JP2021504443A5 - - Google Patents

Info

Publication number

JP2021504443A5

JP2021504443A5 JP2020545054A JP2020545054A JP2021504443A5 JP 2021504443 A5 JP2021504443 A5 JP 2021504443A5 JP 2020545054 A JP2020545054 A JP 2020545054A JP 2020545054 A JP2020545054 A JP 2020545054A JP 2021504443 A5 JP2021504443 A5 JP 2021504443A5

Authority

JP

Japan

Prior art keywords

substituted

amino

alkyl

methyl

carboxamide

Prior art date

2018-11-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000000217 alkyl group Chemical group 0.000 claims 114
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 99
• 229910052739 hydrogen Inorganic materials 0.000 claims 95
• 239000001257 hydrogen Substances 0.000 claims 85
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 85
• 125000005842 heteroatom Chemical group 0.000 claims 62
• 125000000623 heterocyclic group Chemical group 0.000 claims 62
• 229910052760 oxygen Inorganic materials 0.000 claims 61
• 229910052717 sulfur Inorganic materials 0.000 claims 58
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 40
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 30
• 125000005843 halogen group Chemical group 0.000 claims 30
• -1 5-fluoropyridin-2-yl Chemical group 0.000 claims 28
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 20
• 125000002837 carbocyclic group Chemical group 0.000 claims 13
• 150000001875 compounds Chemical class 0.000 claims 13
• 150000003839 salts Chemical class 0.000 claims 12
• 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 10
• 125000003545 alkoxy group Chemical group 0.000 claims 10
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
• 125000000304 alkynyl group Chemical group 0.000 claims 9
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 8
• ASFAFOSQXBRFMV-LJQANCHMSA-N 3-n-(2-benzyl-1,3-dihydroxypropan-2-yl)-1-n-[(1r)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzene-1,3-dicarboxamide Chemical compound N([C@H](C)C=1C=CC(F)=CC=1)C(=O)C(C=1)=CC(N(C)S(C)(=O)=O)=CC=1C(=O)NC(CO)(CO)CC1=CC=CC=C1 ASFAFOSQXBRFMV-LJQANCHMSA-N 0.000 claims 7
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 6
• 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 5
• BMTRQKSIZCYODG-UHFFFAOYSA-N 4-methylpyridazine-3-carboxamide Chemical compound CC1=CC=NN=C1C(N)=O BMTRQKSIZCYODG-UHFFFAOYSA-N 0.000 claims 4
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
• FFOLNPHHJUGQBY-UHFFFAOYSA-N n-methylpyridazine-3-carboxamide Chemical compound CNC(=O)C1=CC=CN=N1 FFOLNPHHJUGQBY-UHFFFAOYSA-N 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• JRYYVMDEUJQWRO-UHFFFAOYSA-N 2-methylnicotinamide Chemical compound CC1=NC=CC=C1C(N)=O JRYYVMDEUJQWRO-UHFFFAOYSA-N 0.000 claims 3
• 208000023275 Autoimmune disease Diseases 0.000 claims 3
• 208000027866 inflammatory disease Diseases 0.000 claims 3
• 230000002757 inflammatory effect Effects 0.000 claims 3
• 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims 3
• KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
• SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 2
• DMYLUKNFEYWGCH-UHFFFAOYSA-N pyridazine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=N1 DMYLUKNFEYWGCH-UHFFFAOYSA-N 0.000 claims 2
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
• 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 1
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
• WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
• 206010039710 Scleroderma Diseases 0.000 claims 1
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
• 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 1
• 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 125000001188 haloalkyl group Chemical group 0.000 claims 1
• ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 1
• CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 1
• PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
• 150000003852 triazoles Chemical class 0.000 claims 1