TW201533043A - 作爲ｌｒｒｋ２抑制劑的芳基吡咯并吡啶衍生化合物 - Google Patents
作爲ｌｒｒｋ２抑制劑的芳基吡咯并吡啶衍生化合物 Download PDFInfo
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- TW201533043A TW201533043A TW103112818A TW103112818A TW201533043A TW 201533043 A TW201533043 A TW 201533043A TW 103112818 A TW103112818 A TW 103112818A TW 103112818 A TW103112818 A TW 103112818A TW 201533043 A TW201533043 A TW 201533043A
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- Prior art keywords
- pyridine
- carbonitrile
- pyrrolo
- compound
- amino
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
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| DKPA201300231 | 2013-04-18 |
Publications (1)
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| AR (1) | AR095885A1 (enExample) |
| ES (1) | ES2642204T3 (enExample) |
| TW (1) | TW201533043A (enExample) |
| WO (1) | WO2014170248A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111235B2 (en) | 2016-06-16 | 2021-09-07 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| TWI798905B (zh) * | 2020-10-29 | 2023-04-11 | 大陸商蘇州亞寶藥物研發有限公司 | 取代的二芳基胺化合物及其藥物組合物、製備方法和用途 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201533043A (zh) | 2013-04-18 | 2015-09-01 | Lundbeck & Co As H | 作爲ｌｒｒｋ２抑制劑的芳基吡咯并吡啶衍生化合物 |
| US11214565B2 (en) | 2015-11-20 | 2022-01-04 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| CN108934162A (zh) | 2015-12-16 | 2018-12-04 | 南方研究所 | 吡咯并嘧啶化合物、作为激酶lrrk2抑制剂的用途及其制备方法 |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
| JOP20190126A1 (ar) * | 2016-12-22 | 2019-05-28 | H Lundbeck As | بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1 |
| SG11201908234WA (en) | 2017-02-24 | 2019-10-30 | Daegu Gyeongbuk Medical Innovation Found | Pharmaceutical composition comprising compound capable of penetrating blood-brain barrier as effective ingredient for preventing or treating brain cancer |
| FI3604304T3 (fi) * | 2017-03-23 | 2022-12-15 | Pyrrolopyridiinijohdannaisyhdiste, menetelmä sen valmistamiseksi ja sitä vaikuttavana ainesosana sisältävä farmaseuttinen koostumus proteiinikinaasiin liittyvien tautien ehkäisemiseksi tai hoitamiseksi | |
| KR20190043437A (ko) * | 2017-10-18 | 2019-04-26 | 씨제이헬스케어 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| JP7230053B2 (ja) * | 2017-12-05 | 2023-02-28 | オスコテック インコーポレイテッド | Ｌｒｒｋ２阻害剤としてのピロロ（ピラゾロ）ピリミジン誘導体 |
| AR113926A1 (es) | 2017-12-14 | 2020-07-01 | H Lundbeck As | Derivados de 1h-pirazolo[4,3-b]piridinas |
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| GB201008134D0 (en) * | 2010-05-14 | 2010-06-30 | Medical Res Council Technology | Compounds |
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| US11111235B2 (en) | 2016-06-16 | 2021-09-07 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| TWI786049B (zh) * | 2016-06-16 | 2022-12-11 | 美商戴納立製藥公司 | 化合物、組合物及方法 |
| US11591316B2 (en) | 2016-06-16 | 2023-02-28 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| US11834439B2 (en) | 2016-06-16 | 2023-12-05 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| TWI798905B (zh) * | 2020-10-29 | 2023-04-11 | 大陸商蘇州亞寶藥物研發有限公司 | 取代的二芳基胺化合物及其藥物組合物、製備方法和用途 |
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| JP6461097B2 (ja) | 2019-01-30 |
| AR095885A1 (es) | 2015-11-18 |
| EP2986608B1 (en) | 2017-08-23 |
| US9675594B2 (en) | 2017-06-13 |
| CN105263930B (zh) | 2017-06-09 |
| WO2014170248A1 (en) | 2014-10-23 |
| US9499542B2 (en) | 2016-11-22 |
| HK1222387A1 (en) | 2017-06-30 |
| US20160102089A1 (en) | 2016-04-14 |
| US20140315901A1 (en) | 2014-10-23 |
| ES2642204T3 (es) | 2017-11-15 |
| EP2986608A1 (en) | 2016-02-24 |
| CN105263930A (zh) | 2016-01-20 |
| JP2016516791A (ja) | 2016-06-09 |
| US20170020850A1 (en) | 2017-01-26 |
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