JP2017519802A - 犬糸状虫に対する駆虫薬の使用 - Google Patents
犬糸状虫に対する駆虫薬の使用 Download PDFInfo
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- JP2017519802A JP2017519802A JP2017500886A JP2017500886A JP2017519802A JP 2017519802 A JP2017519802 A JP 2017519802A JP 2017500886 A JP2017500886 A JP 2017500886A JP 2017500886 A JP2017500886 A JP 2017500886A JP 2017519802 A JP2017519802 A JP 2017519802A
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- alkyl
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- alkoxy
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- 229940079593 drug Drugs 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 title abstract description 5
- 230000000507 anthelmentic effect Effects 0.000 title description 4
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- 208000015181 infectious disease Diseases 0.000 claims abstract description 44
- 241000282465 Canis Species 0.000 claims abstract description 35
- 241001465754 Metazoa Species 0.000 claims abstract description 18
- 201000006353 Filariasis Diseases 0.000 claims abstract description 13
- -1 nitro, aminosulfonyl Chemical group 0.000 claims description 189
- 125000001424 substituent group Chemical group 0.000 claims description 178
- 229910052736 halogen Inorganic materials 0.000 claims description 125
- 150000002367 halogens Chemical class 0.000 claims description 112
- 125000000217 alkyl group Chemical group 0.000 claims description 94
- 229910052739 hydrogen Inorganic materials 0.000 claims description 71
- 239000001257 hydrogen Substances 0.000 claims description 71
- 125000005647 linker group Chemical group 0.000 claims description 69
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 67
- 125000001072 heteroaryl group Chemical group 0.000 claims description 59
- 125000003118 aryl group Chemical group 0.000 claims description 51
- 125000003545 alkoxy group Chemical group 0.000 claims description 43
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 41
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 38
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 34
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 30
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims description 27
- 125000004043 oxo group Chemical group O=* 0.000 claims description 27
- 229910052799 carbon Inorganic materials 0.000 claims description 26
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 24
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
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- 125000004104 aryloxy group Chemical group 0.000 claims description 19
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- 125000001153 fluoro group Chemical group F* 0.000 claims description 15
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 14
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- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 10
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- 238000000034 method Methods 0.000 claims description 9
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 7
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- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims description 6
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- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 4
- 229920000578 graft copolymer Polymers 0.000 claims description 4
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- 239000004615 ingredient Substances 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 241000002163 Mesapamea fractilinea Species 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 4
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- 125000000623 heterocyclic group Chemical group 0.000 description 19
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- 241000282472 Canis lupus familiaris Species 0.000 description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 241000894007 species Species 0.000 description 14
- 125000002837 carbocyclic group Chemical group 0.000 description 12
- 239000002904 solvent Substances 0.000 description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 11
- 238000001514 detection method Methods 0.000 description 11
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 11
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- 150000001768 cations Chemical class 0.000 description 9
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- 238000011067 equilibration Methods 0.000 description 8
- 241000255925 Diptera Species 0.000 description 7
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 7
- 238000012856 packing Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 241000282421 Canidae Species 0.000 description 6
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 241000282326 Felis catus Species 0.000 description 6
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- 125000004602 benzodiazinyl group Chemical group N1=NC(=CC2=C1C=CC=C2)* 0.000 description 6
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- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 6
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- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP14176733 | 2014-07-11 | ||
| EP14176733.5 | 2014-07-11 | ||
| PCT/EP2015/065868 WO2016005576A1 (en) | 2014-07-11 | 2015-07-10 | Use of anthelmintic agents against dirofilaria immitis |
Publications (2)
| Publication Number | Publication Date |
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| JP2017519802A true JP2017519802A (ja) | 2017-07-20 |
| JP2017519802A5 JP2017519802A5 (enExample) | 2018-08-16 |
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| US (2) | US10010538B2 (enExample) |
| EP (1) | EP3177291A1 (enExample) |
| JP (1) | JP2017519802A (enExample) |
| CN (1) | CN106659720A (enExample) |
| AU (1) | AU2015286634A1 (enExample) |
| BR (1) | BR112017000398A2 (enExample) |
| WO (1) | WO2016005576A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR102007135B1 (ko) | 2017-03-20 | 2019-08-02 | 포르마 세라퓨틱스 인크. | 피루베이트 키나제 (pkr) 활성화제로서의 피롤로피롤 조성물 |
| KR102704242B1 (ko) | 2017-06-20 | 2024-09-09 | 임브리아 파마슈티칼스, 인크. | 심장 대사의 효율을 증가시키기 위한 조성물 및 방법 |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| EP3852791B1 (en) | 2018-09-19 | 2024-07-03 | Novo Nordisk Health Care AG | Activating pyruvate kinase r |
| WO2020081361A1 (en) | 2018-10-17 | 2020-04-23 | Imbria Pharmaceuticals, Inc. | Methods of treating rheumatic diseases using trimetazidine-based compounds |
| US20220378756A1 (en) | 2019-09-19 | 2022-12-01 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
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| BR9607262A (pt) | 1995-02-24 | 1997-12-30 | Norvatis Ag Novartis Sa Novart | Composição para controlar parasitas |
| TW200938203A (en) * | 2007-12-17 | 2009-09-16 | Intervet Int Bv | Anthelmintic agents and their use |
| TW201041868A (en) | 2009-03-20 | 2010-12-01 | Intervet Int Bv | Anthelmintic agents and their use |
| TW201111358A (en) | 2009-06-18 | 2011-04-01 | Intervet Int Bv | Anthelmintic agents and their use |
| EP2468096A1 (en) * | 2010-12-21 | 2012-06-27 | Intervet International BV | Anthelmintic combinations |
| AU2013348175B2 (en) | 2012-11-20 | 2016-11-17 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic compounds and compositions and method of using thereof |
-
2015
- 2015-07-10 EP EP15736503.2A patent/EP3177291A1/en not_active Withdrawn
- 2015-07-10 BR BR112017000398A patent/BR112017000398A2/pt not_active Application Discontinuation
- 2015-07-10 WO PCT/EP2015/065868 patent/WO2016005576A1/en not_active Ceased
- 2015-07-10 CN CN201580037656.3A patent/CN106659720A/zh active Pending
- 2015-07-10 AU AU2015286634A patent/AU2015286634A1/en not_active Abandoned
- 2015-07-10 JP JP2017500886A patent/JP2017519802A/ja not_active Withdrawn
- 2015-07-10 US US15/324,875 patent/US10010538B2/en not_active Expired - Fee Related
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2018
- 2018-06-04 US US15/996,951 patent/US20180280367A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20180280367A1 (en) | 2018-10-04 |
| WO2016005576A1 (en) | 2016-01-14 |
| US20170202816A1 (en) | 2017-07-20 |
| BR112017000398A2 (pt) | 2018-01-23 |
| US10010538B2 (en) | 2018-07-03 |
| CN106659720A (zh) | 2017-05-10 |
| AU2015286634A1 (en) | 2017-01-19 |
| EP3177291A1 (en) | 2017-06-14 |
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