JP2016516791A5 - - Google Patents

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Publication number
JP2016516791A5
JP2016516791A5 JP2016508109A JP2016508109A JP2016516791A5 JP 2016516791 A5 JP2016516791 A5 JP 2016516791A5 JP 2016508109 A JP2016508109 A JP 2016508109A JP 2016508109 A JP2016508109 A JP 2016508109A JP 2016516791 A5 JP2016516791 A5 JP 2016516791A5
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JP
Japan
Prior art keywords
pyrrolo
pyridine
carbonitrile
amino
alkoxy
Prior art date
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Application number
JP2016508109A
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English (en)
Japanese (ja)
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JP6461097B2 (ja
JP2016516791A (ja
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Priority claimed from PCT/EP2014/057482 external-priority patent/WO2014170248A1/en
Publication of JP2016516791A publication Critical patent/JP2016516791A/ja
Publication of JP2016516791A5 publication Critical patent/JP2016516791A5/ja
Application granted granted Critical
Publication of JP6461097B2 publication Critical patent/JP6461097B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2016508109A 2013-04-18 2014-04-14 Ｌｒｒｋ２阻害剤としてのアリールピロロピリジン誘導化合物 Expired - Fee Related JP6461097B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201300231 2013-04-18
DKPA201300231 2013-04-18
PCT/EP2014/057482 WO2014170248A1 (en) 2013-04-18 2014-04-14 Arylpyrrolopyridine derived compounds as lrrk2 inhibitors

Publications (3)

Publication Number Publication Date
JP2016516791A JP2016516791A (ja) 2016-06-09
JP2016516791A5 true JP2016516791A5 (enExample) 2018-08-09
JP6461097B2 JP6461097B2 (ja) 2019-01-30

Family

ID=59093654

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016508109A Expired - Fee Related JP6461097B2 (ja) 2013-04-18 2014-04-14 Ｌｒｒｋ２阻害剤としてのアリールピロロピリジン誘導化合物

Country Status (8)

Country Link
US (3) US9499542B2 (enExample)
EP (1) EP2986608B1 (enExample)
JP (1) JP6461097B2 (enExample)
CN (1) CN105263930B (enExample)
AR (1) AR095885A1 (enExample)
ES (1) ES2642204T3 (enExample)
TW (1) TW201533043A (enExample)
WO (1) WO2014170248A1 (enExample)

Families Citing this family (26)

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WO2017156493A1 (en) 2016-03-11 2017-09-14 Denali Therapeutics Inc. Compounds, compositions, and methods
TW201533043A (zh) 2013-04-18 2015-09-01 Lundbeck & Co As H 作爲ｌｒｒｋ２抑制劑的芳基吡咯并吡啶衍生化合物
US11214565B2 (en) 2015-11-20 2022-01-04 Denali Therapeutics Inc. Compound, compositions, and methods
JP2018537502A (ja) 2015-12-16 2018-12-20 サウザーン リサーチ インスチチュート ピロロピリミジン化合物、キナーゼｌｒｒｋ２阻害剤としての使用、及びその調製方法
PT3472153T (pt) * 2016-06-16 2021-12-31 Denali Therapeutics Inc Pirimidin-2-ilamino-1h-pirazóis como inibidores de lrrk2 para uso no tratamento de distúrbios neurodegenerativos
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
JOP20190126A1 (ar) * 2016-12-22 2019-05-28 H Lundbeck As بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
WO2018155947A1 (ko) 2017-02-24 2018-08-30 재단법인 대구경북첨단의료산업진흥재단 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물
AU2018239798B2 (en) 2017-03-23 2020-08-27 Daegu Gyeongbuk Institute Of Science And Technology Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
SG11202005264PA (en) * 2017-12-05 2020-07-29 Oscotec Inc Pyrrolo(pyrazolo)pyrimidine derivative as lrrk2 inhibitor
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
RU2020118913A (ru) 2017-12-14 2022-01-14 Х. Лундбекк А/С (H. Lundbeck A/S) Виды комбинированного лечения, предусматривающего введение 1h-пиразолo[4,3-b]пиридинов
US11535611B2 (en) 2017-12-20 2022-12-27 H. Lundbeck A/S Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
WO2020023393A1 (en) * 2018-07-23 2020-01-30 Bioblocks, Inc. Kinase antagonists and methods for making and using them
KR101990739B1 (ko) * 2018-07-24 2019-06-19 재단법인 대구경북첨단의료산업진흥재단 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물
KR101992059B1 (ko) * 2018-08-23 2019-06-21 재단법인 대구경북첨단의료산업진흥재단 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
CA3168211A1 (en) 2019-01-18 2020-07-23 Voronoi Co., Ltd. Pyrrolopyridine derivative and use thereof for preventing or treating protein kinase related disease
KR102133595B1 (ko) * 2019-05-31 2020-07-13 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
KR20230091150A (ko) * 2020-10-29 2023-06-22 수저우 야바오 파마슈티걸 알앤디 컴퍼니 리미티드 치환된 디아릴아민 화합물 및 이의 약학적 조성물, 제조 방법과 용도
KR20220081631A (ko) 2020-12-09 2022-06-16 보로노이 주식회사 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도
CN112852954A (zh) * 2021-03-16 2021-05-28 江苏贝格尔生物医药有限公司 一种检测lrrk2基因1628多态性的引物和探针及试剂盒
WO2023076404A1 (en) 2021-10-27 2023-05-04 Aria Pharmaceuticals, Inc. Methods for treating systemic lupus erythematosus
US20250361230A1 (en) * 2022-06-06 2025-11-27 The USA, as Represented by the Secretary, Dept. of Heath and Human Services LATS Inhibitors and Uses Thereof
CN119707961B (zh) * 2024-12-02 2025-10-24 重庆飞因科生物科技有限公司 吡啶并吡咯类氨基酸衍生物及其在制备富亮氨酸重复激酶2抑制剂中的应用

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EP1968568A4 (en) 2005-12-22 2011-04-13 Glaxosmithkline Llc HEMMER OF NUTS ACTIVITY
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WO2007090141A2 (en) * 2006-02-01 2007-08-09 Smithkline Beecham Corporation Pyrrolo [2, 3, b] pyridine derivatives useful as raf kinase inhibitors
GB0617161D0 (en) 2006-08-31 2006-10-11 Vernalis R&D Ltd Enzyme inhibitors
WO2008110508A1 (en) * 2007-03-09 2008-09-18 Glaxo Group Limited Pyrrolo-pyridine derivatives for the treatment of disorders associated with inappropriate ikk1 activity
NZ579635A (en) 2007-03-20 2011-07-29 Curis Inc Fused amino pyridine as hsp90 inhibitors
KR101700229B1 (ko) * 2009-03-19 2017-01-26 메디칼 리서치 카운실 테크놀로지 화합물들
GB201008134D0 (en) * 2010-05-14 2010-06-30 Medical Res Council Technology Compounds
GB201015949D0 (en) 2010-09-22 2010-11-03 Medical Res Council Technology Compounds
KR101984480B1 (ko) 2011-04-05 2019-05-31 슬로안-케테링인스티튜트퍼캔서리서치 Ｈｓｐ９０ 억제제
TW201533043A (zh) 2013-04-18 2015-09-01 Lundbeck & Co As H 作爲ｌｒｒｋ２抑制劑的芳基吡咯并吡啶衍生化合物

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