JP2011503230A5 - - Google Patents
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- Publication number
- JP2011503230A5 JP2011503230A5 JP2010534947A JP2010534947A JP2011503230A5 JP 2011503230 A5 JP2011503230 A5 JP 2011503230A5 JP 2010534947 A JP2010534947 A JP 2010534947A JP 2010534947 A JP2010534947 A JP 2010534947A JP 2011503230 A5 JP2011503230 A5 JP 2011503230A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- haloalkyl
- pyridin
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 139
- 229910052799 carbon Inorganic materials 0.000 claims 42
- 229910052739 hydrogen Inorganic materials 0.000 claims 38
- 125000001424 substituent group Chemical group 0.000 claims 29
- 229910052757 nitrogen Inorganic materials 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 21
- 150000002367 halogens Chemical class 0.000 claims 19
- -1 1-azetidinyl Chemical group 0.000 claims 18
- 239000000651 prodrug Substances 0.000 claims 18
- 229940002612 prodrug Drugs 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 229910052794 bromium Inorganic materials 0.000 claims 12
- 229910052801 chlorine Inorganic materials 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 10
- 102100034184 Macrophage scavenger receptor types I and II Human genes 0.000 claims 10
- 101710134306 Macrophage scavenger receptor types I and II Proteins 0.000 claims 10
- 125000001624 naphthyl group Chemical group 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 125000005842 heteroatom Chemical group 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 229910052731 fluorine Inorganic materials 0.000 claims 8
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000002619 bicyclic group Chemical group 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- RQNBQSFOFRVNOT-UHFFFAOYSA-N 1-[(6-amino-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-3-(3,5-dichlorophenoxy)-4-(trifluoromethyl)pyridin-2-one Chemical compound C=1NC2=NC(N)=CC=C2C=1CN(C1=O)C=CC(C(F)(F)F)=C1OC1=CC(Cl)=CC(Cl)=C1 RQNBQSFOFRVNOT-UHFFFAOYSA-N 0.000 claims 4
- GMCYQWDQLIDMII-UHFFFAOYSA-N 3-(3,5-dichlorophenoxy)-1-(2h-pyrazolo[3,4-b]pyridin-3-ylmethyl)-4-(trifluoromethyl)pyridin-2-one Chemical compound FC(F)(F)C=1C=CN(CC=2C3=CC=CN=C3NN=2)C(=O)C=1OC1=CC(Cl)=CC(Cl)=C1 GMCYQWDQLIDMII-UHFFFAOYSA-N 0.000 claims 4
- LIVDFVFPMFJQMJ-UHFFFAOYSA-N 3-[1-[(6-amino-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-oxo-4-(trifluoromethyl)pyridin-3-yl]oxy-5-chlorobenzonitrile Chemical compound C=1NC2=NC(N)=CC=C2C=1CN(C1=O)C=CC(C(F)(F)F)=C1OC1=CC(Cl)=CC(C#N)=C1 LIVDFVFPMFJQMJ-UHFFFAOYSA-N 0.000 claims 4
- CVAURPNMBSXXSS-UHFFFAOYSA-N 3-chloro-5-[2-oxo-1-(2h-pyrazolo[3,4-b]pyridin-3-ylmethyl)-4-(trifluoromethyl)pyridin-3-yl]oxybenzonitrile Chemical compound FC(F)(F)C=1C=CN(CC=2C3=CC=CN=C3NN=2)C(=O)C=1OC1=CC(Cl)=CC(C#N)=C1 CVAURPNMBSXXSS-UHFFFAOYSA-N 0.000 claims 4
- ZSDYTNJSFLYICM-UHFFFAOYSA-N 3-chloro-5-[4-chloro-2-oxo-1-(2h-pyrazolo[3,4-b]pyridin-3-ylmethyl)pyridin-3-yl]oxybenzonitrile Chemical compound N#CC1=CC(Cl)=CC(OC=2C(N(CC=3C4=CC=CN=C4NN=3)C=CC=2Cl)=O)=C1 ZSDYTNJSFLYICM-UHFFFAOYSA-N 0.000 claims 4
- YMRUCOCNLHJFRC-UHFFFAOYSA-N 3-chloro-5-[4-methyl-2-oxo-1-(2h-pyrazolo[3,4-b]pyridin-3-ylmethyl)pyridin-3-yl]oxybenzonitrile Chemical compound CC=1C=CN(CC=2C3=CC=CN=C3NN=2)C(=O)C=1OC1=CC(Cl)=CC(C#N)=C1 YMRUCOCNLHJFRC-UHFFFAOYSA-N 0.000 claims 4
- XUIZIBCKVKBTGV-UHFFFAOYSA-N 3-chloro-5-[4-methyl-2-oxo-1-[2-(2h-pyrazolo[3,4-b]pyridin-3-yl)ethyl]pyridin-3-yl]oxybenzonitrile Chemical compound CC=1C=CN(CCC=2C3=CC=CN=C3NN=2)C(=O)C=1OC1=CC(Cl)=CC(C#N)=C1 XUIZIBCKVKBTGV-UHFFFAOYSA-N 0.000 claims 4
- CBFKUUGIHWKPLR-UHFFFAOYSA-N 5-[2-oxo-1-(2h-pyrazolo[3,4-b]pyridin-3-ylmethyl)-4-(trifluoromethyl)pyridin-3-yl]oxybenzene-1,3-dicarbonitrile Chemical compound FC(F)(F)C=1C=CN(CC=2C3=CC=CN=C3NN=2)C(=O)C=1OC1=CC(C#N)=CC(C#N)=C1 CBFKUUGIHWKPLR-UHFFFAOYSA-N 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000002883 imidazolyl group Chemical group 0.000 claims 4
- ABOZXYNAPFTBHX-UHFFFAOYSA-N 3-chloro-5-[4,5-dichloro-2-oxo-1-(2h-pyrazolo[3,4-b]pyridin-3-ylmethyl)pyridin-3-yl]oxybenzonitrile Chemical compound N#CC1=CC(Cl)=CC(OC=2C(N(CC=3C4=CC=CN=C4NN=3)C=C(Cl)C=2Cl)=O)=C1 ABOZXYNAPFTBHX-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 2
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- ATGKQOUKJPVTKE-UHFFFAOYSA-N 2-[3-(3-chloro-5-cyanophenoxy)-2-oxo-4-(trifluoromethyl)pyridin-1-yl]-n-[(2-chlorophenyl)methyl]-n-methylacetamide Chemical compound C1=CC(C(F)(F)F)=C(OC=2C=C(C=C(Cl)C=2)C#N)C(=O)N1CC(=O)N(C)CC1=CC=CC=C1Cl ATGKQOUKJPVTKE-UHFFFAOYSA-N 0.000 claims 2
- YCIPBZALVAZULV-UHFFFAOYSA-N 3-[1-[(6-amino-2h-pyrazolo[3,4-b]pyridin-3-yl)methyl]-4-chloro-2-oxopyridin-3-yl]oxy-5-chlorobenzonitrile Chemical compound N=1NC2=NC(N)=CC=C2C=1CN(C1=O)C=CC(Cl)=C1OC1=CC(Cl)=CC(C#N)=C1 YCIPBZALVAZULV-UHFFFAOYSA-N 0.000 claims 2
- DZUHNBJTDWFYCJ-UHFFFAOYSA-N 3-[6-[(6-amino-2h-pyrazolo[3,4-b]pyridin-3-yl)methylamino]-5-chloro-3-fluoropyridin-2-yl]oxy-5-chlorobenzonitrile Chemical compound N=1NC2=NC(N)=CC=C2C=1CNC(C(=CC=1F)Cl)=NC=1OC1=CC(Cl)=CC(C#N)=C1 DZUHNBJTDWFYCJ-UHFFFAOYSA-N 0.000 claims 2
- TXIDGJNYVPGVEG-UHFFFAOYSA-N 3-[[6-[2-(6-amino-2h-pyrazolo[3,4-b]pyridin-3-yl)ethyl]-3-chloro-2-oxo-1h-pyridin-4-yl]oxy]-5-chlorobenzonitrile Chemical compound N=1NC2=NC(N)=CC=C2C=1CCC(NC(=O)C=1Cl)=CC=1OC1=CC(Cl)=CC(C#N)=C1 TXIDGJNYVPGVEG-UHFFFAOYSA-N 0.000 claims 2
- UXWKLSXBOSOYHN-UHFFFAOYSA-N 3-chloro-5-[5-chloro-3-fluoro-6-(2h-pyrazolo[3,4-b]pyridin-3-ylmethylamino)pyridin-2-yl]oxybenzonitrile Chemical compound FC1=CC(Cl)=C(NCC=2C3=CC=CN=C3NN=2)N=C1OC1=CC(Cl)=CC(C#N)=C1 UXWKLSXBOSOYHN-UHFFFAOYSA-N 0.000 claims 2
- GIOABAWLXRZDTF-UHFFFAOYSA-N 3-chloro-5-[[2-oxo-6-[2-(2h-pyrazolo[3,4-b]pyridin-3-yl)ethyl]-1h-pyridin-4-yl]oxy]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(OC2=CC(=O)NC(CCC=3C4=CC=CN=C4NN=3)=C2)=C1 GIOABAWLXRZDTF-UHFFFAOYSA-N 0.000 claims 2
- MEFSIZQEXHEOCA-UHFFFAOYSA-N 3-chloro-5-[[3,5-dichloro-2-oxo-6-[2-(2h-pyrazolo[3,4-b]pyridin-3-yl)ethyl]-1h-pyridin-4-yl]oxy]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(OC2=C(C(=O)NC(CCC=3C4=CC=CN=C4NN=3)=C2Cl)Cl)=C1 MEFSIZQEXHEOCA-UHFFFAOYSA-N 0.000 claims 2
- CCEYNDRKIOXUGP-UHFFFAOYSA-N 3-chloro-5-[[3-chloro-2-oxo-6-(2h-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1h-pyridin-4-yl]oxy]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(OC2=C(C(=O)NC(CC=3C4=CC=CN=C4NN=3)=C2)Cl)=C1 CCEYNDRKIOXUGP-UHFFFAOYSA-N 0.000 claims 2
- KDKUQACKJMWZJZ-UHFFFAOYSA-N 3-chloro-5-[[3-chloro-2-oxo-6-(2h-pyrazolo[3,4-b]pyridin-3-ylmethylamino)-1h-pyridin-4-yl]oxy]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(OC2=C(C(=O)NC(NCC=3C4=CC=CN=C4NN=3)=C2)Cl)=C1 KDKUQACKJMWZJZ-UHFFFAOYSA-N 0.000 claims 2
- GZVLIXZYBWGUTC-UHFFFAOYSA-N 3-chloro-5-[[3-chloro-2-oxo-6-[(2-oxo-3h-benzimidazol-1-yl)methyl]-1h-pyridin-4-yl]oxy]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(OC2=C(C(=O)NC(CN3C(NC4=CC=CC=C43)=O)=C2)Cl)=C1 GZVLIXZYBWGUTC-UHFFFAOYSA-N 0.000 claims 2
- NCPJKBVDFNPLLG-UHFFFAOYSA-N 3-chloro-5-[[3-chloro-2-oxo-6-[2-(2h-pyrazolo[3,4-b]pyridin-3-yl)ethyl]-1h-pyridin-4-yl]oxy]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(OC2=C(C(=O)NC(CCC=3C4=CC=CN=C4NN=3)=C2)Cl)=C1 NCPJKBVDFNPLLG-UHFFFAOYSA-N 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 101100273648 Mus musculus Ccna2 gene Proteins 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical group OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 claims 2
- 239000002835 hiv fusion inhibitor Substances 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- YIQIGLZIZPIAGP-UHFFFAOYSA-N 1-[(3-methyl-4-phenoxypyridin-2-yl)methyl]benzimidazole Chemical compound C1=CN=C(CN2C3=CC=CC=C3N=C2)C(C)=C1OC1=CC=CC=C1 YIQIGLZIZPIAGP-UHFFFAOYSA-N 0.000 claims 1
- YXVABPSUOVOEJJ-UHFFFAOYSA-N 2-methyl-6-[(6-phenoxypyridin-2-yl)methyl]pyridine Chemical compound CC1=CC=CC(CC=2N=C(OC=3C=CC=CC=3)C=CC=2)=N1 YXVABPSUOVOEJJ-UHFFFAOYSA-N 0.000 claims 1
- KBLCUCFITXXEQF-UHFFFAOYSA-N 3-chloro-5-[3,5-dichloro-2-methyl-6-(2h-pyrazolo[3,4-b]pyridin-3-ylmethoxy)pyridin-4-yl]oxybenzonitrile Chemical compound ClC=1C(C)=NC(OCC=2C3=CC=CN=C3NN=2)=C(Cl)C=1OC1=CC(Cl)=CC(C#N)=C1 KBLCUCFITXXEQF-UHFFFAOYSA-N 0.000 claims 1
- FTFUKUWGDBEIJI-UHFFFAOYSA-N 3-chloro-5-[3-chloro-2,5-difluoro-6-(2h-pyrazolo[3,4-b]pyridin-3-ylmethylamino)pyridin-4-yl]oxybenzonitrile Chemical compound ClC=1C(F)=NC(NCC=2C3=CC=CN=C3NN=2)=C(F)C=1OC1=CC(Cl)=CC(C#N)=C1 FTFUKUWGDBEIJI-UHFFFAOYSA-N 0.000 claims 1
- RRYPCILBOZGVEJ-UHFFFAOYSA-N 3-chloro-5-[5-chloro-2-[2-(2h-pyrazolo[3,4-b]pyridin-3-yl)ethyl]pyridin-4-yl]oxybenzonitrile Chemical compound N#CC1=CC(Cl)=CC(OC=2C(=CN=C(CCC=3C4=CC=CN=C4NN=3)C=2)Cl)=C1 RRYPCILBOZGVEJ-UHFFFAOYSA-N 0.000 claims 1
- JJIJSDYPXLKHIO-UHFFFAOYSA-N 3-chloro-5-[[3-chloro-6-[hydroxy(2h-pyrazolo[3,4-b]pyridin-3-yl)methyl]-2-oxo-1h-pyridin-4-yl]oxy]benzonitrile Chemical compound N=1NC2=NC=CC=C2C=1C(O)C(NC(=O)C=1Cl)=CC=1OC1=CC(Cl)=CC(C#N)=C1 JJIJSDYPXLKHIO-UHFFFAOYSA-N 0.000 claims 1
- 229940099797 HIV integrase inhibitor Drugs 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical group C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 239000003084 hiv integrase inhibitor Substances 0.000 claims 1
- 239000004030 hiv protease inhibitor Substances 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 0 *c1ccccc1 Chemical compound *c1ccccc1 0.000 description 9
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US376907P | 2007-11-20 | 2007-11-20 | |
| US61/003,769 | 2007-11-20 | ||
| PCT/US2008/012774 WO2009067166A2 (en) | 2007-11-20 | 2008-11-14 | Non-nucleoside reverse transcriptase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503230A JP2011503230A (ja) | 2011-01-27 |
| JP2011503230A5 true JP2011503230A5 (enExample) | 2012-01-05 |
| JP5539216B2 JP5539216B2 (ja) | 2014-07-02 |
Family
ID=40336474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534947A Expired - Fee Related JP5539216B2 (ja) | 2007-11-20 | 2008-11-14 | 非ヌクレオシド系逆転写酵素阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8404856B2 (enExample) |
| EP (1) | EP2222661B1 (enExample) |
| JP (1) | JP5539216B2 (enExample) |
| KR (1) | KR20100088142A (enExample) |
| CN (1) | CN101952274A (enExample) |
| AU (1) | AU2008326784B2 (enExample) |
| BR (1) | BRPI0820162A2 (enExample) |
| CA (1) | CA2705834A1 (enExample) |
| IL (1) | IL205386A0 (enExample) |
| MX (1) | MX2010005483A (enExample) |
| RU (1) | RU2010125220A (enExample) |
| WO (1) | WO2009067166A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010026075A1 (en) * | 2008-09-04 | 2010-03-11 | F. Hoffmann-La Roche Ag | Pyridine derivatives as inhibitors of hiv-i reverse transcriptase |
| CN102666537A (zh) * | 2009-10-20 | 2012-09-12 | 艾格尔生物制药股份有限公司 | 治疗黄病毒科病毒感染的氮杂吲唑 |
| MX2012011379A (es) | 2010-03-30 | 2012-11-30 | Merck Canada Inc | Inhibidores no nucleosidicos de la transcriptasa inversa. |
| WO2011126969A1 (en) * | 2010-04-08 | 2011-10-13 | Merck Sharp & Dohme Corp. | Prodrugs of an hiv reverse transcriptase inhibitor |
| EP2900240B1 (en) * | 2012-09-26 | 2020-01-08 | Merck Sharp & Dohme Corp. | Crystalline form of a reverse transcriptase inhibitor |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| CN104994855B (zh) * | 2012-12-05 | 2018-06-05 | 默沙东公司 | 制备逆转录酶抑制剂的方法 |
| KR101803671B1 (ko) * | 2013-12-04 | 2017-11-30 | 머크 샤프 앤드 돔 코포레이션 | 역전사효소 억제제의 제조 방법 |
| SI3125894T1 (sl) | 2014-04-01 | 2020-12-31 | Merck Sharp & Dohme Corp. | Predzdravila inhibitorjev reverzne transkriptaze HIV |
| CA2957785C (en) | 2014-08-11 | 2023-01-03 | Angion Biomedica Corporation | Cytochrome p450 inhibitors and uses thereof |
| CA2970819A1 (en) | 2014-12-31 | 2016-07-07 | Angion Biomedica Corp. | Methods and agents for treating disease |
| JP6768796B2 (ja) * | 2015-09-23 | 2020-10-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ４’−置換ヌクレオシド逆転写酵素阻害剤及びその調製 |
| CN114702495A (zh) | 2015-11-20 | 2022-07-05 | 福马治疗有限公司 | 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮 |
| EP3562828B1 (en) | 2016-12-28 | 2026-03-18 | Dart Neuroscience LLC | Substituted pyrazolopyrimidinone compounds as pde2 inhibitors |
| MX2020005447A (es) | 2017-11-27 | 2020-12-03 | Dart Neuroscience Llc | Compuestos de furanopirimidina sustituida como inhibidores de pde1. |
| MX2021007382A (es) | 2018-12-18 | 2021-07-15 | Merck Sharp & Dohme Llc | Derivados de pirimidona como agentes citotoxicos selectivos contra celulas infectadas por vih. |
| AU2020279954B2 (en) * | 2019-05-22 | 2025-11-13 | Merck Sharp & Dohme Llc | Pyridinone derivatives as selective cytotoxic agents against HIV infected cells |
| CN110066273A (zh) * | 2019-06-05 | 2019-07-30 | 山东大学 | 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用 |
| CN112876409A (zh) * | 2021-01-20 | 2021-06-01 | 都创(上海)医药科技股份有限公司 | 一种2-(5-溴-6-甲氧基吡啶-2-基)乙腈及其衍生物的合成方法 |
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| IL99731A0 (en) | 1990-10-18 | 1992-08-18 | Merck & Co Inc | Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them |
| ZA945609B (en) * | 1993-07-28 | 1995-05-12 | Rhone Poulenc Rorer Ltd | [Di(ether or thioether)heteroaryl or fluoro substituted aryl] compounds |
| CZ20003978A3 (cs) * | 1998-04-27 | 2001-09-12 | Centre National De La Recherche Scientifique | Deriváty 3-(amino- nebo aminoalkyl) pyridinonu a jejich použití |
| GB9910577D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| SE9904045D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
| AU2001234420A1 (en) | 2000-02-03 | 2001-08-14 | Eli Lilly And Company | Potentiators of glutamate receptors |
| AU2001290912A1 (en) * | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| ATE319706T1 (de) * | 2000-09-19 | 2006-03-15 | Centre Nat Rech Scient | Pyridinon und pyridinethion-derivate mit hiv- hemmenden eigenschaften |
| GB0129260D0 (en) * | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
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| WO2004085406A1 (en) | 2003-03-24 | 2004-10-07 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| WO2004096147A2 (en) * | 2003-04-28 | 2004-11-11 | Idenix (Cayman) Limited | Oxo-pyrimidine compounds |
| AU2005235692B2 (en) | 2004-04-23 | 2011-11-10 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| TWI360539B (en) * | 2004-10-28 | 2012-03-21 | Shionogi & Co | 3-carbamoyl-2-pyridone derivatives |
| JP2008525419A (ja) | 2004-12-22 | 2008-07-17 | ファイザー・リミテッド | Ｈｉｖ−１逆転写酵素の非ヌクレオシド阻害剤 |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| ES2320042T3 (es) | 2005-10-19 | 2009-05-18 | F. Hoffmann-La Roche Ag | Inhibidores de transcriptasa reversa con nucleosidos de n-fenil fenilacetamida. |
| EP1940781A1 (en) | 2005-10-19 | 2008-07-09 | F.Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
| ES2431466T3 (es) * | 2006-06-30 | 2013-11-26 | Sunesis Pharmaceuticals, Inc. | Inhibidores de piridinonil pdk1 |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| WO2008098143A2 (en) * | 2007-02-08 | 2008-08-14 | Trius Therapeutics | Antimicrobial compounds and methods of use |
-
2008
- 2008-11-14 CN CN2008801168055A patent/CN101952274A/zh active Pending
- 2008-11-14 RU RU2010125220/04A patent/RU2010125220A/ru unknown
- 2008-11-14 KR KR1020107011127A patent/KR20100088142A/ko not_active Withdrawn
- 2008-11-14 MX MX2010005483A patent/MX2010005483A/es not_active Application Discontinuation
- 2008-11-14 BR BRPI0820162A patent/BRPI0820162A2/pt not_active IP Right Cessation
- 2008-11-14 US US12/742,159 patent/US8404856B2/en active Active
- 2008-11-14 CA CA2705834A patent/CA2705834A1/en active Pending
- 2008-11-14 WO PCT/US2008/012774 patent/WO2009067166A2/en not_active Ceased
- 2008-11-14 AU AU2008326784A patent/AU2008326784B2/en not_active Ceased
- 2008-11-14 EP EP08851089.6A patent/EP2222661B1/en not_active Not-in-force
- 2008-11-14 JP JP2010534947A patent/JP5539216B2/ja not_active Expired - Fee Related
-
2010
- 2010-04-27 IL IL205386A patent/IL205386A0/en unknown
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