JP2010511635A5 - - Google Patents
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- Publication number
- JP2010511635A5 JP2010511635A5 JP2009539574A JP2009539574A JP2010511635A5 JP 2010511635 A5 JP2010511635 A5 JP 2010511635A5 JP 2009539574 A JP2009539574 A JP 2009539574A JP 2009539574 A JP2009539574 A JP 2009539574A JP 2010511635 A5 JP2010511635 A5 JP 2010511635A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- het
- independently selected
- substituted
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 164
- 125000005842 heteroatom Chemical group 0.000 claims 24
- 125000000623 heterocyclic group Chemical group 0.000 claims 22
- 229910052760 oxygen Inorganic materials 0.000 claims 22
- 229910052717 sulfur Inorganic materials 0.000 claims 21
- 125000001424 substituent group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000005843 halogen group Chemical group 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 11
- -1 -N 3 Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000000815 N-oxide group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86836306P | 2006-12-04 | 2006-12-04 | |
| PCT/CA2007/002155 WO2008067644A1 (en) | 2006-12-04 | 2007-12-03 | Inhibitors of hiv replication |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010511635A JP2010511635A (ja) | 2010-04-15 |
| JP2010511635A5 true JP2010511635A5 (enExample) | 2011-01-27 |
Family
ID=39491602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539574A Pending JP2010511635A (ja) | 2006-12-04 | 2007-12-03 | Ｈｉｖ複製の阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8039638B2 (enExample) |
| EP (1) | EP2099789A4 (enExample) |
| JP (1) | JP2010511635A (enExample) |
| CA (1) | CA2670103C (enExample) |
| WO (1) | WO2008067644A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101959867A (zh) | 2007-12-27 | 2011-01-26 | 出光兴产株式会社 | 含氮杂环衍生物及使用该衍生物的有机电致发光元件 |
| TW201035088A (en) | 2009-02-27 | 2010-10-01 | Supergen Inc | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors |
| EP2509975B1 (en) * | 2009-12-04 | 2014-04-23 | Boehringer Ingelheim International GmbH | Benzimidazole inhibitors of leukotriene production |
| JP5928958B2 (ja) * | 2010-10-29 | 2016-06-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のベンゾイミダゾールインヒビター |
| JP5789888B2 (ja) | 2010-11-01 | 2015-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のベンゾイミダゾールインヒビター |
| DE102011055815A1 (de) * | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
| WO2013091089A1 (en) * | 2011-12-22 | 2013-06-27 | UNIVERSITé LAVAL | Three-dimensional cavities of dendritic cell immunoreceptor (dcir), compounds binding thereto and therapeutic applications related to inhibition of human immunodeficiency virus type-1 (hiv-1) |
| EP2821082A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| UA126421C2 (uk) | 2018-07-13 | 2022-09-28 | Гіліад Сайєнсіз, Інк. | Інгібітори pd-1/pd-l1 |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002502844A (ja) * | 1998-02-03 | 2002-01-29 | ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト | ５員複素環縮合ベンゾ誘導体、その調製及び医薬品としてのそれらの使用 |
| EP1109555A4 (en) * | 1998-08-31 | 2001-11-21 | Merck & Co Inc | Novel angiogenesis inhibitors |
| DE19907813A1 (de) | 1999-02-24 | 2000-08-31 | Boehringer Ingelheim Pharma | Substituierte bicyclische Heterocyclen, deren Herstellung und deren Verwendung als Arzneimittel |
| US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| DE102005031580A1 (de) * | 2005-07-06 | 2007-01-11 | Aicuris Gmbh & Co. Kg | Substituierte Sulfolanylpyrazole und ihre Verwendung |
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2007
- 2007-12-03 EP EP07855439A patent/EP2099789A4/en not_active Withdrawn
- 2007-12-03 WO PCT/CA2007/002155 patent/WO2008067644A1/en not_active Ceased
- 2007-12-03 US US12/517,310 patent/US8039638B2/en active Active
- 2007-12-03 JP JP2009539574A patent/JP2010511635A/ja active Pending
- 2007-12-03 CA CA2670103A patent/CA2670103C/en not_active Expired - Fee Related