CA2705834A1 - Pyridinone non-nucleoside reverse transcriptase inhibitors - Google Patents

Pyridinone non-nucleoside reverse transcriptase inhibitors Download PDF

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Publication number
CA2705834A1
CA2705834A1 CA2705834A CA2705834A CA2705834A1 CA 2705834 A1 CA2705834 A1 CA 2705834A1 CA 2705834 A CA2705834 A CA 2705834A CA 2705834 A CA2705834 A CA 2705834A CA 2705834 A1 CA2705834 A1 CA 2705834A1
Authority
CA
Canada
Prior art keywords
alkyl
independently
compound
chloro
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2705834A
Other languages
English (en)
French (fr)
Inventor
Thomas J. Tucker
Robert Tynebor
John T. Sisko
Neville Anthony
Robert Gomez
Samson M. Jolly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2705834A1 publication Critical patent/CA2705834A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2705834A 2007-11-20 2008-11-14 Pyridinone non-nucleoside reverse transcriptase inhibitors Pending CA2705834A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US376907P 2007-11-20 2007-11-20
US61/003,769 2007-11-20
PCT/US2008/012774 WO2009067166A2 (en) 2007-11-20 2008-11-14 Non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
CA2705834A1 true CA2705834A1 (en) 2009-05-28

Family

ID=40336474

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2705834A Pending CA2705834A1 (en) 2007-11-20 2008-11-14 Pyridinone non-nucleoside reverse transcriptase inhibitors

Country Status (12)

Country Link
US (1) US8404856B2 (enExample)
EP (1) EP2222661B1 (enExample)
JP (1) JP5539216B2 (enExample)
KR (1) KR20100088142A (enExample)
CN (1) CN101952274A (enExample)
AU (1) AU2008326784B2 (enExample)
BR (1) BRPI0820162A2 (enExample)
CA (1) CA2705834A1 (enExample)
IL (1) IL205386A0 (enExample)
MX (1) MX2010005483A (enExample)
RU (1) RU2010125220A (enExample)
WO (1) WO2009067166A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011120133A1 (en) * 2010-03-30 2011-10-06 Merck Frosst Canada Ltd. Non-nucleoside reverse transcriptase inhibitors

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* Cited by examiner, † Cited by third party
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WO2010026075A1 (en) * 2008-09-04 2010-03-11 F. Hoffmann-La Roche Ag Pyridine derivatives as inhibitors of hiv-i reverse transcriptase
WO2011049987A2 (en) * 2009-10-20 2011-04-28 Eiger Biopharmaceuticals, Inc. Azaindazoles to treat flaviviridae virus infection
WO2011126969A1 (en) * 2010-04-08 2011-10-13 Merck Sharp & Dohme Corp. Prodrugs of an hiv reverse transcriptase inhibitor
US9150539B2 (en) * 2012-09-26 2015-10-06 Merck Sharp & Dohme Corp. Crystalline form of a reverse transcriptase inhibitor
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
EP2928472B1 (en) * 2012-12-05 2018-05-02 Merck Sharp & Dohme Corp. Process for making reverse transcriptase inhibitors
ES2759976T3 (es) * 2013-12-04 2020-05-12 Merck Sharp & Dohme Proceso para fabricar inhibidores de la transcriptasa inversa
RU2693622C2 (ru) 2014-04-01 2019-07-03 Мерк Шарп И Доум Корп. Пролекарственные средства ингибиторов обратной транскриптазы вич
ES2886641T3 (es) 2014-08-11 2021-12-20 Angion Biomedica Corp Inhibidores de citocromo P450 y sus usos
EP3240778A4 (en) 2014-12-31 2018-07-11 Angion Biomedica Corp. Methods and agents for treating disease
CA2998646C (en) * 2015-09-23 2021-05-18 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof
SG11201804098TA (en) 2015-11-20 2018-06-28 Forma Therapeutics Inc Purinones as ubiquitin-specific protease 1 inhibitors
US10981916B2 (en) 2016-12-28 2021-04-20 Dart Neuroscience, Llc Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors
EP3717488B1 (en) 2017-11-27 2021-09-29 Dart NeuroScience, LLC Substituted furanopyrimidine compounds as pde1 inhibitors
PH12021551408A1 (en) 2018-12-18 2022-05-16 Merck Sharp & Dohme Llc Pyrimidone derivatives as selective cytotoxic agents against hiv infected cells
CN114026081B (zh) * 2019-05-22 2025-02-11 默沙东有限责任公司 作为针对hiv感染的细胞的选择性细胞毒性剂的吡啶酮衍生物
CN110066273A (zh) * 2019-06-05 2019-07-30 山东大学 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
CN112876409A (zh) * 2021-01-20 2021-06-01 都创(上海)医药科技股份有限公司 一种2-(5-溴-6-甲氧基吡啶-2-基)乙腈及其衍生物的合成方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99731A0 (en) * 1990-10-18 1992-08-18 Merck & Co Inc Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them
CA2160928C (en) * 1993-07-28 2005-07-05 Garry Fenton Compounds as pde iv and tnf inhibitors
AU4137899A (en) * 1998-04-27 1999-11-16 Centre National De La Recherche Scientifique 3-(amino-or aminoalkyl)pyridinone derivatives and their use for the treatment of HIV related diseases
GB9910577D0 (en) 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds
SE9904045D0 (sv) 1999-11-09 1999-11-09 Astra Ab Compounds
AU2001234420A1 (en) * 2000-02-03 2001-08-14 Eli Lilly And Company Potentiators of glutamate receptors
WO2002022604A1 (en) 2000-09-15 2002-03-21 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2002024650A2 (en) * 2000-09-19 2002-03-28 Centre National De La Recherche Scientifique (Cnrs) Pyridinone and pyridinethione derivatives having hiv inhibiting properties
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
CA2476012C (en) * 2002-02-14 2011-04-19 Pharmacia Corporation Substituted pyridinones as modulators of p38 map kinase
JP5602333B2 (ja) 2003-02-07 2014-10-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖ感染の予防のためのピリミジン誘導体
WO2004085406A1 (en) * 2003-03-24 2004-10-07 F. Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
US20050014774A1 (en) * 2003-04-28 2005-01-20 Richard Storer Oxo-pyrimidine compounds
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
EP1742908B1 (en) 2004-04-23 2009-11-11 F.Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
TWI360539B (en) * 2004-10-28 2012-03-21 Shionogi & Co 3-carbamoyl-2-pyridone derivatives
CA2592092A1 (en) * 2004-12-22 2006-06-29 Pfizer Limited Nonnucleoside inhibitors of hiv-1 reverse transcriptase
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
JP2009515826A (ja) * 2005-10-19 2009-04-16 エフ．ホフマン−ラ ロシュ アーゲー フェニル−アセトアミドｎｎｒｔ阻害剤
RU2008119412A (ru) 2005-10-19 2009-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) N-фенил-фенилацетамидные ненуклеозидные ингибиторы обратной транскриптазы
US8778977B2 (en) * 2006-06-30 2014-07-15 Sunesis Pharmaceuticals, Inc. Pyridinonyl PDK1 inhibitors
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
TW200831085A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
WO2008098143A2 (en) * 2007-02-08 2008-08-14 Trius Therapeutics Antimicrobial compounds and methods of use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011120133A1 (en) * 2010-03-30 2011-10-06 Merck Frosst Canada Ltd. Non-nucleoside reverse transcriptase inhibitors
US8486975B2 (en) 2010-03-30 2013-07-16 Merck Canada Inc. Non-nucleoside reverse transcriptase inhibitors
EA024804B1 (ru) * 2010-03-30 2016-10-31 Мерк Кэнэда Инк. Ненуклеозидные ингибиторы обратной транскриптазы, композиции, их содержащие, и их применение

Also Published As

Publication number Publication date
RU2010125220A (ru) 2011-12-27
EP2222661B1 (en) 2016-04-20
EP2222661A2 (en) 2010-09-01
US20100256181A1 (en) 2010-10-07
US8404856B2 (en) 2013-03-26
KR20100088142A (ko) 2010-08-06
WO2009067166A3 (en) 2009-07-16
MX2010005483A (es) 2010-06-11
BRPI0820162A2 (pt) 2019-09-24
IL205386A0 (en) 2010-12-30
JP2011503230A (ja) 2011-01-27
AU2008326784B2 (en) 2014-04-24
WO2009067166A2 (en) 2009-05-28
CN101952274A (zh) 2011-01-19
AU2008326784A1 (en) 2009-05-28
JP5539216B2 (ja) 2014-07-02

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Effective date: 20130802