JP2018527324A5 - - Google Patents
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- Publication number
- JP2018527324A5 JP2018527324A5 JP2018503213A JP2018503213A JP2018527324A5 JP 2018527324 A5 JP2018527324 A5 JP 2018527324A5 JP 2018503213 A JP2018503213 A JP 2018503213A JP 2018503213 A JP2018503213 A JP 2018503213A JP 2018527324 A5 JP2018527324 A5 JP 2018527324A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- aryl
- thiazole
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000000155 isotopic effect Effects 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000012453 solvate Substances 0.000 claims description 4
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 21
- -1 octa-1-ynyl Chemical group 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 13
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 4
- 150000002430 hydrocarbons Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- RGICCULPCWNRAB-UHFFFAOYSA-N 2-[2-(2-hexoxyethoxy)ethoxy]ethanol Chemical compound CCCCCCOCCOCCOCCO RGICCULPCWNRAB-UHFFFAOYSA-N 0.000 claims 2
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- WGEWFHNQCHZZMF-UHFFFAOYSA-N 3-ethynylbenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC(C#C)=C1 WGEWFHNQCHZZMF-UHFFFAOYSA-N 0.000 claims 1
- ZZLCFHIKESPLTH-UHFFFAOYSA-N 4-Methylbiphenyl Chemical compound C1=CC(C)=CC=C1C1=CC=CC=C1 ZZLCFHIKESPLTH-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15306213.8 | 2015-07-24 | ||
| EP15306213 | 2015-07-24 | ||
| PCT/EP2016/067506 WO2017017004A1 (en) | 2015-07-24 | 2016-07-22 | Substituted hydrophobic benzene sulfonamide thiazole compounds for use in treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527324A JP2018527324A (ja) | 2018-09-20 |
| JP2018527324A5 true JP2018527324A5 (enExample) | 2020-12-17 |
| JP6867998B2 JP6867998B2 (ja) | 2021-05-12 |
Family
ID=53758161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503213A Active JP6867998B2 (ja) | 2015-07-24 | 2016-07-22 | ガンを処置するのに使用するための置換疎水性ベンゼンスルホンアミドチアゾール化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10815207B2 (enExample) |
| EP (1) | EP3325452B1 (enExample) |
| JP (1) | JP6867998B2 (enExample) |
| WO (1) | WO2017017004A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3117916A1 (en) | 2018-11-23 | 2020-05-28 | Martin Quibell | Compounds |
| CN115477626B (zh) * | 2021-06-16 | 2024-08-02 | 上海璃道医药科技有限公司 | N-取代苯基磺酰胺类化合物及其用途 |
| EP4201928A1 (en) | 2021-12-21 | 2023-06-28 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Benzene sulfonamide thiazole compounds and their use for the treatment of cancers |
| WO2024084013A1 (en) * | 2022-10-20 | 2024-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination therapy for the treatment of cancer |
| WO2025219595A1 (en) * | 2024-04-19 | 2025-10-23 | Biper Therapeutics | Method for combination treatments using alkynylbenzenesulphonamides for cancer therapy |
| EP4635480A1 (en) | 2024-04-19 | 2025-10-22 | Biper Therapeutics SAS | Compositions comprising a benzene sulfonamide thiazole compound |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2817219B2 (ja) | 1988-09-08 | 1998-10-30 | 武田薬品工業株式会社 | カルバジン酸誘導体、その製造法及び製剤 |
| US7163952B2 (en) | 2001-12-03 | 2007-01-16 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
| EP1971597A2 (en) | 2005-12-12 | 2008-09-24 | Genelabs Technologies, Inc. | N-(5-membered heteroaromatic ring)-amido anti-viral compounds |
| EP2062181A2 (en) * | 2006-08-28 | 2009-05-27 | Dan Theodorescu | Prediction of an agent's or agents' activity across different cells and tissue types |
| BRPI0814432A2 (pt) | 2007-07-17 | 2017-05-09 | Rigel Pharmaceuticals Inc | pirimidinadiaminas substituídas por amina cíclica como inibidores de pkc |
| WO2009146013A1 (en) * | 2008-03-31 | 2009-12-03 | Georgetown University | Myosin light chain phosphatase inhibitors |
| JP6539839B2 (ja) * | 2012-11-09 | 2019-07-10 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル）Ｉｎｓｅｒｍ（Ｉｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅｌａ Ｓａｎｔｅ Ｅｔ Ｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｍｅｄｉｃａｌｅ） | 新規のベンゼンスルホンアミドチアゾール化合物 |
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2016
- 2016-07-22 EP EP16741632.0A patent/EP3325452B1/en active Active
- 2016-07-22 US US15/746,630 patent/US10815207B2/en active Active
- 2016-07-22 WO PCT/EP2016/067506 patent/WO2017017004A1/en not_active Ceased
- 2016-07-22 JP JP2018503213A patent/JP6867998B2/ja active Active
-
2020
- 2020-09-21 US US17/026,395 patent/US20210040054A1/en not_active Abandoned