JP2016518399A5 - - Google Patents
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- JP2016518399A5 JP2016518399A5 JP2016512427A JP2016512427A JP2016518399A5 JP 2016518399 A5 JP2016518399 A5 JP 2016518399A5 JP 2016512427 A JP2016512427 A JP 2016512427A JP 2016512427 A JP2016512427 A JP 2016512427A JP 2016518399 A5 JP2016518399 A5 JP 2016518399A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- hydroxy
- benzamide
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201308409A GB201308409D0 (en) | 2013-05-10 | 2013-05-10 | Compounds |
| GB1308409.0 | 2013-05-10 | ||
| GB1315253.3 | 2013-08-28 | ||
| GB201315253A GB201315253D0 (en) | 2013-08-28 | 2013-08-28 | Compounds |
| PCT/GB2014/051454 WO2014181137A1 (en) | 2013-05-10 | 2014-05-12 | Novel histone deacetylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019015446A Division JP2019077721A (ja) | 2013-05-10 | 2019-01-31 | 新規ヒストンデアセチラーゼインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518399A JP2016518399A (ja) | 2016-06-23 |
| JP2016518399A5 true JP2016518399A5 (enExample) | 2017-03-16 |
| JP6513078B2 JP6513078B2 (ja) | 2019-05-15 |
Family
ID=50736120
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512427A Expired - Fee Related JP6513078B2 (ja) | 2013-05-10 | 2014-05-12 | 新規ヒストンデアセチラーゼインヒビター |
| JP2019015446A Withdrawn JP2019077721A (ja) | 2013-05-10 | 2019-01-31 | 新規ヒストンデアセチラーゼインヒビター |
| JP2020103565A Pending JP2020158523A (ja) | 2013-05-10 | 2020-06-16 | 新規ヒストンデアセチラーゼインヒビター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019015446A Withdrawn JP2019077721A (ja) | 2013-05-10 | 2019-01-31 | 新規ヒストンデアセチラーゼインヒビター |
| JP2020103565A Pending JP2020158523A (ja) | 2013-05-10 | 2020-06-16 | 新規ヒストンデアセチラーゼインヒビター |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9862685B2 (enExample) |
| EP (1) | EP2994465B1 (enExample) |
| JP (3) | JP6513078B2 (enExample) |
| KR (1) | KR20160007577A (enExample) |
| CN (1) | CN105358550B (enExample) |
| AU (1) | AU2014264370B2 (enExample) |
| BR (1) | BR112015028215A2 (enExample) |
| CA (1) | CA2911856A1 (enExample) |
| CY (1) | CY1120705T1 (enExample) |
| DK (1) | DK2994465T3 (enExample) |
| ES (1) | ES2688815T3 (enExample) |
| HR (1) | HRP20181381T1 (enExample) |
| HU (1) | HUE039690T2 (enExample) |
| IL (1) | IL242388B (enExample) |
| LT (1) | LT2994465T (enExample) |
| MX (1) | MX373196B (enExample) |
| NZ (1) | NZ714283A (enExample) |
| PL (1) | PL2994465T3 (enExample) |
| PT (1) | PT2994465T (enExample) |
| RS (1) | RS57816B1 (enExample) |
| SG (1) | SG11201509174UA (enExample) |
| SI (1) | SI2994465T1 (enExample) |
| SM (1) | SMT201800501T1 (enExample) |
| WO (1) | WO2014181137A1 (enExample) |
Families Citing this family (41)
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| CN105669540A (zh) | 2009-01-28 | 2016-06-15 | 卡鲁斯治疗有限公司 | Scriptaid电子等排体及其在治疗中的用途 |
| AU2010286168B2 (en) | 2009-08-20 | 2014-05-15 | Karus Therapeutics Limited | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors |
| GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
| IN2015DN03235A (enExample) | 2012-11-07 | 2015-10-02 | Karus Therapeutics Ltd | |
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| GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
| GB201514756D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compound and method of use |
| GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| GB201514754D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| GB201514758D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
| WO2017087905A1 (en) | 2015-11-20 | 2017-05-26 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| TWI659949B (zh) * | 2016-05-16 | 2019-05-21 | 臺北醫學大學 | 組蛋白去乙醯酶6抑制劑及其用途 |
| GB201609786D0 (en) * | 2016-06-03 | 2016-07-20 | Karus Therapeutics Ltd | Compounds and method of use |
| IL299415B2 (en) | 2016-06-16 | 2025-09-01 | Denali Therapeutics Inc | Pyrimidine-2-ylamino-1H-pyrazoles as LRRK2 inhibitors for use in the treatment of neurodegenerative disorders |
| KR102556214B1 (ko) * | 2016-07-08 | 2023-07-19 | 주식회사유한양행 | 벤조[d]싸이아졸 유도체 또는 그의 염 및 이를 포함하는 약학 조성물 |
| WO2018089651A1 (en) | 2016-11-10 | 2018-05-17 | Acetylon Pharmaceuticals, Inc. | Phenyl and pyridinyl hydroxamic acids |
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| AU2018258338B2 (en) * | 2017-04-26 | 2022-07-14 | The Board Of Trustees Of The University Of Illinois | Nrf and HIF activators/HDAC inhibitors and therapeutic methods using the same |
| GB201803361D0 (en) * | 2018-03-01 | 2018-04-18 | Karus Therapeutics Ltd | Histone deacetylase inhibitors |
| KR102328682B1 (ko) | 2018-08-27 | 2021-11-18 | 주식회사 대웅제약 | 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물 |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
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| WO2020097400A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| BR112021026334A2 (pt) | 2019-06-27 | 2022-05-10 | Medstar Health | Macrófagos ativados por hdac6, composições, e usos dos mesmos |
| GB201909468D0 (en) | 2019-07-01 | 2019-08-14 | Karus Therapeutics Ltd | Compounds for treating cancer |
| GB201909466D0 (en) * | 2019-07-01 | 2019-08-14 | Karus Therapeutics Ltd | Compounds for treating cancer |
| WO2021021979A2 (en) | 2019-07-30 | 2021-02-04 | Eikonizo Therapapeutics, Inc. | Hdac6 inhibitors and uses thereof |
| WO2021067859A1 (en) * | 2019-10-03 | 2021-04-08 | Tenaya Therapeutics, Inc. | 5-fluoronicotinamide derivatives and uses thereof |
| CN114980887A (zh) | 2019-12-20 | 2022-08-30 | 特纳亚治疗股份有限公司 | 氟代烷基-噁二唑及其用途 |
| BR112022022409A2 (pt) | 2020-05-06 | 2023-02-07 | Ajax Therapeutics Inc | 6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2 |
| WO2022140527A1 (en) | 2020-12-23 | 2022-06-30 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| WO2022235842A1 (en) | 2021-05-04 | 2022-11-10 | Tenaya Therapeutics, Inc. | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| CN117897384A (zh) | 2021-06-28 | 2024-04-16 | 缆图药品公司 | Cdk2抑制剂 |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
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| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201514756D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compound and method of use |
| GB201609786D0 (en) | 2016-06-03 | 2016-07-20 | Karus Therapeutics Ltd | Compounds and method of use |
| WO2017222952A1 (en) | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| WO2017222951A1 (en) | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| WO2017222950A1 (en) | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3-heterocyclyl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| GB201803361D0 (en) | 2018-03-01 | 2018-04-18 | Karus Therapeutics Ltd | Histone deacetylase inhibitors |
-
2014
- 2014-05-12 ES ES14725240.7T patent/ES2688815T3/es active Active
- 2014-05-12 NZ NZ714283A patent/NZ714283A/en not_active IP Right Cessation
- 2014-05-12 RS RS20181097A patent/RS57816B1/sr unknown
- 2014-05-12 EP EP14725240.7A patent/EP2994465B1/en active Active
- 2014-05-12 KR KR1020157034809A patent/KR20160007577A/ko not_active Abandoned
- 2014-05-12 CA CA2911856A patent/CA2911856A1/en not_active Abandoned
- 2014-05-12 BR BR112015028215A patent/BR112015028215A2/pt not_active IP Right Cessation
- 2014-05-12 PT PT14725240T patent/PT2994465T/pt unknown
- 2014-05-12 DK DK14725240.7T patent/DK2994465T3/en active
- 2014-05-12 HU HUE14725240A patent/HUE039690T2/hu unknown
- 2014-05-12 PL PL14725240T patent/PL2994465T3/pl unknown
- 2014-05-12 SG SG11201509174UA patent/SG11201509174UA/en unknown
- 2014-05-12 SI SI201430874T patent/SI2994465T1/sl unknown
- 2014-05-12 AU AU2014264370A patent/AU2014264370B2/en not_active Ceased
- 2014-05-12 SM SM20180501T patent/SMT201800501T1/it unknown
- 2014-05-12 JP JP2016512427A patent/JP6513078B2/ja not_active Expired - Fee Related
- 2014-05-12 MX MX2015015450A patent/MX373196B/es active IP Right Grant
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- 2014-05-12 WO PCT/GB2014/051454 patent/WO2014181137A1/en not_active Ceased
- 2014-05-12 CN CN201480035628.3A patent/CN105358550B/zh not_active Expired - Fee Related
- 2014-05-12 LT LTEP14725240.7T patent/LT2994465T/lt unknown
- 2014-05-12 US US14/890,331 patent/US9862685B2/en not_active Expired - Fee Related
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2015
- 2015-11-01 IL IL242388A patent/IL242388B/en active IP Right Grant
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2017
- 2017-08-02 US US15/667,069 patent/US10870624B2/en not_active Expired - Fee Related
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2019
- 2019-01-31 JP JP2019015446A patent/JP2019077721A/ja not_active Withdrawn
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2020
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