group Chemical group 0.000 claims 22
- 125000005843 halogen group Chemical group 0.000 claims 21
- 208000015181 infectious disease Diseases 0.000 claims 21
- -1 nitro, aminosulfonyl Chemical group 0.000 claims 21
- 241000282465 Canis Species 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000004414 alkyl thio group Chemical group 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 11
- 201000006353 Filariasis Diseases 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 9
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 239000004215 Carbon black (E152) Substances 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 6
- 229930195733 hydrocarbon Natural products 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- 241000002163 Mesapamea fractilinea Species 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000004043 oxo group Chemical group O=* 0.000 claims 5
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 5
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 4
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 4
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000004439 haloalkylsulfanyl group Chemical group 0.000 claims 4
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 4
- 125000005150 heteroarylsulfinyl group Chemical group 0.000 claims 4
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 150000002430 hydrocarbons Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14176733 | 2014-07-11 | ||
| EP14176733.5 | 2014-07-11 | ||
| PCT/EP2015/065868 WO2016005576A1 (en) | 2014-07-11 | 2015-07-10 | Use of anthelmintic agents against dirofilaria immitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017519802A JP2017519802A (ja) | 2017-07-20 |
| JP2017519802A5 true JP2017519802A5 (enExample) | 2018-08-16 |
Family
ID=51167758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017500886A Withdrawn JP2017519802A (ja) | 2014-07-11 | 2015-07-10 | 犬糸状虫に対する駆虫薬の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10010538B2 (enExample) |
| EP (1) | EP3177291A1 (enExample) |
| JP (1) | JP2017519802A (enExample) |
| CN (1) | CN106659720A (enExample) |
| AU (1) | AU2015286634A1 (enExample) |
| BR (1) | BR112017000398A2 (enExample) |
| WO (1) | WO2016005576A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE045261T2 (hu) | 2017-03-20 | 2019-12-30 | Forma Therapeutics Inc | Pirrolopirrol kompozíciók piruvát kináz (PKR) aktivátorokként |
| ES2919779T3 (es) | 2017-06-20 | 2022-07-28 | Imbria Pharmaceuticals Inc | Derivado de 1-[(2,3,4-trimetoxifenil)metil]-piperazina, composiciones del mismo y métodos para aumentar la eficiencia del metabolismo cardíaco |
| US12122778B2 (en) | 2018-09-19 | 2024-10-22 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| CN113166060B (zh) | 2018-09-19 | 2024-01-09 | 诺沃挪第克健康护理股份公司 | 用丙酮酸激酶激活化合物治疗镰状细胞病 |
| WO2020081361A1 (en) | 2018-10-17 | 2020-04-23 | Imbria Pharmaceuticals, Inc. | Methods of treating rheumatic diseases using trimetazidine-based compounds |
| ES3042390T3 (en) | 2019-09-19 | 2025-11-20 | Novo Nordisk Healthcare Ag | Pyruvate kinase r (pkr) activating compositions |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69612088T2 (de) | 1995-02-24 | 2001-08-30 | Novartis Ag, Basel | Zusammensetzung zur bekämpfung von parasiten |
| TW200938203A (en) | 2007-12-17 | 2009-09-16 | Intervet Int Bv | Anthelmintic agents and their use |
| TW201041868A (en) | 2009-03-20 | 2010-12-01 | Intervet Int Bv | Anthelmintic agents and their use |
| TW201111358A (en) | 2009-06-18 | 2011-04-01 | Intervet Int Bv | Anthelmintic agents and their use |
| EP2468096A1 (en) * | 2010-12-21 | 2012-06-27 | Intervet International BV | Anthelmintic combinations |
| LT2922845T (lt) * | 2012-11-20 | 2018-09-10 | Merial, Inc. | Antihelmintiniai junginiai ir kompozicijos ir jų naudojimo būdai |
-
2015
- 2015-07-10 EP EP15736503.2A patent/EP3177291A1/en not_active Withdrawn
- 2015-07-10 WO PCT/EP2015/065868 patent/WO2016005576A1/en not_active Ceased
- 2015-07-10 JP JP2017500886A patent/JP2017519802A/ja not_active Withdrawn
- 2015-07-10 BR BR112017000398A patent/BR112017000398A2/pt not_active Application Discontinuation
- 2015-07-10 AU AU2015286634A patent/AU2015286634A1/en not_active Abandoned
- 2015-07-10 US US15/324,875 patent/US10010538B2/en not_active Expired - Fee Related
- 2015-07-10 CN CN201580037656.3A patent/CN106659720A/zh active Pending
-
2018
- 2018-06-04 US US15/996,951 patent/US20180280367A1/en not_active Abandoned
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