MX2010005483A - Inhibidores de transcriptasa inversa no nucleosidos. - Google Patents
Inhibidores de transcriptasa inversa no nucleosidos.Info
- Publication number
- MX2010005483A MX2010005483A MX2010005483A MX2010005483A MX2010005483A MX 2010005483 A MX2010005483 A MX 2010005483A MX 2010005483 A MX2010005483 A MX 2010005483A MX 2010005483 A MX2010005483 A MX 2010005483A MX 2010005483 A MX2010005483 A MX 2010005483A
- Authority
- MX
- Mexico
- Prior art keywords
- reverse transcriptase
- transcriptase inhibitors
- compounds
- nucleoside reverse
- prodrugs
- Prior art date
Links
- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 title 1
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 title 1
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 150000002390 heteroarenes Chemical class 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229940042443 other antivirals in atc Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US376907P | 2007-11-20 | 2007-11-20 | |
| PCT/US2008/012774 WO2009067166A2 (en) | 2007-11-20 | 2008-11-14 | Non-nucleoside reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010005483A true MX2010005483A (es) | 2010-06-11 |
Family
ID=40336474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010005483A MX2010005483A (es) | 2007-11-20 | 2008-11-14 | Inhibidores de transcriptasa inversa no nucleosidos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8404856B2 (enExample) |
| EP (1) | EP2222661B1 (enExample) |
| JP (1) | JP5539216B2 (enExample) |
| KR (1) | KR20100088142A (enExample) |
| CN (1) | CN101952274A (enExample) |
| AU (1) | AU2008326784B2 (enExample) |
| BR (1) | BRPI0820162A2 (enExample) |
| CA (1) | CA2705834A1 (enExample) |
| IL (1) | IL205386A0 (enExample) |
| MX (1) | MX2010005483A (enExample) |
| RU (1) | RU2010125220A (enExample) |
| WO (1) | WO2009067166A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010026075A1 (en) * | 2008-09-04 | 2010-03-11 | F. Hoffmann-La Roche Ag | Pyridine derivatives as inhibitors of hiv-i reverse transcriptase |
| CN102666537A (zh) * | 2009-10-20 | 2012-09-12 | 艾格尔生物制药股份有限公司 | 治疗黄病毒科病毒感染的氮杂吲唑 |
| HUE025336T2 (en) * | 2010-03-30 | 2016-03-29 | Merck Canada Inc | Non-nucleoside reverse transcriptase inhibitors |
| WO2011126969A1 (en) * | 2010-04-08 | 2011-10-13 | Merck Sharp & Dohme Corp. | Prodrugs of an hiv reverse transcriptase inhibitor |
| BR112015005997A8 (pt) * | 2012-09-26 | 2023-04-11 | Merck Sharp & Dohme | Composto |
| JO3470B1 (ar) * | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| EP2928472B1 (en) * | 2012-12-05 | 2018-05-02 | Merck Sharp & Dohme Corp. | Process for making reverse transcriptase inhibitors |
| BR112016012658B1 (pt) * | 2013-12-04 | 2022-06-21 | Merck Sharp & Dohme Corp | Métodos para sintetizar inibidores da transcriptase reversa e composto |
| PL3125894T3 (pl) * | 2014-04-01 | 2021-02-08 | Merck Sharp & Dohme Corp. | Proleki inhibitorów odwrotnej transkryptazy hiv |
| EP3180335B1 (en) | 2014-08-11 | 2021-05-05 | Angion Biomedica Corporation | Cytochrome p450 inhibitors and uses thereof |
| CA2970819A1 (en) | 2014-12-31 | 2016-07-07 | Angion Biomedica Corp. | Methods and agents for treating disease |
| MX391226B (es) * | 2015-09-23 | 2025-03-21 | Merck Sharp & Dohme Llc | Inhibidores de transcriptasa inversa de nucleosido 4'-substituido y preparaciones de los mismos. |
| CN108473495B (zh) | 2015-11-20 | 2022-04-12 | 福马治疗有限公司 | 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮 |
| KR102590848B1 (ko) | 2016-12-28 | 2023-10-19 | 다트 뉴로사이언스, 엘엘씨 | Pde2 억제제로서 치환된 피라졸로피리미디논 화합물 |
| DK3717488T3 (da) | 2017-11-27 | 2021-12-13 | Dart Neuroscience Llc | Substituerede furanopyrimidinforbindelser som pde1-inhibitorer |
| PE20211704A1 (es) | 2018-12-18 | 2021-09-01 | Merck Sharp & Dohme | Derivados de pirimidona como agentes citotoxicos selectivos contra celulas infectadas por vih |
| US20220242847A1 (en) * | 2019-05-22 | 2022-08-04 | Merck Sharp & Dohme Corp. | Pyridinone derivatives as selective cytotoxic agents against hiv infected cells |
| CN110066273A (zh) * | 2019-06-05 | 2019-07-30 | 山东大学 | 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用 |
| CN112876409A (zh) * | 2021-01-20 | 2021-06-01 | 都创(上海)医药科技股份有限公司 | 一种2-(5-溴-6-甲氧基吡啶-2-基)乙腈及其衍生物的合成方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99731A0 (en) * | 1990-10-18 | 1992-08-18 | Merck & Co Inc | Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them |
| JP3775685B2 (ja) * | 1993-07-28 | 2006-05-17 | ローン−プーラン・ロレ・リミテツド | Ｐｄｅ▲ｉｖ▼およびｔｎｆ抑制剤としての化合物 |
| RU2000129671A (ru) * | 1998-04-27 | 2004-02-20 | Сантр Насьональ Де Ля Решерш Сьентифик (Fr) | Производные 3-(амино- или аминоалкил) пиридинона и их применение для лечения болезней, связанных с ВИЧ |
| GB9910577D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| SE9904045D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
| US6800651B2 (en) | 2000-02-03 | 2004-10-05 | Eli Lilly And Company | Potentiators of glutamate receptors |
| WO2002022605A1 (en) * | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| WO2002024650A2 (en) * | 2000-09-19 | 2002-03-28 | Centre National De La Recherche Scientifique (Cnrs) | Pyridinone and pyridinethione derivatives having hiv inhibiting properties |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| ATE448784T1 (de) * | 2002-02-14 | 2009-12-15 | Pharmacia Corp | Substituierte pyridinone als modulatoren für p38 map kinase |
| BRPI0407329A (pt) * | 2003-02-07 | 2006-01-10 | Janssen Pharmaceutica Nv | Derivados de pirimidina para a prevenção de infecção de hiv |
| CN100469769C (zh) | 2003-03-24 | 2009-03-18 | 弗·哈夫曼-拉罗切有限公司 | 作为逆转录酶抑制剂的苄基-哒嗪酮 |
| US20050014774A1 (en) * | 2003-04-28 | 2005-01-20 | Richard Storer | Oxo-pyrimidine compounds |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| BRPI0510059B8 (pt) | 2004-04-23 | 2021-05-25 | Hoffmann La Roche | inibidores da transcriptase reversa não-nucleosídica e seus usos |
| TWI360539B (en) * | 2004-10-28 | 2012-03-21 | Shionogi & Co | 3-carbamoyl-2-pyridone derivatives |
| CA2592092A1 (en) | 2004-12-22 | 2006-06-29 | Pfizer Limited | Nonnucleoside inhibitors of hiv-1 reverse transcriptase |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| CA2625039A1 (en) | 2005-10-19 | 2007-04-26 | F. Hoffmann-La Roche Ag | N-phenyl phenylacetamide non-nucleoside reverse transcriptase inihibitors |
| CN101291905A (zh) | 2005-10-19 | 2008-10-22 | 弗·哈夫曼-拉罗切有限公司 | 苯乙酰胺nnrt抑制剂 |
| EP2038272B8 (en) * | 2006-06-30 | 2013-10-23 | Sunesis Pharmaceuticals, Inc. | Pyridinonyl pdk1 inhibitors |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| US20080194545A1 (en) * | 2007-02-08 | 2008-08-14 | Trius Therapeutics | Antimicrobial compositions and methods of use |
-
2008
- 2008-11-14 KR KR1020107011127A patent/KR20100088142A/ko not_active Withdrawn
- 2008-11-14 AU AU2008326784A patent/AU2008326784B2/en not_active Ceased
- 2008-11-14 CA CA2705834A patent/CA2705834A1/en active Pending
- 2008-11-14 BR BRPI0820162A patent/BRPI0820162A2/pt not_active IP Right Cessation
- 2008-11-14 MX MX2010005483A patent/MX2010005483A/es not_active Application Discontinuation
- 2008-11-14 WO PCT/US2008/012774 patent/WO2009067166A2/en not_active Ceased
- 2008-11-14 US US12/742,159 patent/US8404856B2/en active Active
- 2008-11-14 EP EP08851089.6A patent/EP2222661B1/en not_active Not-in-force
- 2008-11-14 JP JP2010534947A patent/JP5539216B2/ja not_active Expired - Fee Related
- 2008-11-14 RU RU2010125220/04A patent/RU2010125220A/ru unknown
- 2008-11-14 CN CN2008801168055A patent/CN101952274A/zh active Pending
-
2010
- 2010-04-27 IL IL205386A patent/IL205386A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009067166A2 (en) | 2009-05-28 |
| RU2010125220A (ru) | 2011-12-27 |
| WO2009067166A3 (en) | 2009-07-16 |
| JP5539216B2 (ja) | 2014-07-02 |
| JP2011503230A (ja) | 2011-01-27 |
| US8404856B2 (en) | 2013-03-26 |
| EP2222661A2 (en) | 2010-09-01 |
| EP2222661B1 (en) | 2016-04-20 |
| AU2008326784A1 (en) | 2009-05-28 |
| CN101952274A (zh) | 2011-01-19 |
| CA2705834A1 (en) | 2009-05-28 |
| BRPI0820162A2 (pt) | 2019-09-24 |
| US20100256181A1 (en) | 2010-10-07 |
| KR20100088142A (ko) | 2010-08-06 |
| IL205386A0 (en) | 2010-12-30 |
| AU2008326784B2 (en) | 2014-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2010005483A (es) | Inhibidores de transcriptasa inversa no nucleosidos. | |
| MX2009006285A (es) | Inhibidores de transcriptasa inversa no nucleosidicos. | |
| MY163979A (en) | Non-nucleoside reverse transcriptase inhibitors | |
| MD4625B1 (ro) | Derivaţi de 5-fenoxi-3H-pirimidin-4-onă şi utilizarea acestora ca inhibitori ai transcriptazei inverse a HIV | |
| WO2008054605A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2007146230A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2006103399A8 (en) | Hiv integrase inhibitors | |
| IS7892A (is) | Tetrahýdró-4H-pýridó[1,2-A]pýrimidín og tengd efnasambönd sem nýtast sem HIV integrasa hindrar | |
| WO2005086700A3 (en) | Hiv integrase inhibitors | |
| MX2019007262A (es) | Compuestos antivirales de bencilamina fosfodiamida. | |
| TW200738702A (en) | HIV reverse transcriptase inhibitors | |
| WO2010042391A3 (en) | Hiv integrase inhibitors | |
| WO2011025683A8 (en) | Hiv integrase inhibitors | |
| WO2009042094A3 (en) | Hiv protease inhibitors | |
| ATE517899T1 (de) | Hiv-integrasehemmer | |
| WO2007050510A3 (en) | Hiv integrase inhibitors | |
| WO2007002458A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2007002481A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2007002368A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2007021629A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| TN2011000151A1 (en) | Hiv integrase inhibitors | |
| CY1116437T1 (el) | Μη νουκλεοσιδικοι αναστολεις αναστροφης μεταγραφασης | |
| TW200640460A (en) | HIV integrase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |