JP2009531322A5 - - Google Patents
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- JP2009531322A5 JP2009531322A5 JP2009500923A JP2009500923A JP2009531322A5 JP 2009531322 A5 JP2009531322 A5 JP 2009531322A5 JP 2009500923 A JP2009500923 A JP 2009500923A JP 2009500923 A JP2009500923 A JP 2009500923A JP 2009531322 A5 JP2009531322 A5 JP 2009531322A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- pharmaceutical composition
- composition according
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 18
- -1 cyano, acetyl Chemical group 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 125000006413 ring segment Chemical group 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000001309 chloro group Chemical group Cl* 0.000 claims 7
- 125000001153 fluoro group Chemical group F* 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- XQAKCTOPIYMCFH-UHFFFAOYSA-N [(2-aminoacetyl)-(methylamino)amino]-(dimethylamino)carbamic acid Chemical compound CNN(C(=O)CN)N(C(=O)O)N(C)C XQAKCTOPIYMCFH-UHFFFAOYSA-N 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 125000004190 benzothiazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)SC2=C1[H] 0.000 claims 3
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 3
- 125000001246 bromo group Chemical group Br* 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 claims 3
- 125000003145 oxazol-4-yl group Chemical group O1C=NC(=C1)* 0.000 claims 3
- 125000004159 quinolin-2-yl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C([H])C(*)=NC2=C1[H] 0.000 claims 3
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims 3
- 125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 claims 3
- 125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 150000003936 benzamides Chemical class 0.000 claims 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 238000011109 contamination Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 150000002825 nitriles Chemical group 0.000 claims 2
- 125000004304 oxazol-5-yl group Chemical group O1C=NC=C1* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0605881A GB0605881D0 (en) | 2006-03-23 | 2006-03-23 | Antibacterial Agents |
| GB0623070A GB0623070D0 (en) | 2006-11-16 | 2006-11-16 | Antibacterial agents |
| PCT/GB2007/001012 WO2007107758A1 (en) | 2006-03-23 | 2007-03-22 | Antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009531322A JP2009531322A (ja) | 2009-09-03 |
| JP2009531322A5 true JP2009531322A5 (enExample) | 2010-05-06 |
Family
ID=38045577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500923A Pending JP2009531322A (ja) | 2006-03-23 | 2007-03-22 | 抗菌剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US8088791B2 (enExample) |
| EP (1) | EP1996180B1 (enExample) |
| JP (1) | JP2009531322A (enExample) |
| KR (1) | KR20090017483A (enExample) |
| CN (1) | CN102008459B (enExample) |
| AT (1) | ATE518564T1 (enExample) |
| AU (1) | AU2007228539B2 (enExample) |
| BR (1) | BRPI0709110A2 (enExample) |
| CA (1) | CA2648785A1 (enExample) |
| DK (1) | DK1996180T3 (enExample) |
| EA (1) | EA015198B1 (enExample) |
| IL (1) | IL193834A0 (enExample) |
| MX (1) | MX2008011857A (enExample) |
| MY (1) | MY148430A (enExample) |
| NZ (1) | NZ571271A (enExample) |
| PL (1) | PL1996180T3 (enExample) |
| WO (1) | WO2007107758A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8653115B2 (en) * | 2006-06-13 | 2014-02-18 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Heterocyclic non-nucleoside compounds, their preparation, pharmaceutical composition and their use as antiviral agents |
| BRPI0720057A2 (pt) | 2006-12-04 | 2013-12-17 | Astrazeneca Ab | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de inibição de girase bacteriana de dna e/ou topoisomerase iv bacteriana em um animal de sangue quente, de produção de um efeito antibacteriano em um animal de sangue quente e de tratamento de uma infecção bacteriana em um animal de sangue quente, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo |
| GB0718335D0 (en) * | 2007-09-20 | 2007-10-31 | Prolysis Ltd | Antibacterial agents |
| GB0718735D0 (en) * | 2007-09-25 | 2007-11-07 | Prolysis Ltd | Antibacterial agents |
| CN106243100B (zh) * | 2008-10-10 | 2019-04-09 | Vm生物医药公司 | 治疗酒精使用障碍，疼痛和其他疾病的药物组合与方法 |
| ES2603032T3 (es) | 2010-07-15 | 2017-02-23 | Bayer Intellectual Property Gmbh | Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas |
| WO2012109527A2 (en) | 2011-02-10 | 2012-08-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Class of hdac inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury |
| EP2699557B1 (en) | 2011-04-20 | 2017-08-16 | Biota Scientific Management Pty Ltd | 3-(oxazol-2-yl-ethoxy)- and 3-(thiazol-2-yl-ethoxy)-benzamide derivatives as anti-bacterial agents |
| WO2013106756A2 (en) | 2012-01-13 | 2013-07-18 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| EP2822931B1 (en) | 2012-03-09 | 2017-05-03 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| EP2828245A1 (en) | 2012-03-21 | 2015-01-28 | Rutgers, The State University of New Jersey | Antimicrobial agents |
| CN103724360B (zh) * | 2012-10-10 | 2016-08-10 | 上海医药工业研究院 | 吡啶(或苯)并噻唑化合物及其中间体、制备方法和应用 |
| US9670236B2 (en) | 2012-10-31 | 2017-06-06 | University of Pittsburgh—of the Commonwealth System of Higher Education | Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury |
| WO2014074932A1 (en) * | 2012-11-08 | 2014-05-15 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| EP2945936A1 (en) | 2012-11-12 | 2015-11-25 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
| JP6404230B2 (ja) | 2012-12-20 | 2018-10-10 | インセプション ２、 インコーポレイテッド | トリアゾロン化合物およびその使用 |
| CA2921420A1 (en) | 2013-09-06 | 2015-03-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| US9458150B2 (en) | 2013-11-08 | 2016-10-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| JP6327841B2 (ja) * | 2013-12-06 | 2018-05-23 | 住友精化株式会社 | 芳香族チアゾール化合物の製造方法 |
| US20170305943A1 (en) | 2014-05-21 | 2017-10-26 | Taxis Pharmaceuticals, Inc. | Compounds for the treatment of bacterial infections |
| CN105461585A (zh) * | 2014-09-09 | 2016-04-06 | 香港理工大学 | 作为β-内酰胺辅助抗生素的3-氨基苯甲酰胺衍生物、制备方法及应用 |
| CN107980040B (zh) | 2015-07-27 | 2021-11-26 | 株式会社钟根堂 | 作为组蛋白去乙酰酶6抑制剂的1,3,4-噁二唑磺酰胺衍生物及含其的医药组合物 |
| US10584117B2 (en) | 2015-07-27 | 2020-03-10 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same |
| MY197262A (en) | 2015-07-27 | 2023-06-08 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| HRP20220003T1 (hr) | 2015-08-04 | 2022-04-01 | Chong Kun Dang Pharmaceutical Corp. | Spojevi derivata 1,3,4-oksadiazola kao inhibitori histonske deacetilaze 6, i farmaceutski pripravak koji ih sadrži |
| HUE061967T2 (hu) | 2015-10-12 | 2023-09-28 | Chong Kun Dang Pharmaceutical Corp | Hiszton deacetiláz-6 inhibitor oxadiazol-amin származékok és az azokat tartalmazó gyógyászati készítmény |
| CA3015768A1 (en) * | 2016-02-25 | 2017-08-31 | Taxis Pharmaceuticals, Inc. | Synthetic processes and intermediates |
| EP3600298A4 (en) | 2017-03-30 | 2020-11-11 | Taxis Pharmaceuticals, Inc. | SYNTHESIS AND SYNTHESIS INTERMEDIARIES |
| HUE066783T2 (hu) | 2018-04-18 | 2024-09-28 | Constellation Pharmaceuticals Inc | Metil módosító enzimek modulátorai, ezek készítményei és alkalmazásuk |
| WO2019226491A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| CN108929273A (zh) * | 2018-06-27 | 2018-12-04 | 合肥医工医药有限公司 | 一种咪唑乙基香草酸醚钠盐的制备方法 |
| KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| EP3643705A1 (en) * | 2018-10-24 | 2020-04-29 | Basf Se | Pesticidal compounds |
| AR118673A1 (es) * | 2019-04-18 | 2021-10-20 | Syngenta Crop Protection Ag | Procedimiento para la preparación de derivados de oxadiazol microbiocidas |
| CA3136223C (en) | 2019-05-31 | 2023-09-12 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| CN111728837A (zh) * | 2020-07-22 | 2020-10-02 | 万贤能 | 一种能揉动腹胸和甩蝴蝶袖运动按摩带及其制备方法 |
| CN117510431A (zh) * | 2023-11-08 | 2024-02-06 | 浙江雅辰药物科技股份有限公司 | 一种异噻唑-3-酮及其衍生物、合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5032617A (en) * | 1985-05-03 | 1991-07-16 | Sri International | Substituted benzamide radiosensitizers |
| US5510375A (en) * | 1993-11-19 | 1996-04-23 | Warner-Lambert Company | Coumarin derivatives as protease inhibitors and antiviral agents |
| JP2002543130A (ja) * | 1999-05-05 | 2002-12-17 | メルク エンド カムパニー インコーポレーテッド | 抗微生物剤としての新規なカテコール類 |
| JPWO2003082808A1 (ja) * | 2002-04-03 | 2005-08-04 | 住友製薬株式会社 | ベンズアミド誘導体 |
| JP5229853B2 (ja) * | 2003-02-28 | 2013-07-03 | ニッポネックス インコーポレイテッド | 癌その他の疾患の治療に有用な新規な二環尿素誘導体 |
| PE20050444A1 (es) * | 2003-10-31 | 2005-08-09 | Takeda Pharmaceutical | Compuestos de piridina como inhibidores de la peptidasa |
| JP2006063064A (ja) * | 2004-07-27 | 2006-03-09 | Takeda Chem Ind Ltd | 受容体作動剤 |
-
2007
- 2007-03-22 DK DK07712942.7T patent/DK1996180T3/da active
- 2007-03-22 CN CN2010105379406A patent/CN102008459B/zh active Active
- 2007-03-22 WO PCT/GB2007/001012 patent/WO2007107758A1/en not_active Ceased
- 2007-03-22 MY MYPI20083737A patent/MY148430A/en unknown
- 2007-03-22 KR KR1020087025801A patent/KR20090017483A/ko not_active Ceased
- 2007-03-22 NZ NZ571271A patent/NZ571271A/en unknown
- 2007-03-22 PL PL07712942T patent/PL1996180T3/pl unknown
- 2007-03-22 JP JP2009500923A patent/JP2009531322A/ja active Pending
- 2007-03-22 US US12/293,608 patent/US8088791B2/en active Active
- 2007-03-22 BR BRPI0709110-9A patent/BRPI0709110A2/pt not_active IP Right Cessation
- 2007-03-22 AT AT07712942T patent/ATE518564T1/de not_active IP Right Cessation
- 2007-03-22 MX MX2008011857A patent/MX2008011857A/es active IP Right Grant
- 2007-03-22 CA CA002648785A patent/CA2648785A1/en not_active Abandoned
- 2007-03-22 EP EP07712942A patent/EP1996180B1/en active Active
- 2007-03-22 AU AU2007228539A patent/AU2007228539B2/en active Active
- 2007-03-22 EA EA200802036A patent/EA015198B1/ru not_active IP Right Cessation
-
2008
- 2008-09-02 IL IL193834A patent/IL193834A0/en unknown
-
2011
- 2011-11-28 US US13/304,748 patent/US8865736B2/en active Active
-
2014
- 2014-08-18 US US14/462,256 patent/US20150191420A1/en not_active Abandoned
-
2025
- 2025-01-27 US US19/037,815 patent/US20250179008A1/en active Pending
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