CN111315737B - 经砜吡啶烷基酰胺取代的杂芳基化合物 - Google Patents
经砜吡啶烷基酰胺取代的杂芳基化合物 Download PDFInfo
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- CN111315737B CN111315737B CN201880072389.7A CN201880072389A CN111315737B CN 111315737 B CN111315737 B CN 111315737B CN 201880072389 A CN201880072389 A CN 201880072389A CN 111315737 B CN111315737 B CN 111315737B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762589165P | 2017-11-21 | 2017-11-21 | |
| US62/589,165 | 2017-11-21 | ||
| PCT/US2018/061726 WO2019103952A1 (en) | 2017-11-21 | 2018-11-19 | Sulfone pyridine alkyl amide-substituted heteroaryl compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111315737A CN111315737A (zh) | 2020-06-19 |
| CN111315737B true CN111315737B (zh) | 2024-06-18 |
Family
ID=65036887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880072389.7A Active CN111315737B (zh) | 2017-11-21 | 2018-11-19 | 经砜吡啶烷基酰胺取代的杂芳基化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11021462B2 (enExample) |
| EP (1) | EP3713930A1 (enExample) |
| JP (2) | JP7258903B2 (enExample) |
| KR (1) | KR102702228B1 (enExample) |
| CN (1) | CN111315737B (enExample) |
| AR (1) | AR113895A1 (enExample) |
| AU (3) | AU2018371010C1 (enExample) |
| BR (1) | BR112020009606A2 (enExample) |
| CA (1) | CA3083122A1 (enExample) |
| CL (1) | CL2020001338A1 (enExample) |
| CO (1) | CO2020006139A2 (enExample) |
| EA (1) | EA202091269A1 (enExample) |
| IL (1) | IL274816B2 (enExample) |
| MX (1) | MX2020005210A (enExample) |
| MY (1) | MY202167A (enExample) |
| PE (1) | PE20211461A1 (enExample) |
| SG (1) | SG11202004592TA (enExample) |
| TW (1) | TWI776994B (enExample) |
| WO (1) | WO2019103952A1 (enExample) |
| ZA (1) | ZA202003717B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202004592TA (en) * | 2017-11-21 | 2020-06-29 | Bristol Myers Squibb Co | Sulfone pyridine alkyl amide-substituted heteroaryl compounds |
| CN111484480B (zh) * | 2019-01-29 | 2023-08-11 | 上海翰森生物医药科技有限公司 | 一种多环类衍生物抑制剂、其制备方法和应用 |
| KR20220042159A (ko) | 2019-08-01 | 2022-04-04 | 인테그랄 바이오사이언스 피브이티. 엘티디. | 키나제 억제제로서의 헤테로사이클릭 화합물 및 이의 용도 |
| US12492184B2 (en) | 2020-12-22 | 2025-12-09 | InventisBio Co., Ltd. | Heteroaryl compounds, preparation methods and uses thereof |
| WO2022175747A1 (en) | 2021-02-19 | 2022-08-25 | Sudo Biosciences Limited | Tyk2 inhibitors and uses thereof |
| MX2023009685A (es) | 2021-02-19 | 2023-10-30 | Sudo Biosciences Ltd | Inhibidores de tyk2 y sus usos. |
| US20240246944A1 (en) | 2021-03-16 | 2024-07-25 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Amino heteroaryl compounds and compositions |
| JP2024512497A (ja) * | 2021-03-17 | 2024-03-19 | 武田薬品工業株式会社 | 血漿カリクレインの阻害剤 |
| WO2022206705A1 (zh) * | 2021-03-30 | 2022-10-06 | 浙江文达医药科技有限公司 | 作为tyk2假激酶结构域抑制剂的杂环化合物及合成方法和用途 |
| EP4337650A1 (en) * | 2021-05-14 | 2024-03-20 | Bristol-Myers Squibb Company | Substituted heterocyclic compounds |
| CN115466289A (zh) * | 2021-06-11 | 2022-12-13 | 爱科诺生物医药(香港)有限公司 | 具有tyk2抑制活性的化合物，包含其的药物组合物，及其应用 |
| CN115724830A (zh) * | 2021-08-31 | 2023-03-03 | 浙江文达医药科技有限公司 | 作为tyk2/jak1假激酶结构域(jh2)抑制剂的化合物及合成和使用方法 |
| JP2025503448A (ja) | 2021-12-16 | 2025-02-04 | リンク ファーマシューティカルズ シーオー．エルティーディー． | Ｔｙｋ２阻害剤および組成物ならびにその方法 |
| CN116693449A (zh) * | 2022-03-04 | 2023-09-05 | 上海致根医药科技有限公司 | 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用 |
| CN120661462A (zh) * | 2022-06-20 | 2025-09-19 | 益方生物科技(上海)股份有限公司 | 药物组合物及其用途 |
| US20240025876A1 (en) * | 2022-06-20 | 2024-01-25 | InventisBio Co., Ltd. | Heteroaryl compounds, solid forms, preparation methods and uses thereof |
| CN120303268A (zh) * | 2022-12-16 | 2025-07-11 | 津药生物科技（天津）有限公司 | 新型含杂环取代的丙烯酸衍生物及其用途 |
| CN121057725A (zh) | 2023-04-19 | 2025-12-02 | 上海复宏汉霖生物技术股份有限公司 | 一种杂环取代的芳香化合物、其制备方法及用途 |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104781252A (zh) * | 2012-11-08 | 2015-07-15 | 百时美施贵宝公司 | 用作IL-12、IL-23和/或IFNα应答调节剂的被烷基-酰胺取代的吡啶化合物 |
| CN104884454A (zh) * | 2012-11-08 | 2015-09-02 | 百时美施贵宝公司 | 用作IL-12、IL-23和/或IFNα应答调节剂的酰胺取代的杂环化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013104573A1 (en) * | 2012-01-10 | 2013-07-18 | F. Hoffmann-La Roche Ag | Pyridazine amide compounds and their use as syk inhibitors |
| JP2015534959A (ja) | 2012-10-19 | 2015-12-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｓｙｋの阻害剤 |
| TWI582077B (zh) * | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物 |
| AU2014360446A1 (en) | 2013-12-05 | 2016-06-09 | Pharmacyclics, Llc | Inhibitors of Bruton's tyrosine kinase |
| KR102602558B1 (ko) | 2016-12-13 | 2023-11-14 | 브리스톨-마이어스 스큅 컴퍼니 | Il-12, il-23 및/또는 ifn 알파 반응의 조정제로서의 포스핀 옥시드 알킬 아미드 치환된 헤테로아릴 화합물 |
| SG11202004592TA (en) * | 2017-11-21 | 2020-06-29 | Bristol Myers Squibb Co | Sulfone pyridine alkyl amide-substituted heteroaryl compounds |
-
2018
- 2018-11-19 SG SG11202004592TA patent/SG11202004592TA/en unknown
- 2018-11-19 PE PE2020000703A patent/PE20211461A1/es unknown
- 2018-11-19 WO PCT/US2018/061726 patent/WO2019103952A1/en not_active Ceased
- 2018-11-19 IL IL274816A patent/IL274816B2/en unknown
- 2018-11-19 CN CN201880072389.7A patent/CN111315737B/zh active Active
- 2018-11-19 MX MX2020005210A patent/MX2020005210A/es unknown
- 2018-11-19 EA EA202091269A patent/EA202091269A1/ru unknown
- 2018-11-19 MY MYPI2020002150A patent/MY202167A/en unknown
- 2018-11-19 JP JP2020545054A patent/JP7258903B2/ja active Active
- 2018-11-19 EP EP18836556.3A patent/EP3713930A1/en active Pending
- 2018-11-19 KR KR1020207017459A patent/KR102702228B1/ko active Active
- 2018-11-19 AU AU2018371010A patent/AU2018371010C1/en active Active
- 2018-11-19 BR BR112020009606-7A patent/BR112020009606A2/pt unknown
- 2018-11-19 CA CA3083122A patent/CA3083122A1/en active Pending
- 2018-11-20 TW TW107141159A patent/TWI776994B/zh active
- 2018-11-20 AR ARP180103395A patent/AR113895A1/es unknown
- 2018-11-20 US US16/195,951 patent/US11021462B2/en active Active
-
2020
- 2020-05-19 CO CONC2020/0006139A patent/CO2020006139A2/es unknown
- 2020-05-20 CL CL2020001338A patent/CL2020001338A1/es unknown
- 2020-06-19 ZA ZA2020/03717A patent/ZA202003717B/en unknown
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2021
- 2021-04-28 US US17/242,428 patent/US11787779B2/en active Active
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2022
- 2022-09-06 AU AU2022228101A patent/AU2022228101B2/en active Active
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2023
- 2023-04-05 JP JP2023061359A patent/JP7490107B2/ja active Active
- 2023-09-05 US US18/461,093 patent/US12365667B2/en active Active
- 2023-10-27 AU AU2023255024A patent/AU2023255024B2/en active Active
-
2025
- 2025-06-11 US US19/234,470 patent/US20250304555A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104781252A (zh) * | 2012-11-08 | 2015-07-15 | 百时美施贵宝公司 | 用作IL-12、IL-23和/或IFNα应答调节剂的被烷基-酰胺取代的吡啶化合物 |
| CN104884454A (zh) * | 2012-11-08 | 2015-09-02 | 百时美施贵宝公司 | 用作IL-12、IL-23和/或IFNα应答调节剂的酰胺取代的杂环化合物 |
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