JP2016518399A5 - - Google Patents
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- JP2016518399A5 JP2016518399A5 JP2016512427A JP2016512427A JP2016518399A5 JP 2016518399 A5 JP2016518399 A5 JP 2016518399A5 JP 2016512427 A JP2016512427 A JP 2016512427A JP 2016512427 A JP2016512427 A JP 2016512427A JP 2016518399 A5 JP2016518399 A5 JP 2016518399A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- hydroxy
- benzamide
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201308409A GB201308409D0 (en) | 2013-05-10 | 2013-05-10 | Compounds |
| GB1308409.0 | 2013-05-10 | ||
| GB201315253A GB201315253D0 (en) | 2013-08-28 | 2013-08-28 | Compounds |
| GB1315253.3 | 2013-08-28 | ||
| PCT/GB2014/051454 WO2014181137A1 (en) | 2013-05-10 | 2014-05-12 | Novel histone deacetylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019015446A Division JP2019077721A (ja) | 2013-05-10 | 2019-01-31 | 新規ヒストンデアセチラーゼインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518399A JP2016518399A (ja) | 2016-06-23 |
| JP2016518399A5 true JP2016518399A5 (enExample) | 2017-03-16 |
| JP6513078B2 JP6513078B2 (ja) | 2019-05-15 |
Family
ID=50736120
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512427A Expired - Fee Related JP6513078B2 (ja) | 2013-05-10 | 2014-05-12 | 新規ヒストンデアセチラーゼインヒビター |
| JP2019015446A Withdrawn JP2019077721A (ja) | 2013-05-10 | 2019-01-31 | 新規ヒストンデアセチラーゼインヒビター |
| JP2020103565A Pending JP2020158523A (ja) | 2013-05-10 | 2020-06-16 | 新規ヒストンデアセチラーゼインヒビター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019015446A Withdrawn JP2019077721A (ja) | 2013-05-10 | 2019-01-31 | 新規ヒストンデアセチラーゼインヒビター |
| JP2020103565A Pending JP2020158523A (ja) | 2013-05-10 | 2020-06-16 | 新規ヒストンデアセチラーゼインヒビター |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9862685B2 (enExample) |
| EP (1) | EP2994465B1 (enExample) |
| JP (3) | JP6513078B2 (enExample) |
| KR (1) | KR20160007577A (enExample) |
| CN (1) | CN105358550B (enExample) |
| AU (1) | AU2014264370B2 (enExample) |
| BR (1) | BR112015028215A2 (enExample) |
| CA (1) | CA2911856A1 (enExample) |
| CY (1) | CY1120705T1 (enExample) |
| DK (1) | DK2994465T3 (enExample) |
| ES (1) | ES2688815T3 (enExample) |
| HR (1) | HRP20181381T1 (enExample) |
| HU (1) | HUE039690T2 (enExample) |
| IL (1) | IL242388B (enExample) |
| LT (1) | LT2994465T (enExample) |
| MX (1) | MX373196B (enExample) |
| NZ (1) | NZ714283A (enExample) |
| PL (1) | PL2994465T3 (enExample) |
| PT (1) | PT2994465T (enExample) |
| RS (1) | RS57816B1 (enExample) |
| SG (1) | SG11201509174UA (enExample) |
| SI (1) | SI2994465T1 (enExample) |
| SM (1) | SMT201800501T1 (enExample) |
| WO (1) | WO2014181137A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010086646A1 (en) | 2009-01-28 | 2010-08-05 | Karus Therapeutics Limited | Scriptaid isosteres and their use in therapy |
| JP5746172B2 (ja) | 2009-08-20 | 2015-07-08 | カルス セラピューティクス リミテッド | ホスホイノシチド３−キナーゼ阻害剤としての三環式複素環化合物 |
| GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
| AU2013343291B2 (en) * | 2012-11-07 | 2018-05-10 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors and their use in therapy |
| WO2017156493A1 (en) | 2016-03-11 | 2017-09-14 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| EP2994465B1 (en) | 2013-05-10 | 2018-08-15 | Karus Therapeutics Limited | Novel histone deacetylase inhibitors |
| GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419264D0 (en) * | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201514756D0 (en) * | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compound and method of use |
| GB201514758D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
| GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
| GB201514754D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| US11214565B2 (en) | 2015-11-20 | 2022-01-04 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| TWI659949B (zh) * | 2016-05-16 | 2019-05-21 | 臺北醫學大學 | 組蛋白去乙醯酶6抑制劑及其用途 |
| GB201609786D0 (en) * | 2016-06-03 | 2016-07-20 | Karus Therapeutics Ltd | Compounds and method of use |
| SI3472153T1 (sl) | 2016-06-16 | 2022-01-31 | Denali Therapeutics Inc. | Pirimidin-2-ilamino-1H-pirazoli kot zaviralci LRRK2 za uporabo pri zdravljenju nevrodegenerativnih motenj |
| KR102556214B1 (ko) * | 2016-07-08 | 2023-07-19 | 주식회사유한양행 | 벤조[d]싸이아졸 유도체 또는 그의 염 및 이를 포함하는 약학 조성물 |
| JP7068297B2 (ja) | 2016-11-10 | 2022-05-16 | アセチロン ファーマシューティカルズ インコーポレイテッド | フェニル及びピリジニルヒドロキサム酸 |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| EP3615025A4 (en) * | 2017-04-26 | 2020-11-25 | The Board of Trustees of the University of Illionis | NRF AND HIF ACTIVATORS / HDAC INHIBITORS AND THERAPEUTIC METHODS USING THEM |
| GB201803361D0 (en) * | 2018-03-01 | 2018-04-18 | Karus Therapeutics Ltd | Histone deacetylase inhibitors |
| KR102328682B1 (ko) | 2018-08-27 | 2021-11-18 | 주식회사 대웅제약 | 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물 |
| WO2020097400A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| US12415816B2 (en) | 2018-11-07 | 2025-09-16 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| JP2022538284A (ja) | 2019-06-27 | 2022-09-01 | ザ ジョージ ワシントン ユニバーシティ， ア コングレッショナリー チャータード ノット－フォー－プロフィット コーポレイション | Ｈｄａｃ６活性化マクロファージ、その組成物および使用 |
| GB201909468D0 (en) | 2019-07-01 | 2019-08-14 | Karus Therapeutics Ltd | Compounds for treating cancer |
| GB201909466D0 (en) * | 2019-07-01 | 2019-08-14 | Karus Therapeutics Ltd | Compounds for treating cancer |
| CN114727974A (zh) | 2019-07-30 | 2022-07-08 | 艾科尼佐治疗股份有限公司 | Hdac6抑制剂及其用途 |
| EP4037670A4 (en) * | 2019-10-03 | 2023-09-27 | Tenaya Therapeutics, Inc. | 5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF |
| EP4076448A4 (en) | 2019-12-20 | 2024-03-27 | Tenaya Therapeutics, Inc. | Fluoroalkyl-oxadiazoles and uses thereof |
| TW202204350A (zh) | 2020-05-06 | 2022-02-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| EP4333841A1 (en) | 2021-05-04 | 2024-03-13 | Tenaya Therapeutics, Inc. | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| KR20240046167A (ko) | 2021-06-28 | 2024-04-08 | 블루프린트 메디신즈 코포레이션 | Cdk2 저해제 |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
| CN120917006A (zh) * | 2023-03-14 | 2025-11-07 | 米拉林制药有限公司 | 作为选择性hdac6抑制剂的杂环化合物 |
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| EP2994465B1 (en) | 2013-05-10 | 2018-08-15 | Karus Therapeutics Limited | Novel histone deacetylase inhibitors |
| US20150105383A1 (en) | 2013-10-10 | 2015-04-16 | Acetylon Pharmaceuticals, Inc. | HDAC Inhibitors, Alone Or In Combination With PI3K Inhibitors, For Treating Non-Hodgkin's Lymphoma |
| GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
| JP6556146B2 (ja) | 2014-08-26 | 2019-08-07 | 武田薬品工業株式会社 | 複素環化合物 |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201514756D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compound and method of use |
| GB201609786D0 (en) | 2016-06-03 | 2016-07-20 | Karus Therapeutics Ltd | Compounds and method of use |
| US11066396B2 (en) | 2016-06-23 | 2021-07-20 | Merck Sharp & Dohme Corp. | 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors |
| WO2017222950A1 (en) | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3-heterocyclyl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| WO2017222952A1 (en) | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| GB201803361D0 (en) | 2018-03-01 | 2018-04-18 | Karus Therapeutics Ltd | Histone deacetylase inhibitors |
-
2014
- 2014-05-12 EP EP14725240.7A patent/EP2994465B1/en active Active
- 2014-05-12 SG SG11201509174UA patent/SG11201509174UA/en unknown
- 2014-05-12 CA CA2911856A patent/CA2911856A1/en not_active Abandoned
- 2014-05-12 KR KR1020157034809A patent/KR20160007577A/ko not_active Abandoned
- 2014-05-12 HU HUE14725240A patent/HUE039690T2/hu unknown
- 2014-05-12 CN CN201480035628.3A patent/CN105358550B/zh not_active Expired - Fee Related
- 2014-05-12 JP JP2016512427A patent/JP6513078B2/ja not_active Expired - Fee Related
- 2014-05-12 DK DK14725240.7T patent/DK2994465T3/en active
- 2014-05-12 RS RS20181097A patent/RS57816B1/sr unknown
- 2014-05-12 LT LTEP14725240.7T patent/LT2994465T/lt unknown
- 2014-05-12 BR BR112015028215A patent/BR112015028215A2/pt not_active IP Right Cessation
- 2014-05-12 ES ES14725240.7T patent/ES2688815T3/es active Active
- 2014-05-12 NZ NZ714283A patent/NZ714283A/en not_active IP Right Cessation
- 2014-05-12 PL PL14725240T patent/PL2994465T3/pl unknown
- 2014-05-12 SI SI201430874T patent/SI2994465T1/sl unknown
- 2014-05-12 WO PCT/GB2014/051454 patent/WO2014181137A1/en not_active Ceased
- 2014-05-12 MX MX2015015450A patent/MX373196B/es active IP Right Grant
- 2014-05-12 US US14/890,331 patent/US9862685B2/en not_active Expired - Fee Related
- 2014-05-12 SM SM20180501T patent/SMT201800501T1/it unknown
- 2014-05-12 HR HRP20181381TT patent/HRP20181381T1/hr unknown
- 2014-05-12 AU AU2014264370A patent/AU2014264370B2/en not_active Ceased
- 2014-05-12 PT PT14725240T patent/PT2994465T/pt unknown
-
2015
- 2015-11-01 IL IL242388A patent/IL242388B/en active IP Right Grant
-
2017
- 2017-08-02 US US15/667,069 patent/US10870624B2/en not_active Expired - Fee Related
-
2018
- 2018-09-18 CY CY181100964T patent/CY1120705T1/el unknown
-
2019
- 2019-01-31 JP JP2019015446A patent/JP2019077721A/ja not_active Withdrawn
-
2020
- 2020-06-16 JP JP2020103565A patent/JP2020158523A/ja active Pending
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